Estrogen Receptors

Author : George G. Chen,Michael C. F. Tong,CA Van Hasselt
Publisher : Unknown
Page : 212 pages
File Size : 46,8 Mb
Release : 2020
Category : Estrogen
ISBN : 1536182281

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Estrogen Receptors by George G. Chen,Michael C. F. Tong,CA Van Hasselt Pdf

"This 8-chapter book is written by experts from China, Mexico, Portugal, United Kingdom and the United States of America. The book is focused on estrogen receptor structure, functions and clinical significance. Though we are unable to address all aspects of the estrogen receptors, we have analysed and discussed estrogen receptors or their isoforms in some major estrogen receptor-related disorders including cancers, endocrine diseases, respiratory diseases and obesity. The information provided by this book should aid our understanding the role of estrogen receptors in human diseases. This book will be of great value not only for clinicians interested in estrogen receptor-related diseases but also for basic scientists working in the field of estrogen receptors"--

Author : Anonim
Publisher : ScholarlyEditions
Page : 143 pages
File Size : 48,6 Mb
Release : 2012-01-09
Category : Medical
ISBN : 9781464931802

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Estrogen Receptors: Advances in Research and Application: 2011 Edition by Anonim Pdf

Estrogen Receptors: Advances in Research and Application: 2011 Edition is a ScholarlyBrief™ that delivers timely, authoritative, comprehensive, and specialized information about Estrogen Receptors in a concise format. The editors have built Estrogen Receptors: Advances in Research and Application: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Estrogen Receptors in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Estrogen Receptors: Advances in Research and Application: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Author : Kathleen M. Eyster
Publisher : Unknown
Page : 427 pages
File Size : 52,6 Mb
Release : 2022
Category : Electronic books
ISBN : 1071619209

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Estrogen Receptors by Kathleen M. Eyster Pdf

This fully updated collection includes chapters on a wide array of techniques that are vital for advancing our understanding of the physiological and pathological effects of estrogen, mediated by estrogen receptor [alpha] (ER [alpha]) and estrogen receptor [beta] (ER [beta]) as well as the non-genomic membrane-bound G-protein coupled estrogen receptor (GPER/GPR30). The protocols range from standard methods and important laboratory workhorses such as immunoblot and RT-qPCR, to newer technologies such as PET imaging, reporter animal models, polysome fractionation, and many others, involving a broad range of tissue types to demonstrate the variety of estrogen receptor effects. Written for this highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Estrogen Receptors: Methods and Protocols, Second Edition serves as an ideal guide to researchers working to explore the vibrancy and excitement of the field of estrogen receptors and estrogen actions.

Author : Xiaoting Zhang
Publisher : Humana Press
Page : 432 pages
File Size : 50,9 Mb
Release : 2019-11-08
Category : Electronic
ISBN : 3030075931

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Estrogen Receptor and Breast Cancer by Xiaoting Zhang Pdf

The discovery of ER by Dr. Elwood Jensen exactly 60 years ago has not only led to the birth of a whole new vital nuclear receptor research field but also made a rapid, direct and lasting impact on the treatment and prevention of breast cancer. Since that landmark discovery, tremendous progress has been made in our understanding of the molecular functions of ER and development of targeted therapies against ER pathways for breast cancer treatment. However, there is currently no book available addressing these discoveries and recent advancement in a historical and systematic fashion. This book is intended to provide comprehensive, most up-to-date information on the history and recent advancement of ER and breast cancer by world renowned leaders in the field. These chapters include the history of the discovery of ER; physiological and pathological roles of ER; recent discovery of ER cistrome, transcriptome and its regulation of noncoding RNAs such as microRNAs and enhancer RNAs in breast cancer; development and clinical practices of the first targeted therapy Tamoxifen and other antiestrogens for breast cancer treatment; structural basis of ER and antiestrogen actions; molecular insights into endocrine resistance; the role of ER mutants, ER-beta and environmental estrogens in breast cancer; and emerging state-of-the-art therapeutic approaches currently in development to overcome treatment resistance and future perspectives. The book will provide undergraduate and graduate students, basic scientists and clinical cancer researchers, residents, fellows, as well as clinicians, oncology educators and the general public a thorough and authoritative review of these exciting topics.

Author : George Chen
Publisher : Nova Science Publishers
Page : 188 pages
File Size : 52,5 Mb
Release : 2012
Category : Endometriosis
ISBN : 1622571800

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Estrogen Receptors by George Chen Pdf

Estrogen receptors (ER) are emerging as important molecules involved in the variety of physiological and pathological activities. There are two classic estrogen receptors: alpha and beta. Different cells and tissues have shown divergent responses to these two estrogen receptors. While we are starting to understand the interaction between estrogen receptors and its ligands contributes to the development of various diseases, the discovery of sub-isoforms of estrogen receptor alpha and beta has further complicated the mechanism of estrogen receptors. Nevertheless, continuing efforts in the study of estrogen receptors have helped us to define their roles in diseases and to develop novel therapies against these disorders. The 11 chapters in this book are the excellent evidence to summarize our efforts in this direction. This book should be of great value to not only clinicians and medical students interested in estrogen/ER- related diseases but also basic scientists working in the field of estrogens/ERs.

