Final Report Of The National Academies Human Embryonic Stem Cell Research Advisory Committee And 2010 Amendments To The National Academies Guidelines For Human Embryonic Stem Cell Research

Author : National Research Council,Institute of Medicine,Board on Health Sciences Policy,Division on Earth and Life Studies,Board on Life Sciences,Human Embryonic Stem Cell Research Advisory Committee
Publisher : National Academies Press
Page : 58 pages
File Size : 46,8 Mb
Release : 2010-08-13
Category : Medical
ISBN : 9780309156004

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Final Report of the National Academies' Human Embryonic Stem Cell Research Advisory Committee and 2010 Amendments to the National Academies' Guidelines for Human Embryonic Stem Cell Research by National Research Council,Institute of Medicine,Board on Health Sciences Policy,Division on Earth and Life Studies,Board on Life Sciences,Human Embryonic Stem Cell Research Advisory Committee Pdf

In 2005, the National Academies released the book, Guidelines for Human Embryonic Stem Cell Research, which offered a common set of ethical standards for a field that, due to the absence of comprehensive federal funding, was lacking national standards for research. In order to keep the Guidelines up to date, given the rapid pace of scientific and policy developments in the field of stem cell research, the Human Embryonic Stem Cell Research Advisory Committee was established in 2006 with support from The Ellison Medical Foundation, The Greenwall Foundation, and the Howard Hughes Medical Institute. As it did in 2007 and 2008, the Committee identified issues that warranted revision, and this book addresses those issues in a third and final set of amendments. Specifically, this book sets out an updated version of the National Academies' Guidelines, one that takes into account the new, expanded role of the NIH in overseeing hES cell research. It also identifies those avenues of continuing National Academies' involvement deemed most valuable by the research community and other significant stakeholders.

Author : National Research Council,Institute of Medicine,Board on Health Sciences Policy,Division on Earth and Life Studies,Board on Life Sciences,Committee on Guidelines for Human Embryonic Stem Cell Research
Publisher : National Academies Press
Page : 224 pages
File Size : 49,5 Mb
Release : 2005-09-15
Category : Medical
ISBN : 9780309096539

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Guidelines for Human Embryonic Stem Cell Research by National Research Council,Institute of Medicine,Board on Health Sciences Policy,Division on Earth and Life Studies,Board on Life Sciences,Committee on Guidelines for Human Embryonic Stem Cell Research Pdf

Since 1998, the volume of research being conducted using human embryonic stem (hES) cells has expanded primarily using private funds because of restrictions on the use of federal funds for such research. Given limited federal involvement, privately funded hES cell research has thus far been carried out under a patchwork of existing regulations, many of which were not designed with this research specifically in mind. In addition, hES cell research touches on many ethical, legal, scientific, and policy issues that are of concern to the public. This report provides guidelines for the conduct of hES cell research to address both ethical and scientific concerns. The guidelines are intended to enhance the integrity of privately funded hES cell research by encouraging responsible practices in the conduct of that research.

Author : National Academies of Sciences, Engineering, and Medicine,National Academy of Medicine,National Academy of Sciences,Committee on Human Gene Editing: Scientific, Medical, and Ethical Considerations
Publisher : National Academies Press
Page : 329 pages
File Size : 51,6 Mb
Release : 2017-08-13
Category : Medical
ISBN : 9780309452885

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Human Genome Editing by National Academies of Sciences, Engineering, and Medicine,National Academy of Medicine,National Academy of Sciences,Committee on Human Gene Editing: Scientific, Medical, and Ethical Considerations Pdf

Genome editing is a powerful new tool for making precise alterations to an organism's genetic material. Recent scientific advances have made genome editing more efficient, precise, and flexible than ever before. These advances have spurred an explosion of interest from around the globe in the possible ways in which genome editing can improve human health. The speed at which these technologies are being developed and applied has led many policymakers and stakeholders to express concern about whether appropriate systems are in place to govern these technologies and how and when the public should be engaged in these decisions. Human Genome Editing considers important questions about the human application of genome editing including: balancing potential benefits with unintended risks, governing the use of genome editing, incorporating societal values into clinical applications and policy decisions, and respecting the inevitable differences across nations and cultures that will shape how and whether to use these new technologies. This report proposes criteria for heritable germline editing, provides conclusions on the crucial need for public education and engagement, and presents 7 general principles for the governance of human genome editing.

