Glycosciences

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Transforming Glycoscience

National Research Council,Division on Earth and Life Studies,Board on Life Sciences,Board on Chemical Sciences and Technology,Committee on Assessing the Importance and Impact of Glycomics and Glycosciences
Transforming Glycoscience Book PDF

Author : National Research Council,Division on Earth and Life Studies,Board on Life Sciences,Board on Chemical Sciences and Technology,Committee on Assessing the Importance and Impact of Glycomics and Glycosciences
Publisher : National Academies Press
Page : 171 pages
File Size : 47,9 Mb
Release : 2012-10-23
Category : Science
ISBN : 9780309260862

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Transforming Glycoscience by National Research Council,Division on Earth and Life Studies,Board on Life Sciences,Board on Chemical Sciences and Technology,Committee on Assessing the Importance and Impact of Glycomics and Glycosciences Pdf

A new focus on glycoscience, a field that explores the structures and functions of sugars, promises great advances in areas as diverse as medicine, energy generation, and materials science, this report finds. Glycans-also known as carbohydrates, saccharides, or simply as sugars-play central roles in many biological processes and have properties useful in an array of applications. However, glycans have received little attention from the research community due to a lack of tools to probe their often complex structures and properties. Transforming Glycoscience: A Roadmap for the Future presents a roadmap for transforming glycoscience from a field dominated by specialists to a widely studied and integrated discipline, which could lead to a more complete understanding of glycans and help solve key challenges in diverse fields.

Essentials of Glycobiology

Ajit Varki,Maarten J. Chrispeels
Essentials of Glycobiology Book PDF

Author : Ajit Varki,Maarten J. Chrispeels
Publisher : CSHL Press
Page : 694 pages
File Size : 42,8 Mb
Release : 1999
Category : Medical
ISBN : 0879696818

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Essentials of Glycobiology by Ajit Varki,Maarten J. Chrispeels Pdf

Sugar chains (glycans) are often attached to proteins and lipids and have multiple roles in the organization and function of all organisms. "Essentials of Glycobiology" describes their biogenesis and function and offers a useful gateway to the understanding of glycans.

Comprehensive Glycoscience

Anonim
Comprehensive Glycoscience Book PDF

Author : Anonim
Publisher : Elsevier
Page : 0 pages
File Size : 41,7 Mb
Release : 2021-06-21
Category : Science
ISBN : 9780128222447

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Comprehensive Glycoscience by Anonim Pdf

Comprehensive Glycoscience, Second Edition, Five Volume Set assembles the top minds in this area who provide an update on the renowned 2007 first edition, including new discoveries and latest advances in glycoscience-related research areas such as glycan microarrays, carbohydrate materials, glycoengineering and microbiome research. The result is an up-to-date work which will impress readers with the many new advances that are outlined and taught in this second edition. Most areas of the original edition have been majorly updated, some overlapping topics have been consolidated, and several topics have been rearranged into more appropriate sections. Combines multiple aspects of glycoscience in one comprehensive and reliable reference work Includes all major developments since 2007 (e.g. nanotechnology) Places glycoscience at the crossroads of several disciplines, including biology, biochemistry, glycobiology and synthetic chemistry, thus offering a truly interdisciplinary perspective

Glycoscience: Chemistry and Chemical Biology I–III

Bertram O. Fraser-Reid,Kuniaki Tatsuta,Joachim Thiem
Glycoscience Chemistry and Chemical Biology I III Book PDF

Author : Bertram O. Fraser-Reid,Kuniaki Tatsuta,Joachim Thiem
Publisher : Springer Science & Business Media
Page : 2817 pages
File Size : 50,6 Mb
Release : 2012-12-06
Category : Science
ISBN : 9783642568749

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Glycoscience: Chemistry and Chemical Biology I–III by Bertram O. Fraser-Reid,Kuniaki Tatsuta,Joachim Thiem Pdf

Glycostructures play a highly diverse and crucial role in a myriad of organisms and systems in biology, physiology, medicine, and bioengineering and technology. Only in recent years have the tools been developed to partly understand the highly complex functions and chemistry behind them. In this set the editors present up-to-date information on glycostructures, their chemistry and chemical biology, in the form of a comprehensive survey. The text is accompanied by over 2000 figures, chemical structures and reaction schemes and more than 9000 references. The accompanying CD-ROM enables, besides text searches, searches for structures, schemes, and other information.

