Extracellular Matrix Biomineralization Of Dental Tissue Structures

Author : Michel Goldberg,Pamela Den Besten
Publisher : Springer Nature
Page : 305 pages
File Size : 53,9 Mb
Release : 2021-09-30
Category : Medical
ISBN : 9783030762834

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Extracellular Matrix Biomineralization of Dental Tissue Structures by Michel Goldberg,Pamela Den Besten Pdf

This book addresses the structural and biological properties of dental and peridental tissue structures and covers their mineralization process. The book contains a description of dentines, cementum, enamel and bone, including collagens, as well as non-collagenous proteins (SIBLINGs, SLRPs, GAGs, PGs, lipids, and MMPs). The mechanisms of mineralization are described in detail and the book is focused on matrix vesicles, collagen mineralization and the role of non-collagenous extracellular matrix components either as promoters or inhibitors of mineralization. In addition, the matrix components (non-collagenous) of enamel (amelogenin, ameloblastin, enamelin, MMP4, MMP20 and other proteases) are reviewed and their respective roles in dental tissues biomineralizations and tissue turnover are discussed. Additionally, environmental factors involved in enamel / dentin defects are adressed. With state-of-the-art contributions from experts in the respective domains, the book is a useful introduction to the field for junior scientists, interested in dental and peridental tissue biomineralization. It is also an interesting read for advanced scientists and clinicians working in dental research, giving them a broader view of the topic beyond their area of specialization. The series Biology of Extracellular Matrix is published in collaboration with the American Society for Matrix Biology.

Author : Michel Goldberg
Publisher : Bentham Science Publishers
Page : 464 pages
File Size : 40,5 Mb
Release : 2012-09-11
Category : Medical
ISBN : 9781608054657

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Phosphorylated Extracellular Matrix Proteins of Bone and Dentin by Michel Goldberg Pdf

Phosphorylated Extracellular Matrix Proteins of Bone and Dentin is the second volume of the e-book series Frontiers between Science and Clinic in Odontology. The phosphorylated proteins of the extracellular matrix of bone and teeth play a crucial structural role in the two tissues. They also act as signaling molecules. Phosphorylated extracellular matrix proteins have been implicated in nucleation and mineralization of skeletal tissues. This e-book covers research on these specific proteins, including details about the cells producing these molecules, their impact on bone and teeth pathology (osteogenesis and dentinogenesis imperfecta) and the potential of these molecules in promoting of inhibiting mineralization. This e-book also explains processes under the control of some enzymes - TNAP and metalloproteases (MMPs) - such as intracellular regulation in bone and dentine, splicing, respective roles of cleavage products, SIBLINGs, nucleation and crystal growth and regulation. This second volume serves as a valuable reference to practicing odontologists, biology and biomaterials scientists and tissue engineers interested in protein research related to tooth and bone formation.

Author : Irving M. Shapiro,William J. Landis
Publisher : Springer
Page : 0 pages
File Size : 48,6 Mb
Release : 2023-08-10
Category : Science
ISBN : 3031343026

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Mechanisms of Mineralization of Vertebrate Skeletal and Dental Tissues by Irving M. Shapiro,William J. Landis Pdf

The book presents a multi-disciplinary approach to understanding mechanisms regulating the formation of mineral in vertebrate skeletal and dental tissues. The focus of the book is directed toward the mineralization process, an evolutionarily conserved system in which cells synthesize a complex and unique extracellular matrix into which mineral is deposited. Regulatory control is viewed though lenses that emphasize the genetic, physical-chemical, biochemical, structural, cellular and extracellular aspects of the mineralization process as they relate to crystal nucleation, growth and maturation. Throughout the book, defects in regulation at the genetic and transcriptional levels are linked to the numerous clinical problems associated with the mineralization of bone, cartilage, tendon, tooth, and soft tissues. The book serves as a comprehensive text for basic scientists and scholars working in the many areas that comprise hard tissue research, as well as undergraduate and graduate students, postdoctoral fellows and those contemplating working in the field of biomineralization or who need a review of a specific mineralization topic. The information contained in the book is relevant for clinicians and clinical scientists in the fields of orthopaedic surgery, veterinary medicine, dentistry, endocrinology, aging and genetics.

