Environmental Epigenomics In Health And Disease

Author : Randy L Jirtle,Frederick L. Tyson
Publisher : Springer Science & Business Media
Page : 309 pages
File Size : 47,5 Mb
Release : 2013-05-16
Category : Medical
ISBN : 9783642233807

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Environmental Epigenomics in Health and Disease by Randy L Jirtle,Frederick L. Tyson Pdf

There are now compelling human epidemiological and animal experimental data that indicate the risk of developing adult-onset complex diseases and neurological disorders are influenced by persistent epigenetic adaptations in response to prenatal and early postnatal exposures to environmental factors. Epigenetics refers to heritable changes in gene function that occur without a change in the sequence of the DNA. The main components of the epigenetic code are DNA methylation, histone modifications, and non-coding RNAs. The epigenetic programs are established as stem cell differentiate during embryogenesis, and they are normally faithfully reproduced during mitosis. Moreover, they can also be maintained during meiosis, resulting in epigenetic transgenerational disease inheritance, and also potentially introducing phenotypic variation that is selected for in the evolution of new species. The objective of this book is to provide evidence that environmental exposures during early development can alter the risk of developing medical conditions, such as asthma, autism, cancer, cardiovascular disease, diabetes, obesity, and schizophrenia later in life by modifying the epigenome.

Author : Randy L. Jirtle,Frederick L. Tyson
Publisher : Springer Science & Business Media
Page : 361 pages
File Size : 44,6 Mb
Release : 2013-05-13
Category : Medical
ISBN : 9783642368271

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Environmental Epigenomics in Health and Disease by Randy L. Jirtle,Frederick L. Tyson Pdf

There are now compelling human epidemiological and animal experimental data that indicate the risk of developing adult-onset complex diseases and neurological disorders are influenced by persistent epigenetic adaptations in response to prenatal and early postnatal exposures to environmental factors. Epigenetics refers to heritable changes in gene function that occur without a change in the sequence of the DNA. The main components of the epigenetic code are DNA methylation, histone modifications, and non-coding RNAs. The epigenetic programs are established as stem cell differentiate during embryogenesis, and they are normally faithfully reproduced during mitosis. Moreover, they can also be maintained during meiosis, resulting in epigenetic transgenerational disease inheritance, and also potentially introducing phenotypic variation that is selected for in the evolution of new species. The objective of this two volume book is to provide evidence that environmental exposures during early development can alter the risk of developing medical conditions, such as asthma, autism, cancer, cardiovascular disease, diabetes, obesity, and schizophrenia later in life by modifying the epigenome. Consequently, epigenetic research promises to markedly improve our ability to diagnosis, prevent, and treat the pathological conditions of humans; however, it also introduces unique legal and ethical issues. This volume highlights the correlation between environmental factors and complex diseases, such as autism, addiction, neurological diseases, diabetes, obesity and cancer. It concludes with a chapter on legal and ethical implications of epigenetics. ​

Author : Randy L. Jirtle,Frederick L. Tyson
Publisher : Unknown
Page : 356 pages
File Size : 53,7 Mb
Release : 2013-05-31
Category : Electronic
ISBN : 364236828X

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Environmental Epigenomics in Health and Disease by Randy L. Jirtle,Frederick L. Tyson Pdf

Author : Rebecca Fry
Publisher : Academic Press
Page : 364 pages
File Size : 54,5 Mb
Release : 2020-10-18
Category : Medical
ISBN : 9780128199695

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Environmental Epigenetics in Toxicology and Public Health by Rebecca Fry Pdf

Environmental Epigenetics in Toxicology and Public Health provides in-depth discussions of the suite of complex environmental factors shown to impact epigenetic components within the cell, as well as evidence that these epigenetic modifications are tied to early and later life health effects. This book offers a translational research perspective, highlighting both in vivo and human population-based evidence for ties between the environment, the epigenome, and health outcomes, with an emphasis on evidence for transgenerational effects of exposures, as well as developmental windows of susceptibility to environmentally-linked epigenetic effects. This volume in the Translational Epigenetics series aides in the development of new therapeutic options meant to reverse inappropriate epigenetic alterations, helping researchers in their efforts prevent and treat a variety of chronic diseases tied to environmental exposures. Offers a thorough discussion of the environmental factors influencing epigenetic mechanisms in early and late life, and in transgenerational inheritance Examines both animal model and human population-based research in environmental epigenetics, highlighting developmental windows of vulnerability to epigenetic modification Features contributions from international experts in the field

