Electrophysiology Of The Neuron

Author : John Huguenard,David McCormick
Publisher : Oxford University Press, USA
Page : 92 pages
File Size : 52,8 Mb
Release : 1994
Category : Medical
ISBN : UOM:39015032435599

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Electrophysiology of the Neuron by John Huguenard,David McCormick Pdf

This manual and disk, available in IBM PC and Macintosh formats, accompanies Shepherd's Neurobiology, 3/e. It can be used separately even though it is keyed to the textbook. The 17 experiments investigate such areas as the resting membrane potential, action potential, voltage clamp, physiological properties of nerve cells, and synaptic potentials. The program allows students to propagate the action potential, adjust various parameters and observe the effects on nerve cell firing. Students will learn about equilibrium potentials and the effects of changing ion concentrations, as well as passive and active membrane properties. Separate experiments analyze sodium ion and potassium ion currents, the voltage dependence of these currents, and sleep vs. waking in single neurons. Study questions are provided throughout. This ingeniously-designed program will benefit all undergraduate students of neuroscience.

Author : Mohammad M. Aria
Publisher : Academic Press
Page : 180 pages
File Size : 52,5 Mb
Release : 2020-05-15
Category : Medical
ISBN : 9780128170717

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Electrophysiology Measurements for Studying Neural Interfaces by Mohammad M. Aria Pdf

Electrophysiology Measurements for Studying Neural Interfaces helps readers to choose a proper cell line and set-up for studying different bio-electronic interfaces before delving into the electrophysiology techniques available. Therefore, this book details the materials and devices needed for different types of neural stimulation such as photoelectrical and photothermal stimulations. Also, modern techniques like optical electrophysiology and calcium imaging in this book provides readers with more available approaches to monitor neural activities in addition to whole-cell patch-clamp technology. Details steps of an electrophysiology project from start to finish for graduate students employing the technique in their research Includes sample electrophysiological studies with multiple cell lines (PC12, N2a, NG108, SHSY, and embryonic stem cell lines) to facilitate research Features data analysis of electrophysiology results from various relevant experiments and cell culture tips

Author : Ellen Covey,Matt Carter
Publisher : Oxford University Press, USA
Page : 241 pages
File Size : 44,6 Mb
Release : 2015
Category : Medical
ISBN : 9780199939800

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Basic Electrophysiological Methods by Ellen Covey,Matt Carter Pdf

A broad, concise, and no-nonsense guide to contemporary electrophysiological techniques, covering intracellular and extracellular recording through recording of population activity, neuropharmacology, dye imaging, voltammetry, and optogenetics.

Author : Nicholas Graziane,Yan Dong
Publisher : Springer Nature
Page : 283 pages
File Size : 42,9 Mb
Release : 2022-08-03
Category : Medical
ISBN : 9781071625897

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Electrophysiological Analysis of Synaptic Transmission by Nicholas Graziane,Yan Dong Pdf

This second edition volume expands on the previous edition with discussions on the latest techniques used to study synaptic transmissions. The chapters in this book are organized into six parts. Part One looks at the basic concepts, such as extracellular and intracellular recordings, and spatiotemporal effects of synaptic currents. Part Two describes the recording of synaptic currents, such as measuring kinetics of synaptic current and measuring reversal potentials. Part Three discusses basic experimentations of synaptic transmission and covers run-up and run-down, and amplitude. Parts Four and Five cover experimentations with computational components and molecular and visual components, such as measurement of a single synapse and electrophysiological and visual tags. Part Six explores in vivo recordings and talks about general considerations for in vivo exploration of synaptic plasticity. In the Neuromethods series style, chapters include the kind of detail and key advice from the specialists needed to get successful results in your laboratory. Authoritative and thorough, Electrophysiological Analysis of Synaptic Transmission, Second Edition is a valuable resource that introduces graduate students and postdoctoral fellows to important topics in this field and also expands these topics to practical electrophysiological approaches.

