Gene Expression Profiling By Microarrays

Author : Wolf-Karsten Hofmann
Publisher : Cambridge University Press
Page : 230 pages
File Size : 43,6 Mb
Release : 2006-06-22
Category : Medical
ISBN : 9781139456913

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Gene Expression Profiling by Microarrays by Wolf-Karsten Hofmann Pdf

Microarray analysis is a highly efficient tool for assessing the expression of a large number of genes simultaneously, and offers a new means to classify cancer and other diseases. Gene expression profiling can also be used to predict clinical outcome and response to specific therapeutic agents. This survey spans recent applications of microarrays in clinical medicine, covering malignant disease including acute leukaemias, lymphoid malignancies and breast cancer, together with diabetes and heart disease. Investigators in oncology, pharmacology and related clinical sciences, as well as basic scientists, will value this review of a promising new diagnostic and prognostic technology.

Author : Geoffrey J. McLachlan,Kim-Anh Do,Christophe Ambroise
Publisher : John Wiley & Sons
Page : 366 pages
File Size : 41,9 Mb
Release : 2005-02-18
Category : Mathematics
ISBN : 9780471726128

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Analyzing Microarray Gene Expression Data by Geoffrey J. McLachlan,Kim-Anh Do,Christophe Ambroise Pdf

A multi-discipline, hands-on guide to microarray analysis of biological processes Analyzing Microarray Gene Expression Data provides a comprehensive review of available methodologies for the analysis of data derived from the latest DNA microarray technologies. Designed for biostatisticians entering the field of microarray analysis as well as biologists seeking to more effectively analyze their own experimental data, the text features a unique interdisciplinary approach and a combined academic and practical perspective that offers readers the most complete and applied coverage of the subject matter to date. Following a basic overview of the biological and technical principles behind microarray experimentation, the text provides a look at some of the most effective tools and procedures for achieving optimum reliability and reproducibility of research results, including: An in-depth account of the detection of genes that are differentially expressed across a number of classes of tissues Extensive coverage of both cluster analysis and discriminant analysis of microarray data and the growing applications of both methodologies A model-based approach to cluster analysis, with emphasis on the use of the EMMIX-GENE procedure for the clustering of tissue samples The latest data cleaning and normalization procedures The uses of microarray expression data for providing important prognostic information on the outcome of disease

Author : Hinrich Gohlmann,Willem Talloen
Publisher : CRC Press
Page : 361 pages
File Size : 53,5 Mb
Release : 2009-07-15
Category : Science
ISBN : 9781420065169

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Gene Expression Studies Using Affymetrix Microarrays by Hinrich Gohlmann,Willem Talloen Pdf

The Affymetrix GeneChip system is one of the most widely adapted microarray platforms. However, due to the overwhelming amount of information available, many Affymetrix users tend to stick to the default analysis settings and may end up drawing sub-optimal conclusions. Written by a molecular biologist and a biostatistician with a combined decade of

Author : Aidong Zhang
Publisher : World Scientific Publishing Company
Page : 356 pages
File Size : 55,9 Mb
Release : 2006-06-27
Category : Science
ISBN : 9789813106642

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Advanced Analysis Of Gene Expression Microarray Data by Aidong Zhang Pdf

This book focuses on the development and application of the latest advanced data mining, machine learning, and visualization techniques for the identification of interesting, significant, and novel patterns in gene expression microarray data.Biomedical researchers will find this book invaluable for learning the cutting-edge methods for analyzing gene expression microarray data. Specifically, the coverage includes the following state-of-the-art methods:• Gene-based analysis: the latest novel clustering algorithms to identify co-expressed genes and coherent patterns in gene expression microarray data sets• Sample-based analysis: supervised and unsupervised methods for the reduction of the gene dimensionality to select significant genes. A series of approaches to disease classification and discovery are also described• Pattern-based analysis: methods for ascertaining the relationship between (subsets of) genes and (subsets of) samples. Various novel pattern-based clustering algorithms to find the coherent patterns embedded in the sub-attribute spaces are discussed• Visualization tools: various methods for gene expression data visualization. The visualization process is intended to transform the gene expression data set from high-dimensional space into a more easily understood two- or three-dimensional space.

Author : B.R. Jordan
Publisher : Springer Science & Business Media
Page : 139 pages
File Size : 40,8 Mb
Release : 2013-12-01
Category : Medical
ISBN : 9783642565175

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DNA Microarrays: Gene Expression Applications by B.R. Jordan Pdf

This complete and practical manual on expression measurement using DNA arrays covers the existing methods (from nylon macroarrays to oligonucleotide chips) and includes detailed protocols. It has been written by practising scientists who have experienced the difficulties involved in actually using microarrays, and provides helpful advice and hints on setting up these powerful but sometimes tricky methods. Software, data mining procedures and probable future developments, which should be useful to any practising scientist interested in expression measurement, are also covered in this book.

