Fast Facts Leukemia

Author : Justin Loke,Ankit J. Kansagra
Publisher : Karger Medical and Scientific Publishers
Page : 138 pages
File Size : 55,5 Mb
Release : 2022-02-22
Category : Medical
ISBN : 9783318069969

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Fast Facts: Leukemia by Justin Loke,Ankit J. Kansagra Pdf

Leukemia is a hematologic malignancy arising from hematopoietic stem cells (HSCs) in the bone marrow. Starting with a detailed description of hematopoiesis and what goes wrong in leukemia, this concise guide covers all aspects of the four most common subtypes of the disease. Although the incidence and prevalence of leukemia are rising worldwide, survival rates are also increasing. However, both the effects of the disease and the adverse effects of treatment remain complex challenges. Yet, as our understanding of the molecular landscape increases, therapeutic options are becoming more personalized. This revised and updated second edition of 'Fast Facts: Leukemia' addresses the causes and risk factors for each subtype of leukemia, the initial and confirmatory diagnostic tests, and the latest treatment options. Designed as a comprehensive primer for physician assistants, nurse practitioners, primary care providers, oncology nurses, hematology/ oncology trainees and pharmacists, this resource will help the non-specialist and those in training to identify leukemia early and provide a thorough understanding of the pathology and genetic basis of the disease, treatment options, and effective approaches to emergency and supportive care. Table of Contents: • Understanding blood and its components • What is leukemia? • Epidemiology, etiology and risk factors • Diagnosis • Staging and general management • Supportive care • Emergencies in leukemia

Author : Kathryn Huntley,Anna Schuh,Alessandra Tedeschi
Publisher : Unknown
Page : 0 pages
File Size : 50,5 Mb
Release : 2023
Category : Medical
ISBN : 3318072273

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Fast Facts for Patients: Chronic Lymphocytic Leukemia by Kathryn Huntley,Anna Schuh,Alessandra Tedeschi Pdf

Chronic lymphocytic leukemia (CLL) is a slow-growing type of blood cancer and the most common form of leukemia in adults. CLL results in large numbers of abnormal B lymphocytes in the bone marrow and prevents the production of healthy blood cells. It is more commonly diagnosed in older people: almost 80% of cases are in people over 60 years old. Changes in chromosomes or genes in some patients affect how the disease develops and what treatment is prescribed. CLL cannot be completely cured but many people will have a normal lifespan and a good quality of life.

Author : William Blum,Vikram Mathews
Publisher : Karger Medical and Scientific Publishers
Page : 90 pages
File Size : 40,5 Mb
Release : 2018-05-14
Category : Medical
ISBN : 9781910797594

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Fast Facts: Acute Myeloid Leukemia by William Blum,Vikram Mathews Pdf

This last year has seen the approval of the first targeted treatments for acute myeloid leukemia (AML) - following decades with no new developments and a poor prognosis for most patients with the disease. The new drugs reflect the remarkable progress that has been made in our understanding of the pathophysiology of AML and its underlying cytogenetic and molecular abnormalities - which differ not only between patients but also within a patient over time and with treatment. 'Fast Facts: Acute Myeloid Leukemia' provides a comprehensive yet concise foundation for understanding AML: from basic epidemiology, diagnosis, classification and the current 'standard' treatment, through to recent advances in our understanding of the cytogenetic and molecular underpinnings of the disease, such as the IDH2 mutation, and the future for tailored therapy. It will be useful to primary care providers, medical students, specialist nurses, junior doctors and allied healthcare professionals who want to develop a thorough grounding in our evolving understanding of AML and its treatment. Contents: • Epidemiology, pathophysiology and etiology • Diagnosis • Treatment • Supportive care • Prognosis and monitoring • Emerging treatments • Useful resources

Author : T.A. Eyre,P. Jasani,L.E. Roeker
Publisher : Karger Medical and Scientific Publishers
Page : 74 pages
File Size : 50,5 Mb
Release : 2022-02-11
Category : Medical
ISBN : 9783318069747