Author : Makoto Taketani,Michel Baudry
Publisher : Springer Science & Business Media
Page : 488 pages
File Size : 43,7 Mb
Release : 2006-11-22
Category : Medical
ISBN : 9780387258584

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Advances in Network Electrophysiology by Makoto Taketani,Michel Baudry Pdf

Advances in Network Electrophysiology: Using Multi Electrode Arrays explores methods for using electrophysiological techniques for monitoring the concurrent activity of ensembles of single neurons. It reviews the recent progress in both electronics and computational tools developed to analyze the functional operations of large ensembles of neurons using multi-electrode arrays and in vitro preparations. In addition, it gives readers a sense of the applications made possible by these technological tools. This volume is the reference for researchers, industry, graduate students, and postdoctoral fellows in all areas of neuroscience, cognitive neuroscience, pharmaceutical science, and bioengineering.

Author : Robert P. Vertes,Robert W. Stackman, Jr.
Publisher : Humana Press
Page : 0 pages
File Size : 43,7 Mb
Release : 2010-11-19
Category : Medical
ISBN : 1603272011

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Electrophysiological Recording Techniques by Robert P. Vertes,Robert W. Stackman, Jr. Pdf

Applying neurophysiological methods to the study of brain-behavior relationships proved to be a major advance in the early days of neuroscience research. Considerable technological progress has been made very recently, and the impact on modern neuroscience will be invaluable. In Electrophysiological Recording Techniques, experts in the field present a current view of the widespread application of electrophysiological methods to the study of the brain and to the problem of brain-behavior relationships. The book has been organized to display the range of modern neurophysiological methods ranging from the recordings of single neurons and neuronal ensembles to recordings of field potentials within discrete brain regions and across multiple brain areas. Many of the chapters also address the major challenge of applying the appropriate methods to analyze and interpret neurophysiological recording data. As a volume in the popular Neuromethods series, the chapters provide authoritative reviews of many commonly used approaches in the field today in both the basic research level and in clinical settings. Practical and up-to-date, Electrophysiological Recording Techniques serves as a key reference volume for researchers working in this ever-changing and vital field.

Author : Stephen W. Kuffler,John G. Nicholls
Publisher : Unknown
Page : 499 pages
File Size : 47,9 Mb
Release : 1977
Category : Electrophysiology
ISBN : OCLC:1014652776

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From Neuron to Brain by Stephen W. Kuffler,John G. Nicholls Pdf

Author : Michel J.A.M. van Putten
Publisher : Springer Nature
Page : 259 pages
File Size : 54,7 Mb
Release : 2020-12-18
Category : Science
ISBN : 9783662611845

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Dynamics of Neural Networks by Michel J.A.M. van Putten Pdf

This book treats essentials from neurophysiology (Hodgkin–Huxley equations, synaptic transmission, prototype networks of neurons) and related mathematical concepts (dimensionality reductions, equilibria, bifurcations, limit cycles and phase plane analysis). This is subsequently applied in a clinical context, focusing on EEG generation, ischaemia, epilepsy and neurostimulation. The book is based on a graduate course taught by clinicians and mathematicians at the Institute of Technical Medicine at the University of Twente. Throughout the text, the author presents examples of neurological disorders in relation to applied mathematics to assist in disclosing various fundamental properties of the clinical reality at hand. Exercises are provided at the end of each chapter; answers are included. Basic knowledge of calculus, linear algebra, differential equations and familiarity with MATLAB or Python is assumed. Also, students should have some understanding of essentials of (clinical) neurophysiology, although most concepts are summarized in the first chapters. The audience includes advanced undergraduate or graduate students in Biomedical Engineering, Technical Medicine and Biology. Applied mathematicians may find pleasure in learning about the neurophysiology and clinic essentials applications. In addition, clinicians with an interest in dynamics of neural networks may find this book useful, too.

