Genetic Aberrancies And Neurodegenerative Disorders

Genetic Aberrancies And Neurodegenerative Disorders Book in PDF, ePub and Kindle version is available to download in english. Read online anytime anywhere directly from your device. Click on the download button below to get a free pdf file of Genetic Aberrancies And Neurodegenerative Disorders book. This book definitely worth reading, it is an incredibly well-written.

Genetic Aberrancies and Neurodegenerative Disorders

M.P. Mattson
Genetic Aberrancies and Neurodegenerative Disorders Book PDF

Author : M.P. Mattson
Publisher : Elsevier
Page : 427 pages
File Size : 44,6 Mb
Release : 2000-01-28
Category : Science
ISBN : 0080876730

Get Book

Genetic Aberrancies and Neurodegenerative Disorders by M.P. Mattson Pdf

Genetic Aberrancies and Neurodegenerative Disorders presents critical reviews and emerging findings concerning the roles of genetic mutations and polymorphisms in the pathogenesis of a range of neurological disorders including Alzheimer's and Parkinson's diseases, trinucleotide repeat disorders, stroke, epilepsy and others. This volume, written by leading experts, brings together fundamental information concerning the roles of inherited traits in the pathogenesis of different neurodegenerative disorders. In addition to providing a catalogue of the known genetic alterations that are linked to specific neurodegenerative disorders, the chapters detail the current state of understanding of the cellular and biochemical mechanisms whereby the genetic aberrancies lead to neuronal dysfunction and degeneration. The emerging picture of each disorder, painted by pathological, biochemical and molecular brushes, suggests that they share key mechanisms including increased levels of oxidative stress, perturbed ion homeostasis, mitochondrial dysfunction and apoptotic proteolytic cascades. The existence of specific molecular defects provides the opportunity to design experiments that can establish the precise pathogenic mechanism of a specific mutation or genetic risk factor. The value of this approach is exemplified by recent studies of how mutations in Cu/Zn-superoxide dismutase cause amyotrophic lateral sclerosis and how presenilin mutations result in early-onset Alzheimer's disease. A theme developed among the different chapters is that events that occur during aging predispose neurons to genetic aberrancies that promote degenerative cascades, and that specific genetic defects exert their influence on particular populations of neurons in a disorder-specific manner. The chapters in this volume will stimulate readers to generate new hypotheses concerning the pathogenic mechanisms of genetic aberrancies that can be experimentally tested.

Neurodegeneration: From Genetics to Molecules

Victoria Campos-Peña,Marco Antonio Meraz-Ríos,Rosalinda Guevara-Guzmán,Karla Guadalupe Carvajal
Neurodegeneration From Genetics to Molecules Book PDF

Author : Victoria Campos-Peña,Marco Antonio Meraz-Ríos,Rosalinda Guevara-Guzmán,Karla Guadalupe Carvajal
Publisher : Frontiers Media SA
Page : 266 pages
File Size : 40,7 Mb
Release : 2016-11-15
Category : Electronic book
ISBN : 9782889450206

Get Book

Neurodegeneration: From Genetics to Molecules by Victoria Campos-Peña,Marco Antonio Meraz-Ríos,Rosalinda Guevara-Guzmán,Karla Guadalupe Carvajal Pdf

