Download Full eBooks in PDF
Fifty Years Of Antimicrobials Book in PDF, ePub and Kindle version is available to download in english. Read online anytime anywhere directly from your device. Click on the download button below to get a free pdf file of Fifty Years Of Antimicrobials book. This book definitely worth reading, it is an incredibly well-written.
Author : Society for General Microbiology. Symposium
Publisher : Cambridge University Press
Page : 396 pages
File Size : 44,7 Mb
Release : 1995-05-04
Category : Medical
ISBN : 0521481082
A look back over the development of antibiotics since Fleming's day and a look forward to future challenges.
Author : Siouxsie Wiles
Publisher : Bridget Williams Books
Page : 136 pages
File Size : 54,8 Mb
Release : 2017-04-10
Category : Science
ISBN : 9780947518660
In ten years’ time, will antibiotics still work? Have we let bacteria get the upper hand in the evolutionary arms race? In the 1920s the discovery of the antibiotic penicillin started a golden age of medicine. However, experts warn that the end of that age may be just a decade away. In this BWB Text, microbiologist Siouxsie Wiles explores the looming crisis of antibiotic resistance and its threat to New Zealand. Wiles concludes that New Zealand must do more to protect the public from a future without antibiotics.
Author : Thomas J. Dougherty,Michael J. Pucci
Publisher : Springer Science & Business Media
Page : 1119 pages
File Size : 45,8 Mb
Release : 2011-12-18
Category : Medical
ISBN : 9781461414001
This volume covers all aspects of the antibiotic discovery and development process through Phase II/III. The contributors, a group of highly experienced individuals in both academics and industry, include chapters on the need for new antibiotic compounds, strategies for screening for new antibiotics, sources of novel synthetic and natural antibiotics, discovery phases of lead development and optimization, and candidate compound nominations into development. Beyond discovery , the handbook will cover all of the studies to prepare for IND submission: Phase I (safety and dose ranging), progression to Phase II (efficacy), and Phase III (capturing desired initial indications). This book walks the reader through all aspects of the process, which has never been done before in a single reference. With the rise of antibiotic resistance and the increasing view that a crisis may be looming in infectious diseases, there are strong signs of renewed emphasis in antibiotic research. The purpose of the handbook is to offer a detailed overview of all aspects of the problem posed by antibiotic discovery and development.
Author : William Rosen
Publisher : Penguin
Page : 370 pages
File Size : 54,5 Mb
Release : 2017-05-09
Category : Medical
ISBN : 9780525428107
The epic history of how antibiotics were born, saving millions of lives and creating a vast new industry known as Big Pharma. As late as the 1930s, virtually no drug intended for sickness did any good; doctors could set bones, deliver babies, and offer palliative care. That all changed in less than a generation with the discovery and development of a new category of medicine known as antibiotics. By 1955, the age-old evolutionary relationship between humans and microbes had been transformed, trivializing once-deadly infections. William Rosen captures this revolution with all its false starts, lucky surprises, and eccentric characters. He explains why, given the complex nature of bacteria—and their ability to rapidly evolve into new forms—the only way to locate and test potential antibiotic strains is by large-scale, systematic, trial-and-error experimentation. Organizing that research needs large, well-funded organizations and businesses, and so our entire scientific-industrial complex, built around the pharmaceutical company, was born. Timely, engrossing, and eye-opening, Miracle Cure is a must-read science narrative—a drama of enormous range, combining science, technology, politics, and economics to illuminate the reasons behind one of the most dramatic changes in humanity’s relationship with nature since the invention of agriculture ten thousand years ago.
Author : R. S. Singh,Costas B. Krimbas
Publisher : Cambridge University Press
Page : 738 pages
File Size : 44,7 Mb
Release : 2000-03-28
Category : Medical
ISBN : 0521571235
This book brings out the central role of evolutionary genetics in all aspects of its connection to evolutionary biology.