Author : Matt Carter,Rachel Essner,Nitsan Goldstein,Manasi Iyer
Publisher : Academic Press
Page : 416 pages
File Size : 47,7 Mb
Release : 2022-03-26
Category : Medical
ISBN : 9780323915618

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Guide to Research Techniques in Neuroscience by Matt Carter,Rachel Essner,Nitsan Goldstein,Manasi Iyer Pdf

Modern neuroscience research is inherently multidisciplinary, with a wide variety of cutting edge new techniques to explore multiple levels of investigation. This Third Edition of Guide to Research Techniques in Neuroscience provides a comprehensive overview of classical and cutting edge methods including their utility, limitations, and how data are presented in the literature. This book can be used as an introduction to neuroscience techniques for anyone new to the field or as a reference for any neuroscientist while reading papers or attending talks. Nearly 200 updated full-color illustrations to clearly convey the theory and practice of neuroscience methods Expands on techniques from previous editions and covers many new techniques including in vivo calcium imaging, fiber photometry, RNA-Seq, brain spheroids, CRISPR-Cas9 genome editing, and more Clear, straightforward explanations of each technique for anyone new to the field A broad scope of methods, from noninvasive brain imaging in human subjects, to electrophysiology in animal models, to recombinant DNA technology in test tubes, to transfection of neurons in cell culture Detailed recommendations on where to find protocols and other resources for specific techniques "Walk-through" boxes that guide readers through experiments step-by-step

Author : Eugene M. Izhikevich
Publisher : MIT Press
Page : 459 pages
File Size : 41,7 Mb
Release : 2010-01-22
Category : Medical
ISBN : 9780262514200

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Dynamical Systems in Neuroscience by Eugene M. Izhikevich Pdf

Explains the relationship of electrophysiology, nonlinear dynamics, and the computational properties of neurons, with each concept presented in terms of both neuroscience and mathematics and illustrated using geometrical intuition. In order to model neuronal behavior or to interpret the results of modeling studies, neuroscientists must call upon methods of nonlinear dynamics. This book offers an introduction to nonlinear dynamical systems theory for researchers and graduate students in neuroscience. It also provides an overview of neuroscience for mathematicians who want to learn the basic facts of electrophysiology. Dynamical Systems in Neuroscience presents a systematic study of the relationship of electrophysiology, nonlinear dynamics, and computational properties of neurons. It emphasizes that information processing in the brain depends not only on the electrophysiological properties of neurons but also on their dynamical properties. The book introduces dynamical systems, starting with one- and two-dimensional Hodgkin-Huxley-type models and continuing to a description of bursting systems. Each chapter proceeds from the simple to the complex, and provides sample problems at the end. The book explains all necessary mathematical concepts using geometrical intuition; it includes many figures and few equations, making it especially suitable for non-mathematicians. Each concept is presented in terms of both neuroscience and mathematics, providing a link between the two disciplines. Nonlinear dynamical systems theory is at the core of computational neuroscience research, but it is not a standard part of the graduate neuroscience curriculum—or taught by math or physics department in a way that is suitable for students of biology. This book offers neuroscience students and researchers a comprehensive account of concepts and methods increasingly used in computational neuroscience. An additional chapter on synchronization, with more advanced material, can be found at the author's website, www.izhikevich.com.

Author : V. S. Rusinov,Vladimir Sergeevich Rusinov
Publisher : Springer
Page : 536 pages
File Size : 55,7 Mb
Release : 1970-03
Category : Medical
ISBN : UOM:39015004419795

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Electrophysiology of the Central Nervous System by V. S. Rusinov,Vladimir Sergeevich Rusinov Pdf

The most important yet the most difficult scientific task confront ing man is how his brain produces his behavior and his subjective experience. The complexity of this problem is ineffably vast, ex ceeding by many orders of magnitude the theoretical and technical achievements concerning atomic energy or the exploration of space. Unlike these areas of endeavor, neuroscience is fortunate in knowing no national rivalries, and its only secrecies are those of language. The latter, however, are often highly effective in con cealing from workers in Los Angeles the discoveries of their co- leagues in Moscow. A cogent example is provided in this volume by Roy John (p. 179) whose experiments proceeded for several years before he discovered the important body of data accumulated earlier by Prof. Livanov and his colleagues utilizing the same ingenious technique of the "tracer stimulus." Reduction of such occurrences is certainly one of the goals of the present book, which now becomes a double translation, a dozen of the papers having originally been translated into Russian.

