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Handbook of Basic Pharmacokinetics-- Including Clinical Applications by Wolfgang A. Ritschel,Gregory L. Kearns Pdf
First published in 1976, this, 7th edition remains a user-friendly consolidation of principles and techniques for practitioners, researchers, and students involved in the various applications of pharmacokinetics. The book is current, accurate, and presented in a manner that fosters clinical application.
Handbook of Essential Pharmacokinetics, Pharmacodynamics and Drug Metabolism for Industrial Scientists by Younggil Kwon Pdf
In the pharmaceutical industry, the incorporation of the disciplines of pharma- kinetics, pharmacodynamics, and drug metabolism (PK/PD/DM) into various drug development processes has been recognized to be extremely important for approp- ate compound selection and optimization. During discovery phases, the identifi- tion of the critical PK/PD/DM issues of new compounds plays an essential role in understanding their pharmacological profiles and structure-activity relationships. Owing to recent progress in analytical chemistry, a large number of compounds can be screened for their PK/PD/DM properties within a relatively short period of time. During development phases as well, the toxicology and clinical study designs and trials of a compound should be based on a thorough understanding of its PK/PD/DM properties. During my time as an industrial scientist, I realized that a reference work designed for practical industrial applications of PK/PD/DM could be a very valuable tool for researchers not only in the pharmacokinetics and drug metabolism departments, but also for other discovery and development groups in pharmaceutical companies. This book is designed specifically for industrial scientists, laboratory assistants, and managers who are involved in PK/PD/DM-related areas. It consists of thirteen chapters, each of which deals with a particular PK/PD/DM issue and its industrial applications. Chapters 3 and 12 in particular address recent topics on higher throughput in vivo exposure screening and the prediction of pharmacokinetics in humans, respectively. Chapter 8 covers essential information on drug metabolism for industrial scientists.
Pharmacokinetics: Basics to Applications by Biswajit Mukherjee Pdf
This textbook covers all the essential elements of pharmacokinetics, from basics to applications. It describes authoritative equations and methods on pharmacokinetic evaluation procedures with their importance. Each chapter of the book is supplemented with numerous illustrations and figures for easy understanding of the subject. The book presents mathematical techniques, step- by-step descriptive equations, and applicable statistical analysis methods for the easy understanding of the topic. Further, it covers the preclinical applications and methods of pharmacokinetic aspects. The book also contains mathematical problems and questions related to pharmacokinetics for students. Special emphasis is on recent pharmacokinetic methods and their applications for managing clinical data and biostatistical approaches based on the current literature. This book is primarily meant for researchers and students from academic institutions and to R&D professionals.
Clinical Pharmacokinetics Handbook by Larry Bauer Pdf
Designed for pharmacists and clinicians responsible for adjusting drug dosages based on the patient blood serum concentrations and other parameters, this indispensable, portable reference offers a variety of ways to perform pharmacokinetic calculations. Features calculation methods, algorithms for choosing the best calculation method, and case studies.
Handbook of Clinical Pharmacokinetic Data by David B. Jack Pdf
This compendium of essential drug data helps when planning clinical research projects and choosing drugs with specific properties. As well as covering established drugs, data is presented on compounds about to be marketed or in the last stages of clinical development.
This book introduces basic pharmacokinetic concepts to beginner learners to help them understand the absorption, distribution, metabolism, and excretion of drugs. After a basic introduction to pharmacokinetics and its related fields, the book provides a clear introduction to quantitative pharmacokinetic relations and the interplay between pharmacokinetic parameters after different routes of drug administration. Emphasizing the application and importance of pharmacokinetic concepts in clinical practice throughout, the book features: A clear, simple, and concise style with the use of graphs and simulations to aid learning. Bullet point summaries of each concept to demonstrate applications in clinical practice. Practice problems and solved examples to help the reader understand the best approach for calculating pharmacokinetic parameters. A glossary of key words and acronyms. This book is an essential read for undergraduate and graduate pharmacokinetic students in pharmacy, pharmacology, and pharmaceutical science programs worldwide. Accompanying the book is a website with self-instructional tutorials and pharmacokinetic simulations, allowing visualization of concepts for enhanced comprehension. This learning tool received an award from the American Association of Colleges of Pharmacy for innovation in teaching, making it a valuable supplement to this textbook.
Basic Pharmacokinetics, Second Edition by Mohsen A. Hedaya Pdf
Knowledge of pharmacokinetics is critical to understanding the absorption, distribution, metabolism, and excretion of drugs. It is therefore vital to those engaged in the discovery, development, and preclinical and clinical evaluation of drugs, as well as practitioners involved in the clinical use of drugs. Using different approaches accessible to a wide variety of readers, Basic Pharmacokinetics: Second Edition demonstrates the quantitative pharmacokinetic relations and the interplay between pharmacokinetic parameters. After a basic introduction to pharmacokinetics and its related fields, the book examines: Mathematical operations commonly used in pharmacokinetics Drug distribution and clearance and how they affect the rate of drug elimination after a single dose Factors affecting drug absorption following extravascular drug administration, the rate and extent of drug absorption, and drug bioequivalence The steady-state concept during constant rate intravenous infusion and during multiple drug administration Renal drug elimination, drug metabolism, multicompartment models, nonlinear pharmacokinetics, and drug administration by intermittent intravenous infusion Pharmacokinetic-pharmacodynamic modeling, noncompartmental pharmacokinetic data analysis, clearance concept from the physiological point of view, and physiological modeling Clinical applications of pharmacokinetics, including therapeutic drug monitoring, drug pharmacokinetics in special populations, pharmacokinetic drug-drug interactions, pharmacogenomics, and applications of computers in pharmacokinetics Accompanying the book is a CD-ROM with self-instructional tutorials and pharmacokinetic and pharmacokinetic-pharmacodynamic simulations, allowing visualization of concepts for enhanced comprehension. This learning tool received an award from the American Association of Colleges of Pharmacy for innovation in teaching, making it a valuable supplement to this essential text.
Pharmacokinetics and Toxicokinetics by Mehdi Boroujerdi Pdf
Pharmacokinetics and Toxicokinetics provides an overview of pharmacokinetics and toxicokinetics in a comprehensible, interrelated, and applied manner. It integrates the principles held in common by both fields through a logical and systematic approach. The book presents mathematical descriptions of physiological processes employed in different appr
Basic Clinical Pharmacokinetics Handbook by John R. White,Mark W. Garrison Pdf
Designed as a portable companion to Michael E. Winter's classic text, Basic Clinical Pharmacokinetics Handbook is a must for busy practitioners who need a fast-access reference to the specific parameters and equations required for pharmacokinetic evaluations. Part One of the handbook provides common pharmacokinetic equations along with discussions on choosing the appropriate equation for a given situation. Basic pharmacokinetic principles, assessment of renal function, and dialysis of drugs are also discussed in detail. Part Two presents pharmacokinetic data for specific drugs, including aminoglycosides, carbamazepine, cyclic antidepressants, cyclosporine, digoxin, ethosuximide, lidocaine, lithium, methotrexate, phenobarbital, phenytoin, procainamide, primidone, quinidine, salicylates, theophylline, valproic acid, and vancomycin. Appendices contain common abbreviations and a glossary of pharmacokinetic terms.
