Environmental Toxicology And Toxicogenomics

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Environmental Toxicology and Toxicogenomics

Xiaoping Pan,Baohong Zhang
Environmental Toxicology and Toxicogenomics Book PDF

Author : Xiaoping Pan,Baohong Zhang
Publisher : Humana
Page : 366 pages
File Size : 41,6 Mb
Release : 2021-07-09
Category : Medical
ISBN : 1071615130

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Environmental Toxicology and Toxicogenomics by Xiaoping Pan,Baohong Zhang Pdf

This detailed book provides an accessible compendium of up-to-date methods in the fields of environmental toxicology, molecular toxicology, and toxicogenomics. Organized into four major sections, the volume examines methods utilizing model animal species, such as nematode, fruit fly, mice, chicken, and amphibians, methods using plants to study chemical toxicity, applying the Ames assay to chemical mutagenicity study, as well as methods for environmental chemical analysis. Although this book is divided into these parts, the methods can be used across species. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Environmental Toxicology and Toxicogenomics: Principles, Methods, and Applications serves as a valuable resource for the scientific community, particularly for young scientists and graduate and undergraduate students, inspiring more research in the vitally important field of environmental toxicity, molecular toxicology, and toxicogenomics.

Toxicogenomics

Hisham K. Hamadeh,Cynthia A. Afshari
Toxicogenomics Book PDF

Author : Hisham K. Hamadeh,Cynthia A. Afshari
Publisher : John Wiley & Sons
Page : 386 pages
File Size : 53,5 Mb
Release : 2004-09-06
Category : Science
ISBN : 0471434175

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Toxicogenomics by Hisham K. Hamadeh,Cynthia A. Afshari Pdf

Toxicogenomics: Principles and Applications fills the need for a single, thorough text on the key breakthrough technologies in genomics, proteomics, metabolomics, and bioinformatics, and their applications to toxicology research. The first section following a general introduction is on genomics and toxicogenomics, and qPCR. The next sections are toxicoproteomics and metabolomics. The final section covers bioinformatics aspects, from databases to data integration strategies. A practical resource for specialists and non-specialists alike, this book includes numerous illustrations that support the textual explanations. It offers practical guidance to investigators wishing to pursue this line of research, and lists key relevant software and Internet resources.

Applications of Toxicogenomic Technologies to Predictive Toxicology and Risk Assessment

National Research Council,Division on Earth and Life Studies,Board on Life Sciences,Board on Environmental Studies and Toxicology,Committee on Applications of Toxicogenomic Technologies to Predictive Toxicology
Applications of Toxicogenomic Technologies to Predictive Toxicology and Risk Assessment Book PDF

Author : National Research Council,Division on Earth and Life Studies,Board on Life Sciences,Board on Environmental Studies and Toxicology,Committee on Applications of Toxicogenomic Technologies to Predictive Toxicology
Publisher : National Academies Press
Page : 300 pages
File Size : 48,6 Mb
Release : 2007-11-19
Category : Science
ISBN : 9780309178891

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Applications of Toxicogenomic Technologies to Predictive Toxicology and Risk Assessment by National Research Council,Division on Earth and Life Studies,Board on Life Sciences,Board on Environmental Studies and Toxicology,Committee on Applications of Toxicogenomic Technologies to Predictive Toxicology Pdf

The new field of toxicogenomics presents a potentially powerful set of tools to better understand the health effects of exposures to toxicants in the environment. At the request of the National Institute of Environmental Health Sciences, the National Research Council assembled a committee to identify the benefits of toxicogenomics, the challenges to achieving them, and potential approaches to overcoming such challenges. The report concludes that realizing the potential of toxicogenomics to improve public health decisions will require a concerted effort to generate data, make use of existing data, and study data in new waysâ€"an effort requiring funding, interagency coordination, and data management strategies.

