Download Full eBooks in PDF
Free Radical And Radiation Induced Damage To Dna Book in PDF, ePub and Kindle version is available to download in english. Read online anytime anywhere directly from your device. Click on the download button below to get a free pdf file of Free Radical And Radiation Induced Damage To Dna book. This book definitely worth reading, it is an incredibly well-written.
Author : D. Schulte-Frohlinde,C. Von Sonntag,J. Huttermann
Publisher : CRC Press
Page : 138 pages
File Size : 45,9 Mb
Release : 1989
Category : Active oxygen
ISBN : 3718648741
Author : Clemens Sonntag
Publisher : Springer Science & Business Media
Page : 523 pages
File Size : 44,6 Mb
Release : 2006-03-20
Category : Science
ISBN : 9783540305927
The free-radical chemistry of DNA had been discussed in some detail in 1987 in my book The Chemical Basis of Radiation Biology. Obviously, the more recent developments and the concomitant higher level of understanding of mechanistic details are missing. Moreover, in the living cell, free-radical DNA damage is not only induced by ionizing radiation, but free-radical-induced DNA damage is a much more general phenomenon. It was, therefore, felt that it is now timely to review our present knowledge of free-radical-induced DNA damage induced by all conceivable free-radical-generating sources. Originally, it had been thought to include also a very important aspect, the repair of DNA damage by the cell’s various repair enzymes. Kevin Prise (Cancer Campaign, Gray Laboratory, L- don) was so kind to agree to write this part. However, an adequate description of this strongly expanding area would have exceeded the allocated space by much, and this section had to be omitted. The directors of the Max-Planck-Institut für Strahlenchemie (now MPI für Bioanorganische Chemie), Karl Wieghardt and Wolfgang Lubitz, kindly allowed me to continue to use its facilities after my retirement in 2001. Notably, our - brarian, Mrs. Jutta Theurich, and her right-hand help, Mrs. Rosemarie Schr- er, were most helpful in getting hold of the literature. I thank them very much. Without their constant help, this would have been very difficult indeed.
Author : Anonim
Publisher : Unknown
Page : 84 pages
File Size : 47,7 Mb
Release : 1989
Category : Electronic
ISBN : OCLC:35479251
Author : Clemens von Sonntag
Publisher : Springer
Page : 523 pages
File Size : 41,6 Mb
Release : 2009-09-02
Category : Science
ISBN : 3540811397
The free-radical chemistry of DNA had been discussed in some detail in 1987 in my book The Chemical Basis of Radiation Biology. Obviously, the more recent developments and the concomitant higher level of understanding of mechanistic details are missing. Moreover, in the living cell, free-radical DNA damage is not only induced by ionizing radiation, but free-radical-induced DNA damage is a much more general phenomenon. It was, therefore, felt that it is now timely to review our present knowledge of free-radical-induced DNA damage induced by all conceivable free-radical-generating sources. Originally, it had been thought to include also a very important aspect, the repair of DNA damage by the cell’s various repair enzymes. Kevin Prise (Cancer Campaign, Gray Laboratory, L- don) was so kind to agree to write this part. However, an adequate description of this strongly expanding area would have exceeded the allocated space by much, and this section had to be omitted. The directors of the Max-Planck-Institut für Strahlenchemie (now MPI für Bioanorganische Chemie), Karl Wieghardt and Wolfgang Lubitz, kindly allowed me to continue to use its facilities after my retirement in 2001. Notably, our - brarian, Mrs. Jutta Theurich, and her right-hand help, Mrs. Rosemarie Schr- er, were most helpful in getting hold of the literature. I thank them very much. Without their constant help, this would have been very difficult indeed.