Chronic degenerative diseases are one of the major public health problems, particularly those affecting the nervous system. They are characterized by the degeneration of specific cell populations that include several pathologies which contribute significantly to morbidity and mortality in the elderly population. Therefore, in recent years, the study of neuroscience has gained significant importance. Most of these neurodegenerative disorders are the result of a complex interaction between genetic and environmental factors that generate progression and can even determine its severity. The presence of mutations in genes as LRRK2, SNCA, PARK7, PARK2 or PINK1 is associated with Parkinson's disease. Mutations in genes such as APP, PS1 and PS2 are associated with familial Alzheimer's disease; while HTT gene mutations are the cause of Huntington's disease. In most cases, this condition is inherited in an autosomal dominant pattern, which means one copy of the altered gene in each cell is sufficient to cause the disorder. It is known that these mutations can also alter the proteins function; however, it has not yet been possible to fully understand how some genetic changes cause the disease or influence the risk of developing these disorders. Most symptoms seen in these conditions occurs when specific nerve cells are damaged or die generating a loss in brain communication. Also many of these mutations generate aggregation of intracellular or extracellular proteins affecting cell function and eventually causing neuronal death. It is unclear whether the presence of these aggregates play an important role in nerve cell death during the development of neurodegenerative diseases, or if they are simply part of the response of cells to the disease. Other mutations affect the mitochondrial function generating alterations in energy production and promoting the formation of unstable molecules such as free radicals. Under normal conditions, the harmful effects caused by free radicals, are offset within the cell. However, in pathological conditions, the presence of mutations can alter this process by allowing the accumulation of radicals and damaging or killing cells. On the other hand, we also know that these diseases may not have a direct genetic component, thus, the study of sporadic type neurodegenerative diseases is much more complex. Histopathological lesions as well as the cellular and molecular alterations are generally indistinguishable from familial cases. For this reason, it is important to understand the genetic and molecular mechanisms associated with this type of pathologies. In this sense, this issue aims to understand the molecular processes that occur in the brain, and how these are influenced by the environment, genetics and behavior.

Neurodegeneration

Dennis Dickson,Roy O. Weller
Neurodegeneration Book PDF

Author : Dennis Dickson,Roy O. Weller
Publisher : John Wiley & Sons
Page : 497 pages
File Size : 40,7 Mb
Release : 2011-11-07
Category : Medical
ISBN : 9781405196932

Get Book

Neurodegeneration by Dennis Dickson,Roy O. Weller Pdf

Most textbooks on neurodegenerative disorders have used a classification scheme based upon either clinical syndromes or anatomical distribution of the pathology. In contrast, this book looks to the future and uses a classification based upon molecular mechanisms, rather than clinical or anatomical boundaries. Major advances in molecular genetics and the application of biochemical and immunocytochemical techniques to neurodegenerative disorders have generated this new approach. Throughout most of the current volume, diseases are clustered according to the proteins that accumulate within cells (e.g. tau, α-synuclein and TDP-43) and in the extracellular compartments (e.g. β-amyloid and prion proteins) or according to a shared pathogenetic mechanism, such as trinucleotide repeats, that are a feature of specific genetic disorders. Chapters throughout the book conform to a standard lay-out for ease of access by the reader and are written by a panel of International Experts Since the first edition of this book, major advances have been made in the discovery of common molecular mechanisms between many neurodegenerative diseases most notably in the frontotemporal lobar degenerations (FTLD) and motor neuron disease or amyotrophic lateral sclerosis. This book will be essential reading for clinicians, neuropathologists and basic neuroscientists who require the firm up-to-date knowledge of mechanisms, diagnostic pathology and genetics of Neurodegenerative diseases that is required for progress in therapy and management.

Neuropathology and Genetics of Dementia

Markus Tolnay,Alphonse Probst
Neuropathology and Genetics of Dementia Book PDF

Author : Markus Tolnay,Alphonse Probst
Publisher : Springer Science & Business Media
Page : 280 pages
File Size : 48,8 Mb
Release : 2001-05-31
Category : Medical
ISBN : 0306465582

Get Book

Neuropathology and Genetics of Dementia by Markus Tolnay,Alphonse Probst Pdf

This volume is the proceedings from the Swiss Society for Neuropathology XVIIIth International Winter Meeting, held March 23-26, 2000, in St. Moritz, Switzerland. For more than 35 years the Swiss Society of Neuropathology has organised its traditional International Winter Meeting, whose main aim is to bring together neuropathologists and clinicians as well as neuroscientists interested in disease mechanisms. The topic of the 2000 Meeting was Neuropathology and Genetics of Dementia. A programme of invited plenary lectures of high educational value as well as platform and poster presentations given by many participants covered the broad spectrum of dementing disorders. Encouraged by the high standard of the meeting, and probably also influenced by the advent of a new Millennium, it was decided to publish the Proceedings of the 2000 Meeting in the present book.

