Elizabeth Blackburn And The Story Of Telomeres

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Elizabeth Blackburn and the Story of Telomeres

Author : Catherine Brady
Publisher : MIT Press
Page : 405 pages
File Size : 47,6 Mb
Release : 2009-02-13
Category : Biography & Autobiography
ISBN : 9780262261968

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Elizabeth Blackburn and the Story of Telomeres by Catherine Brady Pdf

The story of molecular biologist Elizabeth Blackburn and her groundbreaking research on telomeres and what it reveals about the resourceful opportunism that characterizes the best scientific thinking. Molecular biologist Elizabeth Blackburn—one of Time magazine's 100 “Most Influential People in the World” in 2007—made headlines in 2004 when she was dismissed from the President's Council on Bioethics after objecting to the council's call for a moratorium on stem cell research and protesting the suppression of relevant scientific evidence in its final report. But it is Blackburn's groundbreaking work on telomeric DNA, which launched the field of telomere research, that will have the more profound and long-lasting effect on science and society. In this compelling biography, Catherine Brady tells the story of Elizabeth Blackburn's life and work and the emergence of a new field of scientific research on the specialized ends of chromosomes and the enzyme, telomerase, that extends them. In the early stages of telomere research, telomerase, heralded as a potential cure for cancer and diseases related to aging, attracted the voracious interest of biotech companies. The surrounding hype succeeded in confusing the role of telemorase in extending the life of a cell with a mechanism that might extend the lifespan of an entire organism. In Brady's hands, Blackburn's story reveals much about the tension between pure and applied science, the politicking that makes research science such a competitive field, and the resourceful opportunism that characterizes the best scientific thinking. Brady describes the science accessibly and compellingly. She explores Blackburn's struggle to break down barriers in an elite, male-dominated profession, her role as a mentor to other women scientists (many of whom have made their mark in telomere research), and the collaborative nature of scientific work. This book gives us a vivid portrait of an exceptional woman and a new understanding of the combination of curiosity, imaginative speculation, and aesthetic delight that powers scientific discovery.

Elizabeth Blackburn and the Story of Telomeres

Author : Catherine Brady
Publisher : MIT Press
Page : 413 pages
File Size : 51,5 Mb
Release : 2009-02-13
Category : Biography & Autobiography
ISBN : 9780262512459

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Elizabeth Blackburn and the Story of Telomeres by Catherine Brady Pdf

The story of molecular biologist Elizabeth Blackburn and her groundbreaking research on telomeres and what it reveals about the resourceful opportunism that characterizes the best scientific thinking. Molecular biologist Elizabeth Blackburn—one of Time magazine's 100 “Most Influential People in the World” in 2007—made headlines in 2004 when she was dismissed from the President's Council on Bioethics after objecting to the council's call for a moratorium on stem cell research and protesting the suppression of relevant scientific evidence in its final report. But it is Blackburn's groundbreaking work on telomeric DNA, which launched the field of telomere research, that will have the more profound and long-lasting effect on science and society. In this compelling biography, Catherine Brady tells the story of Elizabeth Blackburn's life and work and the emergence of a new field of scientific research on the specialized ends of chromosomes and the enzyme, telomerase, that extends them. In the early stages of telomere research, telomerase, heralded as a potential cure for cancer and diseases related to aging, attracted the voracious interest of biotech companies. The surrounding hype succeeded in confusing the role of telemorase in extending the life of a cell with a mechanism that might extend the lifespan of an entire organism. In Brady's hands, Blackburn's story reveals much about the tension between pure and applied science, the politicking that makes research science such a competitive field, and the resourceful opportunism that characterizes the best scientific thinking. Brady describes the science accessibly and compellingly. She explores Blackburn's struggle to break down barriers in an elite, male-dominated profession, her role as a mentor to other women scientists (many of whom have made their mark in telomere research), and the collaborative nature of scientific work. This book gives us a vivid portrait of an exceptional woman and a new understanding of the combination of curiosity, imaginative speculation, and aesthetic delight that powers scientific discovery.

