Pharmacology And Pharmacokinetics

Author : Robert C. Bast, Jr.,Carlo M. Croce,William N. Hait,Waun Ki Hong,Donald W. Kufe,Martine Piccart-Gebhart,Raphael E. Pollock,Ralph R. Weichselbaum,Hongyang Wang,James F. Holland
Publisher : John Wiley & Sons
Page : 2008 pages
File Size : 53,5 Mb
Release : 2017-03-10
Category : Medical
ISBN : 9781119000846

Get Book

Holland-Frei Cancer Medicine by Robert C. Bast, Jr.,Carlo M. Croce,William N. Hait,Waun Ki Hong,Donald W. Kufe,Martine Piccart-Gebhart,Raphael E. Pollock,Ralph R. Weichselbaum,Hongyang Wang,James F. Holland Pdf

Holland-Frei Cancer Medicine, Ninth Edition, offers a balanced view of the most current knowledge of cancer science and clinical oncology practice. This all-new edition is the consummate reference source for medical oncologists, radiation oncologists, internists, surgical oncologists, and others who treat cancer patients. A translational perspective throughout, integrating cancer biology with cancer management providing an in depth understanding of the disease An emphasis on multidisciplinary, research-driven patient care to improve outcomes and optimal use of all appropriate therapies Cutting-edge coverage of personalized cancer care, including molecular diagnostics and therapeutics Concise, readable, clinically relevant text with algorithms, guidelines and insight into the use of both conventional and novel drugs Includes free access to the Wiley Digital Edition providing search across the book, the full reference list with web links, illustrations and photographs, and post-publication updates

Author : T. Teorell
Publisher : Springer Science & Business Media
Page : 386 pages
File Size : 42,8 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9781468420555

Get Book

Pharmacology and Pharmacokinetics by T. Teorell Pdf

This collection of papers by leading pharmacokineticists and pharmacolo gists is the proceedings of a conference held at the John E. · Fogarty International Center for Advanced Study in the Health Sciences, National Institutes of Health, October 30 to November 1, 1972. As part of its advanced study program, the Center conducts workshops, seminars, and conferences on topics related to the biomedical interests of the Scholars-in Residence. Professor Torsten Teorell came to the Center in 1970 as one of the first Scholars. In 1971 and 1972, he spent several months at the Center devoting his attention to contemporary problems in the application of pharmacoki netics to experimental and clinical pharmacology. As one of the founders of pharmacokinetics, Professor Teorell has made many contributions to the field since he first presented a formal multicompartment model for the analysis of drug action and drug metabolism in 1937 (Teorell, 1937). Since the appearance of his original paper, pharmacodynamics, or pharmacoki netics, has become increasingly important as a tool for the study of drug action in patients. The translation of experimental pharmacological findings into therapeutic regimens is today increasingly dependent on ade qua te models of drug action. The purpose of the conference, of which this book is the proceedings, was to discuss contemporary findings in this important biomedical research field. The conference program was designed by Professor Teorell with the help of a small committee which included Drs. Edward R.

Author : Mark Tomlin
Publisher : Springer Science & Business Media
Page : 79 pages
File Size : 48,7 Mb
Release : 2010-07-30
Category : Medical
ISBN : 9781849961462

Get Book

Pharmacology & Pharmacokinetics by Mark Tomlin Pdf

Effective drug administration is a crucial skill for any practitioner working in the critical care unit. This book, in providing a concise account of the fundamental principles of pharmacology and pharmacokinetics, equips the critical care physician for such a task. In addition to the principles of pharmacology and pharmacokinetics, this volume alerts the reader to factors that affect drug action such as disease, pregnancy and age, and advises on how to adjust drug dosages accordingly. The specialist therapeutics covered comprise drugs targeting the gastro-intestinal tract, sedation, non-opioid analgesia and opiates. A quick and easy reference, this volume will prove a valuable asset for both trainees and fully qualified practitioners in critical care.

Author : Peter L. Bonate
Publisher : Springer Science & Business Media
Page : 648 pages
File Size : 49,6 Mb
Release : 2005-12-05
Category : Medical
ISBN : 0971176744

Get Book

Pharmacokinetics in Drug Development by Peter L. Bonate Pdf

These volumes are designed to be the most complete guide to pharmacokinetics (PK) and its role in drug development. They fill a gap between the academic science and the practical application of that knowledge in drug development. Volume 1 discusses the role that PK plays in selected clinical study designs. Volume 2 details the key regulatory and development paradigms in which PK supplements decision-making during drug development.