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Fast Facts: Chronic Lymphocytic Leukemia by T.A. Eyre,P. Jasani,L.E. Roeker Pdf

Chronic lymphocytic leukemia (CLL) is the most diagnosed leukemia in the Western world, accounting for approximately 25% of all new leukemia diagnoses. In recent years, remarkable progress has been made in our understanding of both the pathophysiology and genetics of CLL. While the disease generally affects older adults and initially follows an indolent course, cytogenetic and molecular profiling have helped to predict clinical outcomes. Greater prognostication, alongside the development of an increasing armamentarium of novel targeted therapies, has enabled us to provide more personalized management options for patients. 'Fast Facts: Chronic Lymphocytic Leukemia' covers the epidemiology, etiology, diagnosis and staging of the disease, and the molecular and genetic aspects that underpin treatment and prognosis. It provides a concise overview of treatment options, in both the front-line and relapsed/refractory settings, with particular focus on the novel targeted agents that have overcome many adverse prognostic factors, improving overall survival. Table of Contents: • Epidemiology and etiology • Molecular biology and genetics • Diagnosis, staging and prognosis • Management • Research directions

Author : Toby A Eyre,Parag Jasani,Lindsey E Roeker
Publisher : Karger Medical and Scientific Publishers
Page : 74 pages
File Size : 40,7 Mb
Release : 2022-02-11
Category : Medical
ISBN : 9783318069730

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Fast Facts: Chronic Lymphocytic Leukemia by Toby A Eyre,Parag Jasani,Lindsey E Roeker Pdf

Chronic lymphocytic leukemia (CLL) is the most diagnosed leukemia in the Western world, accounting for approximately 25% of all new leukemia diagnoses. In recent years, remarkable progress has been made in our understanding of both the pathophysiology and genetics of CLL. While the disease generally affects older adults and initially follows an indolent course, cytogenetic and molecular profiling have helped to predict clinical outcomes. Greater prognostication, alongside the development of an increasing armamentarium of novel targeted therapies, has enabled us to provide more personalized management options for patients. 'Fast Facts: Chronic Lymphocytic Leukemia' covers the epidemiology, etiology, diagnosis and staging of the disease, and the molecular and genetic aspects that underpin treatment and prognosis. It provides a concise overview of treatment options, in both the front-line and relapsed/refractory settings, with particular focus on the novel targeted agents that have overcome many adverse prognostic factors, improving overall survival. Table of Contents: • Epidemiology and etiology • Molecular biology and genetics • Diagnosis, staging and prognosis • Management • Research directions

Author : Bela Wrench,Anna Castleton,Michael Austin
Publisher : Karger Medical and Scientific Publishers
Page : 108 pages
File Size : 51,6 Mb
Release : 2022-06-30
Category : Medical
ISBN : 9783318069778

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Fast Facts: Acute Lymphoblastic Leukemia by Bela Wrench,Anna Castleton,Michael Austin Pdf

Acute lymphoblastic leukemia (ALL) is the most diagnosed childhood cancer worldwide. Although rare in adults, this aggressive cancer also shows a second smaller incidence peak in later middle age.

Modern genetic profiling techniques are providing a better understanding of the molecular biology of ALL, which, in turn, is leading to significant advances in diagnosis, prognostication and therapy selection. Ongoing refinement of risk-adapted frontline treatment protocols, use of novel targeted therapies and better supportive care are improving outcomes for patients with ALL.

