Gene Therapy And Tissue Engineering In Orthopaedic And Sports Medicine

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Gene Therapy and Tissue Engineering in Orthopaedic and Sports Medicine

Johnny Huard,Freddie H. Fu
Gene Therapy and Tissue Engineering in Orthopaedic and Sports Medicine Book PDF

Author : Johnny Huard,Freddie H. Fu
Publisher : Springer Science & Business Media
Page : 294 pages
File Size : 52,5 Mb
Release : 2013-03-11
Category : Medical
ISBN : 9781461221265

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Gene Therapy and Tissue Engineering in Orthopaedic and Sports Medicine by Johnny Huard,Freddie H. Fu Pdf

This book has been written in response to the many physicians and scien tists working on the development of biological approaches to providing therapies for many orthopaedic disorders as well as to improving the healing of many tissues of the musculoskeletal system. The first goal of this book is to make the language compatible between the bench scientist and the clinician working in orthopaedic and sports medicine in order to cover specific areas of the orthopaedic discipline where the treatment can be improved and/or changed by the advancements in molecular medicine. Advancements in molecular biology, which encompass the study of the genetic basis of disease, have produced new diagnostic methods and drug therapies for genetic diseases and acquired disorders. The growth in the understanding of human genetics has also led to the initiation of many human gene therapy experiments. Although many approved therapeutic clinical trials using this new technology have been performed in the last ten years, the first clinical trial using this technology in the area of orthopaedics was performed at the University of Pittsburgh.

Gene Therapy and Tissue Engineering in Orthopaedic and Sports Medicine

Johnny Huard
Gene Therapy and Tissue Engineering in Orthopaedic and Sports Medicine Book PDF

Author : Johnny Huard
Publisher : Unknown
Page : 286 pages
File Size : 42,5 Mb
Release : 2000
Category : Gene therapy
ISBN : 3764340711

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Gene Therapy and Tissue Engineering in Orthopaedic and Sports Medicine by Johnny Huard Pdf

This book has been written in response to the many physicians and scien- tists working on the development of biological approaches to providing therapies for many orthopaedic disorders as well as to improving the healing of many tissues of the musculoskeletal system. The first goal of this book is to make the language compatible between the bench scientist and the clinician working in orthopaedic and sports medicine in order to cover specific areas of the orthopaedic discipline where the treatment can be improved and/or changed by the advancements in molecular medicine. Advancements in molecular biology, which encompass the study of the genetic basis of disease, have produced new diagnostic methods and drug therapies for genetic diseases and acquired disorders. The growth in the understanding of human genetics has also led to the initiation of many human gene therapy experiments. Although many approved therapeutic clinical trials using this new technology have been performed in the last ten years, the first clinical trial using this technology in the area of orthopaedics was performed at the University of Pittsburgh.

Gene Therapy for Cartilage and Bone Tissue Engineering

Yu-Chen Hu
Gene Therapy for Cartilage and Bone Tissue Engineering Book PDF

Author : Yu-Chen Hu
Publisher : Springer Science & Business Media
Page : 89 pages
File Size : 53,7 Mb
Release : 2014-01-26
Category : Technology & Engineering
ISBN : 9783642539237

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Gene Therapy for Cartilage and Bone Tissue Engineering by Yu-Chen Hu Pdf

"Gene Therapy for Cartilage and Bone Tissue Engineering" outlines the tissue engineering and possible applications of gene therapy in the field of biomedical engineering as well as basic principles of gene therapy, vectors and gene delivery, specifically for cartilage and bone engineering. It is intended for tissue engineers, cell therapists, regenerative medicine scientists and engineers, gene therapist and virologists. Dr. Yu-Chen Hu is a Distinguished Professor at the Department of Chemical Engineering, National Tsing Hua University and has received the Outstanding Research Award (National Science Council), Asia Research Award (Society of Chemical Engineers, Japan) and Professor Tsai-Teh Lai Award (Taiwan Institute of Chemical Engineers). He is also a fellow of the American Institute for Medical and Biological Engineering (AIMBE) and a member of the Tissue Engineering International & Regenerative Medicine Society (TERMIS)-Asia Pacific Council.