Application of Toxicogenomics to Cross-Species Extrapolation

National Research Council,Division on Earth and Life Studies,Board on Life Sciences,Board on Environmental Studies and Toxicology,Committee on Emerging Issues and Data on Environmental Contaminants,Committee on Applications of Toxicogenomics to Cross-Species Extrapolation
Application of Toxicogenomics to Cross Species Extrapolation Book PDF

Author : National Research Council,Division on Earth and Life Studies,Board on Life Sciences,Board on Environmental Studies and Toxicology,Committee on Emerging Issues and Data on Environmental Contaminants,Committee on Applications of Toxicogenomics to Cross-Species Extrapolation
Publisher : National Academies Press
Page : 58 pages
File Size : 43,5 Mb
Release : 2006-04-24
Category : Science
ISBN : 9780309181686

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Application of Toxicogenomics to Cross-Species Extrapolation by National Research Council,Division on Earth and Life Studies,Board on Life Sciences,Board on Environmental Studies and Toxicology,Committee on Emerging Issues and Data on Environmental Contaminants,Committee on Applications of Toxicogenomics to Cross-Species Extrapolation Pdf

Some of what we know about the health effects of exposure to chemicals from food, drugs, and the environment come from studies of occupational, inadvertent, or accident-related exposures. When there is not enough human data, scientists rely on animal data to assess risk from chemical exposure and make health and safety decisions. However, humans and animals can respond differently to chemicals, including the types of adverse effects experienced and the dosages at which they occur. Scientists in the field of toxicogenomics are using new technologies to study the effects of chemicals. For example, in response to a particular chemical exposure, they can study gene expression ("transcriptomics"), proteins ("proteomics") and metabolites ("metabolomics"), and they can also look at how individual and species differences in the underlying DNA sequence itself can result in different responses to the environment. Based on a workshop held in August 2004, this report explores how toxicogenomics could enhance scientists' ability to make connections between data from experimental animal studies and human health.

Toxicogenomic Technologies and Risk Assessment of Environmental Carcinogens

National Research Council,Division on Earth and Life Studies,Board on Life Sciences,Committee on Emerging Issues and Data on Environmental Contaminants,Committee on How Toxicogenomics Could Inform Critical Issues in Carcinogenic Risk Assessment of Environmental Chemicals
Toxicogenomic Technologies and Risk Assessment of Environmental Carcinogens Book PDF

Author : National Research Council,Division on Earth and Life Studies,Board on Life Sciences,Committee on Emerging Issues and Data on Environmental Contaminants,Committee on How Toxicogenomics Could Inform Critical Issues in Carcinogenic Risk Assessment of Environmental Chemicals
Publisher : National Academies Press
Page : 68 pages
File Size : 49,6 Mb
Release : 2005-11-17
Category : Science
ISBN : 9780309097000

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Toxicogenomic Technologies and Risk Assessment of Environmental Carcinogens by National Research Council,Division on Earth and Life Studies,Board on Life Sciences,Committee on Emerging Issues and Data on Environmental Contaminants,Committee on How Toxicogenomics Could Inform Critical Issues in Carcinogenic Risk Assessment of Environmental Chemicals Pdf

Toxicogenomics is a discipline that combines expertise in toxicology, genetics, molecular biology, and environmental health to help understand the response of living organisms to stressful environments. The National Research Council convened a workshop to discuss how toxicogenomic data could be applied to improve risk assessments, particularly cancer risk from environmental exposure to chemicals. Risk assessments serve as the basis of many public-health decisions in environmental, occupational, and consumer protection from chemicals. The workshop provided a forum for communities of experts, including those working in "-omics" and those in the policy arena, to discuss where their fields intersect, and how toxicogenomics could address critical knowledge gaps in risk assessments.

