Protecting Group Free Organic Synthesis

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Protecting-Group-Free Organic Synthesis

Rodney A. Fernandes
Protecting Group Free Organic Synthesis Book PDF

Author : Rodney A. Fernandes
Publisher : John Wiley & Sons
Page : 283 pages
File Size : 43,6 Mb
Release : 2018-08-20
Category : Science
ISBN : 9781119295204

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Protecting-Group-Free Organic Synthesis by Rodney A. Fernandes Pdf

Presents a comprehensive account of established protecting-group-free synthetic routes to molecules of medium to high complexity This book supports synthetic chemists in the design of strategies, which avoid or minimize the use of protecting groups so as to come closer to achieving an “ideal synthesis” and back the global need of practicing green chemistry. The only resource of its kind to focus entirely on protecting-group-free synthesis, it is edited by a leading practitioner in the field, and features enlightening contributions by top experts and researchers from across the globe. The introductory chapter includes a concise review of historical developments, and discusses the concepts, need for, and future prospects of protecting-group-free synthesis. Following this, the book presents information on protecting-group-free synthesis of complex natural products and analogues, heterocycles, drugs, and related pharmaceuticals. Later chapters discuss practicing protecting-group-free synthesis using carbohydrates and of glycosyl derivatives, glycol-polymers and glyco-conjugates. The book concludes with a chapter on latent functionality as a tactic toward formal protecting-group-free synthesis. A comprehensive account of established protecting-group-free (PGF) synthetic routes to molecules of medium to high complexity Benefits total synthesis, methodology development and drug synthesis researchers Supports synthetic chemists in the design of strategies, which avoid or minimize the use of protecting groups so as to come closer to achieving an “ideal synthesis” and support the global need of practicing green chemistry Covers a topic that is gaining importance because it renders syntheses more economical Protecting-Group-Free Organic Synthesis: Improving Economy and Efficiency is an important book for academic researchers in synthetic organic chemistry, green chemistry, medicinal and pharmaceutical chemistry, biochemistry, and drug discovery.

Greene's Protective Groups in Organic Synthesis

Peter G. M. Wuts,Theodora W. Greene
Greene s Protective Groups in Organic Synthesis Book PDF

Author : Peter G. M. Wuts,Theodora W. Greene
Publisher : John Wiley & Sons
Page : 1108 pages
File Size : 41,6 Mb
Release : 2012-12-20
Category : Science
ISBN : 9781118589328

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Greene's Protective Groups in Organic Synthesis by Peter G. M. Wuts,Theodora W. Greene Pdf

The Fourth Edition of Greene's Protective Groups in Organic Synthesis continues to be an indispensable reference for controlling the reactivity of the most common functional groups during a synthetic sequence. This new edition incorporates the significant developments in the field since publication of the third edition in 1998, including... New protective groups such as the fluorous family and the uniquely removable 2-methoxybenzenesulfonyl group for the protection of amines New techniques for the formation and cleavage of existing protective groups, with examples to illustrate each new technique Expanded coverage of the unexpected side reactions that occur with protective groups New chart covering the selective deprotection of silyl ethers 3,100 new references from the professional literature The content is organized around the functional group to be protected, and ranges from the simplest to the most complex and highly specialized protective groups.

Protective Groups in Organic Synthesis

Theodora W. Greene
Protective Groups in Organic Synthesis Book PDF

Author : Theodora W. Greene
Publisher : Unknown
Page : 376 pages
File Size : 41,5 Mb
Release : 1981-05-14
Category : Science
ISBN : UOM:39015015131025

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Protective Groups in Organic Synthesis by Theodora W. Greene Pdf

Provides comprehensive information on the most useful protective groups for the hydroxyl, amino, carboxyl, carbonyl, and sulfhydryl groups. Discusses the chemistry of the classes of protective groups, as well as that of the individual protective groups within the class using structures, equations and references. Reactivity Charts for each class of protective group serve as an aid in their appropriate choice and provide estimates of their relative reactivities toward 108 prototype reagents.

Protecting Groups

Philip J. Kocienski
Protecting Groups Book PDF

Author : Philip J. Kocienski
Publisher : Thieme Medical Publishers
Page : 286 pages
File Size : 43,8 Mb
Release : 2000
Category : Medical
ISBN : UOM:39015049554994

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Protecting Groups by Philip J. Kocienski Pdf

The didactic presentation of the material makes this book an essential bench-top tool not only for specialists in organic chemistry, but also for students and all those involved in the preparation of organic molecules. Key Features: - a critical survey of the most used protecting groups, as used by organic chemists - organization based on functional groups: hydroxyl ; diol; carbonyl; carboxyl; amine - special emphasis placed on deprotection conditions applied to complex structures where selectivity is a prime issue - transformations accompanied by key experimental details - examples from the recent literature span a wide domain of organic synthesis - over 500 schemes aid visual retrieval - end-of-chapter list reviews which amplify topics covered.

