Glycoscience Basic Science To Applications

Author : Naoyuki Taniguchi,Tamao Endo,Jun Hirabayashi,Shoko Nishihara,Kenji Kadomatsu,Kazunari Akiyoshi,Kiyoko F. Aoki-Kinoshita
Publisher : Springer Nature
Page : 405 pages
File Size : 42,5 Mb
Release : 2019-09-12
Category : Medical
ISBN : 9789811358562

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Glycoscience: Basic Science to Applications by Naoyuki Taniguchi,Tamao Endo,Jun Hirabayashi,Shoko Nishihara,Kenji Kadomatsu,Kazunari Akiyoshi,Kiyoko F. Aoki-Kinoshita Pdf

This book presents the state of the art in glycoscience and proposes a road map for the coming decade, focusing on the potential of glycoscience research to shed light on important basic science issues and give rise to exciting new applications, especially in the field of diagnosis and therapeutics. Individual sections offer in-depth coverage of various topics relating to glycans and biopharmaceuticals, glycans in medical science and medicine, glycan technologies, glycans in food and nutrients, and glycan-related materials and their uses. In addition, the book presents an exemplary training course on glycomics and highlights educational and analytical web resources, and also includes glossaries and boxes summarizing key facts to ensure ease of understanding for non-expert readers and students. Written by more than 150 active participants in the Japan Consortium for Glycobiology and Glycotechnology (JCGG), whose goal is to promote the development of interdisciplinary glycoscience and establish a global network in the field, it is a valuable resource for students, postdocs, and researchers in the life sciences as well as for stakeholders and professionals in government, funding agencies and industry.

Author : National Research Council,Division on Earth and Life Studies,Board on Life Sciences,Board on Chemical Sciences and Technology,Committee on Assessing the Importance and Impact of Glycomics and Glycosciences
Publisher : National Academies Press
Page : 171 pages
File Size : 44,8 Mb
Release : 2012-10-23
Category : Science
ISBN : 9780309260862

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Transforming Glycoscience by National Research Council,Division on Earth and Life Studies,Board on Life Sciences,Board on Chemical Sciences and Technology,Committee on Assessing the Importance and Impact of Glycomics and Glycosciences Pdf

A new focus on glycoscience, a field that explores the structures and functions of sugars, promises great advances in areas as diverse as medicine, energy generation, and materials science, this report finds. Glycans-also known as carbohydrates, saccharides, or simply as sugars-play central roles in many biological processes and have properties useful in an array of applications. However, glycans have received little attention from the research community due to a lack of tools to probe their often complex structures and properties. Transforming Glycoscience: A Roadmap for the Future presents a roadmap for transforming glycoscience from a field dominated by specialists to a widely studied and integrated discipline, which could lead to a more complete understanding of glycans and help solve key challenges in diverse fields.

Author : Ajit Varki,Maarten J. Chrispeels
Publisher : CSHL Press
Page : 694 pages
File Size : 41,9 Mb
Release : 1999
Category : Medical
ISBN : 0879696818

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Essentials of Glycobiology by Ajit Varki,Maarten J. Chrispeels Pdf

Sugar chains (glycans) are often attached to proteins and lipids and have multiple roles in the organization and function of all organisms. "Essentials of Glycobiology" describes their biogenesis and function and offers a useful gateway to the understanding of glycans.

Author : National Research Council,Division on Earth and Life Studies,Board on Life Sciences,Board on Chemical Sciences and Technology,Committee on Assessing the Importance and Impact of Glycomics and Glycosciences
Publisher : National Academies Press
Page : 171 pages
File Size : 42,6 Mb
Release : 2012-11-23
Category : Science
ISBN : 9780309260831

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Transforming Glycoscience by National Research Council,Division on Earth and Life Studies,Board on Life Sciences,Board on Chemical Sciences and Technology,Committee on Assessing the Importance and Impact of Glycomics and Glycosciences Pdf

A new focus on glycoscience, a field that explores the structures and functions of sugars, promises great advances in areas as diverse as medicine, energy generation, and materials science, this report finds. Glycans-also known as carbohydrates, saccharides, or simply as sugars-play central roles in many biological processes and have properties useful in an array of applications. However, glycans have received little attention from the research community due to a lack of tools to probe their often complex structures and properties. Transforming Glycoscience: A Roadmap for the Future presents a roadmap for transforming glycoscience from a field dominated by specialists to a widely studied and integrated discipline, which could lead to a more complete understanding of glycans and help solve key challenges in diverse fields.