Communicating Toxicogenomics Information to Nonexperts

National Research Council,Division on Earth and Life Studies,Board on Life Sciences,Board on Environmental Studies and Toxicology,Committee on Emerging Issues and Data on Environmental Contaminants,Committee on Communicating Toxicogenomics Information to Nonexperts
Communicating Toxicogenomics Information to Nonexperts Book PDF

Author : National Research Council,Division on Earth and Life Studies,Board on Life Sciences,Board on Environmental Studies and Toxicology,Committee on Emerging Issues and Data on Environmental Contaminants,Committee on Communicating Toxicogenomics Information to Nonexperts
Publisher : National Academies Press
Page : 60 pages
File Size : 46,7 Mb
Release : 2005-05-14
Category : Science
ISBN : 9780309095389

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Communicating Toxicogenomics Information to Nonexperts by National Research Council,Division on Earth and Life Studies,Board on Life Sciences,Board on Environmental Studies and Toxicology,Committee on Emerging Issues and Data on Environmental Contaminants,Committee on Communicating Toxicogenomics Information to Nonexperts Pdf

Toxicogenomics, the study of how genomes respond to exposure to toxicants, may ultimately hold the promise of detecting changes in the expression of a person's genes if he or she is exposed to these toxicants. As the technology rapidly develops, it is critical that scientists and the public communicate about the promises and limitations of this new field. Communicating technical information to the public about a developing science can be challenging, particularly when the applications of that science are not yet well understood. Communicating Toxicogenomics Information to Nonexperts is the summary of a workshop designed to consider strategies for communicating toxicogenomic information to the public and other non- expert audiences, specifically addressing the communication of some key social, ethical, and legal issues related to toxicogenomics and addressing how information related to the social implications of toxicogenomics might be perceived by nonexperts.

Applications of Toxicogenomics in Safety Evaluation and Risk Assessment

Darrell R. Boverhof,B. Bhaskar Gollapudi
Applications of Toxicogenomics in Safety Evaluation and Risk Assessment Book PDF

Author : Darrell R. Boverhof,B. Bhaskar Gollapudi
Publisher : John Wiley & Sons
Page : 470 pages
File Size : 43,6 Mb
Release : 2011-10-11
Category : Science
ISBN : 9781118008980

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Applications of Toxicogenomics in Safety Evaluation and Risk Assessment by Darrell R. Boverhof,B. Bhaskar Gollapudi Pdf

This book provides a timely overview of toxicogenomics, with special emphasis on the practical applications of this technology to the risk assessment process. Introductory sections are followed by a series of chapters highlighting practical and systematic applications of toxicogenomics in informing the risk assessment process – including the areas of mutagenicity, carcinogenicity, endocrine toxicity, organ-specific toxicity, population monitoring, and ecotoxicology. The book concludes with approaches for the integration of this technology in safety evaluation studies, and an outlook on how toxicogenomics and complementary technologies can reframe the current risk assessment paradigm.

Toxicogenomics

Saura C. Sahu
Toxicogenomics Book PDF

Author : Saura C. Sahu
Publisher : John Wiley & Sons
Page : 422 pages
File Size : 50,5 Mb
Release : 2008-11-20
Category : Science
ISBN : 9780470699645

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Toxicogenomics by Saura C. Sahu Pdf

Toxicogenomics is the integration of genomics to toxicology. This technology is a powerful tool for collecting information from a large number of biological samples simultaneously and thus it is very useful for large-scale screening of potential toxicants. Toxicogenomics: A Powerful Tool For Toxicity Assessment provides up-to-date state-of-the-art information presented by the recognized experts, and is therefore an authoritative source of current knowledge in this field of research. The potential link between toxicology, genetics and human diseases makes this book very useful to investigators in many and varied disciplines of science and toxicology. Topics covered include: mechanistic toxicogenomics analysis and interpretation of toxicogenomic data principles of data mining in toxicogenomics design issues in toxicogenomics studies sources of variability in toxicogenomic assays Escherichia coli stress response as a tool for detection of toxicity toxicogenomics as a tool to assess immunotoxicity toxicogenomics and ecogenomics for studying endocrine disruption and basic biology use of toxicogenomics as an early predictive tool for hepatotoxicity nutrigenomics: the application of genomic signatures in nutrition-related research application of toxicogenomics in drug discovery potential uses of toxicogenomic biomarkers in occupational health and risk assessment usefulness of toxicogenomics in the regulatory environment perspectives on toxicogenomics at the US Environmental Protection Agency Toxicogenomics: A Powerful Tool For Toxicity Assessment is an essential resource for research scientists currently engaged in toxicogenomics, and will also be of interest to researchers working in toxicology, genetics, medicine, pharmacology, and food sciences, and to regulators and risk assessors of drug, food, environmental and agricultural products.

