Evidence Based Clinical Chelation

Author : Dr. Eleonore Blaurock-Busch, PhD,Dr. Swaran J.S. Flora, PhD,Dr. Ebrahim Sulaiman, MD
Publisher : BoD – Books on Demand
Page : 122 pages
File Size : 51,8 Mb
Release : 2020-06-02
Category : Medical
ISBN : 9783750428676

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Evidence-Based Clinical Chelation by Dr. Eleonore Blaurock-Busch, PhD,Dr. Swaran J.S. Flora, PhD,Dr. Ebrahim Sulaiman, MD Pdf

This is an easy-to-read manual about chelation therapy. It contains specific protocols for the treatment of chronic metal overexposure, all of which are evidence-based, aiding the inexperienced and the experienced therapist in selecting the optimal chelating agent for the metal(s) in question. Expert chemists and chelation therapists have contributed invaluable knowledge and experience to this book. Most importantly, this is not a book promoting personal views or preferences. In fact, the information presents and explains different approaches, and allows the reader to draw his own conclusion. All the protocols listed have been modified for the treatment of chronic metal intoxication, included are oral and intravenous treatment plans. The authors explain in simple terms how a chelating agent ́s bioavailability affects metal binding and how various protocols such as the Cutler Protocol affect the detoxification process, why DMPS binds mercury and which chelators are useful for the detoxification of certain organ system. Also discussed is the importance and effect of treatment pauses. Diagnostic tests are discussed, and which are useful under certain conditions. Shown are tables comparing the average metal binding ability of the various EDTAs, DMPS, DMSA and other chelating agents. Detailed information explains which chelator binds which metal and why, all of which aids the therapist in finding optimal treatment schedules. Novel chelating agents are presented such as MIADMSA, a new oral chelator specifically designed for arsenic intoxication, or how natural Pectin may be used an alternative for gadolinium intoxication, which metals are bound by lipoic acid and why a slightly alkaline environment supports metal binding, even preventing the often-feared metal redistribution. All in all, this evidence-based chelation "cookbook" should be in medical libraries and on the bookshelf of every physician treating environmental disease.

Author : Jan Aaseth,Guido Crisponi,Ole Anderson
Publisher : Academic Press
Page : 388 pages
File Size : 45,7 Mb
Release : 2016-04-18
Category : Medical
ISBN : 9780128030738

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Chelation Therapy in the Treatment of Metal Intoxication by Jan Aaseth,Guido Crisponi,Ole Anderson Pdf

Chelation Therapy in the Treatment of Metal Intoxication presents a practical guide to the use of chelation therapy, from its basic chemistry, to available chelating antidotes, and the application of chelating agents. Several metals have long been known to be toxic to humans, and continue to pose great difficulty to treat. These challenges pose particular problems in industrial settings, with lead smelting known to be associated with hemopoietic alterations and paralyses, and the inhalation of mercury vapor in mercury mining being extremely detrimental to the central nervous system. Clinical experience has demonstrated that acute and chronic human intoxications with a range of metals can be treated efficiently by administration of chelating agents. Chelation Therapy in the Treatment of Metal Intoxication describes the chemical and biological principles of chelation in the treatment of these toxic metal compounds, including new chelators such as meso-2,3-dimercaptosuccinic acid (DMSA) and D,L-2,3-dimercapto-1-propanesulfonic acid (DMPS). Presents all the current findings on the potential for chelation as a therapy for metal intoxication Presents practical guidelines for selecting the most appropriate chelating agent Includes coverage on radionuclide exposure and metal storage diseases Describes the chemical and biological principles of chelation in the treatment of toxic metal compounds

Author : Chaim Hershko
Publisher : Springer Science & Business Media
Page : 275 pages
File Size : 53,6 Mb
Release : 2012-12-06
Category : Science
ISBN : 9781461505938

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Iron Chelation Therapy by Chaim Hershko Pdf

