Free Radical Induced Dna Damage And Its Repair

Author : Clemens Sonntag
Publisher : Springer Science & Business Media
Page : 523 pages
File Size : 48,8 Mb
Release : 2006-03-20
Category : Science
ISBN : 9783540305927

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Free-Radical-Induced DNA Damage and Its Repair by Clemens Sonntag Pdf

The free-radical chemistry of DNA had been discussed in some detail in 1987 in my book The Chemical Basis of Radiation Biology. Obviously, the more recent developments and the concomitant higher level of understanding of mechanistic details are missing. Moreover, in the living cell, free-radical DNA damage is not only induced by ionizing radiation, but free-radical-induced DNA damage is a much more general phenomenon. It was, therefore, felt that it is now timely to review our present knowledge of free-radical-induced DNA damage induced by all conceivable free-radical-generating sources. Originally, it had been thought to include also a very important aspect, the repair of DNA damage by the cell’s various repair enzymes. Kevin Prise (Cancer Campaign, Gray Laboratory, L- don) was so kind to agree to write this part. However, an adequate description of this strongly expanding area would have exceeded the allocated space by much, and this section had to be omitted. The directors of the Max-Planck-Institut für Strahlenchemie (now MPI für Bioanorganische Chemie), Karl Wieghardt and Wolfgang Lubitz, kindly allowed me to continue to use its facilities after my retirement in 2001. Notably, our - brarian, Mrs. Jutta Theurich, and her right-hand help, Mrs. Rosemarie Schr- er, were most helpful in getting hold of the literature. I thank them very much. Without their constant help, this would have been very difficult indeed.

Author : Clemens von Sonntag
Publisher : Springer
Page : 523 pages
File Size : 46,9 Mb
Release : 2009-09-02
Category : Science
ISBN : 3540811397

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Free-Radical-Induced DNA Damage and Its Repair by Clemens von Sonntag Pdf

The free-radical chemistry of DNA had been discussed in some detail in 1987 in my book The Chemical Basis of Radiation Biology. Obviously, the more recent developments and the concomitant higher level of understanding of mechanistic details are missing. Moreover, in the living cell, free-radical DNA damage is not only induced by ionizing radiation, but free-radical-induced DNA damage is a much more general phenomenon. It was, therefore, felt that it is now timely to review our present knowledge of free-radical-induced DNA damage induced by all conceivable free-radical-generating sources. Originally, it had been thought to include also a very important aspect, the repair of DNA damage by the cell’s various repair enzymes. Kevin Prise (Cancer Campaign, Gray Laboratory, L- don) was so kind to agree to write this part. However, an adequate description of this strongly expanding area would have exceeded the allocated space by much, and this section had to be omitted. The directors of the Max-Planck-Institut für Strahlenchemie (now MPI für Bioanorganische Chemie), Karl Wieghardt and Wolfgang Lubitz, kindly allowed me to continue to use its facilities after my retirement in 2001. Notably, our - brarian, Mrs. Jutta Theurich, and her right-hand help, Mrs. Rosemarie Schr- er, were most helpful in getting hold of the literature. I thank them very much. Without their constant help, this would have been very difficult indeed.

Author : Barry Halliwell,Okezie I. Aruoma
Publisher : Prentice Hall PTR
Page : 366 pages
File Size : 53,8 Mb
Release : 1993
Category : Active oxygen
ISBN : UOM:39015009119010

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DNA and Free Radicals by Barry Halliwell,Okezie I. Aruoma Pdf

Written by renowned biologists and medical scientists specializing in the field, this volume offers a comprehensive account of the role of oxidative stress and DNA damage in human disease. Emphasizes the role played by free radicals; examines the fundamental mechanisms underlying the pathology of human diseases; shows how DNA is an important target in cellular damage; and outlines the pioneering studies relating to the chemistry of DNA damage. MARKETS: " For research and development personnel in academia and industry involved in investigating drugs and toxic compounds; and for pharmacologists, pathologists, oncologists, chemotherapists, biochemists, chemists, physiologists, biologists, and all those interested in DNA or free radical research.

Author : Michael G. Simic,Lawrence Grossman,Arthur C. Upton,David S. Bergtold
Publisher : Springer Science & Business Media
Page : 567 pages
File Size : 43,7 Mb
Release : 2013-11-21
Category : Science
ISBN : 9781461594628

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Mechanisms of DNA Damage and Repair by Michael G. Simic,Lawrence Grossman,Arthur C. Upton,David S. Bergtold Pdf

This book is based on the papers presented at the conference on "Mecha nisms of DNA Damage and Repair: Implications for Carcinogenesis and Risk Assessment," held at the National Bureau of Standards on June 2-7, 1985, This volume deals with mechanisms of DNA damage and repair at the molecular level; consequences of unrepaired or misrepaired damage, with major emphasis on carcinogenesis; drugs which bind selectively to altered and potentially damaging DNA sequences; and potential utilization of DNA damage as an endpoint for assessing risks of UV light, ionizing radiations, chemicals, drugs, and hazardous agents in foods. Because the induction of mutations by radiation and genotoxic chemicals has been observed to follow one-hit kinetics in some instances, it is generally assumed that any level of exposure to a DNA-damaging agent may increase the risk of genetic disease or cancer in an exposed population. At the same time, however, there is evidence that although the DNA of living cells is continually damaged by natural background radiation, free radicals, and other naturally occurring processes, most of the damage is normally repaired.