Orthobiologics

Giuseppe Filardo,Bert R. Mandelbaum,George F. Muschler,Scott A. Rodeo,Norimasa Nakamura
Orthobiologics Book PDF

Author : Giuseppe Filardo,Bert R. Mandelbaum,George F. Muschler,Scott A. Rodeo,Norimasa Nakamura
Publisher : Springer Nature
Page : 394 pages
File Size : 44,7 Mb
Release : 2021-12-02
Category : Medical
ISBN : 9783030847449

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Orthobiologics by Giuseppe Filardo,Bert R. Mandelbaum,George F. Muschler,Scott A. Rodeo,Norimasa Nakamura Pdf

This book presents the evidence related to the use of injectable biologics to provide faster and better healing for musculoskeletal lesions and conditions. The authors discuss approaches, such as blood derivatives and cell concentrates, applied to lesions of muscles, ligaments, tendons, bones, meniscus and cartilage, as well as osteoarthritis. Chapters are written by some of the most influential opinion leaders in the field, with up-to-date review of the current literature, where the authors explore both the potential and the limitations of these minimally invasive and promising treatments. The first section is devoted to the formulations and rationale for the use of injectable orthobiologics, while the second section reviews current treatment methods applied to specific joints and pathologies – ranging from tendinopathies through non-unions to articular degenerative processes – as well as the results of these treatment approaches. The third section explores future perspectives, such as pluripotent stem cells, gene therapy, and the stimulation of intrinsic stromal cell niches. Appealing to a broad readership, this book will be of interest to both laboratory research scientists and clinicians, including orthopedists, sports physicians, physiatrists, and regenerative medicine experts.

Football Traumatology

Piero Volpi
Football Traumatology Book PDF

Author : Piero Volpi
Publisher : Springer Science & Business Media
Page : 454 pages
File Size : 55,9 Mb
Release : 2006-01-19
Category : Medical
ISBN : 8847004187

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Football Traumatology by Piero Volpi Pdf

Football is probably the most widespread sport in the world: youngsters, adults, women, amateurs, beginners, professionals all make up a legion of practitioners. Lesions associated with football are on the increase and their typology has also changed over the years. Football, like many other sports, has undergone major changes: the increase in the intensity and speed of the game, the modern training methodologies, the technical and tactical innovations are all factors contributing to increased risks of traumatic injury. The footballers, the trainers, the sport's medical staff are asking for greater information and knowledge on the traumatic lesions associated with this sport. The primary role of those who are concerned with the health of footballers is to enforce preventive measures to reduce wherever possible the risks of trauma.

Rehabilitation for the Postsurgical Orthopedic Patient

Lisa Maxey,Jim Magnusson
Rehabilitation for the Postsurgical Orthopedic Patient Book PDF

Author : Lisa Maxey,Jim Magnusson
Publisher : Elsevier Health Sciences
Page : 665 pages
File Size : 50,8 Mb
Release : 2013-01-22
Category : Medical
ISBN : 9780323077477

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Rehabilitation for the Postsurgical Orthopedic Patient by Lisa Maxey,Jim Magnusson Pdf

With detailed descriptions of orthopedic surgeries, Rehabilitation for the Postsurgical Orthopedic Patient, 3rd Edition provides current, evidence-based guidelines to designing effective rehabilitation strategies. Coverage of each condition includes an overview of the orthopedic patient's entire course of treatment from pre- to post-surgery. For each phase of rehabilitation, this book describes the postoperative timeline, the goals, potential complications and precautions, and appropriate therapeutic procedures. New to this edition are a full-color design and new chapters on disc replacement, cartilage replacement, hallux valgus, and transitioning the running athlete. Edited by Lisa Maxey and Jim Magnusson, and with chapters written by both surgeons and physical therapists, Rehabilitation for the Postsurgical Orthopedic Patient provides valuable insights into the use of physical therapy in the rehabilitation process. Comprehensive, evidence-based coverage provides an overview of the orthopedic patient's entire course of treatment from pre- to post-surgery, including a detailed look at the surgical procedures and therapy guidelines that can be used to design the appropriate rehabilitation programs. Case study vignettes with critical thinking questions help you develop critical reasoning skills. Indications and considerations for surgery describe the mechanics of the injury and the repair process so you can plan an effective rehabilitation program. Therapy guidelines cover each phase of rehabilitation with specifics as to the expected time span and goals for each phase. Evidence-based coverage includes the latest clinical research to support treatment decisions. Overview of soft tissue and bone healing considerations after surgery helps you understand the rationale behind the timelines for the various physical therapy guidelines. A Troubleshooting section in each chapter details potential pitfalls in the recovery from each procedure. Over 300 photos and line drawings depict concepts, procedures, and rehabilitation. Detailed tables break down therapy guidelines and treatment options for quick reference. Expert contributors include surgeons describing the indications and considerations for surgery as well as the surgery itself, and physical or occupational therapists discussing therapy guidelines. New coverage of current orthopedic surgeries and rehabilitation includes topics such as disc replacement, cartilage replacement, hallux valgus, and transitioning the running athlete. New full-color design and illustrations visually reinforce the content. Updated Suggested Home Maintenance boxes in every chapter provide guidance for patients returning home. References linked to MEDLINE abstracts make it easy to access evidence-based information for better clinical decision-making.