The Telomere Effect

Author : Dr. Elizabeth Blackburn,Dr. Elissa Epel
Publisher : Grand Central Publishing
Page : 328 pages
File Size : 50,8 Mb
Release : 2017-01-03
Category : Health & Fitness
ISBN : 9781455587964

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The Telomere Effect by Dr. Elizabeth Blackburn,Dr. Elissa Epel Pdf

The New York Times bestselling book coauthored by the Nobel Prize winner who discovered telomerase and telomeres' role in the aging process and the health psychologist who has done original research into how specific lifestyle and psychological habits can protect telomeres, slowing disease and improving life. Have you wondered why some sixty-year-olds look and feel like forty-year-olds and why some forty-year-olds look and feel like sixty-year-olds? While many factors contribute to aging and illness, Dr. Elizabeth Blackburn discovered a biological indicator called telomerase, the enzyme that replenishes telomeres, which protect our genetic heritage. Dr. Blackburn and Dr. Elissa Epel's research shows that the length and health of one's telomeres are a biological underpinning of the long-hypothesized mind-body connection. They and other scientists have found that changes we can make to our daily habits can protect our telomeres and increase our health spans (the number of years we remain healthy, active, and disease-free). The Telemere Effect reveals how Blackburn and Epel's findings, together with research from colleagues around the world, cumulatively show that sleep quality, exercise, aspects of diet, and even certain chemicals profoundly affect our telomeres, and that chronic stress, negative thoughts, strained relationships, and even the wrong neighborhoods can eat away at them. Drawing from this scientific body of knowledge, they share lists of foods and suggest amounts and types of exercise that are healthy for our telomeres, mind tricks you can use to protect yourself from stress, and information about how to protect your children against developing shorter telomeres, from pregnancy through adolescence. And they describe how we can improve our health spans at the community level, with neighborhoods characterized by trust, green spaces, and safe streets. The Telemere Effect will make you reassess how you live your life on a day-to-day basis. It is the first book to explain how we age at a cellular level and how we can make simple changes to keep our chromosomes and cells healthy, allowing us to stay disease-free longer and live more vital and meaningful lives.

The Telomere Effect

Author : Elizabeth Blackburn,Elissa Epel
Publisher : Hachette UK
Page : 416 pages
File Size : 45,8 Mb
Release : 2017-01-26
Category : Self-Help
ISBN : 9781409173014

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The Telomere Effect by Elizabeth Blackburn,Elissa Epel Pdf

Have you ever wondered why some sixty-year-olds look and feel like forty-year-olds, and why some forty-year-olds look and feel like sixty-year-olds? More importantly - can you choose which outcome will happen to you? Written by Nobel Prize winner Elizabeth Blackburn and health psychologist Elissa Epel, The Telomere Effect reveals the ground-breaking science at the heart of ageing - and what you can do to help reverse it. While many factors contribute to ageing and illness, Elizabeth and Elissa's award-winning research has revealed that the length of our telomeres - the part of our chromosomes which determine how fast our cells age and die - can have a direct effect on how quickly or slowly we age. In this pioneering book, discover for the first time the many simple changes you can make to your diet, sleep and mental wellbeing to look after your telomeres. From which foods to eat, types of exercise to practise, various mind tricks to prevent stress - and how to shield your children from developing shorter telomeres from conception through to adolescence - start protecting your telomeres and your youth today.

Telomere Miracle

Author : Ed Park, MD
Publisher : Hay House, Inc
Page : 280 pages
File Size : 47,9 Mb
Release : 2018-01-23
Category : Health & Fitness
ISBN : 9781401952587

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Telomere Miracle by Ed Park, MD Pdf

What if everything you think you know about getting older and staying healthy is wrong? Ed Park, M.D., offers the revolutionary idea that disease and aging in humans all arises from a single source: genetic errors caused by shortening of telomeres, or the sequences of DNA at the ends of our chromosomes. Telomeres naturally wear down over time, and thus when cells replicate (as they do all the time in our bodies), they’re creating progressively poorer-quality duplicates of themselves, like making a Xerox of a Xerox of a Xerox. Ultimately, the body deteriorates, resulting in a range of ailments, many of which we associate with aging—from diabetes to hypertension to macular degeneration to cancer. Happily, Ed tells us, it’s possible to slow or even reverse this process and effectively turn back the clock. In The Telomere Miracle, he explains cutting-edge science in a lively style, using illustrations and metaphors ranging from auto parts to superheroes. Then he shows readers how they can intervene in the aging process by boosting the activity of the enzyme telomerase naturally by understanding and optimizing six key areas of breathing, mindset, sleep, exercise, diet, and supplements.

