Free Radical Research

Author : A.T. Diplock,M.C.R. Symons,C.A. Rice-Evans
Publisher : Elsevier
Page : 290 pages
File Size : 45,5 Mb
Release : 1991-12-11
Category : Science
ISBN : 0080858910

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Techniques in Free Radical Research by A.T. Diplock,M.C.R. Symons,C.A. Rice-Evans Pdf

Free radical species are generally short-lived due to their high reactivity and thus direct measurement and identification are often impossible. ESR is the only technique which has the potential for direct detection of radicals but in biological systems even these must be trapped by a spin-trapping agent. Thus most investigations involve recognition of indicators of the presence of radicals in vivo or "FOOTPRINTS" of radical-mediated damage. Techniques in Free Radical Research assembles and critically assesses the most relevant and reliable experimental approaches used towards the measurement of radicals and radical-mediated damage in chemical systems, in cells and in tissues under the following six headings: a) Footprints of DNA damage, b) Footprints of protein damage, c) Footprints of lipid peroxidation, d) Footprints of antioxidant consumption, e) Footprints via indirect radical assays, and f) Footprints via the availability of transition metal complexes.

Author : John Schostak,Jill Schostak
Publisher : Routledge
Page : 499 pages
File Size : 53,6 Mb
Release : 2007-09-05
Category : Education
ISBN : 9781134149483

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Radical Research by John Schostak,Jill Schostak Pdf

Radical Research explores the view that research is not a neutral tool to be employed without bias in the search for truth. Rather the radical roots of research are to be seen in the focus on freedom and emancipation from blind allegiance to tradition, ‘common sense’, religion, or powerful individuals and organisations. Radical Research introduces and draws upon leading contemporary debates and data gathered from a diversity of funded projects in; health, education, police training, youth and community, schools, business, and the use of information technology. This book presents a radical view of research in a way that enables both beginner and the experienced professional researcher to explore its approaches in the formation of their own views and practices. It progressively leads the reader from discussions of case studies to critical explorations of the philosophical and methodological concepts, theories and arguments that are central to contemporary debates. In essence, this book shows how to design, develop and write radical research under conditions where ‘normal’ research rules apply and it offers a ground-breaking and proven alternative to traditional research techniques.

Author : Ana Čipak Gašparović
Publisher : MDPI
Page : 192 pages
File Size : 46,5 Mb
Release : 2020-06-18
Category : Science
ISBN : 9783039360888

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Free Radical Research in Cancer by Ana Čipak Gašparović Pdf

Cancer is a great challenge to efficient therapy due to biological diversity. Disturbed oxidative homeostasis in cancer cells certainly contributes to differential therapy response. Further, one of the hallmarks of cancer cells is adaptation which includes fine tuning of the cellular metabolic and signalling pathways as well as transcription profiles. There are several factors which contribute to the tumor diversity and therapy response, and oxidative stress is certainly one of them. Changes in oxygen levels due to hypoxia/reoxygenation during tumor growth modulate antioxidative patterns finally supporting increased cell diversity and adaptation to stressing conditions. Additionally, cancer chemotherapy based on ROS production can also induce also adaptation. To counteract these negative effects natural products are often used for their antioxidant activities as well as photodynamic therapy supported by novel chemosensitizers. Understanding of possible pathways which can trigger antioxidant defence at a certain time during cancer development can also provide possible strategies in fighting cancer.

Author : Catherine A. Rice-Evans
Publisher : Unknown
Page : 291 pages
File Size : 41,5 Mb
Release : 1991
Category : Electronic
ISBN : 0720442001

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Techniques in Free Radical Research by Catherine A. Rice-Evans Pdf

Author : Neville A. Punchard,Frank J. Kelly
Publisher : IRL Press
Page : 310 pages
File Size : 40,6 Mb
Release : 1996
Category : History
ISBN : 0199635595

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Free Radicals by Neville A. Punchard,Frank J. Kelly Pdf

With the recognition that oxygen and nitrogen radicals are involved in normal cell metabolism, free radical research has begun to feature in most disciplines in the life sciences. Increasingly, their implication in a number of human disease processes is being accepted, altough conclusive evidence is lacking in many instances, partly due to the difficulties in detecting and measuring free radicals that have lifetimes measured in microseconds. This book outlines the latest techniques for quantifying radicals and their effects, and features detailed protocols, hints, and tips for success, troubleshooting comments, sample data, and key literature citations.