Magnetic Resonance Imaging in Orthopedic Sports Medicine

Robert Pedowitz,Christine B. Chung,Donald Resnick
Magnetic Resonance Imaging in Orthopedic Sports Medicine Book PDF

Author : Robert Pedowitz,Christine B. Chung,Donald Resnick
Publisher : Springer Science & Business Media
Page : 447 pages
File Size : 41,9 Mb
Release : 2008-12-01
Category : Medical
ISBN : 9780387488981

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Magnetic Resonance Imaging in Orthopedic Sports Medicine by Robert Pedowitz,Christine B. Chung,Donald Resnick Pdf

This uniquely interdisciplinary book is a practical resource on orthopedic MR imaging that bridges the backgrounds of radiologists and orthopedic surgeons. Radiologists learn why surgeons order imaging studies. They also learn terminology that will help them tailor reports to the specialty. Orthopedic surgeons gain insight on when to order an MRI, how MRI affects decision making, and how to interpret images. Case studies also depict key clinical and exam points, supplemented by MR images and illustrations. Shorter sections highlight other anatomical areas, and additional chapters address diagnostic accuracy and imaging pitfalls.

Scaffolding In Tissue Engineering

Peter X. Ma,Jennifer Elisseeff
Scaffolding In Tissue Engineering Book PDF

Author : Peter X. Ma,Jennifer Elisseeff
Publisher : CRC Press
Page : 656 pages
File Size : 55,7 Mb
Release : 2005-08-19
Category : Medical
ISBN : 9781420027563

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Scaffolding In Tissue Engineering by Peter X. Ma,Jennifer Elisseeff Pdf

The growing interest in scaffolding design and increasing research programs dedicated to regenerative medicine corroborate the need for Scaffolding in Tissue Engineering. While certain books and journal articles address various aspects in the field, this is the first current, comprehensive text focusing on scaffolding for tissue engineering. Scaffolding in Tissue Engineering reviews the general principles of tissue engineering and concentrates on the principles, methods, and applications for a broad range of tissue engineering scaffolds. The first section presents an in-depth exploration of traditional and novel materials, including alginates, polysaccharides, and fibrillar fibrin gels. The following section covers fabrication technologies, discussing three-dimensional scaffold design, laboratory-scale manufacture of a cell carrier, phase separation, self-assembly, gas foaming, solid freeform fabrication, injectable systems, and immunoisolation techniques. Subsequent chapters examine structural and functional scaffold modification, composite scaffolds, bioactive hydrogels, gene delivery, growth factors, and degradation of biodegradable polymers. The final section explores various tissue engineering applications, comprising chapters on blood cell substitutes, and tissue engineering of nerves, the tendons, ligaments, cornea, cartilage and myocardium, meniscal tissue. While providing a comprehensive summary of current knowledge and technologies, Scaffolding in Tissue Engineering gives readers insight into new trends and directions for scaffold development and for an ever-expanding range of tissue engineering applications.

Sports Injuries

Mahmut Nedim Doral,Reha N. Tandoğan,Gideon Mann,René Verdonk
Sports Injuries Book PDF

Author : Mahmut Nedim Doral,Reha N. Tandoğan,Gideon Mann,René Verdonk
Publisher : Springer Science & Business Media
Page : 1247 pages
File Size : 53,9 Mb
Release : 2011-12-10
Category : Medical
ISBN : 9783642156304

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Sports Injuries by Mahmut Nedim Doral,Reha N. Tandoğan,Gideon Mann,René Verdonk Pdf

In recent years, research studies into sports injuries have provided healthcare professionals with a better understanding of their etiology and natural history. On this basis, novel concepts in the diagnosis and management of these conditions are now being explored. This timely book offers a complete guide to the latest knowledge on the diagnosis and treatment of the full range of possible sports injuries. Individual sections are devoted to biomechanics, injury prevention, and the still emerging treatment role of growth factors, which foster more rapid tissue healing. Sports injuries of each body region are then examined in detail, with special attention to diagnostic issues and the most modern treatment techniques. In addition, pediatric sports injuries, extreme sports injuries, the role of physiotherapy, and future developments are extensively discussed. All who are involved in the care of patients with sports injuries will find this textbook to be an invaluable, comprehensive, and up-to-date reference.

