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Author : Richard Heatley
Publisher : Cambridge University Press
Page : 412 pages
File Size : 43,8 Mb
Release : 1994-10-27
Category : Medical
ISBN : 9780521445092
This 1994 volume summarizes basic scientific advances in the area of the gut immune system and the immune abnormalities relevant to gastrointestinal and liver disease.
Author : A. Ferguson,R.N.M. MacSween
Publisher : Springer Science & Business Media
Page : 413 pages
File Size : 44,8 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9789401161503
We have been privileged to start our academic careers at the begin ning of the decade in which the immunological roles and hypersensitivity diseases of the gastrointestinal tract and liver have been defined. In the early 1960s IgA was reported to be the main secretory immunoglobulin, immunoblasts were shown to home to the intestinal mucosa and certain serum autoantibodies were described in patients with chronic liver disease. Shortly thereafter IgE and Australia antigen were discovered. Parallel advances in clinical investigation, in particular closed biopsy techniques, facilitated correlation of morphological changes with im munological mechanisms in disease of the gastrointestinal tract and liver. Only 10 years later, the concepts of immunity and hypersensitivity are regularly applied to the pathogenesis, diagnosis, treatment and prog nosis of many chronic diseases in these organs. In designing this book we have attempted to integrate theorectical and clinical immunology as they pertain in 1975; our ultimate aim is aptly described by Brachet as quoted by Professor Paronetto (page 319). We would like to think that this review provides a basis for the next major advances in the fields of gastrointestinal and hepatic immunology. As we see it, the outstanding problem in both sites is how to produce protective immunity without hypersensitivity.
Author : Martin F. Heyworth,Albert L. Jones
Publisher : Lippincott Williams & Wilkins
Page : 250 pages
File Size : 50,9 Mb
Release : 1988
Category : Cellular immunity
ISBN : UOM:39015012556182
Author : David R. Triger
Publisher : Butterworth-Heinemann
Page : 260 pages
File Size : 50,6 Mb
Release : 1986
Category : Medical
ISBN : UOM:39015011785980
Author : Stephan R. Targan,Fergus Shanahan
Publisher : Igaku-Shoin Medical Publishers
Page : 680 pages
File Size : 41,5 Mb
Release : 1990
Category : Medical
ISBN : UOM:39015015468815
Author : Ralph Wright (M.D.)
Publisher : Hodder Education
Page : 148 pages
File Size : 43,8 Mb
Release : 1977
Category : Medical
ISBN : UOM:39015000894991
Author : Ralph Wright
Publisher : Unknown
Page : 254 pages
File Size : 52,5 Mb
Release : 1987
Category : Gastrointestinal system
ISBN : 0702012114
Author : M. Eric Gershwin,John M. Vierling,Michael P. Manns
Publisher : Springer Science & Business Media
Page : 480 pages
File Size : 44,7 Mb
Release : 2013-11-19
Category : Medical
ISBN : 9783319020969
Liver Immunology: Principles and Practice, Second Edition begins with important information about the epidemiology and mortality of liver disease worldwide. This information is followed by chapters related to basic immunology, application of liver immunology for diagnosis, and several excellent chapters that provide a solid foundation for understanding immune-mediated liver disease, including those associated with the biliary tree. A chapter on non-hepatic manifestations of immune mediated liver disease helps provide context for how these diseases affect the patient overall. In addition, chapters discuss various discrete immunologically-mediated infectious liver disorders including those related to bacteria, parasites, and all of the classic viruses. Chapters on the traditional autoimmune liver diseases -- primary biliary cirrhosis, autoimmune hepatitis, primary sclerosing cholangitis as well as overlap syndrome – are also included. The breadth of this comprehensive second edition is highlighted by chapters on alcoholic liver disease, non-alcoholic fatty liver disease, and drug-induced liver disease, among others. This invaluable new edition ends with a forward-looking view of future directions and how the field might meet the challenge of refractory patients. Developed by a renowned group of authors, Liver Immunology: Principles and Practice, Second Edition will again serve as a comprehensive textbook by providing an excellent overview for this rapidly evolving field. It greatly adds to the understanding of the pathogenesis of these diseases, while also providing novel insights that can be harnessed into helping improve the care of patients afflicted with various immune-mediated diseases. This volume will again be a must-read for clinicians at all levels, investigators and students.