Author : Gonzalo Alarcón,Antonio Valentín
Publisher : Cambridge University Press
Page : 641 pages
File Size : 45,5 Mb
Release : 2012-04-26
Category : Medical
ISBN : 9780521691581

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Introduction to Epilepsy by Gonzalo Alarcón,Antonio Valentín Pdf

Covers all aspects of epilepsy, from basic mechanisms to diagnosis and management, as well as legal and social considerations.

Author : P. Michael Conn
Publisher : Academic Press
Page : 521 pages
File Size : 49,5 Mb
Release : 2013-10-22
Category : Science
ISBN : 9781483269368

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Methods in Neurosciences by P. Michael Conn Pdf

Methods in Neurosciences, Volume 4: Electrophysiology and Microinjection is a collection of papers that deals with the electrically excitability feature of many cell types. This volume describes the characteristic features of some nervous tissue to conduct signals along cellular paths or ""wires."" The text presents such paths as a way stimuli are transferred in the nervous system. Section I reviews the recording methodologies such as those used in measuring noninactivating calcium current in smooth muscles cells or the two-suction electrode voltage-clamp recording. Section II deals in detail with voltage clamping and voltammetry; the text also explains the practical steps in using the current pump-assisted voltage clamp. One paper examines the X-ray microprobe analysis of voltage clamped single heart ventricular myocytes, while another paper explains in vivo voltammetry. Section III addresses electrophysiology and purification of specific receptors; one paper presents the results of an electrophysiological study of hormone secretion by single adenohypophyseal cells. Section IV describes special electrodes and equipment, while Section V deals with special preparations needed in culture preparation or in the study of pharmacology of excitatory amino acids on neurons found in the central nervous system. Chapter VI addresses data analysis and reduction such as digital filtering of bioelectric potentials in personal computers. This book will prove valuable for microbiologists, cellular scientists, microchemists, and academicians working in the fields of neuroscience.

Author : D. I. Wallis
Publisher : Unknown
Page : 324 pages
File Size : 43,9 Mb
Release : 1993
Category : Cytology
ISBN : UOM:49015002134337

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Electrophysiology by D. I. Wallis Pdf

Electrophysiological techniques are vital to modern biology in general and are of particular significance in neuroscience. This volume provides a practical introduction to the methods used for studying single cells and complex neural tissues. Detailed advice is given not only for handling and culturing neural tissues and cells, but also for the mathematical approaches to modeling neuronal behavior and analysing the quantal release of neurotransmitters. An important sourcebook of protocols, helpful hints, and expert advice, it will prove invaluable to researchers in neuroscience, physiology, cell biology, and related areas

Author : Areles Molleman
Publisher : John Wiley & Sons
Page : 186 pages
File Size : 48,5 Mb
Release : 2003-06-13
Category : Science
ISBN : 9780470856512

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Patch Clamping by Areles Molleman Pdf

Patch clamping is a widely applied electrophysiological technique for the study of ion channels; membrane proteins that regulate the flow of ions across cellular membranes and therefore influence the physiology of all cells. Patch Clamping aims to cover the basic principles and practical applications of this important technique. Starting with a review of the history of patch clamping, the text then goes on to cover the basic principles, platforms, equipment and environmental control, and will also include coverage of preparation types, recording modes and analysis of results. This book will explain the basic principles and practical application of patch clamp electrophysiology Written in a non-technical style to ensure its broad appeal to novice users Takes a practical approach This self-contained guide provides everything a practising patch clamp electrophysiologist needs to know to master this technique, including an overview of membrane biophysics, standard experimental design, data analysis, and technical concerns