Clinical Neurology of Aging

Martin L. Albert,Janice E. Knoefel
Clinical Neurology of Aging Book PDF

Author : Martin L. Albert,Janice E. Knoefel
Publisher : Oxford University Press
Page : 662 pages
File Size : 42,9 Mb
Release : 2011-03-03
Category : Language Arts & Disciplines
ISBN : 9780195369298

Get Book

Clinical Neurology of Aging by Martin L. Albert,Janice E. Knoefel Pdf

This clinically focused book is designed to help clinicians help older persons maintain that joy. Now divided into 9 comprehensive sections, this edition contains subjects ranging from geriatric assessment to pain management and palliative care.

Clinical Neurology of Aging

Martin Albert, MD, PhD, FAAN,Janice Knoefel, MD, MPH
Clinical Neurology of Aging Book PDF

Author : Martin Albert, MD, PhD, FAAN,Janice Knoefel, MD, MPH
Publisher : Oxford University Press
Page : 128 pages
File Size : 48,5 Mb
Release : 2011-01-11
Category : Medical
ISBN : 9780199708963

Get Book

Clinical Neurology of Aging by Martin Albert, MD, PhD, FAAN,Janice Knoefel, MD, MPH Pdf

Clinical Neurology of Aging, Third Edition continues the tradition of the First (1984) and Second (1994) editions with 60 chapters written by the world's elite clinicians from neurology, geriatrics and research on all aspects of geriatric neurology. Aging does not automatically imply decline. Many older people find joy in their friendships and their willingness to look at the world with a calmer view than they may have had in youth. This clinically focused book is designed to help clinicians help older persons maintain that joy. Now divided into 9 comprehensive sections, the Third Edition contains subjects ranging from geriatric assessment to pain management and palliative care. Specific sections include: Introduction to Geriatric Neurology; Neurological Assessment in Aging; Cognitive Disorders in Aging; Motor Disorders in Aging; Neuropsychiatric Illness in Aging; Sensory Disturbance in Aging; Peripheral Neurology of Aging; Disease States in Elderly; and Neurological Therapeutics. With a deft touch, the editors - Drs. Martin Albert and Janice Knoefel - have incorporated the geriatric care perspective and a quality-oriented approach to health care throughout the volume. The result: the definitive reference, useful for all clinicians caring for older people and informative to those who set policies that affect research and clinical practice.

Sleep and Aging

Mark P. Mattson
Sleep and Aging Book PDF

Author : Mark P. Mattson
Publisher : Elsevier
Page : 212 pages
File Size : 55,8 Mb
Release : 2005-06-20
Category : Medical
ISBN : 0444518762

Get Book

Sleep and Aging by Mark P. Mattson Pdf

Sleep and Aging provides a unique and timely collection of review articles that cover the gamut of basic and clinical aspects of sleep and the abnormalities in sleep associated with aging and neurological disorders that occur during aging. From the evolutionary basis of sleep and its normal functions in processes such as learning and memory, to considerations of the roles of sleep abnormalities in neurological disorders such as depression, Alzheimer's and Parkinson's diseases, the chapters are written by experts in the field. Several chapters focus on signalling pathways involved in sleep regulation and abnormalities in sleep, including those activated by serotonin and BDNF. Basic and clinical research on insomnia, sleep apnea and other disorders of sleep, are covered thus providing students and scientists at all levels with a valuable source of information to advance their understanding of this important topic in aging, biology and medicine. The circuits in the brain involved in sleep regulation, their neurochemistry, how they are altered in disorders of sleep and current clinical treatments of various sleep disorders are reviewed. The important role of sleep disturbances in neurodegenerative disorders is described and research in this particular area is leading to a better understanding of the relationships between synaptic plasticity, neuronal degeneration and the clinical manifestations of disorders such as Alzheimer's disease, Parkinson's disease and depression. This book is a must for scientists, as well as non-scientists, who are interested in the neurobiology of aging, sleep and neurodegenerative disorders.