Author : Mona Marei
Publisher : Morgan & Claypool Publishers
Page : 178 pages
File Size : 53,6 Mb
Release : 2010-06-06
Category : Technology & Engineering
ISBN : 9781608452149

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Regenerative Dentistry by Mona Marei Pdf

Dental caries, periodontitis, tooth loss, and bone resorption are considered prevalent health problems that have direct affect on the quality of life. While, advances in stem cell biology and biotechnology have sparked hope for devastating maladies, such as diabetes, cardiovascular diseases, etc., it also provides a strategy of regenerative therapy for dental tissues. From the prospective of tissue engineering, it is of utmost importance to understand and emulate the complex cell interactions that make up a tissue or organ. Unlike other tissues in the body, dental tissues are unique in their development, function, and even in their maintenance throughout life. The harmonized stimulations of biology and mechanical regulators to promote cellular activities have matured our understanding of the value of regenerative therapy of dental tissue versus the reparative treatment. In this book, we review the current knowledge available to regenerate alveolar bone, periodontal structure, and pulp/dentin complex. The book provides researchers with detailed information about development and functional characteristics of the dental unit with detailed protocols covering a comprehensive range of various approaches to engineer dental tissues: to use isolated cells or cell substitutes as cellular replacement, to use acellular biomaterials capable of inducing tissue regeneration, and/or to use a combination of cells, biomaterial and growth factors. We are well aware, with the concept changes in the field toward in-vitro biomimetics of in-vivo tissue development. The theoretical frame work integrating these concepts of developmental biology and developmental engineering is yet to be emphasized and implemented. Until this happens, we consider this book of regenerative dentistry as a call for scientists to achieve, researchers to innovate, practitioners to apply, and students to learn the art and science of regenerative therapy in dentistry. Table of Contents: Introduction to Regenerative Dentistry / Tissue Engineering Alveolar Bone / Tissue Engineering of the Periodontal Tissues / Dynamics for Pulp-Dentin Tissue Engineering in Operative Dentistry

Author : Conrado Aparicio,Maria Pau Ginebra
Publisher : Woodhead Publishing
Page : 482 pages
File Size : 40,9 Mb
Release : 2015-09-28
Category : Technology & Engineering
ISBN : 9781782423560

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Biomineralization and Biomaterials by Conrado Aparicio,Maria Pau Ginebra Pdf

Biomineralization is a natural process by which living organisms form minerals in association with organic biostructures to form hybrid biological materials such as bone, enamel, dentine and nacre among others. Scientists have researched the fundamentals of these processes and the unique structures and properties of the resulting mineralized tissues. Inspired by them, new biomaterials for tissue engineering and regenerative medicine have been developed in recent years. Biomineralization and biomaterials: fundamentals and applications looks at the characteristics of these essential processes and natural materials and describes strategies and technologies to biomimetically design and produce biomaterials with improved biological performance. Provides a thorough overview of the biomineralization process Presents the most recent information on the natural process by which crystals in tissues form into inorganic structures such as bone, teeth, and other natural mineralized tissues Investigates methods for improving mineralization Explores new techniques that will help improve the biomimetic process

Author : Derek J. Chadwick,Gail Cardew
Publisher : John Wiley & Sons
Page : 284 pages
File Size : 50,5 Mb
Release : 2008-04-30
Category : Medical
ISBN : 9780470515327

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Dental Enamel by Derek J. Chadwick,Gail Cardew Pdf

The molecular mechanisms and protein species associated with the mineralization of mature dental enamel are active areas of research. This book focuses on specific areas of research including the structural chemistry, protein biochemistry and genetics of enamel development.

