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Author : David R. Brown Publisher : Springer Science & Business Media Page : 463 pages File Size : 55,5 Mb Release : 2012-12-06 Category : Medical ISBN : 9783642778148
Gastrointestinal Regulatory Peptides by David R. Brown Pdf
The most comprehensive and conceptual one-volume treatment of this field available and the first to emphasize the cellular and molecular aspects of gut peptide biology. Authored by an array of internationally distinguished scientists, it deals with issues of peptide localization and biosynthesis in gastrointestinal cells, mechanisms of peptide release and inactivation and the nature of peptide receptors. The breadth and readability make it an invaluable reference source for scientists in all disciplines interested in any aspect of brain-gut peptides.
Provides a comprehensive approach to gastrointestinal hormones, for clinicians and scientists who are interested in hormonal regulation of the gastrointestinal tract. The first section discusses general issues related to peptides as messengers, including receptors and signal transduction and control of gene expression. The second section presents the biochemical and physiological features of the gastrointestinal hormones and neuropeptides. The third section integrates these peptides into physiological and pathophysiological regulatory pathways of the gut. Annotation copyright by Book News, Inc., Portland, OR
Brain-gut Peptides and Reproductive Function by Charles D. Barnes,Craig Johnston Pdf
This book elucidates the role of brain-gut peptides in neuroendocrine regulation for understanding how these peptides interact with the reproductive neuroendocrine axis and for developing novel therapeutic agents for fertility or contraceptive therapies.
Peptide Transport in Bacteria and Mammalian Gut by Katherine Elliott,Maeve O'Connor Pdf
The Novartis Foundation Series is a popular collection of the proceedings from Novartis Foundation Symposia, in which groups of leading scientists from a range of topics across biology, chemistry and medicine assembled to present papers and discuss results. The Novartis Foundation, originally known as the Ciba Foundation, is well known to scientists and clinicians around the world.
Leading clinical and basic science researchers present the latest molecular and cellular findings on key gut peptides, illuminating their physiology and pathophysiology, as well as highlighting the regulatory mechanisms underlying their action in the intestinal tract. The book focuses on gut peptide physiology and receptor pharmacology, gut processing and receptor biology, and on regulatory mechanisms in the gut, including pancreatic feedback mechanisms. Also included are chapters on the trophic effects of gut peptides on GI and pancreatic cancer; the regulation of gut peptide gene expression; and gastric secretion, especially in diseased states.
Antimicrobial Peptides in Gastrointestinal Diseases by Chi Hin Cho Pdf
Antimicrobial peptides (AMPs), including cathelicidins and defensins are host defence peptides that carry out multiple roles in the gastrointestinal (GI) tract. Antimicrobial Peptides in Gastrointestinal Diseases presents knowledge about the physiological functions and pharmacological actions of AMPs in inflammation, cancer, and further infection of the GI tract. The book provides coverage from the basic research to clinical application for GI diseases. Current research and development of AMPs is presented, opening the way for further work on these peptides, not only in the context of GI diseases, but also for similar pathologies in other organs. AMPs are key to the regulation of human microbiome and second line defence in the GI mucosa, prevent colonization of pathogens and modulation of innate response to invading pathogens, and modify immunological reactions during inflammatory processes and oncogenic development in the GI mucosa. More importantly, AMPs possess diversified anti-microbial actions against various infectious diseases in the GI tract. With these physiological functions and pharmacological actions, AMPs have significant potential as therapeutic agents for the treatment of inflammation, cancer and further infection in the GI tract. Provides an overview of AMPs, particularly cathelicidin and defensin, in different diseases Covers inflammation and ulcer repair in the stomach and colon and carcinogenesis in the GI tract Presents AMP information and knowledge in a concise manner Gives useful information on all aspects of AMPs Promotes research on AMPs and their development as drugs, from bench, to clinical application
Regulation of Gastrointestinal Mucosal Growth by Rao N. Jaladanki,Jian-Ying Wang Pdf
The mammalian gastrointestinal mucosa is a rapidly self-renewing tissue in the body, and its homeostasis is preserved through the strict regulation of epithelial cell proliferation, growth arrest, and apoptosis. The control of the growth of gastrointestinal mucosa is unique and, compared with most other tissue in the body, complex. Mucosal growth is regulated by the same hormones that alter metabolism in other tissues, but the gastrointestinal mucosa also responds to host events triggered by the ingestion and presence of food within the digestive tract. These gut hormones and peptides regulate the growth of the exocrine pancreas, gallbladder epithelium, and the mucosa of the oxyntic gland region of the stomach and the small and large intestines. Luminal factors, including nutrients or other dietary factors, secretions, and microbes that occur within the lumen and distribute over a proximal-to-distal gradient, are also crucial for maintenance of normal gut mucosal regeneration and could explain the villous-height-crypt-depth gradient and variety of adaptation, since these factors are diluted, absorbed, and destroyed as they pass down the digestive tract. Recently, intestinal stem cells, cellular polyamines, and noncoding RNAs are shown to play an important role in the regulation of gastrointestinal mucosal growth under physiological and various pathological conditions. In this book, we highlight key issues and factors that control gastrointestinal mucosal growth and homeostasis, with special emphasis on the mechanisms through which epithelial renewal and apoptosis are regulated at the cellular and molecular levels.