Author : Miral Dizdaroglu,Ali Esat Karakaya
Publisher : Springer Science & Business Media
Page : 502 pages
File Size : 49,9 Mb
Release : 2012-12-06
Category : Science
ISBN : 9781461548652

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Advances in DNA Damage and Repair by Miral Dizdaroglu,Ali Esat Karakaya Pdf

In recent years the field of DNA repair has flourished due to new findings on DNA repair mechanisms and the molecular basis of cancer. This volume covers the most recent developments in this research field and contains contributions from scientists working in various fields.

Author : Antonio Monari,Elise Dumont,Chryssostomos Chatgilialoglu
Publisher : Frontiers Media SA
Page : 95 pages
File Size : 43,5 Mb
Release : 2015-10-02
Category : Chemistry
ISBN : 9782889196609

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Radiation-induced and oxidative DNA damages by Antonio Monari,Elise Dumont,Chryssostomos Chatgilialoglu Pdf

DNA stores and passes the genetic information of almost all living organisms. Its molecular structure and their intramolecular interactions are particularly suitable to maximize stability against oxidative stress and UV-light absorption. Yet the protection and repair strategies are still error-prone: DNA lesions are produced, including the most complex and highly mutagenic ones. An important threat to DNA stability comes from photosensitization, i.e. from the dramatic multiplication of radiation-induced defects mediated by the presence of organic or organometallic dyes compared to the direct exposure to UVA radiation. Moreover, the photo-induced production of singlet oxygen generates an extremely high oxidative stress on DNA that, in vivo, normally results in extended cellular apoptosis. Elucidating the processes leading to DNA damages, from the production of a simple radical entity to deleterious lesions, as well as the opportunities of repair by devoted enzymes, is a cornerstone towards the development of more efficient protection strategies. Sensitization and selective production of DNA lesions can also be exploited to induce the selective apoptosis of cancer cells upon exposition to radiation or to oxidative stress, for instance in the field of photodynamic therapy. The importance and relevance of the field is witnessed by the impressive amount of high-level papers dealing with this complex subject, and notably tackling the structural elucidation of DNA and DNA-drug adducts, the mechanisms of formation of DNA lesions (including the precise detection of the final lesion products), as well as the influence of the lesions on the DNA stability and dynamics and the consequences on the ease of repair. Due to the complexity of the field lying at the frontiers between chemistry, physics and biology, multidisciplinary strategies allying modeling and experience are needed. This topic aims at giving an extended overview of the current research in the domain, with fundamental contribution from the leading groups in the field of DNA reactivity, structural characterization, photo-chemistry and photo-physics, as well as repair mechanism. It will therefore be a fundamental guide for scientists wanting to address the field of DNA lesion and repair, but also more generally for researchers working in rational drug design or in the development of biomarkers and medical imaging techniques

Author : Jac A. Nickoloff,Merl F. Hoekstra
Publisher : Springer Science & Business Media
Page : 639 pages
File Size : 48,7 Mb
Release : 1998-08-12
Category : Science
ISBN : 9781592594559

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DNA Damage and Repair by Jac A. Nickoloff,Merl F. Hoekstra Pdf

Cutting edge reviews by leading researchers illuminate key aspects of DNA repair in mammalian systems and its relationship to human genetic disease and cancer. Major topics include UV and X-Ray repair, repair of chemical damage, recombinational repair, mismatch repair, transcription-repair coupling, and the role of DNA repair in disease prevention. Extensive up-to-date references and rigorous peer-review of each chapter make this volume definitive and bring it to the active frontiers of research.

Author : Clark Chen
Publisher : BoD – Books on Demand
Page : 586 pages
File Size : 46,6 Mb
Release : 2011-10-26
Category : Medical
ISBN : 9789533076065

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Selected Topics in DNA Repair by Clark Chen Pdf

This book is intended for students and scientists working in the field of DNA repair, focusing on a number of topics ranging from DNA damaging agents and mechanistic insights to methods in DNA repair and insights into therapeutic strategies. These topics demonstrate how scientific ideas are developed, tested, dialogued, and matured as it is meant to discuss key concepts in DNA repair. The book should serve as a supplementary text in courses and seminars as well as a general reference for biologists with an interest in DNA repair.