Author : George Chen
Publisher : Nova Science Publishers
Page : 0 pages
File Size : 55,9 Mb
Release : 2012
Category : Endometriosis
ISBN : 1622570987

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Estrogen Receptors by George Chen Pdf

Oestrogen receptors (ER) are emerging as important molecules involved in the variety of physiological and pathological activities. There are two classic oestrogen receptors: alpha and beta. Different cells and tissues have shown divergent responses to these two oestrogen receptors. While we are starting to understand the interaction between oestrogen receptors and its ligands contributes to the development of various diseases, the discovery of sub-isoforms of oestrogen receptor alpha and beta has further complicated the mechanism of oestrogen receptors. Nevertheless, continuing efforts in the study of oestrogen receptors have helped us to define their roles in diseases and to develop novel therapies against these disorders. The 11 chapters in this book are the excellent evidence to summarise our efforts in this direction. This book should be of great value to not only clinicians and medical students interested in oestrogen/ER-related diseases but also basic scientists working in the field of estrogens/ERs.

Author : Fritz F. Parl
Publisher : IOS Press
Page : 280 pages
File Size : 44,9 Mb
Release : 2000
Category : Breast
ISBN : 096733554X

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Estrogens, Estrogen Receptor and Breast Cancer by Fritz F. Parl Pdf

Estrogens have been implicated to play a role in the development of breast cancer. The purpose of this book is to provide a comprehensive analysis of experimental, clinical and epidemiological evidence in support of the carcinogenicity of estrogens.

Author : Andrea Manni,Michael Verderame
Publisher : Springer Science & Business Media
Page : 574 pages
File Size : 40,7 Mb
Release : 2002-01-18
Category : Medical
ISBN : 9781592591572

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Selective Estrogen Receptor Modulators by Andrea Manni,Michael Verderame Pdf

Experimental and clinical researchers from a wide range of disciplines present a wealth of fresh scientific information on the biochemistry, molecular biology, pharmacology, and clinical activity of SERMs. The basic science chapters of the book focus-with an eye to the development of the ideal SERM-on the complex mechanisms of estrogen action, including ligand-dependent conformational changes in alpha and beta, and the recruitment of co-activators and co-repressors which modulate the estrogen receptor transcriptional activity and contribute to its crosstalk with growth factor signaling. The clinical presentation reviews the data accumulated on currently available SERMs, primarily tamoxifen and raloxifene, in cancer treatment and prevention, as well as their effects on the reproductive, vascular, skeletal, and central nervous systems. A tentative approach to menopause-related health issues is also provided for women with and without a previous diagnosis of localized breast cancer.

Author : Kenneth S. Korach,Alexander Hillisch,Karl Heinrich Fritzemeier
Publisher : Springer Science & Business Media
Page : 223 pages
File Size : 51,7 Mb
Release : 2013-11-11
Category : Medical
ISBN : 9783662053867

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New Molecular Mechanisms of Estrogen Action and Their Impact on Future Perspectives in Estrogen Therapy by Kenneth S. Korach,Alexander Hillisch,Karl Heinrich Fritzemeier Pdf

From our current knowledge, it is obvious that estrogen action in volves more than reproduction and fertility. Rather, estrogens affect and influence a number of other organ systems such as the immune, cardiovascular and central nervous system as well as the gastrointes tinal tract, urinary tract and skeleton. The importance of estrogens and estrogen receptor activity is appreciated from the spectrum of significant physiological dysfunctions that occur when there is a loss The participants of the workshop VI Preface of the hormone or the receptor activity. Loss of estrogen, however (for instance during menopause), occurs with time and results in a variety of clinical conditions. We know that the developmental loss of estrogen, as seen in clinical cases of aromatase gene mutations and experimental models, has dramatic effects in both men and women alike. The evidence that these effects are mediated through the estrogen receptor(s) is based on similar but not always identical phenotypes as observed in experimental animal models of estrogen receptor mutations as well as the single clinical case of an estrogen receptor alpha mutant patient. Developing an understanding of the spectrum of estrogen in a variety of tissues related to the condition of estrogen loss is a major and highly active clinical as well as basic scientific research area. Following the discovery of a second estrogen receptor and possible receptor ligand-independent activity as well as the genomic and non genomic actions of estrogen, it is clear that the mechanisms of the effects of estrogen are multifaceted.