Within the last few years, iron research has yielded exciting new insights into the under standing of normal iron homeostasis. However, normal iron physiology offers little protec tion from the toxic effects of pathological iron accumulation, because nature did not equip us with effective mechanisms of iron excretion. Excess iron may be effectively removed by phlebotomy in hereditary hemochromatosis, but this method cannot be applied to chronic anemias associated with iron overload. In these diseases, iron chelating therapy is the only method available for preventing early death caused mainly by myocardial and hepatic iron toxicity. Iron chelating therapy has changed the quality of life and life expectancy of thalassemic patients. However, the high cost and rigorous requirements of deferoxamine therapy, and the significant toxicity of deferiprone underline the need for the continued development of new and improved orally effective iron chelators. Such development, and the evolution of improved strategies of iron chelating therapy require better understanding of the pathophysiology of iron toxicity and the mechanism of action of iron chelating drugs. The timeliness of the present volume is underlined by several significant develop ments in recent years. New insights have been gained into the molecular basis of aberrant iron handling in hereditary disorders and the pathophysiology of iron overload (Chapters 1-5).

Author : Gary Greenberg
Publisher : Humanix Books
Page : 175 pages
File Size : 54,7 Mb
Release : 2020-08-04
Category : Health & Fitness
ISBN : 9781630061203

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The Chelation Revolution by Gary Greenberg Pdf

The Medical Breakthrough of Chelation Therapy: A treatment that uses medicine to remove toxic metals from the body so they don't make you sick. Chelation has long been approved by the FDA to rid the body of lead by using a synthetic amino acid (ethylene diamine tetraacetic acid), which binds to toxic metals and minerals in the bloodstream, allowing a patient to excrete them. When metals like lead, mercury, iron, and arsenic build up in your body, they can be toxic. Alternative medical practitioners have used chelation for nearly 60 years, especially to treat heavy metal contamination that causes or contributes to heart disease. Chelation rids the body of deposits that can lead to atherosclerosis, which causes coronary arteries to narrow, leading to heart attacks. Patients have also found relief through chelation for improving the symptoms of autism. One of the most promising areas of research is in the treatment of Alzheimer’s disease. Because the buildup of metals like copper, iron, and zinc are thought to play a role in Alzheimer's disease, Chelation Therapy might have a place in treating it. Full of hope-inspiring case histories, expert findings and where to find treatment, The Chelation Revolution: Breakthrough Detox Therapy shows how Chelation Therapy can alleviate suffering in numerous medical conditions and lead to a healthier, happier, and longer life. Includes a Foreword by Tammy Born Huizenga, D.O., owner of the internationally recognized Born Clinic in Grand Rapids, MI, an internationally respected organization in preventive medicine with a speciality in Chelation Therapy.

Author : Elmer M. Cranton
Publisher : Hampton Roads Publishing Company
Page : 563 pages
File Size : 55,7 Mb
Release : 2001-04-01
Category : Health & Fitness
ISBN : 1571742530

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A Textbook on Edta Chelation Therapy by Elmer M. Cranton Pdf

EDTA chelation therapy removes from the human body, with relative safety and without surgery, metallic ions that play an important role in the formation of atherosclerotic plaque. Dr. Elmer Cranton's compilation of the most current and pertinent information on EDTA chelation therapy is now back in print, with even more information about chelation's effects, protocols, and status based on the latest research. Find out why more than a thousand physicians in the United States already offer EDTA chelation therapy as a safer and far less expensive alternative to surgical treatments for atherosclerosis.