Author : J. V. Ruch
Publisher : Unknown
Page : 320 pages
File Size : 43,5 Mb
Release : 1995
Category : Dentition
ISBN : UOM:39015034938772

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Odontogenesis by J. V. Ruch Pdf

Author : Laurie K. McCauley,Martha J. Somerman
Publisher : John Wiley & Sons
Page : 391 pages
File Size : 53,8 Mb
Release : 2012-06-05
Category : Medical
ISBN : 9780470958339

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Mineralized Tissues in Oral and Craniofacial Science by Laurie K. McCauley,Martha J. Somerman Pdf

Mineralized Tissues in Oral and Craniofacial Science is a major comprehensive update on knowledge in the field of mineralized tissues in the oral and craniofacial region. Drs. McCauley and Somerman assembled an international team of researchers and clinicians, offering a global perspective on the current knowledge in this field. Basic and clinical correlates reinforce the significance of research to clinical diagnoses and therapies, written in a manner that lends easily to their use for case study teaching venues. Section 1 features the many aspects of bone in the craniofacial region, including embryology, cell biology, and stem cell biology. Section 2 focuses on teeth-tooth development, dentin, enamel, cementum, and tooth regeneration. Section 3 discusses the interaction between bones and teeth, including those associated with inflammatory processes, periodontal ligaments, biomechanics, and other impact factors-such as nutrition, metabolic bone diseases and therapeutic modalities. The novel approach of linking the basic principles of the cell and molecular biology of hard tissues to clinical correlates will appeal to readers at all levels of their research careers, both students and faculty; faculty interested in a comprehensive text for reference; and clinicians interested in the biologic aspects of bones and teeth.

Author : Anonim
Publisher : Unknown
Page : 1398 pages
File Size : 50,8 Mb
Release : 1994
Category : Medicine
ISBN : MINN:31951P003778514

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Biomedical Index to PHS-supported Research: pt. A. Subject access A-H by Anonim Pdf

Author : Michel Goldberg
Publisher : Bentham Science Publishers
Page : 245 pages
File Size : 54,9 Mb
Release : 2010
Category : Medical
ISBN : 9781608051717

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Amelogenins: Multifaceted Proteins for Dental and Bone Formation and Repair by Michel Goldberg Pdf

"This volume is the 1st in a series of Ebooks that bridges the gap between advances in science and clinical practice in odontology. Recent advances in biology, materials science and tissue engineering are increasingly viewed as being of enormous clinical p"

Author : Luiz E. Bertassoni,Paulo G. Coelho
Publisher : Springer
Page : 276 pages
File Size : 45,9 Mb
Release : 2015-11-07
Category : Science
ISBN : 9783319223452

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Engineering Mineralized and Load Bearing Tissues by Luiz E. Bertassoni,Paulo G. Coelho Pdf

This book offers a comprehensive overview of current challenges and strategies to regenerate load-bearing and calcified human tissues, including bone, cartilage,tendon, ligaments and dental structures (dentin, enamel, cementum and periodontal ligament). Tissue engineering has long held great promises as an improved treatment option for conditions affecting mineralized and load-bearing structures in the body. Although significant progress has been achieved in recent years, a number of challenges still exist. Scaffold vascularization, new biofabrication methods (3D printing, lithography, microfabrication), peptide conjugation methods, interface engineering, scaffold mechanical properties, iPS cells, organs-on-a-chip, are some of the topics discussed in this book. More specially, in the first section readers will find an overview of emerging biofabrication methods. In section 2, applied strategies for regeneration of (2.1) bone, cartilage and ligament, as well as (2.2) dentin, cementum, enamel and periodontal ligament are discussed across 14 chapters. While other volumes have addressed the regeneration of individual tissues, or exclusively focused on different regenerative strategies, the focus of this work is to bring together researchers integrating backgrounds in materials sciences, engineering, biology, mechanics, fluidics, etc, to address specific challenges common to regeneration of several load-bearing and calcified tissues. Therefore, this book provides a unique platform to stimulate progress in the regeneration of functional tissue substitutes. We envision that this book will represent a valuable reference source for university and college faculties, post‐doctoral research fellows, senior graduate students, and researchers from R&D laboratories in their endeavors to fabricate biomimetic load bearing tissues.

