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Glial Physiology and Pathophysiology

Alexei Verkhratsky,Arthur Butt

Author : Alexei Verkhratsky,Arthur Butt
Publisher : John Wiley & Sons
Page : 473 pages
File Size : 51,8 Mb
Release : 2013-01-31
Category : Medical
ISBN : 9781118402054

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Glial Physiology and Pathophysiology by Alexei Verkhratsky,Arthur Butt Pdf

Glial Physiology and Pathophysiology provides a comprehensive, advanced text on the biology and pathology of glial cells. Coverae includes: the morphology and interrelationships between glial cells and neurones in different parts of the nervous systems the cellular physiology of the different kinds of glial cells the mechanisms of intra- and inter-cellular signalling in glial networks the mechanisms of glial-neuronal communications the role of glial cells in synaptic plasticity, neuronal survival and development of nervous system the cellular and molecular mechanisms of metabolic neuronal-glial interactions the role of glia in nervous system pathology, including pathology of glial cells and associated diseases - for example, multiple sclerosis, Alzheimer's, Alexander disease and Parkinson's Neuroglia oversee the birth and development of neurones, the establishment of interneuronal connections (the 'connectome'), the maintenance and removal of these inter-neuronal connections, writing of the nervous system components, adult neurogenesis, the energetics of nervous tissue, metabolism of neurotransmitters, regulation of ion composition of the interstitial space and many, many more homeostatic functions. This book primes the reader towards the notion that nervous tissue is not divided into more important and less important cells. The nervous tissue functions because of the coherent and concerted action of many different cell types, each contributing to an ultimate output. This reaches its zenith in humans, with the creation of thoughts, underlying acquisition of knowledge, its analysis and synthesis, and contemplating the Universe and our place in it. An up-to-date and fully referenced text on the most numerous cells in the human brain Detailed coverage of the morphology and interrelationships between glial cells and neurones in different parts of the nervous system Describes the role og glial cells in neuropathology Focus boxes highlight key points and summarise important facts Companion website with downloadable figures and slides

Neuroglia: Function and Pathology

Alexei Verkhratsky,Arthur Butt

Author : Alexei Verkhratsky,Arthur Butt
Publisher : Elsevier
Page : 732 pages
File Size : 40,5 Mb
Release : 2023-05-12
Category : Medical
ISBN : 9780128215661

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Neuroglia: Function and Pathology by Alexei Verkhratsky,Arthur Butt Pdf

Diverse specialised neuroglial cells guarantee the development, preservation, and health of the central nervous system, the peripheral nervous system, the enteric nervous system, and the special senses. In the central nervous system, it is the astrocytes, oligodendrocytes, and microglia that safeguard nerve cell function and integrity that controls all behaviours and encompasses the cerebral cortex of the brain which is the root of humanity. In the peripheral nervous system, Schwann cells play the leading role, together with satellite glial cells of the sensory and autonomic ganglia, ensuring correct communication between the organs and tissues with the brain and the spinal cord. In the enteric nervous system, specialised enteric glial cells maintain all aspects of gastrointestinal function. Then there are distinctive glial cells of the special senses that ensure how the body perceives and reacts to its environment. In pathology, neuroglia strive to protect the diverse cellular components of the nervous system and are responsible for a proactive programme of posttraumatic restructuring that is aimed at recovery of life-sustaining function. Neuroglia: Function and Pathology provides a highly original and comprehensive account of the physiology and pathophysiology of glial cells in the central and peripheral nervous systems. The first part of the book provides a far-reaching description of glial cell form and function, from their evolution in invertebrates to their complexity in humans, encompassing the developmental origin of the varied glial cell types and their diversity of morphology, molecular biology and cellular physiology. The second part of the book is devoted to an all-embracing evaluation of glial cell pathophysiology, commencing with definitive explanations of the fundamental pathologies of the main glial cell types, and ending in a systematic examination of glial contributions to specific neurological diseases. This book emphasises the central roles played by the different classes of neuroglial cells in the progression and outcome of neurological disorders of the central and peripheral nervous systems and highlights potential of glial cells as therapeutic targets. The book contains more than 2500 key references from over 150 years of glial research and is superbly illustrated with over 350 original and explanatory full colour figures that describe the diverse characteristics and properties of glial cells in health and disease. Under the same cover, this book combines an authoritative reference book for research and clinical neuroscientists and at the same time serves as an instructive textbook for students of neuroscience, from undergraduates to postgraduates. Single volume covering key aspects of glial cell physiology and pathology In depth overview of the history of glial cell research Comprehensive review of glial cell physiology and pathology Authoritative special chapters on the major neurological diseases Full colour throughout, with 360 illustrations