Author : Calvin Wai-Loon Ho
Publisher : World Scientific
Page : 504 pages
File Size : 55,9 Mb
Release : 2016-07-28
Category : Law
ISBN : 9781911299646

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Juridification in Bioethics by Calvin Wai-Loon Ho Pdf

What is 'legal' about bioethics? What are the ideas and artefacts that bioethics encompasses, and how are they related to law? What is the role of law in bioethics? In this work, Calvin Ho attempts to address these questions in the context of the governance of human pluripotent stem cell research. In essence, he argues that the hybridization of law, through processes, devices and techniques of juridification, has helped to constitute bioethics as a public sphere and an emergent civic epistemology. Drawing on his multi-sited ethnographic fieldwork and on Actor-Network-Theory, Ho explains how the law has, through bioethics, contributed to the scientific and public understanding of human pluripotent stem cell research and its artefacts, particularly the embryo and human-animal combinations. Although the focus of his work is on bioethical developments in Singapore over a period of more than 15 years, parallel developments in key jurisdictions (especially the United States of America and the United Kingdom) and in international science policy are also evaluated. It is through appreciating how it has progressed that bioethics will be better able to engage with future challenges presented by advances in human embryo research and gene editing techniques, among others.

Author : Joshua Weiser
Publisher : Springer Nature
Page : 286 pages
File Size : 48,7 Mb
Release : 2024-06-29
Category : Electronic
ISBN : 9783031597503

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Embryonic Stem Cells and the Law by Joshua Weiser Pdf

Author : Nagwa El-Badri
Publisher : Springer Nature
Page : 374 pages
File Size : 47,5 Mb
Release : 2020-11-27
Category : Medical
ISBN : 9783030553593

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Regenerative Medicine and Stem Cell Biology by Nagwa El-Badri Pdf

This textbook covers the basic aspects of stem cell research and applications in regenerative medicine. Each chapter includes a didactic component and a practical section. The book offers readers insights into: How to identify the basic concepts of stem cell biology and the molecular regulation of pluripotency and stem cell development. How to produce induced pluripotent stem cells (iPSCs) and the basics of transfection. The biology of adult stem cells, with particular emphasis on mesenchymal stromal cells and hematopoietic stem cells, and the basic mechanisms that regulate them. How cancer stem cells arise and metastasize, and their properties. How to develop the skills needed to isolate, differentiate and characterize adult stem The clinical significance of stem cell research and the potential problems that need to be overcome. Evaluating the use of stem cells for tissue engineering and therapies (the amniotic membrane) The applications of bio-nanotechnology in stem cell research. How epigenetic mechanisms, including various DNA modifications and histone dynamics, are involved in regulating the potentiality and differentiation of stem cells. The scientific methods, ethical considerations and implications of stem cell research.

Author : Matthias Herdegen
Publisher : Edward Elgar Publishing
Page : 219 pages
File Size : 55,5 Mb
Release : 2023-01-20
Category : Law
ISBN : 9781035302055

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The International Law of Biotechnology by Matthias Herdegen Pdf

In this thoroughly updated second edition, Matthias Herdegen provides a comprehensive and contemporary assessment of the regulation of biotechnology processes and products from an international and comparative perspective, complete with analysis of intricate legal and ethical debates.

Author : David Albert Jones
Publisher : Bloomsbury Publishing
Page : 208 pages
File Size : 41,7 Mb
Release : 2012-11-02
Category : Religion
ISBN : 9781441125385

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Chimera's Children by David Albert Jones Pdf

The idea of human-nonhuman combinations has been a recurrent theme throughout the history of humanity. From the myths of the Minotaur and the centaurs in ancient Greece to the dogheads of the Middle Ages right through to the monsters of modern science fiction, these beings have always been a source of fascination. In recent years, however, biomedical advances have demonstrated the potential to make these entities a reality through the creation of inter-species combinations. As a result, pressing and perplexing ethical questions arise. Introducing the reader to the historical context of human-nonhuman experimentation and potential future developments, this volume offers clarification, analysis and a thorough overview of the ethical challenges relating to human-nonhuman chimeras, true hybrids, cybrids and other combinations. This book is the first accessible survey of the different ethical dilemmas facing contemporary society in the creation of human-nonhuman embryonic, foetal and postnatal entities. These include important cultural, legal, philosophical and religious perspectives. As such it will act as a springboard for future debate.