Author : Qiang Zhang,Timothy M. Barrow,Hyang-Min Byun,Yanqiang Li
Publisher : Frontiers Media SA
Page : 111 pages
File Size : 55,6 Mb
Release : 2021-07-14
Category : Science
ISBN : 9782889710447

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Environmental Genomics and Epigenomics: Response, Development and Disease by Qiang Zhang,Timothy M. Barrow,Hyang-Min Byun,Yanqiang Li Pdf

Author : L. Joseph Su,Tung-chin Chiang
Publisher : Springer
Page : 321 pages
File Size : 47,7 Mb
Release : 2015-05-18
Category : Medical
ISBN : 9781447166788

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Environmental Epigenetics by L. Joseph Su,Tung-chin Chiang Pdf

This book examines the toxicological and health implications of environmental epigenetics and provides knowledge through an interdisciplinary approach. Included in this volume are chapters outlining various environmental risk factors such as phthalates and dietary components, life states such as pregnancy and ageing, hormonal and metabolic considerations and specific disease risks such as cancer cardiovascular diseases and other non-communicable diseases. Environmental Epigenetics imparts integrative knowledge of the science of epigenetics and the issues raised in environmental epidemiology. This book is intended to serve both as a reference compendium on environmental epigenetics for scientists in academia, industry and laboratories and as a textbook for graduate level environmental health courses. Environmental Epigenetics imparts integrative knowledge of the science of epigenetics and the issues raised in environmental epidemiology. This book is intended to serve both as a reference compendium on environmental epigenetics for scientists in academia, industry and laboratories and as a textbook for graduate level environmental health courses.

Author : Mario Fraga,Agustin Fernandez Fernandez
Publisher : Academic Press
Page : 328 pages
File Size : 46,5 Mb
Release : 2015-10-12
Category : Science
ISBN : 9780128004968

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Epigenomics in Health and Disease by Mario Fraga,Agustin Fernandez Fernandez Pdf

Epigenomics in Health and Disease discusses the next generation sequencing technologies shaping our current knowledge with regards to the role of epigenetics in normal development, aging, and disease. It includes the consequences for diagnostics, prognostics, and disease-based therapies made possible by the study of the complete set of epigenetic modifications to the genetic material of human cells. With coverage pertinent to both basic biology and translational research, the book will be of particular interest for medical and bioscience researchers and students seeking current translational knowledge in epigenesis and epigenomics. Coverage includes the latest findings on epigenome-wide research in disease-based profiling, epidemiological implications, epigenome-wide epigenetic studies, the cancer epigenome, and other pervasive disease categories. Presents critical reviews that provide the means for reviewing and analyzing the epigenome as a whole, also discussing its translational potential Combines basic epigenomic knowledge with methodological and biostatistical topics related to technology and data analysis Includes coverage of relatively new topics, including DNA methylation dynamics during development and differentiation, genome-wide histone post-translational modifications during development and differentiation, and genome-wide DNA methylation changes during aging

Author : Kylan Russell
Publisher : Unknown
Page : 0 pages
File Size : 40,7 Mb
Release : 2022-09-13
Category : Electronic
ISBN : 1639871977

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Epigenetics and Epigenomics in Health and Disease by Kylan Russell Pdf

Epigenetics is a branch of biology which deals with the study of heritable phenotype changes that are not associated with the alterations in the DNA sequence. It generally involves the alterations which affect gene expression and activity but it may also include any heritable phenotypic change. These effects on cellular and physiological phenotypic characteristics may be a part of normal development or may result from environmental factors. Epigenomics refers to the study of the epigenome which is the complete set of epigenetic modifications taking place in the genetic material of a cell. These epigenetic modifications are reversible in nature. They affect gene expression without altering the DNA sequence. The book studies, analyses and upholds the pillars of epigenetics and epigenomics and their utmost significance in modern times. It consists of contributions made by international experts. As these fields are emerging at a fast pace, this book will help the readers to better understand their concepts.