Author : E. G. Berger,H. Clausen,Richard D. Cummings
Publisher : Springer
Page : 0 pages
File Size : 51,7 Mb
Release : 2012-10-14
Category : Science
ISBN : 1461373972

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Glycotechnology by E. G. Berger,H. Clausen,Richard D. Cummings Pdf

Glycotechnology brings together in one place important contributions and up-to-date research results in this fast moving area. Glycotechnology serves as an excellent reference, providing insight into some of the most challenging research issues in the field.

Author : Rita Gerardy-Schahn,Philippe Delannoy,Mark von Itzstein
Publisher : Springer
Page : 254 pages
File Size : 49,8 Mb
Release : 2015-07-28
Category : Science
ISBN : 9783319213170

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SialoGlyco Chemistry and Biology II by Rita Gerardy-Schahn,Philippe Delannoy,Mark von Itzstein Pdf

The series Topics in Current Chemistry presents critical reviews of the present and future trends in modern chemical research. The scope of coverage is all areas of chemical science including the interfaces with related disciplines such as biology, medicine and materials science. The goal of each thematic volume is to give the non-specialist reader, whether in academia or industry, a comprehensive insight into an area where new research is emerging which is of interest to a larger scientific audience. Each review within the volume critically surveys one aspect of that topic and places it within the context of the volume as a whole. The most significant developments of the last 5 to 10 years are presented using selected examples to illustrate the principles discussed. The coverage is not intended to be an exhaustive summary of the field or include large quantities of data, but should rather be conceptual, concentrating on the methodological thinking that will allow the non-specialist reader to understand the information presented. Contributions also offer an outlook on potential future developments in the field. Review articles for the individual volumes are invited by the volume editors. Readership: research chemists at universities or in industry, graduate students.

Author : Naoyuk Taniguchi,Tamao Endo,Gerald W. Hart,Peter H. Seeberger,Chi-Huey Wong
Publisher : Springer
Page : 0 pages
File Size : 52,5 Mb
Release : 2014-11-14
Category : Science
ISBN : 4431548408

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Glycoscience: Biology and Medicine by Naoyuk Taniguchi,Tamao Endo,Gerald W. Hart,Peter H. Seeberger,Chi-Huey Wong Pdf

The aim of the book is to provide a succinct overview of the current status of glycoscience from both basic biological and medical points of view and to propose future directions, in order to facilitate further integrations of glycoscience with other fields in biological and medical studies. Glycans (carbohydrate oligomers) are the so-called “building blocks” of carbohydrates, nucleic acids, proteins and lipids and play major roles in many biological phenomena as well as in various pathophysiological processes. However, this area of glycoscience has been neglected from the research community because glycan structures are very complex and functionally diverse and as compared to proteins and nucleic acids simple tools for the amplification, sequencing and auto-synthesis of glycans are not available. Many scientists in other fields of research have now realized that glycosylation, i.e. the addition of glycans to a protein backbone, is the most abundant post translational modification reactions and is an important field of research and sometimes they require a glycobiology and/or glycochemistry approach to be used. It is still difficult, however, for non-expert researchers to use these techniques. This book provides numerous but simple overviews of current topics and protocols for the experiments. The book is aimed at university students and above, including non-experts in the field of glycoscience.

Author : Gordan Lauc,Irena Trbojević-Akmačić
Publisher : Springer Nature
Page : 392 pages
File Size : 54,6 Mb
Release : 2021-09-08
Category : Science
ISBN : 9783030701154

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The Role of Glycosylation in Health and Disease by Gordan Lauc,Irena Trbojević-Akmačić Pdf

Glycobiology is an emerging field of studying glycans (sugars) and glycoconjugates that are essentially involved in almost all biological processes, from fine-tuning glycoprotein function to protein-protein interactions, signaling, immune response, host-pathogen interactions, etc. However, due to structural complexity of glycans and analytical challenges this exciting field was lagging behind other areas of biology. With technological advancements growing number of glycans’ functions are being discovered and the study of glycans is becoming a cutting-edge discipline in basic and clinical research. Despite recent developments in glycobiology field, many aspects of glycosylation process still remain unknown, both in a healthy human organism and in pathological states. Human glycome is dynamic and changes with physiological triggers, immune challenges and disease. Atypical glycosylation is consequently a subject of disease biomarker research, and a target for therapeutic interventions. On the other hand, properties of glycosylated biotherapeutics are predominantly determined by their glycans. The Role of Glycosylation in Health and Disease provides a comprehensive overview of types and functions of glycans in a healthy human organism as well as their role in pathophysiology of different diseases and efficiency of glycosylated biotherapeutics. Written by the experts in the field, this book aims to bring glycobiology field closer to students, researchers in life sciences and professionals in biopharmaceutical industry.