Comparative Toxicogenomics

Anonim
Comparative Toxicogenomics Book PDF

Author : Anonim
Publisher : Elsevier
Page : 352 pages
File Size : 43,7 Mb
Release : 2008-07-11
Category : Science
ISBN : 0080560024

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Comparative Toxicogenomics by Anonim Pdf

Functional genomics has come of age. No longer is it an adventure for the avant garde scientist, but it has become an increasingly standardized mainstream tool accessible to any modern biological laboratory. Toxicogenomics studies are now generating an avalanche of data that, with the aid of established informatics methodology, is being translated into biologically meaningful information. This is enabling us to start harvesting the benefits from years of investment in terms of technology, time, and (of course) money. It is therefore timely to bring together leading toxicologists with a wide variety of scientific aims in this book to demonstrate how microarray technology can be successfully applied to different research areas. This book transects biology from bacteria to human, from ecologically relevant sentinel organisms to well-characterized model species, and represents the full toxicogenomics arena from exploratory "blue sky" science to the prospects for incorporation into regulatory frameworks. * Reviews some of the first really fruitful studies made in this area * Covers different organisms ranging from humans to model species and environmental sentinels * Provides a broad view of the area, increasing its attractiveness to researchers working in a variety of specialties

Toxicogenomics in Predictive Carcinogenicity

Russell S Thomas,Michael D Waters
Toxicogenomics in Predictive Carcinogenicity Book PDF

Author : Russell S Thomas,Michael D Waters
Publisher : Royal Society of Chemistry
Page : 524 pages
File Size : 45,5 Mb
Release : 2016-06-16
Category : Medical
ISBN : 9781782624059

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Toxicogenomics in Predictive Carcinogenicity by Russell S Thomas,Michael D Waters Pdf

Research over the past decade has demonstrated that TGx methods of various types can be used to discriminate modes of mutagenesis as a function of dose. TGx can quickly inform safety evaluation regarding potential mechanisms of conventional outcomes and can provide essential dose-response information. This can then be used to ascertain the sequence of key events in a putative mode of action as may apply in quantitative cancer risk assessment. With the increasing complexity of research in mode of action investigations it is important to gain a better understand of approaches to data integration and health risk assessment. Furthermore, it is essential to consider how novel test systems and newer methods and approaches may be used in future to gain a better understanding of mechanisms. Toxicogenomics in Predictive Carcinogenicity describes toxicogenomics methods in predictive carcinogenicity testing, mode of action and safety evaluation, and cancer risk assessment. It illustrates these methods using case studies that have yielded significant new information on compounds and classes of compounds that have proven difficult to evaluate using conventional methods alone. This book additionally covers current and potential toxicogenomic research using stem cells as well as new bioinformatics methods for drug discovery and environmental toxicology. This publication is an indispensable tool for postgraduates, academics and industrialists working in biochemistry, genomics, carcinogenesis, pathology, pharmaceuticals, food technology, bioinformatics, risk assessment and environmental toxicology.

Genomics in Regulatory Ecotoxicology

Gerald Ankley,Ann Miracle,Edward J. Perkins,George P. Daston
Genomics in Regulatory Ecotoxicology Book PDF

Author : Gerald Ankley,Ann Miracle,Edward J. Perkins,George P. Daston
Publisher : CRC Press
Page : 198 pages
File Size : 50,5 Mb
Release : 2007-11-27
Category : Science
ISBN : 9781420066838

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Genomics in Regulatory Ecotoxicology by Gerald Ankley,Ann Miracle,Edward J. Perkins,George P. Daston Pdf

Fueled partially by large, well-publicized efforts such as the Human Genome Project, genomic research is a rapidly growing area in multiple biological disciplines, including toxicology. Much of this potential, however, has been discussed in the literature and at technical meetings only in relatively broad terms, making it difficult to assess exactl