Author : John T. Lett,Warren K. Sinclair
Publisher : Academic Press
Page : 520 pages
File Size : 55,7 Mb
Release : 2013-10-22
Category : Health & Fitness
ISBN : 9781483282275
Advances in Radiation Biology, Volume 17: DNA and Chromatin Damage Caused by Radiation outlines the different biological reactions to radiation. This book discusses the linear energy transfer and energy loss; DNA breaks and track structure; DNA radicals from water radicals; and radiation-induced strand breaks in isolated DNA. The radiation damage to DNA and its nearby environment; thiol radioprotectors and mechanism of action; radiolysis of water and track reactions; and computer simulation of higher order structure of DNA are also elaborated. This publication likewise covers the concept of chromatin structure; DNA supercoiling studied by sedimentation; measurement of radiation-induced DNA breakage; and analysis of damage in interphase cells. This volume is a useful reference to biologists and students concerned with DNA and chromatin damage caused by radiation.
Author : John T. Lett,Howard Adler
Publisher : Academic Press
Page : 493 pages
File Size : 48,6 Mb
Release : 2013-10-22
Category : Science
ISBN : 9781483281896
Advances in Radiation Biology, Volume 9, provides an overview of the state of knowledge in radiation biology. The book contains nine chapters and begins with a study on the ways in which physical and chemical agents might trigger "regulatory dysfunction" and how these agents might interact with each other. This is followed by separate chapters on the mechanisms underlying changes in vascular function after doses of radiation in the therapeutic range and their role in the development of late effects in normal tissues; the future of hypoxic cell sensitizers in the clinical setting; DNA strand break formation by ionizing radiation; and major pathways which result in radiation-induced loss of cellular proliferative capacity. Subsequent chapters deal with the solid-state radiation chemistry of DNA; radiosensitivity of proliferating mammalian cells; the use of microwave/radiofrequency energy cancer treatment; and the decline of basic radiobiology.
Author : Alfred F. Fuciarelli,John D. Zimbrick
Publisher : Unknown
Page : 472 pages
File Size : 47,6 Mb
Release : 1995
Category : Science
ISBN : UOM:39015034418015
Author : National Research Council,Division on Earth and Life Studies,Commission on Life Sciences,Committee on the Biological Effects of Ionizing Radiation (BEIR V)
Publisher : National Academies
Page : 436 pages
File Size : 45,5 Mb
Release : 1990-02-01
Category : Science
ISBN : 9780309039956
This book reevaluates the health risks of ionizing radiation in light of data that have become available since the 1980 report on this subject was published. The data include new, much more reliable dose estimates for the A-bomb survivors, the results of an additional 14 years of follow-up of the survivors for cancer mortality, recent results of follow-up studies of persons irradiated for medical purposes, and results of relevant experiments with laboratory animals and cultured cells. It analyzes the data in terms of risk estimates for specific organs in relation to dose and time after exposure, and compares radiation effects between Japanese and Western populations.
Author : John Lett,Kurt I. Altman
Publisher : Unknown
Page : 348 pages
File Size : 43,6 Mb
Release : 1990
Category : Medical
ISBN : 0120354144
Advances in Radiation Biology, Volume 14: Relative Radiation Sensitivities of Human Organ Systems, Part II focuses on radiation sensitivities of particular human organ systems. The sensitivities are then assessed based on the severity and the rapidity in which the effects of radiation manifest. The opening chapter surveys the clinical and experimental data on approaches toward the prevention of bladder complications in clinical radiotherapy. A discussion on HeLa cells, which are of special importance in human cervical cancer therapy, is then presented. In presenting this topic, this book emph ...
Author : Committee to Assess Health Risks from Exposure to Low Levels of Ionizing Radiation,National Research Council
Publisher : National Academies Press
Page : 422 pages
File Size : 47,6 Mb
Release : 2006-03-23
Category : Science
ISBN : 9780309133340
This book is the seventh in a series of titles from the National Research Council that addresses the effects of exposure to low dose LET (Linear Energy Transfer) ionizing radiation and human health. Updating information previously presented in the 1990 publication, Health Effects of Exposure to Low Levels of Ionizing Radiation: BEIR V, this book draws upon new data in both epidemiologic and experimental research. Ionizing radiation arises from both natural and man-made sources and at very high doses can produce damaging effects in human tissue that can be evident within days after exposure. However, it is the low-dose exposures that are the focus of this book. So-called “late” effects, such as cancer, are produced many years after the initial exposure. This book is among the first of its kind to include detailed risk estimates for cancer incidence in addition to cancer mortality. BEIR VII offers a full review of the available biological, biophysical, and epidemiological literature since the last BEIR report on the subject and develops the most up-to-date and comprehensive risk estimates for cancer and other health effects from exposure to low-level ionizing radiation.
