Gene Therapy For Cartilage And Bone Tissue Engineering

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Gene Therapy for Cartilage and Bone Tissue Engineering

Yu-Chen Hu
Gene Therapy for Cartilage and Bone Tissue Engineering Book PDF

Author : Yu-Chen Hu
Publisher : Springer Science & Business Media
Page : 89 pages
File Size : 54,5 Mb
Release : 2014-01-26
Category : Technology & Engineering
ISBN : 9783642539237

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Gene Therapy for Cartilage and Bone Tissue Engineering by Yu-Chen Hu Pdf

"Gene Therapy for Cartilage and Bone Tissue Engineering" outlines the tissue engineering and possible applications of gene therapy in the field of biomedical engineering as well as basic principles of gene therapy, vectors and gene delivery, specifically for cartilage and bone engineering. It is intended for tissue engineers, cell therapists, regenerative medicine scientists and engineers, gene therapist and virologists. Dr. Yu-Chen Hu is a Distinguished Professor at the Department of Chemical Engineering, National Tsing Hua University and has received the Outstanding Research Award (National Science Council), Asia Research Award (Society of Chemical Engineers, Japan) and Professor Tsai-Teh Lai Award (Taiwan Institute of Chemical Engineers). He is also a fellow of the American Institute for Medical and Biological Engineering (AIMBE) and a member of the Tissue Engineering International & Regenerative Medicine Society (TERMIS)-Asia Pacific Council.

Bone and Cartilage Engineering

Ulrich Meyer,Hans Peter Wiesmann
Bone and Cartilage Engineering Book PDF

Author : Ulrich Meyer,Hans Peter Wiesmann
Publisher : Springer Science & Business Media
Page : 272 pages
File Size : 45,6 Mb
Release : 2006-08-02
Category : Medical
ISBN : 9783540336068

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Bone and Cartilage Engineering by Ulrich Meyer,Hans Peter Wiesmann Pdf

Bone and Cartilage Engineering provides a complete overview of recent knowledge in bone and cartilage tissue engineering. It follows a logical approach to the various aspects of extracorporal bone and cartilage tissue engineering. The cooperation between a basic scientist and a clinician made it possible to structure the book's content and style according to the interdisciplinary character of the field. The comprehensive nature of the book, including detailed descriptions of laboratory procedures, preclinical approaches, clinical applications, and regulatory issues, will make it an invaluable basis for everyone working in this field. This book will serve as a fundamental tool for basic researchers to establish or refine tissue engineering techniques as well as for clinicians to understand and use this modern therapeutic option.

Bone and Cartilage Regeneration

Phuc Van Pham
Bone and Cartilage Regeneration Book PDF

Author : Phuc Van Pham
Publisher : Springer
Page : 315 pages
File Size : 53,6 Mb
Release : 2017-01-24
Category : Science
ISBN : 9783319401447

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Bone and Cartilage Regeneration by Phuc Van Pham Pdf

This invaluable resource discusses clinical applications with effects and side-effects of applications of stem cells in bone and cartilage regeneration. Each chapter is contributed by a pre-eminent scientist in the field and covers such topics as skeletal regeneration by mesenchymal stem cells, clinical improvement of mesenchymal stem cell injection in injured cartilage and osteoarthritis, Good manufacturing practice (GMP), minimal critera of stem cells for clinical applications, future directions of the discussed therapies and much more. Bone & Cartilage Regeneration and the other books in the Stem Cells in Clinical Applications series will be invaluable to scientists, researchers, advanced students and clinicians working in stem cells, regenerative medicine or tissue engineering.