Author : Anonim
Publisher : Unknown
Page : 1398 pages
File Size : 49,6 Mb
Release : 1987
Category : Medicine
ISBN : STANFORD:36105021766048

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Biomedical Index to PHS-supported Research by Anonim Pdf

Author : David Evered,Sara Harnett
Publisher : John Wiley & Sons
Page : 318 pages
File Size : 52,9 Mb
Release : 2008-04-30
Category : Science
ISBN : 9780470513644

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Cell and Molecular Biology of Vertebrate Hard Tissues by David Evered,Sara Harnett Pdf

Brings together the latest research in the cellular and molecular biology of bones and teeth, including applications to medical and dental practice. An interdisciplinary group of contributors addresses control of bone formation, resorption and remodelling, osteoblast differentiation and osteoclast activity, factors influencing dental extracellular matrix biomineralization, non-collagen proteins in bone and their function, hormonal regulation of bone growth, and more.

Author : J.E. Ellingsen,S.P. Lyngstadaas
Publisher : CRC Press
Page : 467 pages
File Size : 41,7 Mb
Release : 2003-04-29
Category : Medical
ISBN : 9780203491430

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Bio-Implant Interface by J.E. Ellingsen,S.P. Lyngstadaas Pdf

Achieving good clinical outcomes with implanted biomaterials depends upon achieving optimal function, both mechanical and biological, which in turn depends upon integrating advances realized in biological science, material science, and tissue engineering. As these advances push back the frontiers of biomaterial medicine , the control and patterning

Author : Ajaykumar Vishwakarma,Paul Sharpe,Songtao Shi,Murugan Ramalingam
Publisher : Academic Press
Page : 933 pages
File Size : 53,5 Mb
Release : 2014-11-05
Category : Technology & Engineering
ISBN : 9780123977786

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Stem Cell Biology and Tissue Engineering in Dental Sciences by Ajaykumar Vishwakarma,Paul Sharpe,Songtao Shi,Murugan Ramalingam Pdf

Stem Cell Biology and Tissue Engineering in Dental Sciences bridges the gap left by many tissue engineering and stem cell biology titles to highlight the significance of translational research in this field in the medical sciences. It compiles basic developmental biology with keen focus on cell and matrix biology, stem cells with relevance to tissue engineering biomaterials including nanotechnology and current applications in various disciplines of dental sciences; viz., periodontology, endodontics, oral & craniofacial surgery, dental implantology, orthodontics & dentofacial orthopedics, organ engineering and transplant medicine. In addition, it covers research ethics, laws and industrial pitfalls that are of particular importance for the future production of tissue constructs. Tissue Engineering is an interdisciplinary field of biomedical research, which combines life, engineering and materials sciences, to progress the maintenance, repair and replacement of diseased and damaged tissues. This ever-emerging area of research applies an understanding of normal tissue physiology to develop novel biomaterial, acellular and cell-based technologies for clinical and non-clinical applications. As evident in numerous medical disciplines, tissue engineering strategies are now being increasingly developed and evaluated as potential routine therapies for oral and craniofacial tissue repair and regeneration. Diligently covers all the aspects related to stem cell biology and tissue engineering in dental sciences: basic science, research, clinical application and commercialization Provides detailed descriptions of new, modern technologies, fabrication techniques employed in the fields of stem cells, biomaterials and tissue engineering research including details of latest advances in nanotechnology Includes a description of stem cell biology with details focused on oral and craniofacial stem cells and their potential research application throughout medicine Print book is available and black and white, and the ebook is in full color