Author : Miral Dizdaroglu,R Stephen Lloyd
Publisher : Royal Society of Chemistry
Page : 509 pages
File Size : 48,8 Mb
Release : 2020-11-11
Category : Science
ISBN : 9781839162565
The DNA of all organisms is constantly being damaged by endogenous and exogenous sources. Oxygen metabolism generates reactive species that can damage DNA, proteins and other organic compounds in living cells. Exogenous sources include ionizing and ultraviolet radiations, carcinogenic compounds and environmental toxins among others. The discovery of multiple DNA lesions and DNA repair mechanisms showed the involvement of DNA damage and DNA repair in the pathogenesis of many human diseases, most notably cancer. These books provide a comprehensive overview of the interdisciplinary area of DNA damage and DNA repair, and their relevance to disease pathology. Edited by recognised leaders in the field, this two-volume set is an appealing resource to a variety of readers including chemists, chemical biologists, geneticists, cancer researchers and drug discovery scientists.
Author : Miral Dizdaroglu,Ali Esat Karakaya
Publisher : Springer Science & Business Media
Page : 502 pages
File Size : 52,5 Mb
Release : 2012-12-06
Category : Science
ISBN : 9781461548652
In recent years the field of DNA repair has flourished due to new findings on DNA repair mechanisms and the molecular basis of cancer. This volume covers the most recent developments in this research field and contains contributions from scientists working in various fields.
Author : R. Stephen Lloyd,Miral Dizdaroglu
Publisher : Royal Society of Chemistry
Page : 429 pages
File Size : 51,8 Mb
Release : 2020-11-19
Category : Science
ISBN : 9781788018890
The overall aim of this book is to give scientists in academia and industry a comprehensive overview of the field of DNA damage and DNA repair and related human diseases.
Author : Giuseppe Cicco,Duane F. Bruley,Marc Ferrari
Publisher : Springer Science & Business Media
Page : 393 pages
File Size : 54,6 Mb
Release : 2006-11-22
Category : Science
ISBN : 9780387295404
This book covers the proceedings of the 32nd scientific meeting of the International Society on Oxygen Transport to Tissue (ISOTT) in Bari, Italy, August 21-26, 2004. It covers all aspects of oxygen delivery to tissue, including blood flow and its regulation as well as oxygen metabolism. Special emphasis is placed on methods of oxygen measurement in living tissue and application of these technologies to understanding physiological and biochemical basis for pathology related to tissue oxygenation. The event hosted was a multidisciplinary meeting designed to bring together experts and students from a range of research fields.
Author : William A. Glass,Matesh N. Varma
Publisher : Springer Science & Business Media
Page : 512 pages
File Size : 52,8 Mb
Release : 2012-12-06
Category : Science
ISBN : 9781468476279
The fundamental understanding of the production of biological effects by ionizing radiation may well be one of the most important scientific objectives of mankind; such understanding could lead to the effective and safe utilization of the nuclear energy option. In addition, this knowledge will be of immense value in such diverse fields as radiation therapy and diagnosis and in the space program. To achieve the above stated objective, the U. S. Department of Energy (DOE) and its predecessors embarked upon a fundamental interdisciplinary research program some 35 years ago. A critical component of this program is the Radiological and Chemical Physics Program (RCPP). When the RCPP was established, there was very little basic knowledge in the fields of physics, chemistry, and biology that could be directly applied to understanding the effects of radiation on biological systems. Progress of the RCPP program in its first 15 years was documented in the proceedings of a conference held at Airlie, Virginia, in 1972. At this conference, it was clear that considerable progr:ess had been made in research on the physical and chemical processes in well-characterized systems that could be used to understand biological effects. During this period of time, most physical knowledge was obtained for the gas phase because the technology and instru mentation had not progressed to the point that measurements could be made in liquids more characteristic of biological materials.