Author : National Research Council,Commission on Life Sciences,Board on Environmental Studies and Toxicology,Committee on the Toxicological Effects of Methylmercury
Publisher : National Academies Press
Page : 364 pages
File Size : 48,6 Mb
Release : 2000-09-27
Category : Nature
ISBN : 9780309171717

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Toxicological Effects of Methylmercury by National Research Council,Commission on Life Sciences,Board on Environmental Studies and Toxicology,Committee on the Toxicological Effects of Methylmercury Pdf

Mercury is widespread in our environment. Methylmercury, one organic form of mercury, can accumulate up the aquatic food chain and lead to high concentrations in predatory fish. When consumed by humans, contaminated fish represent a public health risk. Combustion processes, especially coal-fired power plants, are major sources of mercury contamination in the environment. The U.S. Environmental Protection Agency (EPA) is considering regulating mercury emissions from those plants. Toxicological Effects of Methylmercury reviews the health effects of methylmercury and discusses the estimation of mercury exposure from measured biomarkers, how differences between individuals affect mercury toxicity, and appropriate statistical methods for analysis of the data and thoroughly compares the epidemiological studies available on methylmercury. Included are discussions of current mercury levels on public health and a delineation of the scientific aspects and policy decisions involved in the regulation of mercury. This report is a valuable resource for individuals interested in the public health effects and regulation of mercury. The report also provides an excellent example of the implications of decisions in the risk assessment process for a larger audience.

Author : Elmer M. Cranton
Publisher : Hampton Roads Publishing
Page : 525 pages
File Size : 45,6 Mb
Release : 2001-04-01
Category : Medical
ISBN : 9781612832746

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A Textbook on EDTA Chelation Therapy by Elmer M. Cranton Pdf

Chelation therapy, based on the intravenous infusion of EDTA, is a highly effective treatment for atherosclerotic cardiovasular disease. Saftey and effectivenss are well documented in clinical studies, all of which to date are supportive of this therapy, and there are no studies showing lack of effectiveness. A strong case is made for the use of this safe, efficacious, and inexpensive therapy before resorting to surgery and other risky and invasive treatments. In this newly revised and extensively updated edition of what has come to be regarded as the definitive textbook on the subject, renowned chelation expert Elmer M. Cranton, M.D., presents the work of the world's leading experts in chelation therapy. "This therapy has been proven effective over and over again in clinical practice," says Dr. Cranton. "More than one million patients have recieved more than twenty million infusions with no serious or lasting adverse effects." In his foreword, Nobel Prize winner Dr. Linus Pauling states, "EDTA chelation therapy makes good sense to me as a chemist and medical researcher. It has a rational scientific basis, and the evidence for clinical benefit seems to be quite strong." Here in a single volume you will learn everything you need to know to responsibly administer and advocate chelation therapy. You will find a coherent scientific rationale, clinical trials demonstating effectiveness, guidelines for saftey, detailed protocols for administration, and techniques for pre- and post-treatment laboratory evalutaion.

Author : Swaran Jeet Singh Flora
Publisher : Academic Press
Page : 988 pages
File Size : 48,7 Mb
Release : 2023-02-21
Category : Medical
ISBN : 9780323984713

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Handbook of Arsenic Toxicology by Swaran Jeet Singh Flora Pdf

Handbook of Arsenic Toxicology, Second Edition presents the latest findings on arsenic, including its chemistry, sources and effects on the environment and human health. The book discusses both acute and chronic effects, discussing many aspects of arsenic, from physical and chemical properties, exposure, epidemiology, organ toxicity, diagnosis, prevention and treatment. Fully updated and revised, this new edition includes new topics on risk assessment, molecular mechanisms of arsenic, advances in the integrated approach to testing, assessment and development, evaluation and application of high content predictive models, and new alternative methods (NAMS) in the context of Adverse Outcome Pathways (AOPs) to assess toxicology. This comprehensive resource allows readers to effectively assess the risks related to arsenic, providing them with all they need to know on arsenic exposure, toxicity and toxicity prevention. Brings together current findings on the effects of arsenic on the environment and human health Includes state-of-the-art techniques in arsenic toxicokinetics, speciation and molecular mechanisms Provides all the information needed for effective risk assessment, prevention and countermeasures

Author : Maria-Domenica Cappellini
Publisher : Unknown
Page : 128 pages
File Size : 41,7 Mb
Release : 2008
Category : Electronic
ISBN : 9963623700