Author : Free Radical Research Society. Meeting
Publisher : Unknown
Page : 266 pages
File Size : 41,7 Mb
Release : 1985
Category : Electronic
ISBN : OCLC:756229387

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Free Radicals in Biology and Medicine by Free Radical Research Society. Meeting Pdf

Author : International Society for Free Radical Research. Congress,Society for Free Radical Research International,International Society for Free Radical Research
Publisher : Unknown
Page : 352 pages
File Size : 49,8 Mb
Release : 2006
Category : Medical
ISBN : 8875872740

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Thirteenth Congress of the Society for Free Radical Research International by International Society for Free Radical Research. Congress,Society for Free Radical Research International,International Society for Free Radical Research Pdf

Author : Robert A. Greenwald
Publisher : CRC Press
Page : 467 pages
File Size : 45,9 Mb
Release : 2018-02-01
Category : Medical
ISBN : 9781351081375

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Handbook Methods For Oxygen Radical Research by Robert A. Greenwald Pdf

This volume is divided into five sections. Section I deals with preparative methodology for isolation and purification of the components of the oxy radical experimental systems use most frequently, including all three forms of SOD and several other important scavengers. Section II provides the experimenter with a choice of a dozen oxy radical generating systems which can be used for testing of scavengers or for evaluation of the effects of oxy radicals on target tissues. The reader will note that in this section, as well as in most of the rest of the volume, the orientation is primarily biochemical, biologic, and medical, rather than pure chemistry or pure physics. Nevertheless, the techniques are widely applicable to a variety of disciplines.

Author : POLI
Publisher : Birkhäuser
Page : 540 pages
File Size : 45,8 Mb
Release : 2013-03-11
Category : Science
ISBN : 9783034891165

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Free Radicals: from Basic Science to Medicine by POLI Pdf

Free radical-mediated reactions have been well known in chemistry and physical chemistry for many years. Applying this knowledge to living organisms, biochemists have shown that reactive free radicals are formed at many intracellular sites during normal metabolism, and they have started to suggest possible roles in various pathological processes and conditions, for example in radiation damage, in the metabolism of xenobiotics, in carcinogenesis and in metabolic disorders. At present, a large and relevant mass of experimental evidence supports the view that reactive free radicals are involved in the pathogenesis of several diseases and syndromes. This literature has captured the attention and interest of people involved in the biomedical field. Exciting developments in radical research are probable in the near future, establishing a greater interaction between basic science research and medicine. While the task of defining the involvement of free radicals in human pathology is difficult, it is nonetheless extremely important that such interaction be fulfilled as soon as possible. These were the considerations motivating us during the organization of the VI Biennial Meeting of the International Society for Free Radical Research held in Torino, Italy, in June 1992, and also during the preparation of this book. Experts in the various aspects of free radical research were invited to participate in the Torino Meeting and to contribute chapters for this volume.

Author : Clemens Sonntag
Publisher : Springer Science & Business Media
Page : 528 pages
File Size : 45,8 Mb
Release : 2006-03-20
Category : Science
ISBN : 9783540305927

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Free-Radical-Induced DNA Damage and Its Repair by Clemens Sonntag Pdf

The free-radical chemistry of DNA had been discussed in some detail in 1987 in my book The Chemical Basis of Radiation Biology. Obviously, the more recent developments and the concomitant higher level of understanding of mechanistic details are missing. Moreover, in the living cell, free-radical DNA damage is not only induced by ionizing radiation, but free-radical-induced DNA damage is a much more general phenomenon. It was, therefore, felt that it is now timely to review our present knowledge of free-radical-induced DNA damage induced by all conceivable free-radical-generating sources. Originally, it had been thought to include also a very important aspect, the repair of DNA damage by the cell’s various repair enzymes. Kevin Prise (Cancer Campaign, Gray Laboratory, L- don) was so kind to agree to write this part. However, an adequate description of this strongly expanding area would have exceeded the allocated space by much, and this section had to be omitted. The directors of the Max-Planck-Institut für Strahlenchemie (now MPI für Bioanorganische Chemie), Karl Wieghardt and Wolfgang Lubitz, kindly allowed me to continue to use its facilities after my retirement in 2001. Notably, our - brarian, Mrs. Jutta Theurich, and her right-hand help, Mrs. Rosemarie Schr- er, were most helpful in getting hold of the literature. I thank them very much. Without their constant help, this would have been very difficult indeed.