Energy Metabolism and Lifespan Determination

M.P. Mattson
Energy Metabolism and Lifespan Determination Book PDF

Author : M.P. Mattson
Publisher : Elsevier
Page : 226 pages
File Size : 53,9 Mb
Release : 2003-12-01
Category : Medical
ISBN : 0080494765

Get Book

Energy Metabolism and Lifespan Determination by M.P. Mattson Pdf

Experts in the fields of energy metabolism, aging and oxidative stress provide an integrated view of how mechanisms involved in regulating energy metabolism are linked to fundamental processes of aging including cellular stress resistance and free radical production. During evolution signal transduction pathways and organ systems have been optimised for the efficient seeking, ingestion, storing and using of energy. These signalling pathways play prominent roles in lifespan determination with insulin and related signalling pathways being prime examples. The authors consider how lifespan and healthspan can be extended through knowledge of energy metabolism with the experimental model of dietary restriction being one example. The information in this volume of ACAG will foster novel approaches and experiments for further understanding the roles of energy metabolism in aging and disease.

Basic Biology and Clinical Impact of Immunosenescence

G. Pawelec
Basic Biology and Clinical Impact of Immunosenescence Book PDF

Author : G. Pawelec
Publisher : Elsevier
Page : 322 pages
File Size : 41,7 Mb
Release : 2003-05-01
Category : Medical
ISBN : 008054648X

Get Book

Basic Biology and Clinical Impact of Immunosenescence by G. Pawelec Pdf

Ageing is of perennial interest as a universal feature in all human societies. The genetic background and biochemical bases of ageing processes are currently being revealed in unprecedented detail. It is emerging that one of the main hurdles to be overcome in achieving a long and healthy lifespan is the maintenance of a properly functioning immune system. The main cause of death in people who have achieved "successful ageing" (which mostly means not having succumbed to cancer or cardiovascular disease) is infectious disease, caused by immunosenescence. This book contains chapters by many of the leaders in the field of immune-related issues in ageing and remediation.

Recent Advances in Psychology and Aging

P. Costa,I.C. Siegler
Recent Advances in Psychology and Aging Book PDF

Author : P. Costa,I.C. Siegler
Publisher : Elsevier
Page : 268 pages
File Size : 48,7 Mb
Release : 2003-12-10
Category : Psychology
ISBN : 0080522785

Get Book

Recent Advances in Psychology and Aging by P. Costa,I.C. Siegler Pdf

Recent Events in the Psychology of Aging documents the successful integration of aging into the mainstream of psychology. Leading psychologists present overviews of the key issues and research findings on mainstream topics. These include cognitive neuroscience, visual attention, learning, memory and cognition, as well as personality and happiness. The intersection of aging content with mainstream psychology is also prominent in the areas of emotions, personality, and social psychology as seen in the chapters on subjective well-being, emotional development, self-esteem and personality trajectories. The seven chapters of this book offer information on such topics as: the seven sins of memory, categorizing the common breakdowns of memory in everyday life and the special breakdown of sins that increase with aging; problems with attention and learning; and offers answers to questions such as do emotions get blunted with age; do older people focus more on positive feelings; and the age old question of whether older people are happier than younger people is given in the chapter on the evolving concept of subjective well-being and the multifaceted nature of happiness. Questions about what occurs to one's self-esteem and personality are also masterfully discussed and the answers may be surprising. The concluding seventh chapter provides a cultural lens on the biopsychosocial study of aging.