Glycoscience: Biology and Medicine

Naoyuk Taniguchi,Tamao Endo,Gerald W. Hart,Peter H. Seeberger,Chi-Huey Wong
Glycoscience Biology and Medicine Book PDF

Author : Naoyuk Taniguchi,Tamao Endo,Gerald W. Hart,Peter H. Seeberger,Chi-Huey Wong
Publisher : Springer
Page : 0 pages
File Size : 40,8 Mb
Release : 2014-11-14
Category : Science
ISBN : 4431548408

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Glycoscience: Biology and Medicine by Naoyuk Taniguchi,Tamao Endo,Gerald W. Hart,Peter H. Seeberger,Chi-Huey Wong Pdf

The aim of the book is to provide a succinct overview of the current status of glycoscience from both basic biological and medical points of view and to propose future directions, in order to facilitate further integrations of glycoscience with other fields in biological and medical studies. Glycans (carbohydrate oligomers) are the so-called “building blocks” of carbohydrates, nucleic acids, proteins and lipids and play major roles in many biological phenomena as well as in various pathophysiological processes. However, this area of glycoscience has been neglected from the research community because glycan structures are very complex and functionally diverse and as compared to proteins and nucleic acids simple tools for the amplification, sequencing and auto-synthesis of glycans are not available. Many scientists in other fields of research have now realized that glycosylation, i.e. the addition of glycans to a protein backbone, is the most abundant post translational modification reactions and is an important field of research and sometimes they require a glycobiology and/or glycochemistry approach to be used. It is still difficult, however, for non-expert researchers to use these techniques. This book provides numerous but simple overviews of current topics and protocols for the experiments. The book is aimed at university students and above, including non-experts in the field of glycoscience.

Glycoscience

Bertram O. Fraser-Reid,Kuniaki Tatsuta,Joachim Thiem
Glycoscience Book PDF

Author : Bertram O. Fraser-Reid,Kuniaki Tatsuta,Joachim Thiem
Publisher : Springer Science & Business Media
Page : 2847 pages
File Size : 45,9 Mb
Release : 2008-04-14
Category : Science
ISBN : 9783540361541

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Glycoscience by Bertram O. Fraser-Reid,Kuniaki Tatsuta,Joachim Thiem Pdf

As a reflection of the quantum leap that has been made in the study of glycostructures, the first edition of this book has been completely revised and updated. The editors give up-to-date information on glycostructures, their chemistry and chemical biology in the form of a completely comprehensive survey. Glycostructures play highly diverse and crucial roles in a myriad of organisms and important systems in biology, physiology, medicine, bioengineering and technology. Only in recent years have the tools been developed to partly understand the highly complex functions and the chemistry behind them. While many facts remain undiscovered, this MRW has been contributed to by a large number of the world’s leading researchers in the field.

Click Chemistry in Glycoscience

Zbigniew J. Witczak,Roman Bielski
Click Chemistry in Glycoscience Book PDF

Author : Zbigniew J. Witczak,Roman Bielski
Publisher : John Wiley & Sons
Page : 402 pages
File Size : 52,5 Mb
Release : 2013-03-18
Category : Science
ISBN : 9781118275337

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Click Chemistry in Glycoscience by Zbigniew J. Witczak,Roman Bielski Pdf