Author : Society for Free Radical Research Europe. Meeting
Publisher : Unknown
Page : 193 pages
File Size : 43,7 Mb
Release : 2007
Category : Medical
ISBN : 8875874034

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European Meeting of the Society for Free Radical Research International (Vilamoura, 10-13 October 2007) by Society for Free Radical Research Europe. Meeting Pdf

Author : Barry Halliwell,John M. C. Gutteridge
Publisher : Oxford University Press
Page : 961 pages
File Size : 45,8 Mb
Release : 2015
Category : Science
ISBN : 9780198717478

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Free Radicals in Biology and Medicine by Barry Halliwell,John M. C. Gutteridge Pdf

Free Radicals in Biology and Medicine has become a classic text in the field of free radical and antioxidant research. Now in its fifth edition, the book has been comprehensively rewritten and updated whilst maintaining the clarity of its predecessors. Two new chapters discuss 'in vivo' and 'dietary' antioxidants, the first emphasising the role of peroxiredoxins and integrated defence mechanisms which allow useful roles for ROS, and the second containing new information on the role of fruits, vegetables, and vitamins in health and disease. This new edition also contains expanded coverage of the mechanisms of oxidative damage to lipids, DNA, and proteins (and the repair of such damage), and the roles played by reactive species in signal transduction, cell survival, death, human reproduction, defence mechanisms of animals and plants against pathogens, and other important biological events. The methodologies available to measure reactive species and oxidative damage (and their potential pitfalls) have been fully updated, as have the topics of phagocyte ROS production, NADPH oxidase enzymes, and toxicology. There is a detailed and critical evaluation of the role of free radicals and other reactive species in human diseases, especially cancer, cardiovascular, chronic inflammatory and neurodegenerative diseases. New aspects of ageing are discussed in the context of the free radical theory of ageing. This book is recommended as a comprehensive introduction to the field for students, educators, clinicians, and researchers. It will also be an invaluable companion to all those interested in the role of free radicals in the life and biomedical sciences.

Author : C.A. Rice-Evans,R.H. Burdon
Publisher : Elsevier
Page : 409 pages
File Size : 45,5 Mb
Release : 1994-02-09
Category : Science
ISBN : 9780080860886

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Free Radical Damage and its Control by C.A. Rice-Evans,R.H. Burdon Pdf

This book provides a comprehensive treatise on the chemical and biochemical consequences of damaging free radical reactions, the implications for the pathogenesis of disease and how this might be controlled endogenously and by radical scavenging drugs. Oxidative stress may be influenced by exogenous agents of oxidative stress, radiation, trauma, drug activation, oxygen excess, or by exogenous oxidative stress which is associated with many pathological states including chronic inflammatory disorders, cardiovascular disease, injury to the central nervous system, and connective tissue damage. This and many other such aspects are presented clearly and in depth. The development of antioxidant drugs depends on the understanding of the mechanisms underlying the generation of excessive free radicals in vivo, the factors controlling their release and the site of their action. This excellent volume presents an up-to-date account of the current state of knowledge in these areas.

Author : Neville A. Punchard,Frank J. Kelly
Publisher : IRL Press
Page : 344 pages
File Size : 49,5 Mb
Release : 1996
Category : Antioxidants
ISBN : UOM:39015038155837

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Free Radicals by Neville A. Punchard,Frank J. Kelly Pdf

With the recognition that oxygen and nitrogen radicals are involved in normal cell metabolism, free radical research has begun to feature in most disciplines in the life sciences. Increasingly, their implication in a number of human disease processes is being accepted, altough conclusive evidence is lacking in many instances, partly due to the difficulties in detecting and measuring free radicals that have lifetimes measured in microseconds. This book outlines the latest techniques for quantifying radicals and their effects, and features detailed protocols, hints, and tips for success, troubleshooting comments, sample data, and key literature citations.

Author : Vibha Rani,Umesh Chand Singh Yadav
Publisher : Springer
Page : 427 pages
File Size : 48,9 Mb
Release : 2014-11-14
Category : Science
ISBN : 9788132220350

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Free Radicals in Human Health and Disease by Vibha Rani,Umesh Chand Singh Yadav Pdf

The role of oxidative stress in human disease has become an area of intense interest. Free radicals, a normal product of metabolism, exist in all aerobic cells in balance with biochemical antioxidants. Environmental stress increases the levels of free radicals drastically, thereby disturbing the equilibrium between free radical production and the antioxidant capability causing oxidative stress. Over the years, ROS has been implicated in the pathologies of various diseases like cancer, neurological disorder, cardiovascular diseases rheumatoid arthritis, diabetes etc. This book provides an in depth critical state-of-art reviews from established investigators on free radicals, ROS associated pathogenesis of human diseases, biomarkers of oxidative damage, antioxidants, phytonutrients and other related health concerns of modern society. The present book is aimed at graduate students, researchers in academia, industry and clinicians with the interest in redox biology. Special attention has been devoted to the topic of ROS signalling, oxidative stress induced human pathologies & antioxidative therapies. The book consists of four parts in specified topics based on the current literatures for the better understanding of the readers with respect to their subject-wise interests. The first section of the book provides an overview about the ROS production and their measuring tools and techniques followed by the mechanisms involved in the oxidative stress in the second section. The third section describes the involvement of oxidative stress in different human diseases and the last section focuses on the different strategies to ameliorate oxidative stress induced stress.