Liver Immunology

Author : M. Eric Gershwin,John M. Vierling,Michael P. Manns
Publisher : Springer Science & Business Media
Page : 480 pages
File Size : 51,5 Mb
Release : 2013-11-19
Category : Medical
ISBN : 9783319020969

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Liver Immunology by M. Eric Gershwin,John M. Vierling,Michael P. Manns Pdf

Liver Immunology: Principles and Practice, Second Edition begins with important information about the epidemiology and mortality of liver disease worldwide. This information is followed by chapters related to basic immunology, application of liver immunology for diagnosis, and several excellent chapters that provide a solid foundation for understanding immune-mediated liver disease, including those associated with the biliary tree. A chapter on non-hepatic manifestations of immune mediated liver disease helps provide context for how these diseases affect the patient overall. In addition, chapters discuss various discrete immunologically-mediated infectious liver disorders including those related to bacteria, parasites, and all of the classic viruses. Chapters on the traditional autoimmune liver diseases -- primary biliary cirrhosis, autoimmune hepatitis, primary sclerosing cholangitis as well as overlap syndrome – are also included. The breadth of this comprehensive second edition is highlighted by chapters on alcoholic liver disease, non-alcoholic fatty liver disease, and drug-induced liver disease, among others. This invaluable new edition ends with a forward-looking view of future directions and how the field might meet the challenge of refractory patients. Developed by a renowned group of authors, Liver Immunology: Principles and Practice, Second Edition will again serve as a comprehensive textbook by providing an excellent overview for this rapidly evolving field. It greatly adds to the understanding of the pathogenesis of these diseases, while also providing novel insights that can be harnessed into helping improve the care of patients afflicted with various immune-mediated diseases. This volume will again be a must-read for clinicians at all levels, investigators and students.

Author : H.C. Thomas,J. Waters
Publisher : Springer Science & Business Media
Page : 212 pages
File Size : 41,9 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9789401114288

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Immunology of Liver Disease by H.C. Thomas,J. Waters Pdf

The role of the immune response in both the pathology of liver disease and in the modulation ofliver injury has been the subject of intense research. This book aims to present the current understanding of the involvement of the immune response in liver disease. The first chapters examine the role of the immune response in viral infections of the liver. These viruses cause hepatitis of varying severity and it is thought that many of the mechanisms responsible for liver cell injury are immunologically mediated. In addition three of these viruses, hepatitic B, C, and D, are associated with persistent infection and chronic liver disease. The role of the immune response in viral persistence is discussed. Further chapters are devoted to the three major autoimmune liver diseases which are thought to be the result of loss of tolerance to autologous liver tissue. There has been much recent research on cellular immune responses in these diseases but knowledge of the immunological processes which lead to the breakdown of tolerance and the mechanisms of tissue damage are limited. Other research has concentrated on the identification of the antigens which are the targets of this immune response. Linkage disequilibrium between MHC alleles and autoimmune diseases has suggested a role for immunogenetic factors.

Author : M.P. Manns,G. Paumgartner,U. Leuschner
Publisher : Springer Science & Business Media
Page : 400 pages
File Size : 50,5 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9789401140003

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Immunology and Liver by M.P. Manns,G. Paumgartner,U. Leuschner Pdf

In 1992, the Falk Symposium No. 70 dealt with the topic `Immunology and Liver'. At that time basic mechanisms of immunology as well as immunopathogenetic mechanisms in viral and autoimmune liver diseases were discussed. Now, 7 years later, the Falk Symposium No. 114, held in Basel, Switzerland, October 20-21 1999 (Part I of the Basel Liver Week 1999), focused on immunology in autoimmune liver diseases. In the first section basic mechanisms of autoimmunity are presented, including the relevance of superantigens and the role of apoptosis. A further topic is the latest developments concerning animal models for autoimmune diseases. Recently the International Autoimmune Hepatitis Group newly defined and reclassified the syndrome of autoimmune hepatitis. Autoimmune hepatitis is now identified and studied in all parts of the world, including Asia and South America. A special variant of autoimmune hepatitis was identified as one organ manifestation of the autoimmune polyendocrine syndrome type 1, a genetic disease caused by mutations in a single transcription factor. Drug- and hepatitis-virus induced immune mediated liver diseases may serve as models for nonhepatic immune mediated disorders. DNA technology has increased our knowledge of the immunogenetic background of autoimmune liver diseases. Among the cholestatic immune mediated liver diseases, significant progress has been made concerning primary biliary cirrhosis, in particular regarding the identification of mitochondrial antigens and the characterisation of the immune reactions directed at them. The involvement of infectious agents in PBC as well as the definition of overlap syndromes is a particular focus for basic and clinical research in this area. Concerning the therapy of autoimmune liver diseases, corticosteroids and azathioprin remain the state of the art for autoimmune hepatitis, while bile acids have become well established in treatment of primary biliary cirrhosis as well as primary sclerosing cholangitis. New drugs in the future will include topical steroids such as budesonide and new immunosuppressive agents like mofetil/mycophenolate. Liver transplantation is the treatment of choice for end stage liver diseases; all autoimmune liver diseases are among the best candidates for liver transplantation. Hopefully, new therapeutic strategies based on the results obtained from experimental models will become everyday clinical practice in the next decade. Therefore this symposium concludes with a discussion.