Author : Thorsteinn Loftsson
Publisher : Academic Press
Page : 178 pages
File Size : 40,7 Mb
Release : 2015-03-25
Category : Medical
ISBN : 9780128014912

Get Book

Essential Pharmacokinetics by Thorsteinn Loftsson Pdf

Essential Pharmacokinetics: A Primer for Pharmaceutical Scientists is an introduction to the concepts of pharmacokinetics intended for graduate students and new researchers working in the pharmaceutical sciences. This book describes the mathematics used in the mammillary model as well as the application of pharmacokinetics to pharmaceutical product development, and is useful as both a self-study and classroom resource. Content coverage includes detailed discussions of common models and important pharmacokinetic concepts such as biological half-life, clearance, excretion, multiple dosage regimens and more. Numerous equations, practical examples and figures are incorporated to clearly illustrate the theoretical background of pharmacokinetic behavior of drugs and excipients. Shows how to apply basic pharmacokinetic methods to evaluate drugs, excipients and drug products Uses guided practice questions, mathematical concepts and real-world examples for self-assessment and retention purposes Illustrates how to write and evaluate drug registration files

Author : Siamak Cyrus Khojasteh,Harvey Wong,Cornelis E.C.A. Hop
Publisher : Springer Science & Business Media
Page : 222 pages
File Size : 50,6 Mb
Release : 2011-04-07
Category : Medical
ISBN : 9781441956293

Get Book

Drug Metabolism and Pharmacokinetics Quick Guide by Siamak Cyrus Khojasteh,Harvey Wong,Cornelis E.C.A. Hop Pdf

Drug Metabolism and Pharmacokinetics Quick Guide covers a number of aspects of drug assessment at drug discovery and development stages, topics such as pharmacokinetics, absorption, metabolism, enzyme kinetics, drug transporters, drug interactions, drug-like properties, assays and in silico calculations. It covers key concepts, with useful tables on physiological parameters (eg. blood flow to organs in x-species, expression and localization of enzymes and transporters), chemical structure, nomenclature, and moieties leading to bioactivation (with examples). Overall it includes a number of key topics useful at the drug discovery stage, which would serve as a quick reference with several examples from the literature to illustrate the concept.

Author : Ntambwe Malangu
Publisher : BoD – Books on Demand
Page : 164 pages
File Size : 54,5 Mb
Release : 2018-05-23
Category : Medical
ISBN : 9781789231380

Get Book

Pharmacokinetics and Adverse Effects of Drugs by Ntambwe Malangu Pdf

This book is a fruit of a collaborative work from several international scientists. It will be a useful resource for researchers, students, and clinicians. Each individual chapter could serve as a prescribed reading for postgraduate students and clinicians specializing in and practicing clinical pharmacology and toxicology, pharmacotherapy and pharmacotherapeutics, pharmacovigilance, and toxicovigilance, as well as those involved in clinical research, drug discovery, and development. Every chapter in this book discusses and provides illustrations on the theme discussed based on authors' understanding and experience while summarizing existing knowledge. In doing so, each chapter provides a new insight that would benefit a novice as well as a seasoned reader in understanding the pharmacokinetic mechanisms and risk factors involved in the occurrence of adverse effects of drugs.

Author : David J. Kerr,Daniel G. Haller,Cornelis J. H. van de Velde,Michael Baumann
Publisher : Oxford University Press
Page : 832 pages
File Size : 42,7 Mb
Release : 2016-01-28
Category : Medical
ISBN : 9780191065118

Get Book

Oxford Textbook of Oncology by David J. Kerr,Daniel G. Haller,Cornelis J. H. van de Velde,Michael Baumann Pdf

Now in paperback, the Oxford Textbook of Oncology reflects current best practice in the multidisciplinary management of cancer, written and edited by internationally recognised leaders in the field. Structured in six sections, the book provides an accessible scientific basis to the key topics of oncology, examining how cancer cells grow and function, as well as discussing the aetiology of cancer, and the general principles governing modern approaches to oncology treatment. The book examines the challenges presented by the treatment of cancer on a larger scale within population groups, and the importance of recognising and supporting the needs of individual patients, both during and after treatment. A series of disease-oriented, case-based chapters, ranging from acute leukaemia to colon cancer, highlight the various approaches available for managing the cancer patient, including the translational application of cancer science in order to personalise treatment. The advice imparted in these cases has relevance worldwide, and reflects a modern approach to cancer care. The Oxford Textbook of Oncology provides a comprehensive account of the multiple aspects of best practice in the discipline, making it an indispensable resource for oncologists of all grades and subspecialty interests.

Author : Thomas N. Tozer,Malcolm Rowland
Publisher : Lippincott Williams & Wilkins
Page : 342 pages
File Size : 40,6 Mb
Release : 2006
Category : Medical
ISBN : 0781751497

Get Book

Introduction to Pharmacokinetics and Pharmacodynamics by Thomas N. Tozer,Malcolm Rowland Pdf

This unique text helps students and healthcare professionals master the fundamentals of pharmacokinetics and pharmacodynamics. Written by distinguished international experts, it provides readers with an introduction to the basic principles underlying the establishment and individualization of dosage regimens and their optimal use in drug therapy. Up-to-date examples featuring currently prescribed drugs illustrate how pharmacokinetics and pharmacodynamics relate to contemporary drug therapy. Study problems at the end of each chapter help students and professionals gain a firm grasp of the material covered within the text.