Author : Cheryl S Rosenfeld
Publisher : Academic Press
Page : 560 pages
File Size : 54,7 Mb
Release : 2015-10-10
Category : Science
ISBN : 9780128016725

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The Epigenome and Developmental Origins of Health and Disease by Cheryl S Rosenfeld Pdf

The Epigenome and Developmental Origins of Health and Disease synthesizes the existing knowledge on how the in utero environment could be the most important environment in shaping later risk for various diseases or to conversely promote the health of the offspring. The book mines the existing literature from a variety of disciplines from toxicology to nutrition to epigenetics to reveal how contrasting maternal in utero environmental changes might be leading to epigenetic convergence and the resulting deleterious phenotypic and physiological effects in our offspring. It is increasingly becoming apparent that even subtle changes in the mother’s diet, stress, and exposure to low concentrations of toxic chemicals at levels deemed safe by the EPA and FDA, such as endocrine disrupting compounds (EDC), can dramatically impact the health of our children, possibly leading to metabolic, cardiovascular, immunological, neurobehavioral disorders, and increased risk for cancer to list but a few examples. Informs how everyday choices pregnant women make can impact child development Ties together how in utero environmental changes may be inducing epigenetic changes in the offspring leading to overlapping phenotypes regardless of the initial insult (toxic, nutrition, or stress) Includes a boxed-in area in each chapter for further references and resources to keep up with the field Features video interviews with the authors and other key leaders in the field

Author : David Hollar
Publisher : Springer
Page : 386 pages
File Size : 40,8 Mb
Release : 2016-02-08
Category : Medical
ISBN : 9783319253251

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Epigenetics, the Environment, and Children’s Health Across Lifespans by David Hollar Pdf

This stimulating volume addresses vital questions about gene/environment interactions as they affect cell health from the prenatal period through later life. Beginning with a tour of epigenetic processes in the human body, the book assembles current theoretical and empirical developments across the discipline, among them transgenerational epigenetic inheritance, the effects of maternal nutrition on epigenetic change, and possible links between epigenetics and childhood obesity. Public health and policy aspects of the field are discussed in depth, with the understanding that much can be done to improve our epigenetic health as a species. And in this vein, contributors consider future possibilities, such as the reprogramming of genes to reverse cancer and other diseases. Included in the coverage: The role of environmental epigenetics in perinatal and neonatal development The epigenetic biomarker γH2AX: from bench science to clinical trials What’s the risk? Dental amalgam, mercury exposure, and human health risks throughout the lifespan Post-traumatic stress disorder: neurological, genetic, and epigenetic bases Children’s exposure to alcohol, tobacco, and drugs: long-term outcomes Ethical implications of epigenetics Epigenetics, the Environment, and Children’s Health Across Lifespans brings real-world knowledge and applications of this increasingly important field to public health practitioners, maternal and child health researchers, and environmental health experts.

Author : Peter Gluckman,Mark Hanson
Publisher : Cambridge University Press
Page : 542 pages
File Size : 40,6 Mb
Release : 2006-04-20
Category : Medical
ISBN : 0521847435

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Developmental Origins of Health and Disease by Peter Gluckman,Mark Hanson Pdf

This landmark publication provides the first definitive account of how and why subtle influences on the fetus and during early life can have such profound consequences for adult health and diseases. Although the epidemiological evidence for this link has long proved compelling, it is only much more recently that the scientific and physiological basis has begun to be studied in depth and fully understood. The compilation, written by many of the world's leading experts in this exciting field, summarizes these scientific and clinical advances.

Author : Reinhard Heil,Stefanie B. Seitz,Harald König,Jürgen Robienski
Publisher : Springer
Page : 200 pages
File Size : 48,7 Mb
Release : 2017-01-31
Category : Philosophy
ISBN : 9783658144609

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Epigenetics by Reinhard Heil,Stefanie B. Seitz,Harald König,Jürgen Robienski Pdf

Modern epigenetics unites scientists from life sciences, organic chemistry as well as computer and engineering sciences to find an answer to the question of how environmental influences can have a lasting effect on gene expression, maybe even into the next generations. This volume examines from an interdisciplinary perspective the ethical, legal and social aspects of epigenetics.