Glial Neurobiology

Alexei Verkhratsky,Arthur Butt

Author : Alexei Verkhratsky,Arthur Butt
Publisher : John Wiley & Sons
Page : 230 pages
File Size : 55,7 Mb
Release : 2007-08-20
Category : Medical
ISBN : 0470513071

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Glial Neurobiology by Alexei Verkhratsky,Arthur Butt Pdf

"This volume is a very valuable and much needed contribution." –Quarterly Review of Biology AT LAST - A comprehensive, accessible textbook on glial neurobiology! Glial cells are the most numerous cells in the human brain but for many years have attracted little scientific attention. Neurophysiologists concentrated their research efforts instead, on neurones and neuronal networks because it was thought that they were the key elements responsible for higher brain function. Recent advances, however, indicate this isn’t exactly the case. Not only are astroglial cells the stem elements from which neurones are born, but they also control the development, functional activity and death of neuronal circuits. These ground-breaking developments have revolutionized our understanding of the human brain and the complex interrelationship of glial and neuronal networks in health and disease. Features of this book: an accessible introduction to glial neurobiology including an overview of glial cell function and its active role in neural processes, brain function and nervous system pathology an exploration of all the major types of glial cells including: the astrocytes, oligodendrocytes and microglia of the ACNS and Schwann cells of the peripheral nervous system; the book also presents a broad overview of glial receptors and ion channels an investigation into the role of glial cells in various types of brain diseases including stroke, neurodegenerative diseases such as Alzheimer's, Parkinson's and Alexander's disease, brain oedema, multiple sclerosis and many more a wealth of illustrations, including unique images from the authors' own libraries of images, describing the main features of glial cells Written by two leading experts in the field, Glial Neurobiology provides a concise, authoritative introduction to glial physiology and pathology for undergraduate/postgraduate neuroscience, biomedical, medical, pharmacy, pharmacology, and neurology, neurosurgery and physiology students. It is also an invaluable resource for researchers in neuroscience, physiology, pharmacology and pharmaceutics.

Glial Neurobiology

Alexei Verkhratsky,Arthur Butt

Author : Alexei Verkhratsky,Arthur Butt
Publisher : Wiley
Page : 230 pages
File Size : 41,8 Mb
Release : 2007-09-04
Category : Medical
ISBN : 0470015640

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Glial Neurobiology by Alexei Verkhratsky,Arthur Butt Pdf

"This volume is a very valuable and much needed contribution." –Quarterly Review of Biology AT LAST - A comprehensive, accessible textbook on glial neurobiology! Glial cells are the most numerous cells in the human brain but for many years have attracted little scientific attention. Neurophysiologists concentrated their research efforts instead, on neurones and neuronal networks because it was thought that they were the key elements responsible for higher brain function. Recent advances, however, indicate this isn’t exactly the case. Not only are astroglial cells the stem elements from which neurones are born, but they also control the development, functional activity and death of neuronal circuits. These ground-breaking developments have revolutionized our understanding of the human brain and the complex interrelationship of glial and neuronal networks in health and disease. Features of this book: an accessible introduction to glial neurobiology including an overview of glial cell function and its active role in neural processes, brain function and nervous system pathology an exploration of all the major types of glial cells including: the astrocytes, oligodendrocytes and microglia of the ACNS and Schwann cells of the peripheral nervous system; the book also presents a broad overview of glial receptors and ion channels an investigation into the role of glial cells in various types of brain diseases including stroke, neurodegenerative diseases such as Alzheimer's, Parkinson's and Alexander's disease, brain oedema, multiple sclerosis and many more a wealth of illustrations, including unique images from the authors' own libraries of images, describing the main features of glial cells Written by two leading experts in the field, Glial Neurobiology provides a concise, authoritative introduction to glial physiology and pathology for undergraduate/postgraduate neuroscience, biomedical, medical, pharmacy, pharmacology, and neurology, neurosurgery and physiology students. It is also an invaluable resource for researchers in neuroscience, physiology, pharmacology and pharmaceutics.