Author : D. Schulte-Frohlinde,C. Von Sonntag,J. Huttermann
Publisher : CRC Press
Page : 138 pages
File Size : 51,8 Mb
Release : 1989
Category : Active oxygen
ISBN : 3718648741

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Free-Radical and Radiation-Induced Damage to DNA by D. Schulte-Frohlinde,C. Von Sonntag,J. Huttermann Pdf

Author : Kelvin J. A. Davies
Publisher : Elsevier
Page : 928 pages
File Size : 47,7 Mb
Release : 2013-10-22
Category : Health & Fitness
ISBN : 9781483287669

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Oxidative Damage & Repair by Kelvin J. A. Davies Pdf

This book was inspired by the presentations delivered at the Oxidative Damage & Repair Symposium (November, 1990). The book is organized into 20 chapters which mirror the 20 session topics of the Oxidative Damage & Repair Symposium.

Author : R. Stephen Lloyd,Miral Dizdaroglu
Publisher : Royal Society of Chemistry
Page : 429 pages
File Size : 43,8 Mb
Release : 2020-11-19
Category : Science
ISBN : 9781788018890

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DNA Damage, DNA Repair and Disease Volume 1 by R. Stephen Lloyd,Miral Dizdaroglu Pdf

The overall aim of this book is to give scientists in academia and industry a comprehensive overview of the field of DNA damage and DNA repair and related human diseases.

Author : Mark D. Evans,Marcus S. Cooke
Publisher : Springer Science & Business Media
Page : 228 pages
File Size : 43,9 Mb
Release : 2009-06-11
Category : Science
ISBN : 9780387729749

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Oxidative Damage to Nucleic Acids by Mark D. Evans,Marcus S. Cooke Pdf

This book provides up-to-date coverage of selected topics in nucleic acid oxidation. The topics have been selected to cover everything from basic chemical mechanisms, repair of damage and the biological and pathological meaning of DNA oxidation. The chapters are authored by leading, research active, international experts in the respective topics.

Author : Roberto Improta,Thierry Douki
Publisher : Royal Society of Chemistry
Page : 361 pages
File Size : 55,6 Mb
Release : 2021-12-06
Category : Science
ISBN : 9781839165597

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DNA Photodamage by Roberto Improta,Thierry Douki Pdf

Induction of DNA damage by sunlight is a major deleterious event in living organisms. Recent developments have dramatically improved our understanding of the photochemical processes involved at the sub-picosecond time scale and along with next generation sequencing and data processing has generated a need for a complete up-to-date coverage of the field. Written in an accessible and comprehensive manner, DNA Photodamage will appeal to all scientists working in the area whether specialists in the discipline or not and provides a complete coverage of the field, from ultrafast spectroscopy to biomedical research. Bridging the gap between photophysical and photochemical research on model systems, and in vivo and in vitro biological studies, this book aims to identify the most important research trends in the field and review their major findings.

Author : Errol C. Friedberg,Graham C. Walker,Wolfram Siede,Richard D. Wood
Publisher : American Society for Microbiology Press
Page : 2845 pages
File Size : 55,5 Mb
Release : 2005-11-22
Category : Science
ISBN : 9781555813192

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DNA Repair and Mutagenesis by Errol C. Friedberg,Graham C. Walker,Wolfram Siede,Richard D. Wood Pdf

An essential resource for all scientists researching cellular responses to DNA damage. • Introduces important new material reflective of the major changes and developments that have occurred in the field over the last decade. • Discussed the field within a strong historical framework, and all aspects of biological responses to DNA damage are detailed. • Provides information on covering sources and consequences of DNA damage; correcting altered bases in DNA: DNA repair; DNA damage tolerance and mutagenesis; regulatory responses to DNA damage in eukaryotes; and disease states associated with defective biological responses to DNA damage.

Author : ICN Pharmaceuticals, inc,University of California, Los Angeles. Molecular Biology Institute
Publisher : Unknown
Page : 840 pages
File Size : 49,7 Mb
Release : 1978
Category : Science
ISBN : UOM:39015000284334

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DNA Repair Mechanisms by ICN Pharmaceuticals, inc,University of California, Los Angeles. Molecular Biology Institute Pdf

DNA Repair Mechanisms is an account of the proceedings at a major international conference on DNA Repair Mechanisms held at Keystone, Colorado on February 1978. The conference discusses through plenary sessions the overall standpoint of DNA repair. The papers presented and other important documents, such as short summaries by the workshop session conveners, comprise this book. The compilation describes the opposing views, those that agree and dispute about certain topic areas. This book, divided into 15 parts, is arranged according to the proceedings in the conference. The plenary sessions are ...