The Insulinotropic Gut Hormone Glucagon Like Peptide 1

Author : Hans-Christoph Fehmann,Burkhard Göke
Publisher : Karger Medical and Scientific Publishers
Page : 250 pages
File Size : 53,5 Mb
Release : 1997
Category : Medical
ISBN : 9783805561655

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The Insulinotropic Gut Hormone Glucagon-like Peptide-1 by Hans-Christoph Fehmann,Burkhard Göke Pdf

Glucagon-like peptide-1 (GLP-1) is a promising new therapeutic tool for the treatment of diabetes. Since the first reports describing its potent insulinotropic activity were published about a decade ago, knowledge of the incretin hormones, and GLP-1 in particular, has increased significantly. This timely volume summarizes what is now known about the molecular biology, physiology and pharmacology of GLP-1. Thorough coverage is given to the physiology of the hormone, including its generation, release and actions at pancreatic and extrapancreatic tissues. The intracellular mechanisms of GLP-1 are also described in detail. Discussion of the molecular biology includes the structure and functions of the genes coding for proglucagon and the GLP-1 receptor. A special feature of the book is the clinical information provided which includes data on the expression and release of GLP-1 and its potential use as a therapeutic agent for diabetes. Presenting the results of exciting new research, this book will be a valuable reference for endocrinologists, gastroenterologists, pharmacologists, physiologists and biochemists interested in this important hormone.

Author : Werner Creutzfeldt
Publisher : S. Karger AG (Switzerland)
Page : 328 pages
File Size : 51,5 Mb
Release : 1980
Category : Medical
ISBN : UOM:39015003217927

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The Entero-insular Axis by Werner Creutzfeldt Pdf

Author : Stephen Robert Bloom,Julia M. Polak
Publisher : Unknown
Page : 640 pages
File Size : 49,7 Mb
Release : 1981
Category : Gastrointestinal hormones
ISBN : UOM:39015004413145

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Gut Hormones by Stephen Robert Bloom,Julia M. Polak Pdf

Author : Anonim
Publisher : ScholarlyEditions
Page : 62 pages
File Size : 46,5 Mb
Release : 2012-01-09
Category : Medical
ISBN : 9781464942389

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Glucagon-Like Peptides: Advances in Research and Application: 2011 Edition by Anonim Pdf

Glucagon-Like Peptides: Advances in Research and Application: 2011 Edition is a ScholarlyBrief™ that delivers timely, authoritative, comprehensive, and specialized information about Glucagon-Like Peptides in a concise format. The editors have built Glucagon-Like Peptides: Advances in Research and Application: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Glucagon-Like Peptides in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Glucagon-Like Peptides: Advances in Research and Application: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Author : Silvano Paternoster,Damien Keating,Marco Falasca
Publisher : Frontiers Media SA
Page : 123 pages
File Size : 55,9 Mb
Release : 2019-12-19
Category : Electronic
ISBN : 9782889631674

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Gastrointestinal Hormones by Silvano Paternoster,Damien Keating,Marco Falasca Pdf

Author : Solomon Habtemariam
Publisher : Academic Press
Page : 1180 pages
File Size : 54,8 Mb
Release : 2019-06-08
Category : Medical
ISBN : 9780081029237

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Medicinal Foods as Potential Therapies for Type-2 Diabetes and Associated Diseases by Solomon Habtemariam Pdf

Medicinal Foods as Potential Therapies for Type-2 Diabetes and Associated Diseases: The Chemical and Pharmacological Basis of their Action focuses on active pharmacological principles that modulate diabetes, associated risk factors, complications and the mechanism of action of widely used anti-diabetic herbal plants—rather than just the nutritional composition of certain foods. The book provides up-to-date information on acclaimed antidiabetic super fruits, spices and other food ingredients. Sections cover diabetes and obesity at the global level, the physiological control of carbohydrate and lipid metabolism, the pathophysiology of type-2 diabetes, the chemistry and pharmacology of a variety of spices, and much more. This book will be invaluable for research scientists and students in the medical and pharmaceutical sciences, medicinal chemistry, herbal medicine, drug discovery/development, nutrition science, and for herbal practitioners and those from the nutraceutical and pharm industries. Provides background knowledge on type-2 diabetes and its pathophysiology and therapeutic targets down to the molecular level Explores, in detail, the chemistry or secondary metabolites of the indicated foods that potentially modify diabetes and/or associated diseases Examines the pharmacological findings on medicinal foods, including available clinical trials

Author : M. Wabitsch,C. Posovszky
Publisher : Karger Medical and Scientific Publishers
Page : 188 pages
File Size : 51,7 Mb
Release : 2017-08-16
Category : Medical
ISBN : 9783318059748

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Developmental Biology of Gastrointestinal Hormones by M. Wabitsch,C. Posovszky Pdf