The Role of Glia in Neurotoxicity

Michael Aschner,Lucio G. Costa

Author : Michael Aschner,Lucio G. Costa
Publisher : CRC Press
Page : 480 pages
File Size : 45,9 Mb
Release : 2019-08-30
Category : Electronic
ISBN : 0367393387

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The Role of Glia in Neurotoxicity by Michael Aschner,Lucio G. Costa Pdf

Presenting the latest research in glial cell function gleaned from new techniques in imaging and molecular biology, The Role of Glia in Neurotoxicity, Second Edition covers multiple aspects of glial cells, including morphology, physiology, pharmacology, biochemistry, pathology, and their involvement in the pathophysiology of neurological diseases. The book is structured to examine the interactions between glial cells and neurons during development, adulthood, and senescence, followed by specific examples of directly mediated glial neurotoxicity. The book also covers miscellaneous topics in glial physiology/biochemistry such as signaling and edema. The book includes coverage of advances in our knowledge and understanding of glial physiology and biochemistry. Discover what's new in the Second Edition: Neuronal-glia metabolic interactions Neuronal-glia interactions (glutamate homeostasis) Zinc transporters in glia Energy deprivation/mitochondrial dysfunction - unique astrocyte susceptibilities Astrocytes and MPTP neurotoxicity Astroglia and food toxins Current understanding of the importance of glia has caused a boom in published information. Yet while many of the published textbooks are multifaceted and multidisciplinary, none includes the role of glia in neurotoxicity. Written by leaders in the field of glial research, this text fills this missing gap in the literature. Broader in scope than the first edition, including contributions from internationally known researchers, this is still the only book dedicated to exploring the role of glial cells in mediating neurotoxicology. Features Summarizes the latest research in glial cell function gleaned from new techniques in imaging and molecular biology Contains tables and figures that give you quick and easy access to precise data Includes a contemporary summary of literature that puts information useful for grant submissions at your fingertips

Enteric Glia

Brian D. Gulbransen

Author : Brian D. Gulbransen
Publisher : Biota Publishing
Page : 72 pages
File Size : 41,5 Mb
Release : 2014-07-01
Category : Medical
ISBN : 9781615046614

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Enteric Glia by Brian D. Gulbransen Pdf

The enteric nervous system (ENS) is a complex neural network embedded in the gut wall that orchestrates the reflex behaviors of the intestine. The ENS is often referred to as the “little brain” in the gut because the ENS is more similar in size, complexity and autonomy to the central nervous system (CNS) than other components of the autonomic nervous system. Like the brain, the ENS is composed of neurons that are surrounded by glial cells. Enteric glia are a unique type of peripheral glia that are similar to astrocytes of the CNS. Yet enteric glial cells also differ from astrocytes in many important ways. The roles of enteric glial cell populations in the gut are beginning to come to light and recent evidence implicates enteric glia in almost every aspect of gastrointestinal physiology and pathophysiology. However, elucidating the exact mechanisms by which enteric glia influence gastrointestinal physiology and identifying how those roles are altered during gastrointestinal pathophysiology remain areas of intense research. The purpose of this e-book is to provide an introduction to enteric glial cells and to act as a resource for ongoing studies on this fascinating population of glia. Table of Contents: Introduction / A Historical Perspective on Enteric Glia / Enteric Glia: The Astroglia of the Gut / Molecular Composition of Enteric Glia / Development of Enteric Glia / Functional Roles of Enteric Glia / Enteric Glia and Disease Processes in the Gut / Concluding Remarks / References / Author Biography

Glial Cells in Health and Disease of the CNS

Rommy von Bernhardi

Author : Rommy von Bernhardi
Publisher : Springer
Page : 348 pages
File Size : 48,6 Mb
Release : 2016-10-06
Category : Medical
ISBN : 9783319407647

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Glial Cells in Health and Disease of the CNS by Rommy von Bernhardi Pdf

A timely overview covering the three major types of glial cells in the central nervous system - astrocytes, microglia, and oligodendrocytes. New findings on glia biology are overturning a century of conventional thinking about how the brain operates and are expanding our knowledge about information processing in the brain. The book will present recent research findings on the role of glial cells in both healthy function and disease. It will comprehensively cover a broad spectrum of topics while remaining compact in size.