Author : Martin Smith,Roger Williams
Publisher : Butterworth-Heinemann
Page : 330 pages
File Size : 47,6 Mb
Release : 2014-05-20
Category : Health & Fitness
ISBN : 9781483162812

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Immunology of the Liver by Martin Smith,Roger Williams Pdf

Immunology of the Liver contains the proceedings of an International Meeting held at King's College Hospital Medical School in London on July 6-7, 1970. The meeting provided a forum for discussing progress made in understanding the immunology of the liver and tackled topics ranging from the pathology of chronic hepatitis to the occurrence and distribution of tissue antibodies in liver diseases. Cell-mediated responses and manifestations of immunological damage are also explored. Comprised of 33 chapters, this book begins with an introduction to the clinical, morphological, and virological aspects of liver disease. In particular, the clinical spectrum of autoimmune liver disease is considered, along with the pathology of chronic hepatitis. Morphological and immunological studies on chronic aggressive hepatitis and primary biliary cirrhosis are presented. Subsequent chapters focus on antibodies related to mitochondria; leukocyte migration in active chronic hepatitis and primary biliary cirrhosis; immunologic observations and electron microscopy of halothane-induced hepatic injury; and humoral and delayed hypersensitivity in chronic hepatitis. The final sections deal with results of immunosuppressive therapy and the immunology of liver transplantation. This monograph will be of interest to immunologists, pathologists, physiologists, clinicians, and research workers in the field of medicine.

Author : H.C. Thomas,P.A. Miescher,H.J. Mueller-Eberhard
Publisher : Springer Science & Business Media
Page : 210 pages
File Size : 40,5 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9783642684463

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Immunological Aspects of Liver Disease by H.C. Thomas,P.A. Miescher,H.J. Mueller-Eberhard Pdf

Howard C. Thomas In normal subjects the regulatory apparatus of the immune system permits responses to foreign antigens but suppresses those directed to "self' components. Autoimmune disease occurs as a failure ofthis system either as a result of a primary defect in the regulatory apparatus (primary autoimmunization) or because of a change in the antigenicity of the tissues (secondary autoimmunization). Autoaggressive reactions are characterised by the presence of autoantibodies. When these are directed to membrane displayed antigens (Fig. 1) they are probably of importance in the lysis of hepatocytes. Those directed to cytoplasmic antigens may be useful diagnostically but are of unknown pathogenic significance. When no extrinsic aetiological factor can be identified, the process is assumed to be the result of a failure ofthe regulatory system, allowing the spontaneous expansion of a clone of autoreactive lymphocytes. The defect may be generalised or specific to certain groups of self-antigens and thus the autoimmune disease may be either multi- or unisystemic. The recent development of techniques to enumerate and measure the functional activity of the suppressor lymphocytes which control the effector limbs of the immune system has enabled investigators to test whether the various purported autoimmune diseases do have as their basis a generalised defect in immunoregu lation. Assessment of antigen-specific immunoregulatory function is, however, not yet readily available. liver Membrane I Antigen (LIM) I Liver I HLA, A, B, C, Sensitisation to Specific -;::!IIIL. .

Author : Richard Heatley
Publisher : Cambridge University Press
Page : 412 pages
File Size : 45,7 Mb
Release : 1994-10-27
Category : Medical
ISBN : 9780521445092

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Gastrointestinal and Hepatic Immunology by Richard Heatley Pdf

This 1994 volume summarizes basic scientific advances in the area of the gut immune system and the immune abnormalities relevant to gastrointestinal and liver disease.