Author : Peter G. Welling,Luc P. Balant
Publisher : Springer
Page : 572 pages
File Size : 50,7 Mb
Release : 1994
Category : Pharmacokinetics
ISBN : UOM:39015032596978

Get Book

Pharmacokinetics of Drugs by Peter G. Welling,Luc P. Balant Pdf

Author : Hartmut Derendorf,Guenther Hochhaus
Publisher : CRC Press
Page : 496 pages
File Size : 49,5 Mb
Release : 2019-06-04
Category : Medical
ISBN : 9781000005905

Get Book

Handbook of Pharmacokinetic/Pharmacodynamic Correlation by Hartmut Derendorf,Guenther Hochhaus Pdf

First published in 1995: Combining the established disciplines of pharmacokinetics (PK), the relationship between drug concentration and time, and pharmacodynamics (PD), the relationship between drug effects and concentration, this handbook examines the relevant relationship between drug effects and time.

Author : Mohsen A. Hedaya
Publisher : CRC Press
Page : 595 pages
File Size : 41,9 Mb
Release : 2012-02-09
Category : Medical
ISBN : 9781439850756

Get Book

Basic Pharmacokinetics by Mohsen A. Hedaya Pdf

Knowledge of pharmacokinetics is critical to understanding the absorption, distribution, metabolism, and excretion of drugs. It is therefore vital to those engaged in the discovery, development, and preclinical and clinical evaluation of drugs, as well as practitioners involved in the clinical use of drugs. Using different approaches accessible to

Author : Donald J. Birkett
Publisher : McGraw Hill Professional
Page : 162 pages
File Size : 52,8 Mb
Release : 2002
Category : Medical
ISBN : 0074710729

Get Book

Pharmacokinetics Made Easy by Donald J. Birkett Pdf

Pharmacokinetics Made Easy 1Rpresents the complex subject of pharmacokinetics in a simple, easy-to-understand manner, lending itself to a wide audience including medical practitioners, health professionals and students of pharmacology, medicine and nursing. The physiological approach adopted in the book allows clinical issues in drug therapy to be addressed, making it directly applicable to practice situations. The chapters in this book were initially published as a series of articles inAustralian Prescriberto assist practitioners in drug dosing and therapy. In this revised edition, the book has been updated according to recent developments and a new chapter called 'How to Determine the Pharmacokinetic Parameters of a Drug' added. Each chapter also has a new feature-a list of key points summarising the content to improve accessibility and understanding.

Author : Jennifer B. Dressman,Christos Reppas
Publisher : CRC Press
Page : 432 pages
File Size : 50,6 Mb
Release : 2016-04-19
Category : Medical
ISBN : 9781420077346

Get Book

Oral Drug Absorption by Jennifer B. Dressman,Christos Reppas Pdf

Oral Drug Absorption, Second Edition thoroughly examines the special equipment and methods used to test whether drugs are released adequately when administered orally. The contributors discuss methods for accurately establishing and validating in vitro/in vivo correlations for both MR and IR formulations, as well as alternative approaches for MR an

Author : Notari
Publisher : Routledge
Page : 287 pages
File Size : 46,8 Mb
Release : 2017-11-22
Category : Science
ISBN : 9781351463843

Get Book

Biopharmaceutics and Clinical Pharmacokinetics by Notari Pdf

For a decade and a half, Biopharmaceutics and Clinical Pharmacokinetics has been used in theclassrooms around the world as an introductory textbook on biophannaceutics and phannacokinetics. Now, the new Fourth Edition, Revised and Expanded further enhances the preceding editions'proven features, introducing significant advances in clinical pharmacokinetics, pharmacokineticdesign of drugs and dosage forms, and model-independent analyses. Still usable without prior knowledge of calculus or kinetics, this successfully implemented workbookmaintains a carefully graduated "building block" presentation, incorporating sample problemsand exercises throughout for a thorough understanding of the material.Biopharmaceutics and Clinical Pharmacokinetics features a growth-oriented format that systematicallydevelops and interrelates all subject matter .. . introduces basic theory and fields of application... emphasizes model-independent pharmacokinetic analyses ... presents biopharmaceutical aspectsof product design and evaluation .. . offers a unique approach to teaching dosage regimen design andindividualization . .. and considers structural modification of drug molecules for problems associatedwith pharmacokinetics. As a comprehensive coverage of the basic principles and the recent achievements in the field, noother textbook does as much for students of pharmacy, pharmacology, medicinal chemistry, andmedicine, or for scientists who desire a simple but thorough introduction to theory and application.