Tissue Engineering of Cartilage and Bone

Gregory R. Bock,Jamie A. Goode
Tissue Engineering of Cartilage and Bone Book PDF

Author : Gregory R. Bock,Jamie A. Goode
Publisher : John Wiley & Sons
Page : 262 pages
File Size : 48,7 Mb
Release : 2003-07-22
Category : Medical
ISBN : 9780470864234

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Tissue Engineering of Cartilage and Bone by Gregory R. Bock,Jamie A. Goode Pdf

Tissue engineering takes advantages of the combined use of cultured living cells and three-dimensional scaffolds to reconstruct adult tissues that are absent or malfunctioning. This book brings together scientists and clinicians working on a variety of approaches for regenerating of damaged or lost cartilage and bone to assess the progress of this dynamic field. In its early days, tissue engineering was driven by material scientists who designed novel bio-resorbable scaffolds on which to seed cells and grow tissues. This ground-breaking work generated high expectations, but there have been significant stumbling blocks holding back the widespread use of these techniques in the clinic. These challenges, and potential ways of overcoming them, are given thorough coverage in the discussions that follow each chapter. The key questions addressed in this book include the following. How good must cartilage repair be for it to be worthwhile? What is the best source of cells for tissue engineering of both bone and cartilage? Which are the most effective cell scaffolds? What are the best preclinical models for these technologies? And when it comes to clinical trials, what sort of outcome measures should be used? With contributions from some of the leading experts in this field, this timely publication will prove essential reading for anyone with an interest in the field of tissue engineering.

Cartilage Tissue Engineering and Regeneration Techniques

Dimitrios D. Nikolopoulos,George K. Safos,Kalpaxis Dimitrios
Cartilage Tissue Engineering and Regeneration Techniques Book PDF

Author : Dimitrios D. Nikolopoulos,George K. Safos,Kalpaxis Dimitrios
Publisher : BoD – Books on Demand
Page : 160 pages
File Size : 43,7 Mb
Release : 2019-06-05
Category : Technology & Engineering
ISBN : 9781789238495

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Cartilage Tissue Engineering and Regeneration Techniques by Dimitrios D. Nikolopoulos,George K. Safos,Kalpaxis Dimitrios Pdf

Osteochondral defects can be challenging to treat, first, because the damaged articular cartilage has a poor intrinsic reparative capability, and second, because these defects cause chronic pain and serious disability. That is why cartilage repair remains one of the most challenging issues of musculoskeletal medicine. Arthroscopic and open techniques that have been developed over the last two decades intend to promote the success of complete repair of the articular cartilage defects; nevertheless, these therapies cannot always offer 100% success. Nowadays, cartilage tissue engineering is an emerging technique for the regeneration of cartilage tissue. Taking into consideration these perspectives, this book aims to present a summary of cartilage tissue engineering, including development, recent progress, and major steps taken toward the regeneration of functional cartilage tissue. Special emphasis is placed on the role of stimulating factors, including growth factors, gene therapies, as well as scaffolds, including natural, synthetic, and nanostructured.

Gene Therapy and Tissue Engineering in Orthopaedic and Sports Medicine

Johnny Huard,Freddie H. Fu
Gene Therapy and Tissue Engineering in Orthopaedic and Sports Medicine Book PDF

Author : Johnny Huard,Freddie H. Fu
Publisher : Springer Science & Business Media
Page : 294 pages
File Size : 52,7 Mb
Release : 2013-03-11
Category : Medical
ISBN : 9781461221265

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Gene Therapy and Tissue Engineering in Orthopaedic and Sports Medicine by Johnny Huard,Freddie H. Fu Pdf

This book has been written in response to the many physicians and scien tists working on the development of biological approaches to providing therapies for many orthopaedic disorders as well as to improving the healing of many tissues of the musculoskeletal system. The first goal of this book is to make the language compatible between the bench scientist and the clinician working in orthopaedic and sports medicine in order to cover specific areas of the orthopaedic discipline where the treatment can be improved and/or changed by the advancements in molecular medicine. Advancements in molecular biology, which encompass the study of the genetic basis of disease, have produced new diagnostic methods and drug therapies for genetic diseases and acquired disorders. The growth in the understanding of human genetics has also led to the initiation of many human gene therapy experiments. Although many approved therapeutic clinical trials using this new technology have been performed in the last ten years, the first clinical trial using this technology in the area of orthopaedics was performed at the University of Pittsburgh.