Telomere Timebombs

Author : Ed Park
Publisher : Unknown
Page : 218 pages
File Size : 51,7 Mb
Release : 2013-08
Category : Integrative medicine
ISBN : 0989583708

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Telomere Timebombs by Ed Park Pdf

Telomere Timebombs: Defusing the Terror of Aging showcases a revolutionary new way to think about aging and health. Dr. Ed Park's entertaining and insightful new book introduces readers to Telomeres - repetitive DNA sequences that play a vital role in aging. Telomeres, if kept intact, can afford a lifetime of better sleep, healthier skin, better mood, better exercise recovery time, and even an improved sex life. Life-changing Information For millions, the fear of growing old is in itself enough to force out grey hairs and wrinkles. However, this compelling book presents a wholly-refreshing way to embrace aging and total health. While life-changing, Dr. Park's wisdom is far from complicated. In fact, using entertaining analogies ranging from queen bees to automobile repair, the book is poised to resonate with young and old around the world. Synopsis This fresh, fascinating and often funny book teaches you why we get old and sick and describes the journeys back to health and youth experienced after taking Telomerase Activation Medicine. It outlines a future in which Telomerase Activation Medicine has changed all your expectations about getting old. Dr. Park explains how it works: "Telomeres, or 'end bodies' are the caps that protect our chromosomes like the plastic tips on shoelaces. Each time a cell divides into two daughters, the daughters are left with shorter telomeres. These telomeres caps shorten like burning fuses on the end of a firecracker. When those 'fuses' become too short, the chromosomes are damaged and the cell either stops functioning properly or dies," he says. Continuing, "There is a cure for this erosion called the Telomerase Enzyme, and it is built into every single stem cell in your body. Stem cells are like queen bees that need produce many thousands of worker drones, so a stem cell always needs to add back telomere length to prevent premature damage and death." By keeping the Telomere length as long as possible, the individual can enjoy prolonged vitality, youthfulness and overall health. This is achieved through an ingestible supplement called TA-65, a molecule discovered by scientists to be a Telomerase activator. As one of the first twenty people in the world to trial it and, after noticing astonishing results, Dr. Park became the first medical doctor licensed to prescribe TA-65. Since then, hundreds of physicians and tens of thousands of patients have jumped on board with amazing results and no adverse effects. A Grand Unified Theory of Aging and Disease Dr. Park has developed a simple and intuitive new model of aging based on Telomere erosion and Stem Cell biology that will shift and unify much of the research and efforts currently in vogue. With his renowned knack for presenting his concepts in an engaging and easy-to-understand way, Dr. Park likens it to the on-going upkeep of an automobile. "Why not think of it as car maintenance? You are just changing your oil and replacing old parts. There is a man in New York who has maintained his Volvo for 3 million miles. Is the Volvo Corporation going to strike him down with a lightning bolt? No They love him ," he adds. Those wanting to find out how to embark on their own personal journey back to youthful health by using Telomere Activation Medicine are urged to purchase this book.

A Force of Nature: The Frontier Genius of Ernest Rutherford

Author : Richard Reeves
Publisher : W. W. Norton & Company
Page : 209 pages
File Size : 42,5 Mb
Release : 2008-12-17
Category : Biography & Autobiography
ISBN : 9780393333695

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A Force of Nature: The Frontier Genius of Ernest Rutherford by Richard Reeves Pdf

In this new intellectual biography of Ernest Rutherford, the 20th centurys greatest experimental physicist, Reeves portrays a ruddy, genial man who was also a towering figure in scientific history.

The Right Chemistry

Author : Joe Schwarcz
Publisher : Doubleday Canada
Page : 272 pages
File Size : 41,6 Mb
Release : 2012-11-06
Category : Science
ISBN : 9780385671606

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The Right Chemistry by Joe Schwarcz Pdf