Author : Emily Ho,Frederick Domann
Publisher : CRC Press
Page : 422 pages
File Size : 54,6 Mb
Release : 2014-10-16
Category : Medical
ISBN : 9781482203820

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Nutrition and Epigenetics by Emily Ho,Frederick Domann Pdf

Nutrition and Epigenetics presents new information on the action of diet and nutritional determinants in regulating the epigenetic control of gene expression in health and disease. Each chapter gives a unique perspective on a different nutritional or dietary component or group of components, and reveals novel mechanisms by which dietary factors modulate the epigenome and affect development processes, chronic disease, and the aging process. This pivotal text: Documents the epigenetic effect of antioxidants and their health benefits Adds to the understanding of mechanisms leading to disease susceptibility and healthy aging Illustrates that the epigenetic origins of disease occur in early (fetal) development Synthesizes the data regarding nutrient and epigenomic interactions Nutrition and Epigenetics highlights the interactions among nutrients, epigenetics, and health, providing an essential resource for scientists and clinical researchers interested in nutrition, aging, and metabolic diseases.

Author : Trygve O. Tollefsbol
Publisher : Academic Press
Page : 618 pages
File Size : 51,9 Mb
Release : 2012-07-26
Category : Medical
ISBN : 9780123884152

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Epigenetics in Human Disease by Trygve O. Tollefsbol Pdf

Epigenetics is one of the fastest growing fields of sciences, illuminating studies of human diseases by looking beyond genetic make-up and acknowledging that outside factors play a role in gene expression. The goal of this volume is to highlight those diseases or conditions for which we have advanced knowledge of epigenetic factors such as cancer, autoimmune disorders and aging as well as those that are yielding exciting breakthroughs in epigenetics such as diabetes, neurobiological disorders and cardiovascular disease. Where applicable, attempts are made to not only detail the role of epigenetics in the etiology, progression, diagnosis and prognosis of these diseases, but also novel epigenetic approaches to the treatment of these diseases. Chapters are also presented on human imprinting disorders, respiratory diseases, infectious diseases and gynecological and reproductive diseases. Since epigenetics plays a major role in the aging process, advances in the epigenetics of aging are highly relevant to many age-related human diseases. Therefore, this volume closes with chapters on aging epigenetics and breakthroughs that have been made to delay the aging process through epigenetic approaches. With its translational focus, this book will serve as valuable reference for both basic scientists and clinicians alike. Comprehensive coverage of fundamental and emergent science and clinical usage Side-by-side coverage of the basis of epigenetic diseases and their treatments Evaluation of recent epigenetic clinical breakthroughs

Author : Karin B. Michels
Publisher : Springer Science & Business Media
Page : 450 pages
File Size : 53,9 Mb
Release : 2012-01-02
Category : Medical
ISBN : 9789400724952

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Epigenetic Epidemiology by Karin B. Michels Pdf

The exploding field of epigenetics is challenging the dogma of traditional Mendelian inheritance. Epigenetics plays an important role in shaping who we are and contributes to our prospects of health and disease. While early epigenetic research focused on plant and animal models and in vitro experiments, population-based epidemiologic studies increasingly incorporate epigenetic components. The relevance of epigenetic marks, such as DNA methylation, genomic imprinting, and histone modification for disease causation has yet to be fully explored.This book covers the basic concepts of epigenetic epidemiology, discusses challenges in study design, analysis, and interpretation, epigenetic laboratory techniques, the influence of age and environmental factors on shaping the epigenome, the role of epigenetics in the developmental origins hypothesis, and provides the state of the art on the epigenetic epidemiology of various health conditions including childhood syndromes, cancer, infectious diseases, inflammation and rheumatoid arthritis, asthma, autism and other neurodevelopmental disorders, psychiatric disorders, diabetes, obesity and metabolic disorders, and atherosclerosis. With contributions from: Peter Jones, Jean-Pierre Issa, Gavin Kelsey, Robert Waterland, and many other experts in epigenetics!