Fast Facts: Acute Lymphoblastic Leukemia covers the epidemiology, etiology, diagnosis and classification of ALL as well as the measurement of minimal residual disease to determine prognosis. It provides guidance on frontline therapies and the treatment of relapsed and refractory ALL, including the use of newer targeted agents and the role of allogeneic stem-cell transplantation. Looking to the future, it also considers the approaches and refinements that are in development for ALL. Table of Contents:

Author : Ruben A. Mesa,Claire N. Harrison
Publisher : Karger Medical and Scientific Publishers
Page : 117 pages
File Size : 43,5 Mb
Release : 2019
Category : Medical
ISBN : 9781910797792

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Fast Facts: Myeloproliferative Neoplasms by Ruben A. Mesa,Claire N. Harrison Pdf

Presentation of the myeloproliferative neoplasms (MPNs) varies widely, and correct diagnosis and management can be challenging, and is becoming more complex as understanding of the underlying molecular basis for these disorders emerges. Appropriate management is increasingly informed by accurate risk stratification founded on understanding of cytogenetic and molecular markers, as well as the clinical presentation. 'Fast Facts: myeloproliferative neoplasms' focuses on the three most common chronic MPNs: * Essential thrombocythemia (ET) - characterized by increased platelet count * Polycythemia vera (PV) - characterized by excessive production of red blood cells * Primary myelofibrosis - a more severe and heterogenous disorder that may overlap with ET and PV but is commonly associated with anemia. Written by two leading experts in the field, Fast Facts: myeloproliferative neoplasms provides concise, up-to-date and practical guidance on the accurate diagnosis, risk stratification and management of these MPNs. It also provides key insights into our growing understanding of the underlying molecular and genetic basis of these disorders, and how this is informing risk stratification and management strategies. This concise handbook will be invaluable to clinicians, medical students, nurses, pharmacists and scientists in understanding and overcoming the everyday and rarer challenges associated with MPN.

Author : Karthik Ramasamy,Sagar Lonial
Publisher : Karger Medical and Scientific Publishers
Page : 162 pages
File Size : 51,9 Mb
Release : 2017-01-09
Category : Medical
ISBN : 9781910797334

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Fast Facts: Multiple Myeloma and Plasma Cell Dyscrasias by Karthik Ramasamy,Sagar Lonial Pdf

Our understanding of multiple myeloma (MM) is growing at a formidable pace, particularly in terms of risk factors and potential drug targets. Minimal residual disease (MRD) negativity is set to become the new benchmark in treatment, and cytogenetic analysis is now paving the way for personalized therapies. This second edition of 'Fast Facts: Multiple Myeloma and Plasma Cell Dyscrasias' includes: - the new IMWG SLiM CRAB criteria - the latest advances in diagnostic tests and imaging - cytogenetics and genetic profiling - induction therapy prior to SCT - new lenalidomide- and bortezomib-based regimens - second-generation proteasome inhibitors, histone deacetylase inhibitors and monoclonal antibodies treatments. This Fast Facts handbook provides a comprehensive overview of MM and other plasma cell dyscrasias, from bench to bedside, presenting the pathogenesis, diagnosis and treatment in the context of daily clinical practice. Contents: • Epidemiology and etiology Predisposing conditions associated with MM • Pathophysiology of MM and MGUS • Diagnosis, staging and monitoring of multiple myeloma • Genetics and multiple myeloma • Treatment of newly diagnosed multiple myeloma • Stem cell transplantation in multiple myeloma • Relapsed and refractory multiple myeloma • Bone disease and renal complications • AL amyloidosis • Rare plasma cell dyscrasias • Supportive care

Author : William Blum,Vikram Mathews
Publisher : Unknown
Page : 87 pages
File Size : 45,7 Mb
Release : 2018
Category : Electronic
ISBN : 191079760X

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Fast Facts by William Blum,Vikram Mathews Pdf

Author : Toby A. Eyre,Parag Jasani,Lindsey E. Roeker
Publisher : Karger Medical and Scientific Publishers
Page : 80 pages
File Size : 46,8 Mb
Release : 2023-06-07
Category : Medical
ISBN : 9783318072303

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Fast Facts: Chronic Lymphocytic Leukemia by Toby A. Eyre,Parag Jasani,Lindsey E. Roeker Pdf