A big part of Dr. Joe's job as director of McGill University's Office of Science and Society is persuading people that the pursuit of science knowledge is a potential source of wonder, enlightenment and well-being for everyone. And as a chemist, he's particularly keen to rescue chemistry from the bad rep it's developed over recent decades. There is more to chemistry than toxins, pollution, and "Don't drink that soda--it's full of chemicals." The evangelic zeal Dr. Joe brings to his day job is of course also the driving force behind his work as an author. Once again, here he is to tell that everything is full of chemicals, and that chemistry means health, nutrition, beauty products, cleaning products, DNA, and the means by which Lady Gaga's meat dress was held together. In the style established with the bestselling Brain Fuel, each section here is themed and contains a mixture of short, pithy items and slightly longer mini-essays. And as before--but never with such energy and relish--Dr. Joe goes on the attack against charlatans in the alternative health trade, naming and shaming them in a particularly entertaining and edifying section of the book called "Claptrap." You will learn whether to put broccoli on a pizza before or after baking, whether beauty pills are worth taking, and whether the baby shampoo you're using is poisonous. You will discover but not use, please, the recipe for a Molotov cocktail. You will be enabled to enthrall fellow dinner guests with the derivation of the name Persil, and the definition of a kangarian (it's someone who only eats kangaroo meat). As ever, this torrent of entertainment is delivered in Dr. Joe's unmistakably warm, lively and authorative voice.

The Telomerase Revolution

Author : Michael Fossel
Publisher : Atlantic Books Ltd
Page : 281 pages
File Size : 55,6 Mb
Release : 2015-10-06
Category : Medical
ISBN : 9781782399117

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The Telomerase Revolution by Michael Fossel Pdf

Science is on the cusp of a revolutionary breakthrough. We now understand more about ageing - and how to prevent and reverse it - than ever before. In The Telomerase Revolution, Dr Michael Fossel, who has been at the cutting edge of ageing research for decades, describes how telomerase will soon be used as a powerful therapeutic tool, with the potential to intervene in age-related disease, dramatically extend life spans and even reverse human ageing. Telomerase-based treatments are already on offer, and have shown early promise, but much more potent treatments will become available over the next decade. This is the definitive work on the latest science of human ageing, covering both the theory and the clinical implications, taking readers to the forefront of one of the most remarkable advances in human medicine.

The Vaccine Race

Author : Meredith Wadman
Publisher : Penguin
Page : 464 pages
File Size : 40,8 Mb
Release : 2017-02-07
Category : Science
ISBN : 9780698177789

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The Vaccine Race by Meredith Wadman Pdf

"A real jewel of science history...brims with suspense and now-forgotten catastrophe and intrigue...Wadman’s smooth prose calmly spins a surpassingly complicated story into a real tour de force."—The New York Times “Riveting . . . [The Vaccine Race] invites comparison with Rebecca Skloot's 2007 The Immortal Life of Henrietta Lacks.”—Nature The epic and controversial story of a major breakthrough in cell biology that led to the conquest of rubella and other devastating diseases. Until the late 1960s, tens of thousands of American children suffered crippling birth defects if their mothers had been exposed to rubella, popularly known as German measles, while pregnant; there was no vaccine and little understanding of how the disease devastated fetuses. In June 1962, a young biologist in Philadelphia, using tissue extracted from an aborted fetus from Sweden, produced safe, clean cells that allowed the creation of vaccines against rubella and other common childhood diseases. Two years later, in the midst of a devastating German measles epidemic, his colleague developed the vaccine that would one day wipe out homegrown rubella. The rubella vaccine and others made with those fetal cells have protected more than 150 million people in the United States, the vast majority of them preschoolers. The new cells and the method of making them also led to vaccines that have protected billions of people around the world from polio, rabies, chicken pox, measles, hepatitis A, shingles and adenovirus. Meredith Wadman’s masterful account recovers not only the science of this urgent race, but also the political roadblocks that nearly stopped the scientists. She describes the terrible dilemmas of pregnant women exposed to German measles and recounts testing on infants, prisoners, orphans, and the intellectually disabled, which was common in the era. These events take place at the dawn of the battle over using human fetal tissue in research, during the arrival of big commerce in campus labs, and as huge changes take place in the laws and practices governing who “owns” research cells and the profits made from biological inventions. It is also the story of yet one more unrecognized woman whose cells have been used to save countless lives. With another frightening virus--measles--on the rise today, no medical story could have more human drama, impact, or urgency than The Vaccine Race.