Author : Richard G. Wax,Kim Lewis,Abigail A. Salyers,Harry Taber
Publisher : CRC Press
Page : 530 pages
File Size : 48,7 Mb
Release : 2001-11-21
Category : Science
ISBN : 0824744934
Focuses on combating bacterial pathogens by understanding their strategies of defense! Each chapter begins with a summary of concepts, so those not actively working in the field gain an overall picture of what follows! Highlights antibiotic resistance in pathogens that poses the greatest threat to human health! Containing nearly 2000 references for additional research, Bacterial Resistance to Antimicrobials discusses the ecology of drug resistance genes, acquired response, and selection in natural bacterial populations describes global response systems that are a basis of resistance details antibiotic modification, inactivation, and host target modification as means of resistance development considers efflux mechanisms, one of the major causes of multidrug resistance covers concepts for developing therapies against multidrug resistant organisms emphasizes the structural basis of lactamases and other enzymes involved in inactivation of antibiotics surveys the epidemiology of methicillin resistance among nosocomial isolates and community-acquired strains outlines molecular detection methods for mainstream diagnostic tests assesses the promise of modern genomics to identify novel targets for drug discovery screening Presenting the molecular basis, methods of detection and identification, and concepts for reducing the development and spread of resistant bacterial strains, Bacterial Resistance to Antimicrobials is an excellent reference for microbiologists, pharmacists, public health officials, infectious disease specialists, organic and medicinal chemists, and upper-level undergraduate and graduate students in these disciplines.
Author : Barry P. Rosen,Shahriar Mobashery
Publisher : Springer Science & Business Media
Page : 295 pages
File Size : 52,8 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9781461548973
Antibiotic resistance, once a term appreciated only by microbiologists, has become a common topic in the popular press. Stuart Levy, one of the contributors to this collection, bears some of the responsibility for increasing public awareness with the publication of his book "The Antibiotic Paradox" in 1992: Misuse of antibiotics resulting in increased bacterial resistance had previously been recognized in the infectious disease community. However, Dr. Levy's eloquent public warning about the shrinking efficacy of our antibi otic armamentarium served to alert the lay person to the potential consequences of this de mise in useful therapy. Because of the proliferation of diverse antibiotic classes with increasing potency and broader activity spectra, it had been assumed that any ordinary bacterial infection could be eradicated with the proper selection of drug. However, it has become evident that we are surrounded by resistant bacteria, many of which were introduced unwittingly into our en vironment through the unnecessary use of antibiotics. When it became evident that a number of people were returning for multiple visits to their family physicians for persist ent ear infections or non-responsive bronchitis, questions were raised about the antibiotic treatments that were being prescribed. Bacteria resistant to common antibiotic regimens were being isolated more frequently, often as organisms classified as "multi-resistant" with decreased susceptibilities to two or more structural classes of agents. Nosocomial spread of these resistances was aided by the transmission of plasmid-mediated resistance factors between species.
Author : The Expert Panel on the Potential Socio-Economic Impacts of Antimicrobial Resistance in Canada
Publisher : Council of Canadian Academies
Page : 268 pages
File Size : 52,5 Mb
Release : 2019-11-12
Category : Medical
ISBN : 9781926522753
When Antibiotics Fail examines the current impacts of AMR on our healthcare system, projects the future impact on Canada’s GDP, and looks at how widespread resistance will influence the day-to-day lives of Canadians. The report examines these issues through a One Health lens, recognizing the interconnected nature of AMR, from healthcare settings to the environment to the agriculture sector. It is the most comprehensive report to date on the economic impact of AMR in Canada.
Author : Institute of Medicine,Board on Global Health,Forum on Emerging Infections
Publisher : National Academies Press
Page : 333 pages
File Size : 40,8 Mb
Release : 2003-03-26
Category : Medical
ISBN : 9780309168304
The resistance topic is timely given current events. The emergence of mysterious new diseases, such as SARS, and the looming threat of bioterrorist attacks remind us of how vulnerable we can be to infectious agents. With advances in medical technologies, we have tamed many former microbial foes, yet with few new antimicrobial agents and vaccines in the pipeline, and rapidly increasing drug resistance among infectious microbes, we teeter on the brink of loosing the upperhand in our ongoing struggle against these foes, old and new. The Resistance Phenomenon in Microbes and Infectious Disease Vectors examines our understanding of the relationships among microbes, disease vectors, and human hosts, and explores possible new strategies for meeting the challenge of resistance.