Protective Groups in Organic Chemistry

J. McOmie
Protective Groups in Organic Chemistry Book PDF

Author : J. McOmie
Publisher : Springer Science & Business Media
Page : 423 pages
File Size : 42,7 Mb
Release : 2012-12-06
Category : Science
ISBN : 9781468472189

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Protective Groups in Organic Chemistry by J. McOmie Pdf

During the past decade there has been a great increase in the use of protective groups, especially in the synthesis of large and complex organic molecules. Perhaps the greatest activity has been in the peptide field where such triumphs as the total synthesis of insulin and of bovine ribonuclease (molecular weight 13,700) have been achieved. Correspondingly, more protective groups have been devised for the protection of amino and imino groups than for any other functional group. There are many reviews and books on the synthesis of pep tides but there has been no general survey of protective groups since my 1 own review in 1963. At that time the five main methods for the removal of protective groups involved acid or base hydroly sis, reduction, oxidation, or thermal elimination reactions. Recent advances include the use of photo-sensitive and metal ion sensitive protective groups, and the attachment of functional groups to reactive polymers as a method of protec tion during the solid-phase synthesis of peptides and poly nucleotides. Another interesting development is the design and use of protective groups with a built-in 'safety-catch', which can be 'released' by a specific chemical reaction, so that an otherwise stable bond is made labile at the appropriate moment thereby allowing the protective group to be removed under very 2 mild conditions. My own interest in protective groups dates from 1944 when, as a student, I gave two lectures on the subject and produced an 11 page review including 70 references.

Protecting Groups: Strategies and Applications in Carbohydrate Chemistry

Sebastien Vidal
Protecting Groups Strategies and Applications in Carbohydrate Chemistry Book PDF

Author : Sebastien Vidal
Publisher : John Wiley & Sons
Page : 522 pages
File Size : 46,5 Mb
Release : 2019-04-29
Category : Science
ISBN : 9783527340101

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Protecting Groups: Strategies and Applications in Carbohydrate Chemistry by Sebastien Vidal Pdf

A unique overview of the most important protecting group strategies in carbohydrate chemistry Protecting Groups: Strategies and Applications in Carbohydrate Chemistry provides a detailed account of key strategies and methodologies for the protection of carbohydrates. Divided into two parts, the first focuses on groups that are used best to protect a specific position on a carbohydrate. In the second part, specific carbohydrate residues or compounds are discussed in the context of a specific protecting group strategy used to reach the desired regioisomer. This important book: -Features chapters on protecting groups at the primary and secondary positions of carbohydrates -Describes protecting group strategies towards sialic acid derivatives, glycofuranoses, sulfated glycosaminoglycans, and cyclodextrins -Provides information on automated glycan assembly -Includes a chapter on the industrial scale synthesis of heparin analogs Written by a team of leaders in the field, Protecting Groups: Strategies and Applications in Carbohydrate Chemistry is an indispensable guide for academics and industrial researchers interested in carbohydrate and natural product synthesis, pharmaceutical chemistry, and biochemistry.

Protecting Groups in Organic Synthesis

James R. Hanson
Protecting Groups in Organic Synthesis Book PDF

Author : James R. Hanson
Publisher : Wiley-Blackwell
Page : 140 pages
File Size : 53,8 Mb
Release : 1999-11-15
Category : Science
ISBN : 185075957X

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Protecting Groups in Organic Synthesis by James R. Hanson Pdf

This volume provides, at postgraduate student level, an accessible introduction to a topic of central importance in organic synthesis. It covers the main functional groups requiring protection in organic synthesis, explaining why a particular protecting agent works and how an agent should be chosen. Emphasis is placed on what a protecting group is doing chemically to the structure that it is protecting. Attention is given to removal of the protecting group. This is a clear and thoughtful book, which concentrates on explaining the chemistry. It also provides a convenient point of entry to the primary literature.