The gut not only represents the largest endocrine organ of the human body but is also profoundly involved in the control of metabolism through peptide hormones. Therefore, gastrointestinal hormones are acting via autocrine, paracrine, and classical endocrine pathways and regulate e.g. digestion, hunger, and satiety. Furthermore, they are important regulators of body weight, growth, and glucose metabolism, as well as of mood and behavior. Physicians and scientists in the field of pediatric endocrinology and diabetes, as well as in pediatric gastroenterology, require an extensive understanding of the origin of enteroendocrine cells, factors controlling their differentiation, hormone gene expression, secretion, function and, finally, the complex interaction with other organs, especially the central nervous system. In order to meet these needs, experts in the field have written up-to-date, comprehensive, and illustrated reviews presenting the current knowledge in the field of gastrointestinal endocrinology with a pediatric view. Those reviews comprise this latest volume of Endocrine Development.

Author : Anonim
Publisher : Unknown
Page : 128 pages
File Size : 50,6 Mb
Release : 19??
Category : Electronic
ISBN : 1461464382

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Encyclopedia of Signaling Molecules by Anonim Pdf

Author : Kitty Verhoeckx,Paul Cotter,Iván López-Expósito,Charlotte Kleiveland,Tor Lea,Alan Mackie,Teresa Requena,Dominika Swiatecka,Harry Wichers
Publisher : Springer
Page : 338 pages
File Size : 47,9 Mb
Release : 2015-04-29
Category : Technology & Engineering
ISBN : 9783319161044

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The Impact of Food Bioactives on Health by Kitty Verhoeckx,Paul Cotter,Iván López-Expósito,Charlotte Kleiveland,Tor Lea,Alan Mackie,Teresa Requena,Dominika Swiatecka,Harry Wichers Pdf

“Infogest” (Improving Health Properties of Food by Sharing our Knowledge on the Digestive Process) is an EU COST action/network in the domain of Food and Agriculture that will last for 4 years from April 4, 2011. Infogest aims at building an open international network of institutes undertaking multidisciplinary basic research on food digestion gathering scientists from different origins (food scientists, gut physiologists, nutritionists...). The network gathers 70 partners from academia, corresponding to a total of 29 countries. The three main scientific goals are: Identify the beneficial food components released in the gut during digestion; Support the effect of beneficial food components on human health; Promote harmonization of currently used digestion models Infogest meetings highlighted the need for a publication that would provide researchers with an insight into the advantages and disadvantages associated with the use of respective in vitro and ex vivo assays to evaluate the effects of foods and food bioactives on health. Such assays are particularly important in situations where a large number of foods/bioactives need to be screened rapidly and in a cost effective manner in order to ultimately identify lead foods/bioactives that can be the subject of in vivo assays. The book is an asset to researchers wishing to study the health benefits of their foods and food bioactives of interest and highlights which in vitro/ex vivo assays are of greatest relevance to their goals, what sort of outputs/data can be generated and, as noted above, highlight the strengths and weaknesses of the various assays. It is also an important resource for undergraduate students in the ‘food and health’ arena.

Author : H. Maurice Goodman
Publisher : Lippincott Williams & Wilkins
Page : 360 pages
File Size : 40,6 Mb
Release : 1994
Category : Medical
ISBN : UOM:39015028937723

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Basic Medical Endocrinology by H. Maurice Goodman Pdf

Author : Jonathan C. Schisler,Charles H Lang,Monte Willis
Publisher : Academic Press
Page : 378 pages
File Size : 49,5 Mb
Release : 2016-10-19
Category : Medical
ISBN : 9780128031124

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Endocrinology of the Heart in Health and Disease by Jonathan C. Schisler,Charles H Lang,Monte Willis Pdf

Endocrinology of the Heart in Health and Disease: Integrated, Cellular, and Molecular Endocrinology of the Heart covers the traditional concepts of cardio-endocrinology, the role of the various hormone systems, both in health and disease, therapeutic implications, and other recent advances in the various fields represented. The book explores how cardiac hormones are changed in various cardiac pathologies and the recent success that has been uncovered in their therapeutic use. Additional focus is placed on how the heart responds both physiologically and pathophysiologically to a plethora of circulating hormones, reinforcing the importance of the heart as a target of numerous endocrine systems, such as the brain, renal, and adipose. Significant advances have come from basic, clinical, and translational research from a multiplicity of investigators with diverse backgrounds. The book features over 200 photomicrographs, diagrams of molecular relationships, and tables that complement and support the text. It is aimed at a wide audience, including graduate students and post-doctoral fellows in a wide array of biomedical departments and PhD programs (e.g. Pathology, Physiology, Genetics, Pharmacology, Molecular Biology, and Cell Biology) related to the endocrine and cardiovascular sciences curricula, as well as medical residents in pathology, laboratory medicine, internal medicine, and cardiology. Develops the concept of the heart as both an endocrine organ and an endocrine target, exploring the endocrine function of the heart in both health and disease Explains how the levels of several cardiac hormones are changed in various cardiac pathologies and how some hormones can be used therapeutically Offers a single resource on cardio-endocrine disease which collates and curates the wide range of advances being made in the areas of molecular biology, biochemistry, physiology, and pathology