Developmental Biology and Musculoskeletal Tissue Engineering

Martin J. Stoddart,April M. Craft,Girish Pattappa,Oliver F.W. Gardner
Developmental Biology and Musculoskeletal Tissue Engineering Book PDF

Author : Martin J. Stoddart,April M. Craft,Girish Pattappa,Oliver F.W. Gardner
Publisher : Academic Press
Page : 270 pages
File Size : 41,6 Mb
Release : 2018-04-24
Category : Science
ISBN : 9780128115381

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Developmental Biology and Musculoskeletal Tissue Engineering by Martin J. Stoddart,April M. Craft,Girish Pattappa,Oliver F.W. Gardner Pdf

Developmental Biology and Musculoskeletal Tissue Engineering: Principles and Applications focuses on the regeneration of orthopedic tissue, drawing upon expertise from developmental biologists specializing in orthopedic tissues and tissue engineers who have used and applied developmental biology approaches. Musculoskeletal tissues have an inherently poor repair capacity, and thus biologically-based treatments that can recapitulate the native tissue properties are desirable. Cell- and tissue-based therapies are gaining ground, but basic principles still need to be addressed to ensure successful development of clinical treatments. Written as a source of information for practitioners and those with a nascent interest, it provides background information and state-of-the-art solutions and technologies. Recent developments in orthopedic tissue engineering have sought to recapitulate developmental processes for tissue repair and regeneration, and such developmental-biology based approaches are also likely to be extremely amenable for use with more primitive stem cells. Brings the fields of tissue engineering and developmental biology together to explore the potential for regenerative medicine-based research to contribute to enhanced clinical outcomes Initial chapters provide an outline of the development of the musculoskeletal system in general, and later chapters focus on specific tissues Addresses the effect of mechanical forces on the musculoskeletal system during development and the relevance of these processes to tissue engineering Discusses the role of genes in the development of musculoskeletal tissues and their potential use in tissue engineering Describes how developmental biology is being used to influence and guide tissue engineering approaches for cartilage, bone, disc, and tendon repair

Biomaterials Science

Buddy D. Ratner,Allan S. Hoffman,Frederick J. Schoen,Jack E. Lemons
Biomaterials Science Book PDF

Author : Buddy D. Ratner,Allan S. Hoffman,Frederick J. Schoen,Jack E. Lemons
Publisher : Elsevier
Page : 864 pages
File Size : 42,6 Mb
Release : 2004-08-18
Category : Science
ISBN : 9780080470368

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Biomaterials Science by Buddy D. Ratner,Allan S. Hoffman,Frederick J. Schoen,Jack E. Lemons Pdf

The second edition of this bestselling title provides the most up-to-date comprehensive review of all aspects of biomaterials science by providing a balanced, insightful approach to learning biomaterials. This reference integrates a historical perspective of materials engineering principles with biological interactions of biomaterials. Also provided within are regulatory and ethical issues in addition to future directions of the field, and a state-of-the-art update of medical and biotechnological applications. All aspects of biomaterials science are thoroughly addressed, from tissue engineering to cochlear prostheses and drug delivery systems. Over 80 contributors from academia, government and industry detail the principles of cell biology, immunology, and pathology. Focus within pertains to the clinical uses of biomaterials as components in implants, devices, and artificial organs. This reference also touches upon their uses in biotechnology as well as the characterization of the physical, chemical, biochemical and surface properties of these materials. Provides comprehensive coverage of principles and applications of all classes of biomaterials Integrates concepts of biomaterials science and biological interactions with clinical science and societal issues including law, regulation, and ethics Discusses successes and failures of biomaterials applications in clinical medicine and the future directions of the field Cover the broad spectrum of biomaterial compositions including polymers, metals, ceramics, glasses, carbons, natural materials, and composites Endorsed by the Society for Biomaterials

DeLee and Drez's Orthopaedic Sports Medicine E-Book

Mark D. Miller,Stephen R. Thompson
DeLee and Drez s Orthopaedic Sports Medicine E Book Book PDF

Author : Mark D. Miller,Stephen R. Thompson
Publisher : Elsevier Health Sciences
Page : 2313 pages
File Size : 45,6 Mb
Release : 2009-09-02
Category : Medical
ISBN : 9781437721713

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DeLee and Drez's Orthopaedic Sports Medicine E-Book by Mark D. Miller,Stephen R. Thompson Pdf