Stem Cells: A Cellular Fountain of Youth

M.P. Mattson,G. van Zant
Stem Cells A Cellular Fountain of Youth Book PDF

Author : M.P. Mattson,G. van Zant
Publisher : Elsevier
Page : 240 pages
File Size : 42,7 Mb
Release : 2002-08-21
Category : Medical
ISBN : 0444507310

Get Book

Stem Cells: A Cellular Fountain of Youth by M.P. Mattson,G. van Zant Pdf

The developmental capabilities and therapeutic potential of stem cells are being revealed in studies of cellular signaling mechanisms that regulate their proliferation, differentiation and survival. "Stem Cells: A Cellular Fountain of Youth" reviews the current state of understanding of the molecular mechanisms that regulate embryonic and adult stem cells with an emphasis on how aging and age-related disease impact on these mechanisms. Leading authorities detail the properties and therapeutic potential of embryonic stem cells, and stem cell precursors of blood, nervous and muscle and bone cells. Recent advances in deciphering the environmental signals and intrinsic signal transduction pathways that regulate embryonic stem cells are described, and the potential therapeutic uses of these totipotent cells is considered. Analyses of hematopoietic stem cells during aging suggest an important genetic component to the control of their self-renewing capability which may contribute to determination of lifespan. The contribution of lymphocyte depletion to impaired immune function during aging is considered, as is the potential of hematopoietic cells to form other types of cells including neurons. Several chapters cover the remarkable and rapidly advancing field of neural stem cells. The adult brain contains populations of stem cells capable of forming new neurons and glial cells; the signals that regulate these neural stem cells and the involvement of neurogenesis in normal brain function is described. Because of their potential to replace lost or damaged neurons, there has been intense interest in determining the therapeutic potential of stem cells for the treatment of patients with Parkinson's and Alzheimer's diseases, stroke and traumatic brain and spinal cord injuries. Heart and skeletal muscle contain stem cells and the impact of aging and disease on these stem cell populations and the potential of stem cell therapy to recover function of these organs is reviewed. A final example of the fascinating world of stem cells is a review of the roles of stem cells in bone formation and remodeling. Collectively, this book provides a comprehensive, yet concise, view of stem cell molecular biology in the context of aging and age-related disease. This book will be a valuable reference for graduate students and senior scientists interested in the fascinating world of stem cells and their potential use in the clinic.

The Role of DNA Damage and Repair in Cell Aging

B.A. Gilchrest,V.A. Bohr
The Role of DNA Damage and Repair in Cell Aging Book PDF

Author : B.A. Gilchrest,V.A. Bohr
Publisher : Elsevier
Page : 270 pages
File Size : 51,8 Mb
Release : 2001-03-09
Category : Science
ISBN : 044450494X

Get Book

The Role of DNA Damage and Repair in Cell Aging by B.A. Gilchrest,V.A. Bohr Pdf

Aging occurs at the level of individual cells, a complex interplay between intrinsic "programming" and exogenous "wear and tear", with genetically-determined cellular capacity to repair environmentally-induced DNA damage playing a central role in the rate of aging and its specific manifestations. In 12 chapters, "The Role of DNA Damage and Repair in Cell Aging" provides an intellectual framework for aging of mitotic and post-mitotic cells, describes a variety of model systems for further studies, and reviews current concepts of DNA responses and their relationship to the phenomenon of aging. As part of a series entitled "Advances in Cell Aging and Gerontology," this volume also summarizes seminal recent discoveries such as the molecular basis for Werner syndrome (a mutant DNA helicase), the complementary roles of telomere shortening and telomerase activity in cell senescence versus immortalization, the role of apoptosis in the homeostasis of aging tissue, and the existence of an inducible SOS-like response in mammalian cells that minimizes DNA damage from repeatedly encountered injurious environmental agents. Insights into the relationship between cellular aging and age-associated diseases, particularly malignancies, are also provided in several chapters. This book is an excellent single source of information for anyone interested in DNA repair, mechanisms of aging, or certainly their intersection. Students will gain a general appreciation of these fields, but even the most senior investigators will benefit from the detailed coverage of rapidly advancing areas.