The Knee Joint

Michel Bonnin,Ned Annunziato Amendola,Johan Bellemans,Steven J. MacDonald,Jacques Menetrey
The Knee Joint Book PDF

Author : Michel Bonnin,Ned Annunziato Amendola,Johan Bellemans,Steven J. MacDonald,Jacques Menetrey
Publisher : Springer Science & Business Media
Page : 1079 pages
File Size : 53,6 Mb
Release : 2013-07-04
Category : Medical
ISBN : 9782287993534

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The Knee Joint by Michel Bonnin,Ned Annunziato Amendola,Johan Bellemans,Steven J. MacDonald,Jacques Menetrey Pdf

Pushed by the progress of biology, technology and biomechanics, knee surgery has dramatically evolved in the last decades. This book is a "state of the art" concerning all aspects of knee surgery from ligament reconstruction to Total Knee Arthroplasty. An international panel of renowned authors have worked on this didactic fully illustrated book. It will help young surgeons to understand basic sciences and modern sugical techniques. The experienced surgeon will find help to deal with difficult cases and clarifications in recent technologic advances such as cartilage surgery, navigation and mini invasive surgery.

Cartilage Tissue Engineering

Martin J. Stoddart,Elena Della Bella,Angela R. Armiento
Cartilage Tissue Engineering Book PDF

Author : Martin J. Stoddart,Elena Della Bella,Angela R. Armiento
Publisher : Springer Nature
Page : 392 pages
File Size : 50,7 Mb
Release : 2022-11-10
Category : Science
ISBN : 9781071628393

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Cartilage Tissue Engineering by Martin J. Stoddart,Elena Della Bella,Angela R. Armiento Pdf

This detailed book brings together a collection of methodologies, from the most basic to the more complex, that provides researchers with a platform they can use to embark on a cartilage research career. To aid in the search for novel therapies for cartilage regeneration, this volume addresses 3D cartilage models, challenges associated with RNA and protein extraction, imaging, gene transfer, as well as stable differentiation and variations in cell phenotype from different tissue origins. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step and readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and up-to-date, Cartilage Tissue Engineering serves as an ideal guide for researchers working to advance the vital study of cartilage biology and repair.

A Tissue Regeneration Approach to Bone and Cartilage Repair

Hala Zreiqat,Colin R. Dunstan,Vicki Rosen
A Tissue Regeneration Approach to Bone and Cartilage Repair Book PDF

Author : Hala Zreiqat,Colin R. Dunstan,Vicki Rosen
Publisher : Springer
Page : 254 pages
File Size : 47,6 Mb
Release : 2014-12-05
Category : Technology & Engineering
ISBN : 9783319132662

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A Tissue Regeneration Approach to Bone and Cartilage Repair by Hala Zreiqat,Colin R. Dunstan,Vicki Rosen Pdf

Reviewing exhaustively the current state of the art of tissue engineering strategies for regenerating bones and joints through the use of biomaterials, growth factors and stem cells, along with an investigation of the interactions between biomaterials, bone cells, growth factors and added stem cells and how together skeletal tissues can be optimised, this book serves to highlight the importance of biomaterials composition, surface topography, architectural and mechanical properties in providing support for tissue regeneration. Maximizing reader insights into the importance of the interplay of these attributes with bone cells (osteoblasts, osteocytes and osteoclasts) and cartilage cells (chondrocytes), this book also provides a detailed reference as to how key signalling pathways are activated. The contribution of growth factors to drive tissue regeneration and stem cell recruitment is discussed along with a review the potential and challenges of adult or embryonic mesenchymal stem cells to further enhance the formation of new bone and cartilage tissues. This book serves to demonstrate the interconnectedness of biomaterials, bone/cartilage cells, growth factors and stem cells in determining the regenerative process and thus the clinical outcome.