The Compassionate Equestrian

Author : Allen Schoen,Susan Gordon
Publisher : Trafalgar Square Books
Page : 440 pages
File Size : 55,8 Mb
Release : 2015-08-17
Category : Pets
ISBN : 9781570767173

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The Compassionate Equestrian by Allen Schoen,Susan Gordon Pdf

This marvelous book, borne of a unique collaboration between Dr. Allen Schoen—a world-renowned veterinarian and author—and trainer and competitor of many years Susan Gordon, introduces the 25 Principles of Compassionate Equitation. These Principles, conceived by Dr. Schoen and Gordon, are a set of developmental guidelines, encouraging a level of personal awareness that may be enacted not only through the reader's engagement with horses, but can be extended to all humans and sentient beings he or she encounters. The 25 Principles share stories and outline current, peer-reviewed studies that identify and support methods of training, handling, and caring for horses that constitute a safe, healthy, non-stressful, and pain-free environment. Through their Compassionate Equestrian program, the authors encourage all involved in the horse industry to approach training and handling with compassion and a willingness to alleviate suffering. By developing deeper compassion for their own horses, and subsequently, all equines, equestrians transcend their differences in breed preferences, riding disciplines, and training methodologies. This leads to the ability to empathize and connect more closely with the “global collective” of horses and horse people. In doing so, a worldwide community of compassionate equine practitioners and horse owners will emerge, which will not only benefit the horses: People involved with horses are found in many influential segments of society and have the potential to affect wide circles of friends, acquaintances, and co-workers from every walk of life. These are simple changes any horse person can make that can have a vast impact on the horse industry and society as a whole.

To Build a Better World

Author : Philip Zelikow,Condoleezza Rice
Publisher : Twelve
Page : 528 pages
File Size : 45,9 Mb
Release : 2019-09-10
Category : Political Science
ISBN : 9781538764664

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To Build a Better World by Philip Zelikow,Condoleezza Rice Pdf

A deeply researched international history and "exemplary study" (New York Times Book Review) of how a divided world ended and our present world was fashioned, as the world drifts toward another great time of choosing. Two of America's leading scholar-diplomats, Philip Zelikow and Condoleezza Rice, have combed sources in several languages, interviewed leading figures, and drawn on their own firsthand experience to bring to life the choices that molded the contemporary world. Zeroing in on the key moments of decision, the might-have-beens, and the human beings working through them, they explore both what happened and what could have happened, to show how one world ended and another took form. Beginning in the late 1970s and carrying into the present, they focus on the momentous period between 1988 and 1992, when an entire world system changed, states broke apart, and societies were transformed. Such periods have always been accompanied by terrible wars -- but not this time. This is also a story of individuals coping with uncertainty. They voice their hopes and fears. They try out desperate improvisations and careful designs. These were leaders who grew up in a "postwar" world, who tried to fashion something better, more peaceful, more prosperous, than the damaged, divided world in which they had come of age. New problems are putting their choices, and the world they made, back on the operating table. It is time to recall not only why they made their choices, but also just how great nations can step up to great challenges. Timed for the thirtieth anniversary of the fall of the Berlin Wall, To Build a Better World is an authoritative depiction of contemporary statecraft. It lets readers in on the strategies and negotiations, nerve-racking risks, last-minute decisions, and deep deliberations behind the dramas that changed the face of Europe -- and the world -- forever.

Borrowed Time

Author : Sue Armstrong
Publisher : Bloomsbury Publishing
Page : 273 pages
File Size : 49,9 Mb
Release : 2019-01-24
Category : Science
ISBN : 9781472936073

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Borrowed Time by Sue Armstrong Pdf

As featured on BBC Radio 4's Start the Week 'A rich, timely study for the era of "global ageing"'- Nature The ageing of the world population is one of the most important issues facing humanity in the 21st century – up there with climate change in its potential global impact. Sometime before 2020, the number of people over 65 worldwide will, for the first time, be greater than the number of 0–4 year olds, and it will keep on rising. The strains this is causing on society are already evident as health and social services everywhere struggle to cope with the care needs of the elderly. But why and how do we age? Scientists have been asking this question for centuries, yet there is still no agreement. There are a myriad competing theories, from the idea that our bodies simply wear out with the rough and tumble of living, like well-worn shoes or a rusting car, to the belief that ageing and death are genetically programmed and controlled. In Borrowed Time, Sue Armstrong tells the story of science's quest to understand ageing and to prevent or delay the crippling conditions so often associated with old age. She focusses inward – on what is going on in our bodies at the most basic level of the cells and genes as the years pass – to look for answers to why and how our skin wrinkles with age, our wounds take much longer to heal than they did when we were kids, and why words escape us at crucial moments in conversation.This book explores these questions and many others through interviews with key scientists in the field of gerontology and with people who have interesting and important stories to tell about their personal experiences of ageing.