Author : Ozcan Konur
Publisher : Academic Press
Page : 738 pages
File Size : 41,5 Mb
Release : 2020-03-28
Category : Science
ISBN : 9780128183069

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Handbook of Algal Science, Technology and Medicine by Ozcan Konur Pdf

Handbook of Algal Science, Microbiology, Technology and Medicine provides a concise introduction to the science, biology, technology and medical use of algae that is structured on the major research fronts of the last four decades, such as algal structures and properties, algal biomedicine, algal genomics, algal toxicology, and algal bioremediation, algal photosystems, algal ecology, algal bioenergy and biofuels. It also covers algal production for biomedicine, algal biomaterials, and algal medicinal foods within these primary sections. All chapters are authored by the leading researchers in their respective research fields. Our society currently faces insurmountable challenges in the areas of biomedicine and energy in the face of increasing global population and diminishing natural resources as well as the growing environmental and economic concerns, such as global warming, greenhouse gas emissions and climate change. Algae offer a way to deal with these challenges and concerns for both sustainable and environment friendly bioenergy production and in biomedicine through the development of crucial biotechnology. Provides an essential interdisciplinary introduction and handbook for all the stakeholders engaged in science, technology and medicine of algae Covers the major research streams of the last four decades, ranging from algal structures, to algal biomedicine and algal bioremediation Fills a significant market opening for an interdisciplinary handbook on algal science, technology and medicine

Author : Michelle Kilcoyne,Lokesh Joshi
Publisher : Academic Press
Page : 464 pages
File Size : 42,7 Mb
Release : 2023-11-29
Category : Science
ISBN : 9780128220023

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Translational Glycobiology in Human Health and Disease by Michelle Kilcoyne,Lokesh Joshi Pdf

Along with nucleic acids, proteins, and lipids, carbohydrates stand as one of four main components of cellular architecture. However, glycobiology (or carbohydrate bioscience) is little understood by non-experts, partly because carbohydrates are a complex, diverse class of molecules structurally and functionally. In recent years, advances in computational analytics (glycomics) have allowed us to better interpret and realize the importance of glycobiology in human health and disease, and glycans and their associated processes have been shown to play a significant role across a variety of disease types. As the biomedical sciences continue to adopt multi-omic and precision medicine approaches, a greater understanding of glycobiology is essential for maintaining healthy physiology and advancing disease treatment.Translational Glycobiology in Human Health and Disease offers a deep examination of glycobiology for experts and non-experts alike in areas ranging from the role of glycobiology in chronic and infectious diseases to advances in technologies for higher throughput analysis and diagnosis. While keeping human health in the forefront, this book integrates a thorough discussion of glycobiology fundamentals with its growing areas of application and societal impact. With emphasis throughout on the interdisciplinary nature of glycosciences, this book also features perspectives from the health, computational (glycoanalytics), materials, biopharmaceutical, and diagnostic sciences.Disease and speciality areas addressed include gycoimmunology, neuroglycobiology, commensal glycobiology, gut health, regenerative medicine and glycobiology, glycobiology and cancer, congenital disorders of glycosylation, infectious disease glycobiology, and parasite glycobiology. Computational approaches discussed, supporting the advance of new research, include advanced glycoanalytics, glycomics microarrays, glycoengineering, and glycol systems biology. Additionally, authors consider impact areas for society and public health, such as glycobiology and entrepreneurship, policy and regulatory requirements for glycosylation, future research, and translation to new diagnostics and drug discovery. Provides a deep, foundational overview of glycoscience and its translational potential, highlighting glycobiology’s growing role in human health and disease study Examines a broad range of relevant disease areas and applications of glycobiology in policy and public health Features chapter contributions from leading, international experts in the field, fully integrating perspectives from the health, computational, materials, biopharmaceutical, and diagnostic sciences

Author : Koichi Kato,Thomas Peters
Publisher : Royal Society of Chemistry
Page : 417 pages
File Size : 53,8 Mb
Release : 2017-05-15
Category : Science
ISBN : 9781788011280

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NMR in Glycoscience and Glycotechnology by Koichi Kato,Thomas Peters Pdf