Regenerative Medicine and Cell Therapy

J. F. Stoltz
Regenerative Medicine and Cell Therapy Book PDF

Author : J. F. Stoltz
Publisher : IOS Press
Page : 464 pages
File Size : 50,8 Mb
Release : 2012
Category : Medical
ISBN : 9781614990758

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Regenerative Medicine and Cell Therapy by J. F. Stoltz Pdf

Most human tissues do not regenerate spontaneously. Cell therapy and tissue engineering, which involve collecting cells from either the patient or a donor and introducing them into injured tissues or organs, sometimes after modifying their properties, offer promising solutions for regenerative medicine. Indeed, so promising are these therapies that current research has shifted from organ growth to cell therapy. The range of therapeutic applications is wide, including cardiac insufficiency, atherosclerosis, cartilage defects, bone repair, burns, diabetes and liver or bladder regeneration.This book, whilst not covering all aspects

Engineered Bone

Herve Petite
Engineered Bone Book PDF

Author : Herve Petite
Publisher : CRC Press
Page : 225 pages
File Size : 47,8 Mb
Release : 2005-08-15
Category : Science
ISBN : 9781498713535

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Engineered Bone by Herve Petite Pdf

This book addresses relevant issues that tissue-engineering researchers must consider when planning new strategies, especially in the bone and cartilage field. It describes transcription factors that are essential in bone development, and deals with bone healing.

Articular Cartilage Tissue Engineering

Kyriacos Athanasiou,Eric M. Darling,Jerry C. Hu
Articular Cartilage Tissue Engineering Book PDF

Author : Kyriacos Athanasiou,Eric M. Darling,Jerry C. Hu
Publisher : Springer Nature
Page : 174 pages
File Size : 44,9 Mb
Release : 2022-06-01
Category : Science
ISBN : 9783031025785

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Articular Cartilage Tissue Engineering by Kyriacos Athanasiou,Eric M. Darling,Jerry C. Hu Pdf

Cartilage injuries in children and adolescents are increasingly observed, with roughly 20% of knee injuries in adolescents requiring surgery. In the US alone, costs of osteoarthritis (OA) are in excess of $65 billion per year (both medical costs and lost wages). Comorbidities are common with OA and are also costly to manage. Articular cartilage's low friction and high capacity to bear load makes it critical in the movement of one bone against another, and its lack of a sustained natural healing response has necessitated a plethora of therapies. Tissue engineering is an emerging technology at the threshold of translation to clinical use. Replacement cartilage can be constructed in the laboratory to recapitulate the functional requirements of native tissues. This book outlines the biomechanical and biochemical characteristics of articular cartilage in both normal and pathological states, through development and aging. It also provides a historical perspective of past and current cartilage treatments and previous tissue engineering efforts. Methods and standards for evaluating the function of engineered tissues are discussed, and current cartilage products are presented with an analysis on the United States Food and Drug Administration regulatory pathways that products must follow to market. This book was written to serve as a reference for researchers seeking to learn about articular cartilage, for undergraduate and graduate level courses, and as a compendium of articular cartilage tissue engineering design criteria. Table of Contents: Hyaline Articular Cartilage / Cartilage Aging and Pathology / In Vitro / Bioreactors / Future Directions

Tissue Engineering for Artificial Organs, 2 Volume Set

Anwarul Hasan
Tissue Engineering for Artificial Organs 2 Volume Set Book PDF

Author : Anwarul Hasan
Publisher : John Wiley & Sons
Page : 762 pages
File Size : 44,9 Mb
Release : 2017-06-19
Category : Science
ISBN : 9783527338634

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Tissue Engineering for Artificial Organs, 2 Volume Set by Anwarul Hasan Pdf

A comprehensive overview of the latest achievements, trends, and the current state of the art of this important and rapidly expanding field. Clearly and logically structured, the first part of the book explores the fundamentals of tissue engineering, providing a separate chapter on each of the basic topics, including biomaterials stem cells, biosensors and bioreactors. The second part then follows a more applied approach, discussing various applications of tissue engineering, such as the replacement or repairing of skins, cartilages, livers and blood vessels, to trachea, lungs and cardiac tissues, to musculoskeletal tissue engineering used for bones and ligaments as well as pancreas, kidney and neural tissue engineering for the brain. The book concludes with a look at future technological advances. An invaluable reading for entrants to the field in biomedical engineering as well as expert researchers and developers in industry.