Undo It!

Author : Dean Ornish, M.D.,Anne Ornish
Publisher : Ballantine Books
Page : 530 pages
File Size : 51,8 Mb
Release : 2022-01-04
Category : Health & Fitness
ISBN : 9780525480020

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Undo It! by Dean Ornish, M.D.,Anne Ornish Pdf

NATIONAL BESTSELLER • By the pioneer of lifestyle medicine, a simple, scientifically program proven to often reverse the progression of the most common and costly chronic diseases and even begin reversing aging at a cellular level! Long rated “#1 for Heart Health” by U.S. News & World Report, Dr. Ornish’s Program is now covered by Medicare when offered virtually at home. Dean Ornish, M.D., has directed revolutionary research proving, for the first time, that lifestyle changes can often reverse—undo!—the progression of many of the most common and costly chronic diseases and even begin reversing aging at a cellular level. Medicare and many insurance companies now cover Dr. Ornish’s lifestyle medicine program for reversing chronic disease because it consistently achieves bigger changes in lifestyle, better clinical outcomes, larger cost savings, and greater adherence than have ever been reported—based on forty years of research published in the leading peer-reviewed medical and scientific journals. Now, in this landmark book, he and Anne Ornish present a simple yet powerful new unifying theory explaining why these same lifestyle changes can reverse so many different chronic diseases and how quickly these benefits occur. They describe what it is, why it works, and how you can do it: • Eat well: a whole foods, plant-based diet naturally low in fat and sugar and high in flavor. The “Ornish diet” has been rated “#1 for Heart Health” by U.S. News & World Report for eleven years since 2011. • Move more: moderate exercise such as walking • Stress less: including meditation and gentle yoga practices • Love more: how love and intimacy transform loneliness into healing With seventy recipes, easy-to-follow meal plans, tips for stocking your kitchen and eating out, recommended exercises, stress-reduction advice, and inspiring patient stories of life-transforming benefits—for example, several people improved so much after only nine weeks they were able to avoid a heart transplant—Undo It! empowers readers with new hope and new choices. Praise for Undo It! “The Ornishes’ work is elegant and simple and deserving of a Nobel Prize, since it can change the world!”—Richard Carmona, M.D., MPH, FACS, seventeenth Surgeon General of the United States “If you want to see what medicine will be like ten years from now, read this book today.”—Rita F. Redberg, M.D., editor in chief, JAMA Internal Medicine “This is one of the most important books on health ever written.”—John Mackey, CEO, Whole Foods Market

AARP The Immortality Edge

Author : Michael Fossel,Greta Blackburn,Dave Woynarowski
Publisher : John Wiley & Sons
Page : 251 pages
File Size : 44,9 Mb
Release : 2012-04-23
Category : Health & Fitness
ISBN : 9781118370148

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AARP The Immortality Edge by Michael Fossel,Greta Blackburn,Dave Woynarowski Pdf

AARP Digital Editions offer you practical tips, proven solutions, and expert guidance. Based on Nobel Prize–winning genetic research, AARP The Immortality Edge provides a simple plan to keep your telomeres healthy for better health and longevity. Telomeres play an important role in protecting our chromosomes from critical damage. The shortening of the telomere disrupts vital cellular function and promotes the previously seemingly inevitable onset of aging and various diseases, including cancer and Alzheimer's. Drawing from the groundbreaking discoveries about telomeres that won the 2009 Nobel Prize in Medicine, this book includes a highly prescriptive program that shows you how to live longer by slowing telomere shortening and rejuvenating your cells through relatively simple alterations in nutrition habits and other lifestyle changes. Written by authors with extensive knowledge of genetics, telomeres, and longevity Offers a simple action plan you can start using immediately Includes a revolutionary new eating plan Recommends individualized supplement programs Shares a diet and exercise approach grounded in solid scientific research The exciting recent discoveries about telomeres promise to revolutionize our approach to anti-aging much as antioxidants did ten years ago. Unlike trendy diet and fitness books with no basis in science, The Immortality Edge targets health at its innermost level by laying out a realistic, lifelong plan using easy steps that can fit into any busy schedule-steps that can improve the length and quality of your life.