Lays the foundation for new methods and applications of carbohydrate click chemistry Introduced by K. Barry Sharpless of The Scripps Research Institute in 2001, click chemistry mimics nature, giving researchers the tools needed to generate new substances quickly and reliably by joining small units together. With contributions from more than thirty pioneering researchers in the field, this text explores the many promising applications of click chemistry in glycoscience. Readers will learn both the basic concepts of carbohydrate click chemistry as well as its many biomedical applications, including synthetic antigens, analogs of cell-surface receptors, immobilized enzymes, targeted drug delivery systems, and multivalent cancer vaccines. Click Chemistry in Glycoscience examines a broad range of methodologies and strategies that have emerged from this rapidly evolving field. Each chapter describes new approaches, ideas, consequences, and applications resulting from the introduction of click processes. Divided into four sections, the book covers: Click chemistry strategies and decoupling Thio-click chemistry of carbohydrates Carbohydrate click chemistry for novel synthetic targets Carbohydrate click chemistry in biomedical sciences Thoroughly researched, the book reflects the most recent findings published in the literature. Diagrams and figures throughout the book enable readers to more easily grasp complex concepts and reaction processes. At the end of each chapter, references lead to the primary literature for further investigation of individual topics. The application of click chemistry to carbohydrates has tremendous implications for research. With this book as their guide, researchers have a solid foundation from which they can develop new methods and applications of carbohydrate click chemistry, including new carbohydrate-based therapeutics.

Glycosciences

Hans-Joachim Gabius,Sigrun Gabius
Glycosciences Book PDF

Author : Hans-Joachim Gabius,Sigrun Gabius
Publisher : John Wiley & Sons
Page : 663 pages
File Size : 40,8 Mb
Release : 2008-09-26
Category : Science
ISBN : 9783527614721

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Glycosciences by Hans-Joachim Gabius,Sigrun Gabius Pdf

A comprehensive survey of the topic, ranging from basic molecular research to clinical applications. Critical reviews by leading experts in each field summarize the state of knowledge and discuss the anticipated benefits of novel approaches and strategies. These include the impact of modern analysis techniques on glycobiology, the use of synthetic neoglycoproteins, or the clinical consequences of new insights into the physiological role of lectins and glycoconjugates in pathology, oncology, immunity, neuroscience and reproduction medicine. Throughout, the aim is to separate realistic applications from mere hopes.

NMR in Glycoscience and Glycotechnology

Koichi Kato,Thomas Peters
NMR in Glycoscience and Glycotechnology Book PDF

Author : Koichi Kato,Thomas Peters
Publisher : Royal Society of Chemistry
Page : 402 pages
File Size : 47,7 Mb
Release : 2017-05-15
Category : Science
ISBN : 9781782623946

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NMR in Glycoscience and Glycotechnology by Koichi Kato,Thomas Peters Pdf

This volume focuses on solution and solid-state NMR of carbohydrates, glycoproteins, glyco-technologies, biomass and related topics. It is estimated that at least 80% of all proteins are glycoproteins. Because of the complexity, heterogeneity and flexibility of the sugar chains, the structural biology approaches for glycoconjugates have been generally avoided. NMR techniques although well established for structural analyses of proteins and nucleic acids, cannot be simply applied to this complex class of biomolecules. Nonetheless, recently developed NMR techniques for carbohydrates open the door to conformational studies of a variety of sugar chains of biological interest. NMR studies on glycans will have significant impact on the development of vaccines, adjuvants, therapeutics, biomarkers and on biomass regeneration. In this volume, the Editors have collected the most up-to-date NMR applications from experts in the field of carbohydrate NMR spectroscopy. Timely and useful, not only for NMR specialists, it will appeal to researchers in the general field of structural biology, biochemistry and biophysics, molecular and cellular biology and material science.

Coupling and Decoupling of Diverse Molecular Units in Glycosciences

Zbigniew J. Witczak,Roman Bielski
Coupling and Decoupling of Diverse Molecular Units in Glycosciences Book PDF

Author : Zbigniew J. Witczak,Roman Bielski
Publisher : Springer
Page : 335 pages
File Size : 49,9 Mb
Release : 2017-11-20
Category : Science
ISBN : 9783319655871

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Coupling and Decoupling of Diverse Molecular Units in Glycosciences by Zbigniew J. Witczak,Roman Bielski Pdf

This unique book covers the latest developments in coupling and decoupling of biomolecules containing functionalized carbohydrate components, being one of the first collections in this important area of applied medicinal chemistry. Connecting molecules, often referred as bio-conjugation, has become one of the most often performed procedures in modern medicinal chemistry. Sometimes, when the connected molecules are not useful anymore, they must be disconnected. The molecules that must be connected (coupled) may belong to both small and large molecules and include such constructs as glycoproteins, glycopeptides and glycans. In this work, more than 15 experts address a comprehensive range of potential and current uses of in vitro and in vivo bio-conjugation methodologies, leading to a variety of glycoconjugates. The analytical aspects of bio-conjugation are also here discussed. Medicinal and organic chemists from graduate level onwards will understand the appeal of this important book.