Author : Jun Lin,Kunihiko Nishino,Marilyn C. Roberts,Marcelo Tolmasky,Rustam I. Aminov,Lixin Zhang
Publisher : Frontiers Media SA
Page : 226 pages
File Size : 48,5 Mb
Release : 2015-06-01
Category : Antibiotics
ISBN : 9782889195268
Antibiotics represent one of the most successful forms of therapy in medicine. But the efficiency of antibiotics is compromised by the growing number of antibiotic-resistant pathogens. Antibiotic resistance, which is implicated in elevated morbidity and mortality rates as well as in the increased treatment costs, is considered to be one of the major global public health threats (www.who.int/drugresistance/en/) and the magnitude of the problem recently prompted a number of international and national bodies to take actions to protect the public (http://ec.europa.eu/dgs/health_consumer/docs/road-map-amr_en.pdf: http://www.who.int/drugresistance/amr_global_action_plan/en/; http://www.whitehouse.gov/sites/default/files/docs/carb_national_strategy.pdf). Understanding the mechanisms by which bacteria successfully defend themselves against the antibiotic assault represent the main theme of this eBook published as a Research Topic in Frontiers in Microbiology, section of Antimicrobials, Resistance, and Chemotherapy. The articles in the eBook update the reader on various aspects and mechanisms of antibiotic resistance. A better understanding of these mechanisms should facilitate the development of means to potentiate the efficacy and increase the lifespan of antibiotics while minimizing the emergence of antibiotic resistance among pathogens.
Author : Devarajan Thangadurai,Jeyabalan Sangeetha
Publisher : CRC Press
Page : 484 pages
File Size : 49,6 Mb
Release : 2017-03-03
Category : Science
ISBN : 9781771882620
This important new book covers recent advancements, innovations, and technologies in industrial biotechnology, specifically addressing the application of various biomolecules in industrial production and in cleaning and environmental remediation sectors. The goal of industrial biotechnology is to develop new techniques and technologies to transform renewable raw materials into chemicals, materials, and fuels by the substitution of fossil fuels. With the increase in the world’s population and the resultant growing energy demand, the need for more energy can be successfully met with the advancements in industrial biotechnology. Currently across the globe significant research has been undertaken in the production of cleaner fuels, materials, and semi-synthetic chemicals, with environmental benefits. Developing countries have huge agricultural resources that could be utilized for production of value-added byproducts for the sustainable development of bio-based economy. The book opens with the chapter on the production of exopolysaccharides from halophilic microorganisms, a polymer that is normally very useful in various production sectors of the food, pharmaceutical, and petroleum industries. The book goes on to cover: The production of antimicrobial compounds from alkaliphilic bacteria Thermophilic actinomycetes Food, agro, and pharmaceutical potential and biotechnological applications of biosurfactants, halophiles, cyclodextrin glycosyl transferease, fungal chitinase, proteases, yeasts and yeast products Also covered in the book are the environmental aspects of industrial biotechnology such as the genetic enhancement for biofuel production, the production of biodegradable thermoplastics, advancements in the synthesis of bio-oil, ecofriendly treatment of agro-based lignocelluloses, and anaerobic bio reactors for hydrocarbon remediation. The international roster of chapter authors have been chosen for their renowned expertise and contribution to the various fields of industrial biotechnology. This book is suitable to chemists, biotechnologists from research institutes, academia, and students as well as for industry professionals
Author : Muhammad Abubakar
Publisher : BoD – Books on Demand
Page : 158 pages
File Size : 46,6 Mb
Release : 2020-04-22
Category : Science
ISBN : 9781789859034
Livestock Health and Farming provides a detailed description of key aspects of livestock health issues and farming practices. Chapters cover such topics as antimicrobial resistance in livestock, nutrition and its role in animal health and farming, nutrition and health management in dairy animals, and livestock feeding in semi-arid regions.