Astrocyte

Maria Teresa Gentile,Luca Colucci D’Amato

Author : Maria Teresa Gentile,Luca Colucci D’Amato
Publisher : BoD – Books on Demand
Page : 244 pages
File Size : 53,9 Mb
Release : 2018-03-21
Category : Medical
ISBN : 9789535138853

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Astrocyte by Maria Teresa Gentile,Luca Colucci D’Amato Pdf

A team of authors from prestigious academic schools contributed to draw up a project that would give a detailed account of astrocyte's morphology and physiology, examining thoroughly all the astrocyte's types; giving an accurate description of their morphology, location, function in the brain; and illustrating their physiology and pathology in terms of dealing with neurons through "gliotransmitters," ionic channels, and membrane receptors expression. This book gives an overview of the crucial role of astrocytes in the physiology of the CNS and in the pathogenesis of several CNS disorders suggesting that the shift from a neurocentric view to one that incorporates astrocytes in disease models for drug discovery is a critical step in renewing drug development strategies to treat neurodegenerative diseases.

The Role of Glia in Neurotoxicity, Second Edition

Michael Aschner,Lucio G. Costa

Author : Michael Aschner,Lucio G. Costa
Publisher : CRC Press
Page : 480 pages
File Size : 43,6 Mb
Release : 2004-12-28
Category : Medical
ISBN : 0849317940

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The Role of Glia in Neurotoxicity, Second Edition by Michael Aschner,Lucio G. Costa Pdf

Presenting the latest research in glial cell function gleaned from new techniques in imaging and molecular biology, The Role of Glia in Neurotoxicity, Second Edition covers multiple aspects of glial cells, including morphology, physiology, pharmacology, biochemistry, pathology, and their involvement in the pathophysiology of neurological diseases. The book is structured to examine the interactions between glial cells and neurons during development, adulthood, and senescence, followed by specific examples of directly mediated glial neurotoxicity. The book also covers miscellaneous topics in glial physiology/biochemistry such as signaling and edema. The book includes coverage of advances in our knowledge and understanding of glial physiology and biochemistry. Discover what's new in the Second Edition: Neuronal-glia metabolic interactions Neuronal-glia interactions (glutamate homeostasis) Zinc transporters in glia Energy deprivation/mitochondrial dysfunction - unique astrocyte susceptibilities Astrocytes and MPTP neurotoxicity Astroglia and food toxins Current understanding of the importance of glia has caused a boom in published information. Yet while many of the published textbooks are multifaceted and multidisciplinary, none includes the role of glia in neurotoxicity. Written by leaders in the field of glial research, this text fills this missing gap in the literature. Broader in scope than the first edition, including contributions from internationally known researchers, this is still the only book dedicated to exploring the role of glial cells in mediating neurotoxicology. Features Summarizes the latest research in glial cell function gleaned from new techniques in imaging and molecular biology Contains tables and figures that give you quick and easy access to precise data Includes a contemporary summary of literature that puts information useful for grant submissions at your fingertips Features new chapters covering metabolic interactions, glutamate homeostasis, transporters, energy deprivation/mitochondrial dysfunction, astrocytes, and food toxins Explores the role of glial cells in mediating neurotoxicity and incorporates information on specific effects of many compounds

Introduction to Neuroglia

Alexei Verkhratsky,Professor Alexei Verkhratsky,Vladimir Parpura

Author : Alexei Verkhratsky,Professor Alexei Verkhratsky,Vladimir Parpura
Publisher : Morgan & Claypool Life Sciences
Page : 0 pages
File Size : 45,7 Mb
Release : 2014-02
Category : Medical
ISBN : 1615046488

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Introduction to Neuroglia by Alexei Verkhratsky,Professor Alexei Verkhratsky,Vladimir Parpura Pdf

This book is the introduction to a series of e-books dedicated to the physiology and pathophysiology of neuroglia. The topic of neuroglia is generally overlooked in neuroscience curricula across the world, the main attention being focused on the description of excitability of neurons and neuronal networks. The neuroglia, being electrically non-excitable, are universally regarded as supportive cells which do not contribute to information processing. This oversimplified view, however, ignores the tremendous importance of brain homeostasis, which is imperative for the ongoing activity of neuronal networks. It also ignores the truth that specialization of neurons and their ability for rapid propagation and multi-level integration of signals become possible only because of delegation of homeostatic abilities to neuroglia. Furthermore, glial cells contribute to information processing as they can modulate neuronal synaptic transmission. Finally, neuroglia provide the only system of brain defense and as such these cells are intimately involved in all types of neuropathologies, and contribute to both neuroprotection and regeneration of the nervous system. The e-books in this series provide a platform for in-depth learning of all aspects of neuroglial cells function in health and disease.