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Guidelines for the Clinical Management of Thalassaemia by Maria-Domenica Cappellini Pdf

Author : Hyman J. Zimmerman
Publisher : Lippincott Williams & Wilkins
Page : 848 pages
File Size : 47,7 Mb
Release : 1999
Category : Medical
ISBN : 0781719526

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Hepatotoxicity by Hyman J. Zimmerman Pdf

Written by the foremost authority in the field, this volume is a comprehensive review of the multifaceted phenomenon of hepatotoxicity. Dr. Zimmerman examines the interface between chemicals and the liver; the latest research in experimental hepatotoxicology; the hepatotoxic risks of household, industrial, and environmental chemicals; and the adverse effects of drugs on the liver. This thoroughly revised, updated Second Edition features a greatly expanded section on the wide variety of drugs that can cause liver injury. For quick reference, an appendix lists these medications and their associated hepatic injuries. Also included are in-depth discussions of drug metabolism and factors affecting susceptibility to liver injury.

Author : Richa Saxena
Publisher : JP Medical Ltd
Page : 918 pages
File Size : 51,6 Mb
Release : 2017-04-30
Category : Medical
ISBN : 9789386322876

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An Evidence-based Clinical Textbook in Obstetrics & Gynecology for MRCOG-2 by Richa Saxena Pdf

This book is a practical guide to obstetrics and gynaecology for trainees preparing for the MRCOG Part 2 examination. Beginning with a brief overview of general principles, the rest of the book is clearing set into two sections – Obstetrics, and Gynaecology. Each of these sections is further divided to discuss the diagnosis and management of numerous disorders within each sub-specialty. The book has been written in accordance with the current MRCOG Part 2 curriculum and includes the very latest RCOG Green-top guidelines and NICE guidelines. Additionally, this comprehensive textbook features the latest statistics on maternal and perinatal mortality in the UK, published by MBRRACE-UK in December 2016. Key Points Practical guide to obstetrics and gynaecology for MRCOG Part 2 candidates Written in accordance with current MRCOG Part 2 curriculum Includes latest RCOG Green-top guidelines and NICE guidelines Features latest statistics on maternal and perinatal mortality from MBRRACE-UK

Author : Arthur L. Frank
Publisher : Unknown
Page : 60 pages
File Size : 43,5 Mb
Release : 2001
Category : Environmental monitoring
ISBN : MINN:31951D01956924I

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Taking an Exposure History by Arthur L. Frank Pdf

Author : C. Klaasen
Publisher : Birkhäuser
Page : 650 pages
File Size : 48,7 Mb
Release : 2012-11-05
Category : Science
ISBN : 3034897995

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Metallothionein IV by C. Klaasen Pdf

The Proceedings of the Fourth International Metallothionein Meeting (MT-97) feature the latest research on metallothionein. The book covers a broad range of topics which provide important information for both basic and clinical investigators. The selected 94 articles in this book are written by the leading scientists in the field around the world. This is an increasingly important, multi-disciplinary area of study that has benefitted from recent advances in concepts and methodologies from other fields.

Author : Sarah E. Royce
Publisher : Unknown
Page : 60 pages
File Size : 53,9 Mb
Release : 2000
Category : Lead
ISBN : UOM:39015051606617

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Lead Toxicity by Sarah E. Royce Pdf

Author : P. Apostoli,World Health Organization,United Nations Environment Programme,International Labour Organisation
Publisher : World Health Organization
Page : 257 pages
File Size : 50,7 Mb
Release : 2006
Category : Medical
ISBN : 9789241572347

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Elemental Speciation in Human Health Risk Assessment by P. Apostoli,World Health Organization,United Nations Environment Programme,International Labour Organisation Pdf

Definitions of species and speciation - - Strructural aspects of speciation - - Analytical techniques and methodology - - Bioaccessibility and bioavailability - - Toxicokinetics and biological monitoring - - Molecular and cellular mechanisms of metal toxicity - - Health effects - - Conclusions and recommendations.