Neurodegeneration

Anthony Schapira,Zbigniew K. Wszolek,Ted M. Dawson,Nicholas Wood
Neurodegeneration Book PDF

Author : Anthony Schapira,Zbigniew K. Wszolek,Ted M. Dawson,Nicholas Wood
Publisher : John Wiley & Sons
Page : 348 pages
File Size : 51,5 Mb
Release : 2017-02-08
Category : Medical
ISBN : 9781118661925

Get Book

Neurodegeneration by Anthony Schapira,Zbigniew K. Wszolek,Ted M. Dawson,Nicholas Wood Pdf

This book unites the diverse range of complex neurodegenerative diseases into a textbook designed for clinical practice, edited by globally leading authorities on the subject. Presents a clinically oriented guide to the diseases caused by neurodegeneration Templated chapters combine clinical and research information on neurodegenerative diseases beginning with the common elements before treating each disease individually Diseases are grouped by anatomical regions of degeneration and include common disorders such as Parkinson’s Disease, Alzheimer’s Disease, Amyotrophic Lateral Sclerosis/Motor Neuron Disease, and Multiple Sclerosis as well as less common diseases Edited by globally leading authorities on the subject, and written by expert contributing authors

Alzheimer's Disease

Khalid Iqbal,Sangram S. Sisodia,Bengt Winblad
Alzheimer s Disease Book PDF

Author : Khalid Iqbal,Sangram S. Sisodia,Bengt Winblad
Publisher : John Wiley & Sons
Page : 888 pages
File Size : 46,7 Mb
Release : 2003-01-24
Category : Medical
ISBN : 9780470851746

Get Book

Alzheimer's Disease by Khalid Iqbal,Sangram S. Sisodia,Bengt Winblad Pdf

Alzheimer's Disease is an ever present problem affecting millions of people around the world and, as people's average lifespan lengthens, its prevalence is set to increase. A global effort is needed to combat the disease, including research to investigate the causes, development of effective treatments and, ultimately, prevention of the disease. Published every two years, these timely books discuss the very latest research. This new volume provides a unique source of reference to the important work being done in this field, it gives academics and clinicians an opportunity to learn about cutting edge developments and covers all aspects of Alzheimer's Disease, including diagnosis, clinical course, epidemiological course and therapeutics and disease mechanisms. Alzheimer's Disease: Advances in Etiology, Pathogenesis and Therapeutics will provide essential information for basic and clinical researchers in Alzheimer's Disease and other dementias as well as for those who care for patients.

Connective Tissue and Its Heritable Disorders

Peter M. Royce,Beat Steinmann
Connective Tissue and Its Heritable Disorders Book PDF

Author : Peter M. Royce,Beat Steinmann
Publisher : John Wiley & Sons
Page : 1201 pages
File Size : 41,8 Mb
Release : 2003-04-14
Category : Medical
ISBN : 9780471461173

Get Book

Connective Tissue and Its Heritable Disorders by Peter M. Royce,Beat Steinmann Pdf

The Second Edition of Connective Tissue and Its Heritable Disorders: Molecular, Genetic, and Medical Aspects is the definitive reference text in its field, with over 40% more pages on the nature, diagnosis, and treatment of disease than its predecessor. Collecting new research on disorders detailed in the first edition as well as on those previously excluded, editors Peter Royce and Beat Steinmann provide the most up-to-date clinical and scientific information for medical specialists treating affected individuals. Features of this revised and updated volume include detailed reviews of the clinical diagnosis, mode of inheritance, risk of recurrence, and prenatal diagnosis of each inherited connective tissue disorder; a thorough description of the morphology of connective tissues; a completely updated and revised section on the biology of the extracellular matrix; and the addition of syndromes such as craniosyntosis, and disorders of sulfate metabolism.