This volume focuses on solution and solid-state NMR of carbohydrates, glycoproteins, glyco-technologies, biomass and related topics. It is estimated that at least 80% of all proteins are glycoproteins. Because of the complexity, heterogeneity and flexibility of the sugar chains, the structural biology approaches for glycoconjugates have been generally avoided. NMR techniques although well established for structural analyses of proteins and nucleic acids, cannot be simply applied to this complex class of biomolecules. Nonetheless, recently developed NMR techniques for carbohydrates open the door to conformational studies of a variety of sugar chains of biological interest. NMR studies on glycans will have significant impact on the development of vaccines, adjuvants, therapeutics, biomarkers and on biomass regeneration. In this volume, the Editors have collected the most up-to-date NMR applications from experts in the field of carbohydrate NMR spectroscopy. Timely and useful, not only for NMR specialists, it will appeal to researchers in the general field of structural biology, biochemistry and biophysics, molecular and cellular biology and material science.

Author : Thomas Lütteke,Martin Frank
Publisher : Humana
Page : 0 pages
File Size : 40,6 Mb
Release : 2016-10-05
Category : Science
ISBN : 149394195X

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Glycoinformatics by Thomas Lütteke,Martin Frank Pdf

This book provides current glycoinformatics methods and protocols used to support the determination of carbohydrate structures in biological samples as well as carbohydrate structure databases, the interaction of carbohydrates with proteins, and theoretical and experimental methods to study their three-dimensional structure and dynamics. Glycoinformatics explores this recently emerged field, which has come into being in order to address the needs of encoding, storing, and analyzing carbohydrate ‘sequences’ and their taxonomy using computers. Written in the highly successful Methods in Molecular Biology series format, chapters contain the kind of detailed description and key implementation advice to ensure successful results. Authoritative and timely, Glycoinformatics demonstrates the progress that has been achieved in glycoinformatics, which indicates that it is no longer a niche subject covered by only a few scientists but is truly coming of age.

Author : Gherman Wiederschain
Publisher : CRC Press
Page : 334 pages
File Size : 42,9 Mb
Release : 2016-02-22
Category : Medical
ISBN : 9781498709194

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Glycobiology and Human Diseases by Gherman Wiederschain Pdf

This book discusses glycobiology and various forms of human diseases. Topics covered include immunoglobulins, inflammation and glycosylation, the role and therapeutic significance of natural anti-glycan antibodies in malignancies and in normal and aberrant pregnancy, identifying urinary glycans as a possible method for the diagnosis of lysosomal storage diseases, glycobiology of human milk (biological roles and diseases) and pectins as biological modulators of human physiological reactions. The book includes analysis of comprehensive data and some productive conclusions and perspectives.

Author : Wanyi Guan,Lei Li,Peng George Wang
Publisher : Royal Society of Chemistry
Page : 488 pages
File Size : 46,7 Mb
Release : 2019-04-23
Category : Science
ISBN : 9781788011648

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Synthetic Glycomes by Wanyi Guan,Lei Li,Peng George Wang Pdf

Glycans play essential roles in diverse biological and etiological processes and their structural complexity endow various functions. The glycome is the entire set of glycans produced by an individual organism. As the glycan microarray emerged, a good amount of knowledge has been obtained in understanding the functions of glycans. However, limited accessibility of glycans is a major obstacle to the functional glycomics study. Although isolation from biology samples provided some structures, the low abundance of glycans obtained and the difficulty in complete structural assignment restricted the subsequent assay. To circumvent this limitation, many synthetic strategies, including chemical, enzymatic and chemo-enzymatic ones have been developed to make libraries of structurally defined complex glycans available. The glycans provided by these techniques combined with high-throughput glycoarray techniques have broadened and deepened our understanding about functional glycomics. The aim of this book is to provide a comprehensive review of the current state of the synthetic glycome and a brief introduction of the application of the synthetic glycome in glycoarray assay. Accordingly, synthetic strategies toward generating glycans with comprehensive structures as well as the glycoarrays to unveil the glycan functions are described in this book.

Author : Irena Trbojević-Akmačić,Mohamed Abdel-Mohsen,David Falck,Erdmann Rapp
Publisher : Frontiers Media SA
Page : 136 pages
File Size : 52,6 Mb
Release : 2022-06-14
Category : Medical
ISBN : 9782889763504

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Immunoglobulin Glycosylation Analysis: State-of-the-Art Methods and Applications in Immunology by Irena Trbojević-Akmačić,Mohamed Abdel-Mohsen,David Falck,Erdmann Rapp Pdf