Organic Synthesis

Michael B Smith
Organic Synthesis Book PDF

Author : Michael B Smith
Publisher : Academic Press
Page : 1106 pages
File Size : 45,6 Mb
Release : 2016-11-22
Category : Science
ISBN : 9780128008072

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Organic Synthesis by Michael B Smith Pdf

Organic Synthesis, Fourth Edition, provides a reaction-based approach to this important branch of organic chemistry. Updated and accessible, this eagerly-awaited revision offers a comprehensive foundation for graduate students coming from disparate backgrounds and knowledge levels, to provide them with critical working knowledge of basic reactions, stereochemistry and conformational principles. This reliable resource uniquely incorporates molecular modeling content, problems, and visualizations, and includes reaction examples and homework problems drawn from the latest in the current literature. In the Fourth Edition, the organization of the book has been improved to better serve students and professors and accommodate important updates in the field. The first chapter reviews basic retrosynthesis, conformations and stereochemistry. The next three chapters provide an introduction to and a review of functional group exchange reactions; these are followed by chapters reviewing protecting groups, oxidation and reduction reactions and reagents, hydroboration, selectivity in reactions. A separate chapter discusses strategies of organic synthesis, and he book then delves deeper in teaching the reactions required to actually complete a synthesis. Carbon-carbon bond formation reactions using both nucleophilic carbon reactions are presented, and then electrophilic carbon reactions, followed by pericyclic reactions and radical and carbene reactions. The important organometallic reactions have been consolidated into a single chapter. Finally, the chapter on combinatorial chemistry has been removed from the strategies chapter and placed in a separate chapter, along with valuable and forward-looking content on green organic chemistry, process chemistry and continuous flow chemistry. Throughout the text, Organic Synthesis, Fourth Edition utilizes Spartan-generated molecular models, class tested content, and useful pedagogical features to aid student study and retention, including Chapter Review Questions, and Homework Problems. PowerPoint© presentations and answer keys are also available online to support instructors. Fully revised and updated throughout, and teorganized into 19 chapters for a more cogent and versatile presentation of concepts Includes reaction examples taken from literature research reported between 2010-2015 Features new full-color art and new chapter content on process chemistry and green organic chemistry Offers valuable study and teaching tools, including Chapter Review Questions and Homework Problems for students; Lecture presentations and other useful material for qualified course instructors

Introduction to Strategies for Organic Synthesis

Laurie S. Starkey
Introduction to Strategies for Organic Synthesis Book PDF

Author : Laurie S. Starkey
Publisher : John Wiley & Sons
Page : 360 pages
File Size : 53,8 Mb
Release : 2012-01-18
Category : Science
ISBN : 9781118180853

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Introduction to Strategies for Organic Synthesis by Laurie S. Starkey Pdf

The stepping-stone text for students with a preliminary knowledge of organic chemistry looking to move into organic synthesis research and graduate-level coursework Organic synthesis is an advanced but important field of organic chemistry, however resources for advanced undergraduates and graduate students moving from introductory organic chemistry courses to organic synthesis research are scarce. Introduction to Strategies for Organic Synthesis is designed to fill this void, teaching practical skills for making logical retrosynthetic disconnections, while reviewing basic organic transformations, reactions, and reactivities. Divided into seven parts that include sections on Retrosynthesis and Protective Groups; Overview of Organic Transformations; Synthesis of Monofunctional Target Molecules; Synthesis of Target Molecules with Two Functional Groups; Synthesis of Aromatic Target Molecules; Synthesis of Compounds Containing Rings; and Predicting and Controlling Stereochemistry, the book covers everything students need to successfully perform retrosynthetic analyses of target molecule synthesis. Starting with a review of functional group transformations, reagents, and reaction mechanisms, the book demonstrates how to plan a synthesis, explaining functional group analysis and strategic disconnections. Incorporating a review of the organic reactions covered, it also demonstrates each reaction from a synthetic chemist's point of view, to provide students with a clearer understanding of how retrosynthetic disconnections are made. Including detailed solutions to over 300 problems, worked-through examples and end-of-chapter comprehension problems, Introduction to Strategies for Organic Synthesis serves as a stepping stone for students with an introductory knowledge of organic chemistry looking to progress to more advanced synthetic concepts and methodologies.

Organic Chemistry: 100 Must-Know Mechanisms

Roman Valiulin
Organic Chemistry 100 Must Know Mechanisms Book PDF

Author : Roman Valiulin
Publisher : Walter de Gruyter GmbH & Co KG
Page : 249 pages
File Size : 49,7 Mb
Release : 2020-04-20
Category : Science
ISBN : 9783110608373

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Organic Chemistry: 100 Must-Know Mechanisms by Roman Valiulin Pdf

This book summarizes 100 essential mechanisms in organic chemistry ranging from classical such as the Reformatsky Reaction from 1887 to recently elucidated mechanism such as the copper(I)-catalyzed alkyne-azide cycloaddition. The reactions are easy to grasp, well-illustrated and underpinned with explanations and additional information.