Author : Andrea Stazi
Publisher : Edward Elgar Publishing
Page : 336 pages
File Size : 48,8 Mb
Release : 2015-05-29
Category : Business & Economics
ISBN : 9781784715908

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Biotechnological Inventions and Patentability of Life by Andrea Stazi Pdf

In todayês technological world, biotechnology is one of the most innovative and highly invested-in industries for research, in the field of science. This book analyses the forms and limitations of patent protection recognition for biotechnological inve

Author : Kerry Lynn Macintosh
Publisher : Cambridge University Press
Page : 128 pages
File Size : 53,9 Mb
Release : 2012-10-29
Category : Law
ISBN : 9781139852104

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Human Cloning by Kerry Lynn Macintosh Pdf

Since Dolly the sheep was born, controversy has swirled around the technology of cloning. We recoil at the prospect of human copies, manufactured men and women, nefarious impersonators and resurrections of the dead. Such reactions have serious legal consequences: lawmakers have banned stem cell research along with the cloning of babies. But what if our minds have been playing tricks on us? What if everything we thought we knew about human cloning is rooted in intuition rather than fact? Human Cloning: Four Fallacies and their Legal Consequences is a rollicking ride through science, psychology and the law. Drawing on sources ranging from science fiction films to the Congressional Record, this book unmasks the role that psychological essentialism has played in bringing about cloning bans. It explains how hidden intuitions have caused conservatives and liberals to act contrary to their own most cherished ideals and values.

Author : James M. Goldfarb
Publisher : Springer Science & Business Media
Page : 232 pages
File Size : 44,9 Mb
Release : 2013-10-07
Category : Health & Fitness
ISBN : 9781461471691

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Third-Party Reproduction by James M. Goldfarb Pdf

The first IVF conceived birth in 1978 resulted in a significant growth of third party reproductive options which continue to raise ethical, legal, and psychological questions. Third party reproduction procedures can involve as many as five people: sperm donor, egg donor, gestational carrier, and intended parents. Third-Party Reproduction: A Comprehensive Guide utilizes experts in the field to address the medical, psychological, ethical and legal aspects of sperm donation, egg donation, embryo donation, and the use of gestational carriers. In addition, there are chapters on the medical and ethical aspects of posthumous reproduction, religious aspects of third party reproduction, and how to avoid pitfalls of third party reproduction. Aimed at physicians, trainees, psychologists, nurses, and social workers whose practices may include patients considering third party reproduction, the intent of this book is to provide a comprehensive and practical overview of the many aspects of third party reproduction to help all those involved to better understand them. Patients considering third party reproduction may also find value in this book.

Author : Mark A. Suckow,Bill Yates
Publisher : Academic Press
Page : 344 pages
File Size : 51,6 Mb
Release : 2015-06-14
Category : Medical
ISBN : 9780124200654

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Research Regulatory Compliance by Mark A. Suckow,Bill Yates Pdf

Research Regulatory Compliance offers the latest information on regulations and compliance in the laboratory. With the increasing complexity of regulations and need for institutional infrastructure to deal with compliance of animal use issues, as well as a requirement surrounding human subjects, this publication provides reputable guidance and information. The book is extremely helpful as a resource for researchers, administrators, and technicians in the laboratory, and is also a great asset for faculty or new researchers coming in to the laboratory environment. It will help prepare users for the deluge of regulatory and compliance issues they will face while conducting their scientific programs. The book is edited and authored by known leaders in the field of compliance and regulations, and contains extensive research on the topics. It represents the new standard for information in every laboratory. Provides a “one-stop" , go-to resource for the many regulatory and compliance issues that affect laboratory study and research models Extremely helpful as a resource for researchers, administrators, and technicians in the laboratory, and also a great asset for faculty or new researchers coming in to the laboratory environment Focuses on United States regulations, covering both animal models and human subjects Written and edited by known leaders in the field of regulatory compliance who bring many years of collective experience to the book

Author : Bonnie Steinbock
Publisher : Oxford University Press
Page : 328 pages
File Size : 54,8 Mb
Release : 2011-07-11
Category : Medical
ISBN : 0199712077

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Life Before Birth by Bonnie Steinbock Pdf