Author : Helen Causton,John Quackenbush,Alvis Brazma
Publisher : John Wiley & Sons
Page : 176 pages
File Size : 52,7 Mb
Release : 2009-04-01
Category : Science
ISBN : 9781444311563

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Microarray Gene Expression Data Analysis by Helen Causton,John Quackenbush,Alvis Brazma Pdf

This guide covers aspects of designing microarray experiments and analysing the data generated, including information on some of the tools that are available from non-commercial sources. Concepts and principles underpinning gene expression analysis are emphasised and wherever possible, the mathematics has been simplified. The guide is intended for use by graduates and researchers in bioinformatics and the life sciences and is also suitable for statisticians who are interested in the approaches currently used to study gene expression. Microarrays are an automated way of carrying out thousands of experiments at once, and allows scientists to obtain huge amounts of information very quickly Short, concise text on this difficult topic area Clear illustrations throughout Written by well-known teachers in the subject Provides insight into how to analyse the data produced from microarrays

Author : Gary Hardiman
Publisher : CRC Press
Page : 362 pages
File Size : 52,9 Mb
Release : 2009-04-02
Category : Medical
ISBN : 9781420094510

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Microarray Innovations by Gary Hardiman Pdf

In recent years, high-density DNA microarrays have revolutionized biomedical research and drug discovery efforts by the pharmaceutical industry. Their efficacy in identifying and prioritizing drug targets based on their ability to confirm a large number of gene expression measurements in parallel has become a key element in drug discovery. Microarr

Author : Giovanni Parmigiani,Elizabeth S. Garett,Rafael A. Irizarry,Scott L. Zeger
Publisher : Springer Science & Business Media
Page : 511 pages
File Size : 42,6 Mb
Release : 2006-04-11
Category : Medical
ISBN : 9780387216799

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The Analysis of Gene Expression Data by Giovanni Parmigiani,Elizabeth S. Garett,Rafael A. Irizarry,Scott L. Zeger Pdf

This book presents practical approaches for the analysis of data from gene expression micro-arrays. It describes the conceptual and methodological underpinning for a statistical tool and its implementation in software. The book includes coverage of various packages that are part of the Bioconductor project and several related R tools. The materials presented cover a range of software tools designed for varied audiences.

Author : Mei-Ling Ting Lee
Publisher : Springer Science & Business Media
Page : 378 pages
File Size : 49,7 Mb
Release : 2007-05-08
Category : Science
ISBN : 9781402077883

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Analysis of Microarray Gene Expression Data by Mei-Ling Ting Lee Pdf

After genomic sequencing, microarray technology has emerged as a widely used platform for genomic studies in the life sciences. Microarray technology provides a systematic way to survey DNA and RNA variation. With the abundance of data produced from microarray studies, however, the ultimate impact of the studies on biology will depend heavily on data mining and statistical analysis. The contribution of this book is to provide readers with an integrated presentation of various topics on analyzing microarray data.

Author : Simone Mocellin
Publisher : Springer Science & Business Media
Page : 176 pages
File Size : 49,5 Mb
Release : 2007-08-28
Category : Medical
ISBN : 9780387399782

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Microarray Technology and Cancer Gene Profiling by Simone Mocellin Pdf

Given the revolutionary implications that the use of this technology might have in the clinical management of cancer patients, the principles of DNA array-based tumor gene profiling must be clearly understood for the data to be correctly interpreted and appreciated. This book, written by leading experts, discusses the technical features characterizing the powerful laboratory tool of microarray technology, and reviews applications in the field of oncology.

Author : Steen Knudsen
Publisher : John Wiley & Sons
Page : 148 pages
File Size : 47,9 Mb
Release : 2011-09-23
Category : Science
ISBN : 9780471461180

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A Biologist's Guide to Analysis of DNA Microarray Data by Steen Knudsen Pdf

A great introductory book that details reliable approaches to problems met in standard microarray data analyses. It provides examples of established approaches such as cluster analysis, function prediction, and principle component analysis. Discover real examples to illustrate the key concepts of data analysis. Written for those without any advanced background in math, statistics, or computer sciences, this book is essential for anyone interested in harnessing the immense potential of microarrays in biology and medicine.

Author : Pierre Baldi,G. Wesley Hatfield
Publisher : Unknown
Page : 213 pages
File Size : 44,6 Mb
Release : 2002-09-19
Category : Science
ISBN : 0521800226

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DNA Microarrays and Gene Expression by Pierre Baldi,G. Wesley Hatfield Pdf

Concise, 2002 inter-disciplinary introduction to DNA microarray technology, which is revolutionizing biology and medicine.

Author : Anonim
Publisher : Taylor & Francis
Page : 321 pages
File Size : 46,9 Mb
Release : 2024-07-01
Category : Electronic
ISBN : 9781134182749

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Microarray Technology Through Applications by Anonim Pdf

Author : Ulrike Nuber
Publisher : Taylor & Francis
Page : 320 pages
File Size : 46,5 Mb
Release : 2007-01-24
Category : Science
ISBN : 9781134243990

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DNA Microarrays by Ulrike Nuber Pdf

"DNA Microarrays" introduces the reader to the different types of DNA microarrays and their various applications. Furthermore, several data analysis methods are described. It is written for scientists who are entering the field of DNA microarrays, as well as for those already familiar with the technology, but interested in new applications and methods.

Author : Michael J. Korenberg
Publisher : Springer Science & Business Media
Page : 569 pages
File Size : 46,8 Mb
Release : 2008-02-03
Category : Science
ISBN : 9781597453905

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Microarray Data Analysis by Michael J. Korenberg Pdf

In this new volume, renowned authors contribute fascinating, cutting-edge insights into microarray data analysis. Information on an array of topics is included in this innovative book including in-depth insights into presentations of genomic signal processing. Also detailed is the use of tiling arrays for large genomes analysis. The protocols follow the successful Methods in Molecular BiologyTM series format, offering step-by-step instructions, an introduction outlining the principles behind the technique, lists of the necessary equipment and reagents, and tips on troubleshooting and avoiding pitfalls.