Designing Organic Syntheses

Stuart Warren
Designing Organic Syntheses Book PDF

Author : Stuart Warren
Publisher : John Wiley & Sons
Page : 298 pages
File Size : 42,7 Mb
Release : 1991-01-08
Category : Science
ISBN : 0471996122

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Designing Organic Syntheses by Stuart Warren Pdf

Teaches students to use the language of sythesis directly (utilizing the grammar of synthon and disconnection) rather than translating it into that of organic chemistry.

Glycoscience

Bertram O. Fraser-Reid,Kuniaki Tatsuta,Joachim Thiem
Glycoscience Book PDF

Author : Bertram O. Fraser-Reid,Kuniaki Tatsuta,Joachim Thiem
Publisher : Springer Science & Business Media
Page : 2847 pages
File Size : 42,9 Mb
Release : 2008-04-14
Category : Science
ISBN : 9783540361541

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Glycoscience by Bertram O. Fraser-Reid,Kuniaki Tatsuta,Joachim Thiem Pdf

As a reflection of the quantum leap that has been made in the study of glycostructures, the first edition of this book has been completely revised and updated. The editors give up-to-date information on glycostructures, their chemistry and chemical biology in the form of a completely comprehensive survey. Glycostructures play highly diverse and crucial roles in a myriad of organisms and important systems in biology, physiology, medicine, bioengineering and technology. Only in recent years have the tools been developed to partly understand the highly complex functions and the chemistry behind them. While many facts remain undiscovered, this MRW has been contributed to by a large number of the world’s leading researchers in the field.

Modern Organic Synthesis

George S. Zweifel,Michael H. Nantz,Peter Somfai
Modern Organic Synthesis Book PDF

Author : George S. Zweifel,Michael H. Nantz,Peter Somfai
Publisher : John Wiley & Sons
Page : 416 pages
File Size : 47,7 Mb
Release : 2017-03-13
Category : Science
ISBN : 9781119086765

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Modern Organic Synthesis by George S. Zweifel,Michael H. Nantz,Peter Somfai Pdf

This book bridges the gap between sophomore and advanced / graduate level organic chemistry courses, providing students with a necessary background to begin research in either an industry or academic environment. • Covers key concepts that include retrosynthesis, conformational analysis, and functional group transformations as well as presents the latest developments in organometallic chemistry and C–C bond formation • Uses a concise and easy-to-read style, with many illustrated examples • Updates material, examples, and references from the first edition • Adds coverage of organocatalysts and organometallic reagents

Total Synthesis of Natural Products

Jie Jack Li,E.J. Corey
Total Synthesis of Natural Products Book PDF

Author : Jie Jack Li,E.J. Corey
Publisher : Springer Science & Business Media
Page : 292 pages
File Size : 50,7 Mb
Release : 2013-03-14
Category : Science
ISBN : 9783642340659

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Total Synthesis of Natural Products by Jie Jack Li,E.J. Corey Pdf

'Total Synthesis of Natural Products' is written and edited by some of today's leaders in organic chemistry. Eleven chapters cover a range of natural products, from steroids to alkaloids. Each chapter contains an introduction to the natural product in question, descriptions of its biological and pharmacological properties and outlines of total synthesis procedures already carried out. Particular emphasis is placed on novel methodologies developed by the respective authors and their research groups. This text is ideal for graduate and advanced undergraduate students, as well as organic chemists in academia and industry.

Strategic Applications of Named Reactions in Organic Synthesis

Laszlo Kurti,Barbara Czako
Strategic Applications of Named Reactions in Organic Synthesis Book PDF

Author : Laszlo Kurti,Barbara Czako
Publisher : Elsevier
Page : 808 pages
File Size : 50,9 Mb
Release : 2005-04-29
Category : Science
ISBN : 9780080575414

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Strategic Applications of Named Reactions in Organic Synthesis by Laszlo Kurti,Barbara Czako Pdf

Kurti and Czako have produced an indispensable tool for specialists and non-specialists in organic chemistry. This innovative reference work includes 250 organic reactions and their strategic use in the synthesis of complex natural and unnatural products. Reactions are thoroughly discussed in a convenient, two-page layout--using full color. Its comprehensive coverage, superb organization, quality of presentation, and wealth of references, make this a necessity for every organic chemist. * The first reference work on named reactions to present colored schemes for easier understanding* 250 frequently used named reactions are presented in a convenient two-page layout with numerous examples* An opening list of abbreviations includes both structures and chemical names * Contains more than 10,000 references grouped by seminal papers, reviews, modifications, and theoretical works * Appendices list reactions in order of discovery, group by contemporary usage, and provide additional study tools* Extensive index quickly locates information using words found in text and drawings