The Sugar Code

Hans-Joachim Gabius
The Sugar Code Book PDF

Author : Hans-Joachim Gabius
Publisher : John Wiley & Sons
Page : 560 pages
File Size : 43,8 Mb
Release : 2011-09-19
Category : Science
ISBN : 9783527644940

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The Sugar Code by Hans-Joachim Gabius Pdf

A reader friendly overview of the structure and functional relevance of natural glycosylation and its cognate proteins (lectins), this book is also one of the few books to cover their role in health and disease. Edited by one of the pioneering experts in the field and written by a team of renowned researchers this resource is a perfect introduction for all students in life and medical sciences, biochemistry, chemistry and pharmacy. Website: WWW.WILEY-VCH.DE/HOME/THESUGARCODE

The Role of Glycosylation in Health and Disease

Gordan Lauc,Irena Trbojević-Akmačić
The Role of Glycosylation in Health and Disease Book PDF

Author : Gordan Lauc,Irena Trbojević-Akmačić
Publisher : Springer Nature
Page : 392 pages
File Size : 50,8 Mb
Release : 2021-09-08
Category : Science
ISBN : 9783030701154

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The Role of Glycosylation in Health and Disease by Gordan Lauc,Irena Trbojević-Akmačić Pdf

Glycobiology is an emerging field of studying glycans (sugars) and glycoconjugates that are essentially involved in almost all biological processes, from fine-tuning glycoprotein function to protein-protein interactions, signaling, immune response, host-pathogen interactions, etc. However, due to structural complexity of glycans and analytical challenges this exciting field was lagging behind other areas of biology. With technological advancements growing number of glycans’ functions are being discovered and the study of glycans is becoming a cutting-edge discipline in basic and clinical research. Despite recent developments in glycobiology field, many aspects of glycosylation process still remain unknown, both in a healthy human organism and in pathological states. Human glycome is dynamic and changes with physiological triggers, immune challenges and disease. Atypical glycosylation is consequently a subject of disease biomarker research, and a target for therapeutic interventions. On the other hand, properties of glycosylated biotherapeutics are predominantly determined by their glycans. The Role of Glycosylation in Health and Disease provides a comprehensive overview of types and functions of glycans in a healthy human organism as well as their role in pathophysiology of different diseases and efficiency of glycosylated biotherapeutics. Written by the experts in the field, this book aims to bring glycobiology field closer to students, researchers in life sciences and professionals in biopharmaceutical industry.

Translational Glycobiology in Human Health and Disease

Michelle Kilcoyne,Lokesh Joshi
Translational Glycobiology in Human Health and Disease Book PDF

Author : Michelle Kilcoyne,Lokesh Joshi
Publisher : Academic Press
Page : 464 pages
File Size : 51,6 Mb
Release : 2023-11-29
Category : Science
ISBN : 9780128220023

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Translational Glycobiology in Human Health and Disease by Michelle Kilcoyne,Lokesh Joshi Pdf