Author : M. Lukás,M.P. Manns,J. Spicak,E.-F. Stange
Publisher : Springer Science & Business Media
Page : 338 pages
File Size : 54,7 Mb
Release : 2004-06-30
Category : Medical
ISBN : 0792387929
This book is the proceedings of the Falk Symposium No. 135 held in Prague, Czech Republic, on September 12-13, 2003, and is dedicated to the important issue of immunological aspects of diseases of the liver and gut. Without any doubt, immunological pathways are among the most important and universal factors in the pathogenesis of all diseases. Their importance is also constantly increasing, because these principles have been adopted in clinical practice for both diagnostic and therapeutic procedures. Chapters by prominent experts will stimulate new ideas and set the scene for productive discussion on this topic.
Author : Anonim
Publisher : Unknown
Page : 7 pages
File Size : 40,8 Mb
Release : 1976
Category : Digestive organs
ISBN : OCLC:7524007
Author : Michael P. Manns
Publisher : Unknown
Page : 162 pages
File Size : 41,5 Mb
Release : 1996
Category : Cellular immunity
ISBN : 0702021873
This work on liver and gastroenterology covers such topics as the regulation of the mucosal epithelial cell barrier; antigen preservation in the intestinal tract; special features of the intestinal lymphatic system; and the immunopathology of primary biliary cirrhosis.
Author : H.C. Thomas,P.A. Miescher,H.J. Mueller-Eberhard
Publisher : Springer Science & Business Media
Page : 210 pages
File Size : 54,6 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9783642684463
Howard C. Thomas In normal subjects the regulatory apparatus of the immune system permits responses to foreign antigens but suppresses those directed to "self' components. Autoimmune disease occurs as a failure ofthis system either as a result of a primary defect in the regulatory apparatus (primary autoimmunization) or because of a change in the antigenicity of the tissues (secondary autoimmunization). Autoaggressive reactions are characterised by the presence of autoantibodies. When these are directed to membrane displayed antigens (Fig. 1) they are probably of importance in the lysis of hepatocytes. Those directed to cytoplasmic antigens may be useful diagnostically but are of unknown pathogenic significance. When no extrinsic aetiological factor can be identified, the process is assumed to be the result of a failure ofthe regulatory system, allowing the spontaneous expansion of a clone of autoreactive lymphocytes. The defect may be generalised or specific to certain groups of self-antigens and thus the autoimmune disease may be either multi- or unisystemic. The recent development of techniques to enumerate and measure the functional activity of the suppressor lymphocytes which control the effector limbs of the immune system has enabled investigators to test whether the various purported autoimmune diseases do have as their basis a generalised defect in immunoregu lation. Assessment of antigen-specific immunoregulatory function is, however, not yet readily available. liver Membrane I Antigen (LIM) I Liver I HLA, A, B, C, Sensitisation to Specific -;::!IIIL. .
Author : Ralph Wright
Publisher : Unknown
Page : 128 pages
File Size : 52,8 Mb
Release : 1979
Category : Electronic
ISBN : 081519367X
Author : H.C. Thomas,J. Waters
Publisher : Springer Science & Business Media
Page : 212 pages
File Size : 53,6 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9789401114288
The role of the immune response in both the pathology of liver disease and in the modulation ofliver injury has been the subject of intense research. This book aims to present the current understanding of the involvement of the immune response in liver disease. The first chapters examine the role of the immune response in viral infections of the liver. These viruses cause hepatitis of varying severity and it is thought that many of the mechanisms responsible for liver cell injury are immunologically mediated. In addition three of these viruses, hepatitic B, C, and D, are associated with persistent infection and chronic liver disease. The role of the immune response in viral persistence is discussed. Further chapters are devoted to the three major autoimmune liver diseases which are thought to be the result of loss of tolerance to autologous liver tissue. There has been much recent research on cellular immune responses in these diseases but knowledge of the immunological processes which lead to the breakdown of tolerance and the mechanisms of tissue damage are limited. Other research has concentrated on the identification of the antigens which are the targets of this immune response. Linkage disequilibrium between MHC alleles and autoimmune diseases has suggested a role for immunogenetic factors.
Author : Roy Gerrard Shorter
Publisher : Saunders
Page : 296 pages
File Size : 50,7 Mb
Release : 1985
Category : Gastrointestinal system
ISBN : UCAL:B4530697