Author : I. N. Crispe
Publisher : John Wiley & Sons
Page : 272 pages
File Size : 40,8 Mb
Release : 1999-01-19
Category : Medical
ISBN : 047119218X

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T Lymphocytes in the Liver by I. N. Crispe Pdf

T Lymphocytes in the Liver is the first book to offer a comprehensive review of the newly understood relationship between the liver and the immune system. This edited volume examines the immunobiology of T cells - the way their behavior in the liver differs from that in other organs, and, conversely, the liver's ability to effect changes in the activity of such immune cells. A number of relevant, cutting-edge issues are considered, including vaccine development, the liver's potential role in autoimmune tissue damage, tolerance and transplant rejection, and the use of animal organs for human patients. Contributing authors from diverse specialties discuss topics including: * T cells expressing antigen receptors in the liver * Active T cells in the liver * Extrathymic T cells in the liver * The induction of peripheral tolerance by portal vein administration of antigen * The immunobiology of viral hepatitis * Immunity to Listeria monocytogenes infection of the liver * Malaria and the liver * T cells and autoimmune liver disease * Hepatic T cells in primary sclerosing cholangitis and autoimmune hepatitis

Author : A. Ferguson,R.N.M. MacSween
Publisher : Springer Science & Business Media
Page : 413 pages
File Size : 52,6 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9789401161503

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Immunological Aspects of the Liver and Gastrointestinal Tract by A. Ferguson,R.N.M. MacSween Pdf

We have been privileged to start our academic careers at the begin ning of the decade in which the immunological roles and hypersensitivity diseases of the gastrointestinal tract and liver have been defined. In the early 1960s IgA was reported to be the main secretory immunoglobulin, immunoblasts were shown to home to the intestinal mucosa and certain serum autoantibodies were described in patients with chronic liver disease. Shortly thereafter IgE and Australia antigen were discovered. Parallel advances in clinical investigation, in particular closed biopsy techniques, facilitated correlation of morphological changes with im munological mechanisms in disease of the gastrointestinal tract and liver. Only 10 years later, the concepts of immunity and hypersensitivity are regularly applied to the pathogenesis, diagnosis, treatment and prog nosis of many chronic diseases in these organs. In designing this book we have attempted to integrate theorectical and clinical immunology as they pertain in 1975; our ultimate aim is aptly described by Brachet as quoted by Professor Paronetto (page 319). We would like to think that this review provides a basis for the next major advances in the fields of gastrointestinal and hepatic immunology. As we see it, the outstanding problem in both sites is how to produce protective immunity without hypersensitivity.

Author : International Meeting on the Immunology of the Liver. 1970, London
Publisher : Unknown
Page : 314 pages
File Size : 47,9 Mb
Release : 1971
Category : Liver
ISBN : 0433307250

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Immunology of the Liver by International Meeting on the Immunology of the Liver. 1970, London Pdf

Author : Stephan R. Targan,Fergus Shanahan
Publisher : Igaku-Shoin Medical Publishers
Page : 680 pages
File Size : 53,9 Mb
Release : 1990
Category : Medical
ISBN : UOM:39015015468815

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Immunology and Immunopathology of the Liver and Gastrointestinal Tract by Stephan R. Targan,Fergus Shanahan Pdf

Author : David R. Triger
Publisher : Butterworth-Heinemann
Page : 260 pages
File Size : 51,8 Mb
Release : 1986
Category : Medical
ISBN : UOM:39015011785980

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Clinical Immunology of the Liver and Gastrointestinal Tract by David R. Triger Pdf

Author : Martin F. Heyworth,Albert L. Jones
Publisher : Lippincott Williams & Wilkins
Page : 250 pages
File Size : 52,9 Mb
Release : 1988
Category : Cellular immunity
ISBN : UOM:39015012556182

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Immunology of the Gastrointestinal Tract and Liver by Martin F. Heyworth,Albert L. Jones Pdf

Author : M. Eric Gershwin,John M. Vierling,Michael P. Manns
Publisher : Springer Science & Business Media
Page : 486 pages
File Size : 51,5 Mb
Release : 2008-01-24
Category : Medical
ISBN : 9781597455183

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Liver Immunology by M. Eric Gershwin,John M. Vierling,Michael P. Manns Pdf

Immunology is a broad branch of biomedical science that covers the study of all aspects of the immune system in all organisms. This volume is a must-read for novice and expert alike. In an easy-to-read and thorough format, it covers bacterial, parasitic and viral infections of the liver, autoimmune liver disease, alcoholic and nonalcoholic fatty liver diseases, and transplantation.

Author : Anonim
Publisher : Unknown
Page : 0 pages
File Size : 53,7 Mb
Release : 1970
Category : Autoimmune diseases
ISBN : OCLC:70903810

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Immunology of the Liver by Anonim Pdf

Author : A. L. W. F. Eddleston,John Christian Peter Weber,Roger Williams
Publisher : Unknown
Page : 344 pages
File Size : 55,8 Mb
Release : 1979
Category : Autoimmune diseases
ISBN : UCAL:B4330233

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Immune Reactions in Liver Disease by A. L. W. F. Eddleston,John Christian Peter Weber,Roger Williams Pdf