Along with nucleic acids, proteins, and lipids, carbohydrates stand as one of four main components of cellular architecture. However, glycobiology (or carbohydrate bioscience) is little understood by non-experts, partly because carbohydrates are a complex, diverse class of molecules structurally and functionally. In recent years, advances in computational analytics (glycomics) have allowed us to better interpret and realize the importance of glycobiology in human health and disease, and glycans and their associated processes have been shown to play a significant role across a variety of disease types. As the biomedical sciences continue to adopt multi-omic and precision medicine approaches, a greater understanding of glycobiology is essential for maintaining healthy physiology and advancing disease treatment.Translational Glycobiology in Human Health and Disease offers a deep examination of glycobiology for experts and non-experts alike in areas ranging from the role of glycobiology in chronic and infectious diseases to advances in technologies for higher throughput analysis and diagnosis. While keeping human health in the forefront, this book integrates a thorough discussion of glycobiology fundamentals with its growing areas of application and societal impact. With emphasis throughout on the interdisciplinary nature of glycosciences, this book also features perspectives from the health, computational (glycoanalytics), materials, biopharmaceutical, and diagnostic sciences.Disease and speciality areas addressed include gycoimmunology, neuroglycobiology, commensal glycobiology, gut health, regenerative medicine and glycobiology, glycobiology and cancer, congenital disorders of glycosylation, infectious disease glycobiology, and parasite glycobiology. Computational approaches discussed, supporting the advance of new research, include advanced glycoanalytics, glycomics microarrays, glycoengineering, and glycol systems biology. Additionally, authors consider impact areas for society and public health, such as glycobiology and entrepreneurship, policy and regulatory requirements for glycosylation, future research, and translation to new diagnostics and drug discovery. Provides a deep, foundational overview of glycoscience and its translational potential, highlighting glycobiology’s growing role in human health and disease study Examines a broad range of relevant disease areas and applications of glycobiology in policy and public health Features chapter contributions from leading, international experts in the field, fully integrating perspectives from the health, computational, materials, biopharmaceutical, and diagnostic sciences

Carbon Nanotubes and Graphene

Kazuyoshi Tanaka,S. Iijima
Carbon Nanotubes and Graphene Book PDF

Author : Kazuyoshi Tanaka,S. Iijima
Publisher : Newnes
Page : 458 pages
File Size : 49,6 Mb
Release : 2014-07-10
Category : Science
ISBN : 9780080982687

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Carbon Nanotubes and Graphene by Kazuyoshi Tanaka,S. Iijima Pdf

Carbon Nanotubes and Graphene is a timely second edition of the original Science and Technology of Carbon Nanotubes. Updated to include expanded coverage of the preparation, purification, structural characterization, and common application areas of single- and multi-walled CNT structures, this work compares, contrasts, and, where appropriate, unitizes CNT to graphene. This much expanded second edition reference supports knowledge discovery, production of impactful carbon research, encourages transition between research fields, and aids the formation of emergent applications. New chapters encompass recent developments in the theoretical treatments of electronic and vibrational structures, and magnetic, optical, and electrical solid-state properties, providing a vital base to research. Current and potential applications of both materials, including the prospect for large-scale synthesis of graphene, biological structures, and flexible electronics, are also critically discussed. Updated discussion of properties, structure, and morphology of biological and flexible electronic applications aids fundamental knowledge discovery Innovative parallel focus on nanotubes and graphene enables you to learn from the successes and failures of, respectively, mature and emergent partner research disciplines High-quality figures and tables on physical and mathematical applications expertly summarize key information – essential if you need quick, critically relevant data

Glycoinformatics

Thomas Lütteke,Martin Frank
Glycoinformatics Book PDF

Author : Thomas Lütteke,Martin Frank
Publisher : Humana
Page : 0 pages
File Size : 52,8 Mb
Release : 2016-10-05
Category : Science
ISBN : 149394195X

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Glycoinformatics by Thomas Lütteke,Martin Frank Pdf

This book provides current glycoinformatics methods and protocols used to support the determination of carbohydrate structures in biological samples as well as carbohydrate structure databases, the interaction of carbohydrates with proteins, and theoretical and experimental methods to study their three-dimensional structure and dynamics. Glycoinformatics explores this recently emerged field, which has come into being in order to address the needs of encoding, storing, and analyzing carbohydrate ‘sequences’ and their taxonomy using computers. Written in the highly successful Methods in Molecular Biology series format, chapters contain the kind of detailed description and key implementation advice to ensure successful results. Authoritative and timely, Glycoinformatics demonstrates the progress that has been achieved in glycoinformatics, which indicates that it is no longer a niche subject covered by only a few scientists but is truly coming of age.