Neuroglia

Helmut Kettenmann,Bruce R. Ransom

Author : Helmut Kettenmann,Bruce R. Ransom
Publisher : Oxford University Press, USA
Page : 1079 pages
File Size : 47,6 Mb
Release : 1995
Category : Health & Fitness
ISBN : 0195078470

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Neuroglia by Helmut Kettenmann,Bruce R. Ransom Pdf

Glia are support cells of the nervous system, more numerous than the nerve cells themselves. In recent years it has been discovered that they have a far wider range of functions than was previously known, so this new book is very timely. This is a definitive work covering all aspects of glial cells including glial morphology, physiology, pharmacology, biochemistry, pathology and their involvement in the pathophysiology of neurological diseases. The book is written by leaders in the field of glial research and is carefully edited to ensure consistency and thoroughness in the treatment of each topic. A total of 69 chapters conveys in a highly readable fashion the excitement that pervades this rapidly expanding area of neurobiology. The enormous amount of new information about glial cells that is carefully summarized here leads to the inescapable realization that these cells interact importantly with neurons in all of the brain's main functions.

Astrocytes in (Patho)Physiology of the Nervous System

Vladimir Parpura,Philip G. Haydon

Author : Vladimir Parpura,Philip G. Haydon
Publisher : Springer Science & Business Media
Page : 701 pages
File Size : 45,9 Mb
Release : 2008-12-11
Category : Medical
ISBN : 9780387794921

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Astrocytes in (Patho)Physiology of the Nervous System by Vladimir Parpura,Philip G. Haydon Pdf

Astrocytes were the original neuroglia that Ramón y Cajal visualized in 1913 using a gold sublimate stain. This stain targeted intermediate filaments that we now know consist mainly of glial fibrillary acidic protein, a protein used today as an astrocytic marker. Cajal described the morphological diversity of these cells with some ast- cytes surrounding neurons, while the others are intimately associated with vasculature. We start the book by discussing the heterogeneity of astrocytes using contemporary tools and by calling into question the assumption by classical neuroscience that neurons and glia are derived from distinct pools of progenitor cells. Astrocytes have long been neglected as active participants in intercellular communication and information processing in the central nervous system, in part due to their lack of electrical excitability. The follow up chapters review the “nuts and bolts” of ast- cytic physiology; astrocytes possess a diverse assortment of ion channels, neu- transmitter receptors, and transport mechanisms that enable the astrocytes to respond to many of the same signals that act on neurons. Since astrocytes can detect chemical transmitters that are released from neurons and can release their own extracellular signals there is an increasing awareness that they play physiological roles in regulating neuronal activity and synaptic transmission. In addition to these physiological roles, it is becoming increasingly recognized that astrocytes play critical roles during pathophysiological states of the nervous system; these states include gliomas, Alexander disease, and epilepsy to mention a few.

Acute Pain

Lesley Bromley,Brigitta Brandner

Author : Lesley Bromley,Brigitta Brandner
Publisher : Oxford University Press
Page : 205 pages
File Size : 53,9 Mb
Release : 2010-06-03
Category : Medical
ISBN : 9780199234721

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Acute Pain by Lesley Bromley,Brigitta Brandner Pdf

This text covers the fundamentals of pain, the pharmacology of drugs used, and summarises the current evidence base for the management of acute pain. It provides practical direct clinical applications and strategies for the management of specific medical conditions in patient groups such as the elderly

Physiology and Pathology of Chloride Transporters and Channels in the Nervous System

F. Javier Alvarez-Leefmans,Eric Delpire

Author : F. Javier Alvarez-Leefmans,Eric Delpire
Publisher : Academic Press
Page : 630 pages
File Size : 48,9 Mb
Release : 2009-08-22
Category : Medical
ISBN : 9780080922034