Life Before Birth provides a coherent framework for addressing bioethical issues in which the moral status of embryos and fetuses is relevant. It is based on the "interest view" which ascribes moral standing to beings with interests, and connects the possession of interests with the capacity for conscious awareness or sentience. The theoretical framework is applied to ethical and legal topics, including abortion, prenatal torts, wrongful life, the crime of feticide, substance abuse by pregnant women, compulsory cesareans, assisted reproduction, and stem cell research. Along the way, difficult philosophical problems, such as identity and the non-identity problem are thoroughly explored. The book will be of interest not only to philosophers, but also physicians, lawyers, policy makers, and anyone perplexed by the many difficulties surrounding the unborn. "Bonnie Steinbock's excellent book is . . . consistent, thoroughgoing, and intelligible." --Nature "Steinbock's book is valuable for all interested in the ethical/legal issues surrounding abortion, prenatal injury and liability, maternal-fetal conflict, and fetal/embryo research. The author provides an excellent historical overview of these issues, but she also addresses the issues from the stance of a particular theory of moral status, namely, interest theory. This gives coherence to her discussion as well as allowing testing of the viability of interest theory." --Choice "A focused, lucid, analytically fine-grained discussion of a wide variety of problems. . . extremely useful as a survey of the current state of the debate." --Religious Studies Review "Merits serious consideration by physicians. Steinbock's interests-based approach treats all questions as open -- another and most welcome breath of fresh air." -New England Journal of Medicine "An extremely valuable contribution to the literature. The author carefully identifies the many bioethical issues to which the status of embryos and fetuses is relevant....She thoroughly reviews the extensive medical, bioethical, and legal literature on all of these issues, offering well-developed critiques of many standard positions. She articulates and thoughtfully defends interesting positions on all of theses topics. Anyone with an interest in these issues will learn a great deal from her knowledgeable and judicious treatment of them." -- The Journal of Clinical Ethics

Author : Jan-Thorsten Schantz,Dietmar W Hutmacher
Publisher : World Scientific Publishing Company
Page : 300 pages
File Size : 45,9 Mb
Release : 2015-03-30
Category : Science
ISBN : 9789814630665

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Advanced Therapies in Regenerative Medicine by Jan-Thorsten Schantz,Dietmar W Hutmacher Pdf

Regenerative medicine is a fast developing field which has led to a paradigm shift in treatment of various diseases. Clinician-scientists worldwide constantly develop novel approaches in various medical specialties (surgery, internal medicine, oncology, neurology, gynecology, pediatrics, etc.) using gene therapy approaches, innovative biomaterials or stem cell based therapies. It is difficult even for experts to find out what has already reached a clinical stage. The aim of the second volume in this series is to provide the reader with a current update on the latest therapeutic developments. As such, both patients and doctors will find the information contained within this manual to be useful and relevant. The editors are both international leaders in the field of regenerative medicine, and both possess a broad spectrum of experience from basic research to clinical application and commercialization.

Author : National Academies of Sciences, Engineering, and Medicine,Institute of Medicine,Board on Health Sciences Policy,Committee on the Ethical and Social Policy Considerations of Novel Techniques for Prevention of Maternal Transmission of Mitochondrial DNA Diseases
Publisher : National Academies Press
Page : 201 pages
File Size : 51,8 Mb
Release : 2016-04-17
Category : Medical
ISBN : 9780309388702

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Mitochondrial Replacement Techniques by National Academies of Sciences, Engineering, and Medicine,Institute of Medicine,Board on Health Sciences Policy,Committee on the Ethical and Social Policy Considerations of Novel Techniques for Prevention of Maternal Transmission of Mitochondrial DNA Diseases Pdf

Mitochondrial replacement techniques (MRTs) are designed to prevent the transmission of mitochondrial DNA (mtDNA) diseases from mother to child. While MRTs, if effective, could satisfy a desire of women seeking to have a genetically related child without the risk of passing on mtDNA disease, the technique raises significant ethical and social issues. It would create offspring who have genetic material from two women, something never sanctioned in humans, and would create mitochondrial changes that could be heritable (in female offspring), and therefore passed on in perpetuity. The manipulation would be performed on eggs or embryos, would affect every cell of the resulting individual, and once carried out this genetic manipulation is not reversible. Mitochondrial Replacement Techniques considers the implications of manipulating mitochondrial content both in children born to women as a result of participating in these studies and in descendants of any female offspring. This study examines the ethical and social issues related to MRTs, outlines principles that would provide a framework and foundation for oversight of MRTs, and develops recommendations to inform the Food and Drug Administration's consideration of investigational new drug applications.