Chronic lymphocytic leukemia (CLL) is the most diagnosed leukemia in the Western world, accounting for approximately 25% of all new leukemia diagnoses. In recent years, remarkable progress has been made in our understanding of both the pathophysiology and genetics of CLL. While the disease generally affects older adults and initially follows an indolent course, cytogenetic and molecular profiling have helped to predict clinical outcomes. Greater prognostication, alongside the development of an increasing armamentarium of novel targeted therapies, has enabled us to provide more personalized management options for patients. Table of Contents • Epidemiology and etiology • Molecular biology and genetics • Diagnosis, staging and prognosis • Management • Research directions

Author : Kathryn Huntley,Anna Schuh,Alessandra Tedeschi
Publisher : Karger Medical and Scientific Publishers
Page : 52 pages
File Size : 44,6 Mb
Release : 2023-07-05
Category : Medical
ISBN : 9783318072525

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Fast Facts for Patients: Chronic Lymphocytic Leukemia by Kathryn Huntley,Anna Schuh,Alessandra Tedeschi Pdf

Chronic lymphocytic leukemia (CLL) is a slow-growing type of blood cancer and the most common form of leukemia in adults. CLL results in large numbers of abnormal B lymphocytes in the bone marrow and prevents the production of healthy blood cells. It is more commonly diagnosed in older people: almost 80% of cases are in people over 60 years old. Changes in chromosomes or genes in some patients affect how the disease develops and what treatment is prescribed. CLL cannot be completely cured but many people will have a normal lifespan and a good quality of life.

Author : Sandeep Potluri
Publisher : Karger Medical and Scientific Publishers
Page : 54 pages
File Size : 49,9 Mb
Release : 2021-01-26
Category : Medical
ISBN : 9783318068337

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Fast Facts: Treatment-Free Remission in Chronic Myeloid Leukemia by Sandeep Potluri Pdf

The tyrosine kinase inhibitor (TKI) imatinib was the first treatment to specifically target cancer cells, rather than the relatively indiscriminate effects of conventional chemotherapy on any rapidly dividing cells. This concept of targeted treatment in cancer is one of the important advances in modern medicine in the last 30 years. Indeed, treatment with TKIs has transformed chronic myeloid leukemia (CML) from a cancer with a poor prognosis to one in which many patients can expect a normal lifespan. Success with the TKIs has prompted the question of whether it is desirable – or feasible – for patients to remain on treatment for long periods. While the TKIs are targeted, they are associated with considerable toxicity, and long-term treatment has important economic implications for health services and patients. Thus, the concept of treatment-free remission (TFR) has emerged for patients in deep clinical remission. Clinical research over the last decade has focused on whether treatment can be stopped, how to best monitor patients while off treatment, and how to intervene before a clinical relapse. As this research progresses, the tantalizing prospect of a cure for some patients seems increasingly feasible. This new Fast Facts title outlines this trail-blazing approach to the long-term management of patients living with CML in remission. It explains the concepts of molecular and hematologic relapse, the highly sensitive technologies that allow disease monitoring, and how TFR is best managed in practice. It is a concise educational resource, ideal for any healthcare professional involved in the treatment of patients with CML who wants to understand TFR, particularly clinical nurse specialists and pharmacists who increasingly help clinicians to run CML clinics. Table of Contents: • The concept of treatment-free remission • Measurement of disease burden • Clinical practice • Future directions

Author : William Blum,Vikram Mathews
Publisher : Unknown
Page : 0 pages
File Size : 55,7 Mb
Release : 2018
Category : Acute myeloid leukemia
ISBN : OCLC:1397879588

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Fast Facts : Acute Myeloid Leukemia by William Blum,Vikram Mathews Pdf