Author : V. Craig Jordan
Publisher : World Scientific
Page : 544 pages
File Size : 50,7 Mb
Release : 2013
Category : Medical
ISBN : 9781848169586

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Estrogen Action, Selective Estrogen Receptor Modulators, and Women's Health by V. Craig Jordan Pdf

This volume presents the evolution of the authors' ideas about estrogen action and its modulation by a new group of drugs called SERMs (Selective Estrogen Receptor Modulators). The pioneering SERMs OCo tamoxifen and raloxifene OCo are known to have saved the lives of millions of women around the world and improved the health of millions more. Estrogen is the central hormone of women's health and reproduction. The book is a journey through 40 years of discovery and success in advancing women's health, with the prospect of improved innovation through medicinal chemistry for the future.

Author : Anonim
Publisher : ScholarlyEditions
Page : 135 pages
File Size : 43,5 Mb
Release : 2012-12-26
Category : Medical
ISBN : 9781481601658

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Estrogen Receptors—Advances in Research and Application: 2012 Edition by Anonim Pdf

Estrogen Receptors—Advances in Research and Application: 2012 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Estrogen Receptors. The editors have built Estrogen Receptors—Advances in Research and Application: 2012 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Estrogen Receptors in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Estrogen Receptors—Advances in Research and Application: 2012 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Author : William L. McGuire,Paul Peter Carbone,Erwin Paul Vollmer
Publisher : Unknown
Page : 308 pages
File Size : 47,9 Mb
Release : 1975
Category : Breast
ISBN : UCAL:B4978292

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Estrogen Receptors in Human Breast Cancer by William L. McGuire,Paul Peter Carbone,Erwin Paul Vollmer Pdf

Author : George G. Chen,Michael C. F. Tong,C. A. van Hasselt
Publisher : Nova Science Publishers
Page : 212 pages
File Size : 46,7 Mb
Release : 2020
Category : Medical
ISBN : 1536182966

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Estrogen Receptors by George G. Chen,Michael C. F. Tong,C. A. van Hasselt Pdf

"This 8-chapter book is written by experts from China, Mexico, Portugal, United Kingdom and the United States of America. The book is focused on estrogen receptor structure, functions and clinical significance. Though we are unable to address all aspects of the estrogen receptors, we have analysed and discussed estrogen receptors or their isoforms in some major estrogen receptor-related disorders including cancers, endocrine diseases, respiratory diseases and obesity. The information provided by this book should aid our understanding the role of estrogen receptors in human diseases. This book will be of great value not only for clinicians interested in estrogen receptor-related diseases but also for basic scientists working in the field of estrogen receptors"--

Author : Antonio Cano,Joacquim Calaf i Alsina,Jose Luis Duenas-Diez
Publisher : Springer Science & Business Media
Page : 357 pages
File Size : 42,6 Mb
Release : 2006-09-22
Category : Medical
ISBN : 9783540347422

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Selective Estrogen Receptor Modulators by Antonio Cano,Joacquim Calaf i Alsina,Jose Luis Duenas-Diez Pdf

The increasing awareness on the varied consequences of hypogonadism in distinct organs and systems has supported the notion of estrogens as systemic agents. This observation is congruent with the variety of tissues affected by - trogens when used in hormone therapy formulations on hypogonadic women. Apart from the genital tract and the breast, recognized as traditional targets for estrogens, the skeleton, the vascular tree, or the central nervous system, are good examples of territories that have demonstrated sensitivity to estrogens. This evidence has created great interest, as shown by the great amount of lit- ature that has been produced on the bene?ts and risks associated with the use of estrogens. In parallel to the clinical interest, basic research has improved our kno- edge on the complexities involved in estrogen action at the molecular level. Together with effects mediated through speci?c receptors, a concept that has been the mainstay of the interpretation of estrogen action for years, there is enough evidence to hold the notion of receptor-independent effects. The substantial advances in modern technology applied to research have helped in enlightening the particulars of this versatile action of estrogens. This more detailed knowledge on the sophisticated mechanism of action of estrogens has nourished the emergence of multiple hypotheses speculating with the p- sibility of manipulating estrogen action. The notion that a widely extended regulatory system of cell function, as it is the estrogen receptor machinery, might be modulated at wish has arisen as an attractive, although still elusive postulate.

Author : Anonim
Publisher : ScholarlyEditions
Page : 100 pages
File Size : 50,9 Mb
Release : 2013-06-21
Category : Medical
ISBN : 9781481675499

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Estrogen Receptors—Advances in Research and Application: 2013 Edition by Anonim Pdf

Estrogen Receptors—Advances in Research and Application: 2013 Edition is a ScholarlyBrief™ that delivers timely, authoritative, comprehensive, and specialized information about Estrogen Receptor alpha in a concise format. The editors have built Estrogen Receptors—Advances in Research and Application: 2013 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Estrogen Receptor alpha in this book to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Estrogen Receptors—Advances in Research and Application: 2013 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.