The Insulinotropic Gut Hormone Glucagon-like Peptide-1 by Hans-Christoph Fehmann,Burkhard Göke Pdf
Glucagon-like peptide-1 (GLP-1) is a promising new therapeutic tool for the treatment of diabetes. Since the first reports describing its potent insulinotropic activity were published about a decade ago, knowledge of the incretin hormones, and GLP-1 in particular, has increased significantly. This timely volume summarizes what is now known about the molecular biology, physiology and pharmacology of GLP-1. Thorough coverage is given to the physiology of the hormone, including its generation, release and actions at pancreatic and extrapancreatic tissues. The intracellular mechanisms of GLP-1 are also described in detail. Discussion of the molecular biology includes the structure and functions of the genes coding for proglucagon and the GLP-1 receptor. A special feature of the book is the clinical information provided which includes data on the expression and release of GLP-1 and its potential use as a therapeutic agent for diabetes. Presenting the results of exciting new research, this book will be a valuable reference for endocrinologists, gastroenterologists, pharmacologists, physiologists and biochemists interested in this important hormone.
Gut-brain Peptides in the New Millennium by John H. Walsh Pdf
Dr. John Walsh was a towering figure in gastroenterology and had a profound impact on the study of gut-brain peptides in health and diseases. This commemorative book contains a collection of papers by former trainees and collaborators, which reflect the wide array of investigations to which Dr. Walsh brought his keen intellectual influence and support
The Comparative Physiology of Regulatory Peptides by Susanne Holmgren Pdf
Strictly speaking, the term regulatory peptides may include any peptide which has a regulatory function in any organism. In recent years, how ever, the term has come to mean those originally classified as brain-gut peptides. The peptides initially defined as those belonging to the brain gut axis had a dual location in neurones of the brain and endocrine cells of the gut. We now include a number of neuropeptides found in the autonomic nervous system of the gut, the cardiovascular system and other systems. To many scientists comparative physiology means comparison of the mechanisms of certain functions in the rat, the guinea-pig, the cat and maybe some other mammal. If the philosophy is that man is the centre of the universe and other mammals can be used as 'models' of man, this may well be the most useful way to study the functions of the human being, without actually chopping somebody up. However, with a some what wider perspective on life, it is easy to see the importance of a full understanding of the function of all living organisms, in its own right as well as a link in the evolution towards individuals able to survive and reproduce in very different environments. The importance of com parative studies in all living organisms cannot be emphasized too much. It has been the ambition with this book to treat all animals as equally important.
Vasoactive Intestinal Peptides Pituitary Adenylate Cyclase Activating Polypeptide And Related Regulatory Peptides: From Molecular Biology To Clinical Applications by G Rosselin Pdf
This book provides the most up-to-date information on the ever-growing class of peptides with high biological activity, which function as hormones or neurotransmitters and have analogous structures. These peptides include the Vasoactive Intestinal Peptide (VIP), the Pituitary Adenylate Cyclase-Activating Polypeptides (PACAP 38 and PACAP 27), the Peptide Histidyl-Isoleucylamide and the Histidyl-Methionine Peptide (PHI and PHM), Helodermin, Helospectin, the Growth Hormone Releasing Factor (GRF), Glucagon, the Glucagon-like Peptides I and II, Oxyntomodulin, Glicentin and Secretin.Selection, organization and special subject matter: The contributors to this volume who are leading experts in their fields, present a valuable synopsis of the significant research in the transduction of the peptide signals, and how it helps to maintain the essential environment for cellular functions and adaptation. Contributions are organized around the molecular systems involved in the normal and altered functions of the central nervous system, the endocrine systems and cellular proliferation. In addition, the book identifies potential sites to be targeted for drug design and therapeutic development in the domain of biosynthesis, inflammation and cardiovascular and digestive diseases.This book draws together information from widely-scattered literature and thus obviates the need for time-consuming research on the part of the readers. It is aimed at an international audience of pharmacologists, physiologists, clinical investigators, biochemists and researchers.