Toxicology and Human Environments

Anonim
Toxicology and Human Environments Book PDF

Author : Anonim
Publisher : Academic Press
Page : 451 pages
File Size : 51,6 Mb
Release : 2012-12-31
Category : Science
ISBN : 9780124159082

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Toxicology and Human Environments by Anonim Pdf

Environmental toxicology is generally held to be the study of the potential of constituents of outdoor environments to impact either human health or the biological structure of the ecosystems involved. This volume is a first attempt to integrate toxicological studies of all of the many human environments, both indoor and outdoor, and their complex interrelationships. Included are considerations of natural environments, the agroecosystem, occupational, urban and domestic environments as well as the environment associated with Superfund sites and military deployments. The primary emphasis is on public health, including the potential health effects of toxicants found in different environments, the bioprocessing of such toxicants in humans and surrogate animals and the principles of risk analysis. Approaches the toxicology of human environments in a new and unique way, stressing the complex interrelationships of all human environments and the implication for human and environmental health Each chapter is written by an acknowledged expert and is addressed to those interested in the broader implications of the environmental modifications that are always associated with the activities of humans living and working in them

Integrative Toxicogenomics: Analytical Strategies to Amalgamate Exposure Effects with Genomic Sciences

Pierre R. Bushel,Weida Tong
Integrative Toxicogenomics Analytical Strategies to Amalgamate Exposure Effects with Genomic Sciences Book PDF

Author : Pierre R. Bushel,Weida Tong
Publisher : Frontiers Media SA
Page : 112 pages
File Size : 52,5 Mb
Release : 2019-04-09
Category : Electronic
ISBN : 9782889457663

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Integrative Toxicogenomics: Analytical Strategies to Amalgamate Exposure Effects with Genomic Sciences by Pierre R. Bushel,Weida Tong Pdf

Toxicogenomics combines the use of toxicology and genomic sciences to elucidate chemical, toxic and environmental stressor effects on biological systems. Integrative toxicogenomics requires innovation in bioinformatics, statistics and systems toxicology and typically a combination of the utility of two of more of these disciplines to better understand molecular mechanisms involved in toxic responses. This Frontiers in Toxicogenomics Research Topic eBook focuses on integrative toxicogenomics more so at the late stage (analyzing each data set separately and then merging the results ) and brings together analyses that combine gene expression (microarray, TempO-Seq or RNA-Seq) with other data (biological assays, clinical chemistry, therapeutic categories or molecular pathways) or highlights data analytics that leverage bioinformatics and statistics. The eight articles illustrate the state-of-art in the field and the analysis of toxicogenomics data for a more comprehensive deduction of biological mechanisms and cellular functions associated with adverse outcomes from environmental exposures, chemicals and toxicants. However, it is clear that the field of integrative toxicogenomics needs considerably more attention paid to it in order to develop other clever ways of integrating the data for analysis.

Toxicogenomics and Proteomics

J. J. Valdes
Toxicogenomics and Proteomics Book PDF

Author : J. J. Valdes
Publisher : Unknown
Page : 216 pages
File Size : 50,7 Mb
Release : 2004
Category : Electronic
ISBN : 1601294735

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Toxicogenomics and Proteomics by J. J. Valdes Pdf

Toxicology uses a variety of models to assess the behavioral and histopathological consequences of exposure to certain chemicals, primarily those described here as "environmental insults.

Principles of Toxicology

Stine Karen,Thomas M. Brown
Principles of Toxicology Book PDF

Author : Stine Karen,Thomas M. Brown
Publisher : CRC Press
Page : 370 pages
File Size : 52,5 Mb
Release : 2006-01-24
Category : Medical
ISBN : 9781420004403

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Principles of Toxicology by Stine Karen,Thomas M. Brown Pdf

Written by two experienced toxicology lecturers, Principles of Toxicology provides a broad-based yet in-depth introduction to this diverse subject. Comprehensive and easy-to-read, the book covers this broad and interdisciplinary field from the viewpoint of three different functional levels: molecular and cellular; physiological; and ecological and