Author : Monica Fedele
Publisher : BoD – Books on Demand
Page : 278 pages
File Size : 48,8 Mb
Release : 2013-05-08
Category : Medical
ISBN : 9789535110804

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Hot Topics in Endocrine and Endocrine-Related Diseases by Monica Fedele Pdf

This book covers a selected number of hot topics in endocrine and hormone-related pathologies, discussed by eminent scientists and clinicians coming from different countries of the world. It deals with advanced recent trends in the field, including neuroendocrine and pituitary tumors, thyroid dysfunctions, diabetes and a series of endocrine-related diseases, such as those related to the anabolic effects of testosterone, obesity, cancer, the liver complications of diabetes and the pediatric nonalcoholic fatty liver disease. The readers should be able to have a basic, as well as critic and advanced, overview of these selected hot pathologies of the endocrine system.

Author : John H. Walsh,G. J. Dockray
Publisher : Raven Press (ID)
Page : 904 pages
File Size : 50,6 Mb
Release : 1994
Category : Medical
ISBN : UOM:39015032878392

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Gut Peptides by John H. Walsh,G. J. Dockray Pdf

Provides a comprehensive approach to gastrointestinal hormones, for clinicians and scientists who are interested in hormonal regulation of the gastrointestinal tract. The first section discusses general issues related to peptides as messengers, including receptors and signal transduction and control of gene expression. The second section presents the biochemical and physiological features of the gastrointestinal hormones and neuropeptides. The third section integrates these peptides into physiological and pathophysiological regulatory pathways of the gut. Annotation copyright by Book News, Inc., Portland, OR

Author : C. Robin Ganellin,Roy Jefferis,Stanley M. Roberts
Publisher : Academic Press
Page : 472 pages
File Size : 43,5 Mb
Release : 2013-05-07
Category : Science
ISBN : 9780123977700

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Introduction to Biological and Small Molecule Drug Research and Development by C. Robin Ganellin,Roy Jefferis,Stanley M. Roberts Pdf

Introduction to Biological and Small Molecule Drug Research and Development provides, for the first time, an introduction to the science behind successful pharmaceutical research and development programs. The book explains basic principles, then compares and contrasts approaches to both biopharmaceuticals (proteins) and small molecule drugs, presenting an overview of the business and management issues of these approaches. The latter part of the book provides carefully selected real-life case studies illustrating how the theory presented in the first part of the book is actually put into practice. Studies include Herceptin/T-DM1, erythropoietin (Epogen/Eprex/NeoRecormon), anti-HIV protease inhibitor Darunavir, and more. Introduction to Biological and Small Molecule Drug Research and Development is intended for late-stage undergraduates or postgraduates studying chemistry (at the biology interface), biochemistry, medicine, pharmacy, medicine, or allied subjects. The book is also useful in a wide variety of science degree courses, in post-graduate taught material (Masters and PhD), and as basic background reading for scientists in the pharmaceutical industry. For the first time, the fundamental scientific principles of biopharmaceuticals and small molecule chemotherapeutics are discussed side-by-side at a basic level Edited by three senior scientists with over 100 years of experience in drug research who have compiled the best scientific comparison of small molecule and biopharmaceuticals approaches to new drugs Illustrated with key examples of important drugs that exemplify the basic principles of pharmaceutical drug research and development

Author : Abba Kastin,Abba J. Kastin
Publisher : Elsevier
Page : 1682 pages
File Size : 55,9 Mb
Release : 2011-04-28
Category : Science
ISBN : 9780080463797

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Handbook of Biologically Active Peptides by Abba Kastin,Abba J. Kastin Pdf

Peptides play a crucial role in many physiological processes including actions as neurotransmitters, hormones, and antibiotics. Research has shown their importance in such fields as neuroscience, immunology, pharmacology, and cell biology. The Handbook of Biologically Active Peptides presents, for the first time, this tremendous body of knowledge in the field of biologically active peptides in one single reference. The section editors and contributors represent some of the most sophisticated and distinguished scientists working in basic sciences and clinical medicine. The Handbook of Biologically Active Peptides is a definitive, all-encompassing reference that will be indispensable for individuals ranging from peptide researchers, to biochemists, cell and molecular biologists, neuroscientists, pharmacologists, and to endocrinologists. Chapters are designed to be a source for workers in the field and will enable researchers working in a specific area to examine other related areas with which they would not ordinarily be familiar. *Chapters are designed to be a source for workers in the field and will enable researchers working in a specific area to examine other related areas that they would not ordinarily be familiar.*Fascinating relationships described in the book include the presence of some peptides originally found in frog skin that persist in the human human and brain where they can affect food intake and obesity.