Author : Peter Davey,Mark H. Wilcox,William Irving,Guy Thwaites
Publisher : OUP Oxford
Page : 450 pages
File Size : 42,6 Mb
Release : 2015-05-07
Category : Medical
ISBN : 9780191004001
Antimicrobial agents are essential for the treatment of life-threatening infections and for managing the burden of minor infections in the community. In addition, they play a key role in organ and bone marrow transplantation, cancer chemotherapy, artificial joint and heart valve surgery. Unlike other classes of medicines, they are vulnerable to resistance from mutations in target microorganisms, and their adverse effects may extend to other patients (increased risk of cross-infection). As a consequence, there is a constant requirement for new agents, as well as practices that ensure the continued effective prescribing of licensed agents. The fully revised and updated seventh edition of Antimicrobial Chemotherapy is an essential guide to the principles of antimicrobial chemotherapy, the problem of resistance and its control through policies, antimicrobial stewardship and surveillance. The book provides an aid to informed, rational prescribing for common bacterial, fungal, parasitic and viral infections. Divided in five parts, the book cover issues specific to both the developed and developing world. Part 1 'General property of antimicrobial agents' discusses mechanisms of action and resistance to antibacterial, antifungal antiprotozoal, antiviral, and antiviral agents. Part 2 'Resistance to antimicrobial agents' provides guidance about the problem of resistance, mechanisms of acquired resistance and genetics of resistance. Part 3 'General principles of usage of antimicrobial agents' analyses the use of the laboratory, general principles of the treatment of infection, dosing in special groups (extremes of age, pregnancy, obesity), safe prescribing, prophylaxis and the role of policies in antimicrobial stewardship. Part 4 'Therapeutic use of antimicrobial agents' provides advice about the treatment of common infections which are described by anatomical. There are also chapters on the management of mycobacterial disease, viral infections, HIV/AIDS and parasitic infections. The final part of the book analyses the development and marketing of antimicrobial drugs. This seventh edition of Antimicrobial Chemotherapy continues to be a valuable resource for undergraduates and graduates requiring a thorough grounding in the scientific basis and clinical application of these drugs.
Author : D. Barug,J. de Jong,A.K. Kies,M.W.A. Verstegen
Publisher : BRILL
Page : 422 pages
File Size : 54,7 Mb
Release : 2023-08-28
Category : Medical
ISBN : 9789086865703
"It is widely acknowledged that the inclusion of antimicrobial growth promoters (AGPs) in the diet of livestock increases growth rate. However, many questions arise on whether the benefits outweigh the risks, or vice versa. Recent legislative developments in the European Union and USA, recommendations by the World Health Organization, initiatives taken by the food chain, and consumer concerns all point to a widespread (voluntary) removal of antibiotic feed additives for animal growth promotion. In particular, Regulation (EC) 1831/2003 lays down provisions phasing out the authorisations of AGPs in the European Union as from 1 January 2006. This book discusses how this will affect the use/non-use practice of AGPs. Attention is given to the current status and rational design of developments and strategies for animal feeding without the inclusion of AGPs. Topics covered include benefits and risks of AGPs, risk assessment, consumer concerns and demands, regulatory aspects and international developments, mode of action and innovative alternatives, and recent advances in the analysis of AGPs and related products. This book contains peer-reviewed papers presented at the international conference ""Antimicrobial Growth Promoters: Worldwide Ban on the Horizon?"". The book is filled with valuable information on the pros and cons of use of AGPs as well as on alternative nutritional solutions. It is aimed at professionals and researchers in the feed and food industry."
Author : World Health Organization
Publisher : World Health Organization
Page : 0 pages
File Size : 54,6 Mb
Release : 2017-11-10
Category : Business & Economics
ISBN : 9241550139
WHO has launched new guidelines on use of medically important antimicrobials in food-producing animals, recommending that farmers and the food industry stop using antibiotics routinely to promote growth and prevent disease in healthy animals. These guidelines aim to help preserve the effectiveness of antibiotics that are important for human medicine by reducing their use in animals.