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Physiology and Pathology of Chloride Transporters and Channels in the Nervous System by F. Javier Alvarez-Leefmans,Eric Delpire Pdf

The importance of chloride ions in cell physiology has not been fully recognized until recently, in spite of the fact that chloride (Cl-), together with bicarbonate, is the most abundant free anion in animal cells, and performs or determines fundamental biological functions in all tissues. For many years it was thought that Cl- was distributed in thermodynamic equilibrium across the plasma membrane of most cells. Research carried out during the last couple of decades has led to a dramatic change in this simplistic view. We now know that most animal cells, neurons included, exhibit a non-equilibrium distribution of Cl- across their plasma membranes. Over the last 10 to 15 years, with the growth of molecular biology and the advent of new optical methods, an enormous amount of exciting new information has become available on the molecular structure and function of Cl- channels and carriers. In nerve cells, Cl- channels and carriers play key functional roles in GABA- and glycine-mediated synaptic inhibition, neuronal growth and development, extracellular potassium scavenging, sensory-transduction, neurotransmitter uptake and cell volume control. Disruption of Cl- homeostasis in neurons underlies pathological conditions such as epilepsy, deafness, imbalance, brain edema and ischemia, pain and neurogenic inflammation. This book is about how chloride ions are regulated and how they cross the plasma membrane of neurons. It spans from molecular structure and function of carriers and channels involved in Cl- transport to their role in various diseases. The first comprehensive book on the structure, molecular biology, cell physiology, and role in diseases of chloride transporters / channels in the nervous system in almost 20 years Chloride is the most abundant free anion in animal cells. THis book summarizes and integrates for the first time the important research of the past two decades that has shown that Cl- channels and carriers play key functional roles in GABA- and glycine-mediated synaptic inhibition, neuronal growth and development, extracellular potassium scavenging, sensory-transduction, neurotransmitter uptake and cell volume control The first book that systematically discusses the result of disruption of Cl- homeostasis in neurons which underlies pathological conditions such as epilepsy, deafness, imbalance, brain edema and ischemia, pain and neurogenic inflammation Spanning topics from molecular structure and function of carriers and channels involved in Cl- transport to their role in various diseases Involves all of the leading researchers in the field Includes an extensive introductory section that covers basic thermodynamic and kinetics aspects of Cl- transport, as well as current methods for studying Cl- regulation, spanning from fluorescent dyes in single cells to knock-out models to make the book available for a growing population of graduate students and postdocs entering the field

Glial Cells

Peter R. Laming,Eva Syková

Author : Peter R. Laming,Eva Syková
Publisher : Cambridge University Press
Page : 448 pages
File Size : 53,8 Mb
Release : 1998-06-28
Category : Medical
ISBN : 0521573688

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Glial Cells by Peter R. Laming,Eva Syková Pdf

This 1998 book discusses how neurons and glial cells interact with each other to influence behaviour.

Glial Physiology And Pathophysiology

Glial Physiology and Pathophysiology by Alexei Verkhratsky,Arthur Butt Pdf

Neuroglia: Function and Pathology by Alexei Verkhratsky,Arthur Butt Pdf

Glial Neurobiology by Alexei Verkhratsky,Arthur Butt Pdf

Glial Neurobiology by Alexei Verkhratsky,Arthur Butt Pdf

The Role of Glia in Neurotoxicity by Michael Aschner,Lucio G. Costa Pdf

Enteric Glia by Brian D. Gulbransen Pdf

Glial Cells in Health and Disease of the CNS by Rommy von Bernhardi Pdf

Astrocyte by Maria Teresa Gentile,Luca Colucci D’Amato Pdf

The Role of Glia in Neurotoxicity, Second Edition by Michael Aschner,Lucio G. Costa Pdf

Introduction to Neuroglia by Alexei Verkhratsky,Professor Alexei Verkhratsky,Vladimir Parpura Pdf

Neuroglia by Helmut Kettenmann,Bruce R. Ransom Pdf

Astrocytes in (Patho)Physiology of the Nervous System by Vladimir Parpura,Philip G. Haydon Pdf

Acute Pain by Lesley Bromley,Brigitta Brandner Pdf

Physiology and Pathology of Chloride Transporters and Channels in the Nervous System by F. Javier Alvarez-Leefmans,Eric Delpire Pdf

Glial Cells by Peter R. Laming,Eva Syková Pdf

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