Here's the New Edition of the must-have reference in sports medicine! Covering all athletes throughout their lifespan, this 2-volume reference explores the pathophysiology, diagnosis, and treatment of the full spectrum of sports-related injuries and medical disorders. It provides the most clinically focused, comprehensive guidance available in any single source, with contributions from the most respected authorities in the field. Thoroughly revised and updated, you’ll find state-of-the-art coverage in an all-new full-color format and access to the complete contents online, with video clips and more! Encompasses imaging techniques, the management of both adult and child/adolescent injuries, and sports-related fractures to help you meet for every clinical challenge. Includes coverage of important non-orthopaedic conditions in the management of the athlete for a complete guide to treatment. Integrates coverage of pediatric and aging athletes to help you meet the unique needs of these patients. Covers rehabilitation and other therapeutic modalities in the context of return to play. lDelivers new and expanded coverage of arthroscopic techniques, including ACL reconstruction, allograft cartilage transplantation, rotator cuff repair, and complications in athletes, as well as injury prevention, nutrition, pharmacology, and psychology in sports. Offers unprecedented reference power with access to the full text online, with links to PubMed, an image library, self-assessment material, and more. Includes video clips demonstrating arthroscopic and open surgical techniques on the website to enhance your mastery of essential skills. Offers a new full-color design and format including over 3000 superb illustrations, intraoperative and clinical photos, and boxed and color-coded text features to clarify key concepts, diagnostic landmarks, and operative techniques.

Orthopedic Sports Medicine

Fabrizio Margheritini,Roberto Rossi
Orthopedic Sports Medicine Book PDF

Author : Fabrizio Margheritini,Roberto Rossi
Publisher : Springer Science & Business Media
Page : 527 pages
File Size : 48,8 Mb
Release : 2011-12-21
Category : Medical
ISBN : 8847017025

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Orthopedic Sports Medicine by Fabrizio Margheritini,Roberto Rossi Pdf

Aim of this book is to give an update on the main issues in sports traumatology and orthopedics, involving different body sections. Exploring the most important aspects of sports medicine - from anatomy to normal movements description, from diagnosis to sports injuries treatment, from conservative to surgical treatments - it gives a global overview of the field, describing also diagnostic tools recently introduced in this field, such as hip arthroscopy, and taking into consideration related areas like nutrition, prevention, training and rehabilitation. The single chapters deal with relevant problems such as emergencies on the field, pathologies of the upper and lower extremity, spine problems in athletes. Each injury is approached on the basis of both the specific body area and of the different sports/activities. Written by a multidisciplinary team of experts, this volume will be a fundamental book for orthopedic surgeons, physiotherapists, general practitioners, personal and athletic trainers, offering them a useful tool for the management of most frequent injuries in sports medicine.

Orthopedic Tissue Engineering

Victor M. Goldberg,Arnold I. Caplan
Orthopedic Tissue Engineering Book PDF

Author : Victor M. Goldberg,Arnold I. Caplan
Publisher : CRC Press
Page : 425 pages
File Size : 53,9 Mb
Release : 2004-01-21
Category : Medical
ISBN : 0824747496

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Orthopedic Tissue Engineering by Victor M. Goldberg,Arnold I. Caplan Pdf

This book explores the basic science and clinical concepts impacting bone tissue engineering; considers advances in gene therapy for enhancement of bone and cartilage repair; and presents the biomechanical factors affecting articular cartilage engineering.

Bio-orthopaedics

Alberto Gobbi,João Espregueira-Mendes,John G. Lane,Mustafa Karahan
Bio orthopaedics Book PDF

Author : Alberto Gobbi,João Espregueira-Mendes,John G. Lane,Mustafa Karahan
Publisher : Springer
Page : 696 pages
File Size : 41,9 Mb
Release : 2017-05-26
Category : Medical
ISBN : 9783662541814

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Bio-orthopaedics by Alberto Gobbi,João Espregueira-Mendes,John G. Lane,Mustafa Karahan Pdf

This book introduces the exciting field of orthobiology, which will usher in a new array of therapeutic approaches that stimulate the body’s natural resources to regenerate musculoskeletal tissues damaged by trauma or disease. The book addresses a range of key topics and discusses emerging approaches that promise to offer effective alternatives to traditional treatments for injuries to bone, cartilage, muscles, ligaments, and tendons. It explains in detail how a variety of innovative products, including biomaterials, growth factors, and autogenous cells, together provide the basis for the regeneration of these musculoskeletal structures and how recent scientific progress has created unique opportunities to address pathological situations that until recently have been treated with unsatisfactory results. The authors are experts from across the world who come together to provide a truly global overview. The book is published in collaboration with ISAKOS. It will be invaluable for all with an interest in this area of medicine, which has already attained huge popularity in Orthopaedics and Sports Medicine and has also attracted the attention of the lay public.