Stem Cell and Tissue Engineering

Krishna Pramanik
Stem Cell and Tissue Engineering Book PDF

Author : Krishna Pramanik
Publisher : CRC Press
Page : 416 pages
File Size : 44,7 Mb
Release : 2024-03-29
Category : Technology & Engineering
ISBN : 9781000999501

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Stem Cell and Tissue Engineering by Krishna Pramanik Pdf

This book covers conventional clinical treatment methods for handling bone, cartilage, and related disorders along with their limitations and highlights the current state of the art of tissue engineering as an alternative for regenerating such defective tissue. Potential biomimetic scaffolding materials and their development, desired properties, modifications, and optimizations are described. The design and advancement in fabrication, characterization, properties, and biological functions of scaffolds, their integration with stem cells, and various bioreactor systems for tissue regeneration are presented. It further reviews in vitro and in vivo (pre-clinical) assessments of tissue constructs, involved translational challenges, and strategies in various stages of neo-tissue production. Features: Discusses the key aspects of generating engineered bone, cartilage, and associated tissues through tissue engineering approach Describes multiple engineering principles, and processes involved in the various stages of developing biomaterials and scaffolds Covers integration of stem cells with scaffolds, including assessment of tissue grafts, and translational strategy Explores key factors influencing tissue graft generation in bioreactors and challenges involved in various stages Includes several exercises including review questions and numerical problems for better understanding of the subject This book is aimed at researchers, students, and professionals in biomedical engineering, tissue engineering, stem cells, biomaterials, and orthopaedics.

Nanoengineering in Musculoskeletal Regeneration

Mehdi Razavi
Nanoengineering in Musculoskeletal Regeneration Book PDF

Author : Mehdi Razavi
Publisher : Academic Press
Page : 290 pages
File Size : 43,6 Mb
Release : 2020-05-22
Category : Science
ISBN : 9780128202623

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Nanoengineering in Musculoskeletal Regeneration by Mehdi Razavi Pdf

Nanoengineering in Musculoskeletal Regeneration provides the reader an updated summary of the therapeutic pipeline-from biomedical discovery to clinical implementation-aimed at improving treatments for patients with conditions of the muscles, tendons, cartilage, meniscus, and bone. Regenerative medicine focuses on using stem cell biology to advance medical therapies for devastating disorders. This text presents novel, significant, and interdisciplinary theoretical and experimental results related to nanoscience and nanotechnology in musculoskeletal regeneration. Content includes basic, translational, and clinical research addressing musculoskeletal repair and regeneration for the treatment of diseases and injuries of the skeleton and its associated tissues. Musculoskeletal degeneration and complications from injuries have become more prevalent as people live longer and increasingly participate in rigorous athletic and recreational activities. Additionally, defects in skeletal tissues may immobilize people and cause inflammation and pain. Musculoskeletal regeneration research provides solutions to repair, restore, or replace skeletal elements and associated tissues that are affected by acute injury, chronic degeneration, genetic dysfunction, and cancer-related defects. The goal of musculoskeletal regeneration medicine research is to improve quality of life and outcomes for people with musculoskeletal injury or degradation. Provides broad coverage in all research areas focused on the applications of nanotechnology in musculoskeletal regeneration Offers useful guidance for physician-scientists with expertise in orthopedics, regenerative medicine, bioengineering, biomaterials, nanoengineering, stem cell biology, and chemistry Serves as a practical reference for many disciplines, including bioengineering, biomaterials, tissue engineering, regenerative medicine, musculoskeletal regenerative medicine, and nanomedicine