This last year has seen the approval of the first targeted treatments for acute myeloid leukemia (AML) - following decades with no new developments and a poor prognosis for most patients with the disease. The new drugs reflect the remarkable progress that has been made in our understanding of the pathophysiology of AML and its underlying cytogenetic and molecular abnormalities - which differ not only between patients but also within a patient over time and with treatment. 'Fast Facts: Acute Myeloid Leukemia' provides a comprehensive yet concise foundation for understanding AML: from basic epidemiology, diagnosis, classification and the current 'standard' treatment, through to recent advances in our understanding of the cytogenetic and molecular underpinnings of the disease, such as the IDH2 mutation, and the future for tailored therapy. It will be useful to primary care providers, medical students, specialist nurses, junior doctors and allied healthcare professionals who want to develop a thorough grounding in our evolving understanding of AML and its treatment. Contents: • Epidemiology, pathophysiology and etiology • Diagnosis • Treatment • Supportive care • Prognosis and monitoring • Emerging treatments • Useful resources.

Author : S. Potluri
Publisher : Karger Medical and Scientific Publishers
Page : 54 pages
File Size : 54,6 Mb
Release : 2021-01-26
Category : Medical
ISBN : 9783318068344

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Fast Facts: Treatment-Free Remission in Chronic Myeloid Leukemia by S. Potluri Pdf

The tyrosine kinase inhibitor (TKI) imatinib was the first treatment to specifically target cancer cells, rather than the relatively indiscriminate effects of conventional chemotherapy on any rapidly dividing cells. This concept of targeted treatment in cancer is one of the important advances in modern medicine in the last 30 years. Indeed, treatment with TKIs has transformed chronic myeloid leukemia (CML) from a cancer with a poor prognosis to one in which many patients can expect a normal lifespan. Success with the TKIs has prompted the question of whether it is desirable – or feasible – for patients to remain on treatment for long periods. While the TKIs are targeted, they are associated with considerable toxicity, and long-term treatment has important economic implications for health services and patients. Thus, the concept of treatment-free remission (TFR) has emerged for patients in deep clinical remission. Clinical research over the last decade has focused on whether treatment can be stopped, how to best monitor patients while off treatment, and how to intervene before a clinical relapse. As this research progresses, the tantalizing prospect of a cure for some patients seems increasingly feasible. This new Fast Facts title outlines this trail-blazing approach to the long-term management of patients living with CML in remission. It explains the concepts of molecular and hematologic relapse, the highly sensitive technologies that allow disease monitoring, and how TFR is best managed in practice. It is a concise educational resource, ideal for any healthcare professional involved in the treatment of patients with CML who wants to understand TFR, particularly clinical nurse specialists and pharmacists who increasingly help clinicians to run CML clinics. Table of Contents: • The concept of treatment-free remission • Measurement of disease burden • Clinical practice • Future directions

Author : Ailsa E. Gebbie,Katharine O'Connell White
Publisher : Karger Medical and Scientific Publishers
Page : 117 pages
File Size : 44,8 Mb
Release : 2009-02-01
Category : Medical
ISBN : 9781905832507

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Fast Facts: Contraception by Ailsa E. Gebbie,Katharine O'Connell White Pdf

One of the major roles of anyone working in sexual health is that of educator, and many people rely on well-informed healthcare professionals to help them choose the most appropriate method of contraception. This completely revised third edition of 'Fast Facts: Contraception', by two new authors of international renown, provides a concise and practical review of all the available contraceptive methods on the market in a highly readable well-illustrated format. Highlights of this comprehensive handbook include: • A commonsense approach to the contraception consultation • Fully updated information on recently licensed products • Discussion of the risks, benefits and contraindications for all contraceptive methods. 'Fast Facts: Contraception' is an invaluable resource that will help healthcare professionals and specialists offer a broader range of contraceptive methods along with appropriate advice on the most suitable options. Contents: • Choosing a contraceptive method • Combined hormonal contraception • Progestogen-only methods • Intrauterine devices and systems • Barrier methods • Emergency contraception • Female sterilization • Vasectomy and hormonal methods for men • Biologically based methods • Postpartum contraception • Useful resources