Handbook Of Downstream Processing

Author : E. Goldberg
Publisher : Springer Science & Business Media
Page : 745 pages
File Size : 42,5 Mb
Release : 2012-12-06
Category : Science
ISBN : 9789400915633

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Handbook of Downstream Processing by E. Goldberg Pdf

The last two decades have seen a phenomenal growth of the field of genetic or biochemical engineering and have witnessed the development and ultimately marketing of a variety of products-typically through the manipulation and growth of different types of microorganisms, followed by the recovery and purification of the associated products. The engineers and biotechnologists who are involved in the full-scale process design of such facilities must be familiar with the variety of unit operations and equipment and the applicable regulatory requirements. This book describes current commercial practice and will be useful to those engineers working in this field in the design, construction and operation of pharmaceutical and biotechnology plants. It will be of help to the chemical or pharmaceutical engineer who is developing a plant design and who faces issues such as: Should the process be batch or continuous or a combination of batch and continuous? How should the optimum process design be developed? Should one employ a new revolutionary separation which could be potentially difficult to validate or use accepted technology which involves less risk? Should the process be run with ingredients formulated from water for injection, deionized water, or even filtered tap water? Should any of the separations be run in cold rooms or in glycol jacketed lines to minimize microbial growth where sterilization is not possible? Should the process equipment and lines be designed to be sterilized in-place, cleaned-in-place, or should every piece be broken down, cleaned and autoclaved after every turn?

Author : Gunter Jagschies,Gail K. Sofer,Lars Hagel
Publisher : Elsevier
Page : 382 pages
File Size : 49,9 Mb
Release : 2007-12-08
Category : Science
ISBN : 0080554512

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Handbook of Process Chromatography by Gunter Jagschies,Gail K. Sofer,Lars Hagel Pdf

This book will update the original edition published in 1997. Since the publication of the first edition, the biotechnology and biologics industries have gained extensive knowledge and experience in downstream processing using chromatography and other technologies associated with recovery and purification unit operations. This book will tie that experience together for the next generation of readers. Updates include: - sources and productivity - types of products made today - experiences in clinical and licensed products - economics - current status of validation - illustrations and tables - automated column packing - automated systems New topics include: - the use of disposables - multiproduct versus dedicated production - design principles for chromatography media and filters - ultrafiltration principles and optimization - risk assessments - characterization studies - design space - platform technologies - process analytical technologies (PATs) - biogenerics - comparability assessments Key Features: - new approaches to process optimiaztion - use of patform technologies - applying risk assessment to process design

Author : M. S. Verrall
Publisher : John Wiley & Sons
Page : 384 pages
File Size : 47,9 Mb
Release : 1996-08-06
Category : Science
ISBN : UOM:39015037454355

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Downstream Processing of Natural Products by M. S. Verrall Pdf

Natural Products, broadly defined as high value chemical entities derived from plants or microbial sources, have been known and exploited for many years. In recent years, as the need for higher potency and predictability of such products has increased, more sophisticated concentration and isolation procedures have been developed. With the passage of time, such procedures have been rationalized in terms of scientific principles but, in general, theory has followed behind practice, leading at any given time to an absence from the literature of methods which are truly state of the art. Downstream Processing of Natural Products: A Practical Handbook is a highly practical manual which addresses this issue, and guides researchers and industrial workers through the many potential pitfalls of natural product isolation. The contributors to this volume, all of whom have wide practical experience in this field, present state-of-the-art techniques and observations. The three main stages of natural product purification are covered, namely product release, capture, and purification, and both proteins and secondary metabolites are covered. There is special mention of the requirements of the regulatory authorities with respect to Good Manufacturing Practice, and practical guidance is given on scale-up procedures and process scale instrumentation. Downstream Processing of Natural Products: A Practical Handbook will provide essential practical guidance to all those involved in natural product isolation. This includes academic and industrial researchers, postgraduate students and technicians working in the biotechnology field.

Author : Venko N. Beschkov,Dragomir Yankov
Publisher : Walter de Gruyter GmbH & Co KG
Page : 177 pages
File Size : 42,9 Mb
Release : 2021-06-21
Category : Science
ISBN : 9783110574111

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Downstream Processing in Biotechnology by Venko N. Beschkov,Dragomir Yankov Pdf

The current book gives an excellent insight into downstream processing technology and explains how to establish a successful strategy for an efficient recovery, isolation and purification of biosynthetic products. In addition to the overview of purification steps and unit operations, the authors provide practical information on capital and operating costs related to downstream processing.

Author : Sanjay Sahay
Publisher : Academic Press
Page : 692 pages
File Size : 55,5 Mb
Release : 2021-10-31
Category : Science
ISBN : 9780128231333

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Handbook of Biofuels by Sanjay Sahay Pdf

Handbook of Biofuels looks at the many new developments in various type of bioenergy, along with the significant constraints in their production and/or applications. Beyond introducing current approaches and possible future directions of research, this title covers sources and processing of raw materials to downstream processing, constraints involved and research approaches to address and overcome these needs. Different combinations of products from the biorefinery are included, along with the material to answer questions surrounding the optimum process conditions for conversion of different feedstocks to bioenergy, the basis for choosing conversion technology, and what bioenergy products make economic sense. With chapters on the techno-economic analysis of biofuel production and concepts and step-by-step approaches in bioenergy processing, the objective of this book is to present a comprehensive and all-encompassing reference about bioenergy to students, teachers, researchers and professionals. Reviews all existing and emerging technologies surrounding the production of advanced biofuels, including biodiesel and bioethanol Includes biofuel applications with compatible global application case studies Offers new pathways for converting biomass

Author : Amos Richmond
Publisher : John Wiley & Sons
Page : 587 pages
File Size : 45,8 Mb
Release : 2008-04-15
Category : Technology & Engineering
ISBN : 9781405172493

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Handbook of Microalgal Culture by Amos Richmond Pdf

Handbook of Microalgal Culture is truly a landmarkpublication, drawing on some 50 years of worldwide experience inmicroalgal mass culture. This important book comprisescomprehensive reviews of the current available information onmicroalgal culture, written by 40 contributing authors from aroundthe globe. The book is divided into four parts, with Part I detailingbiological and environmental aspects of microalgae with referenceto microalgal biotechnology and Part II looking in depth at majortheories and techniques of mass cultivation. Part III compriseschapters on the economic applications of microalgae, includingcoverage of industrial production, the use of microalgae in humanand animal nutrition and in aquaculture, in nitrogen fixation,hydrogen and methane production, and in bioremediation of pollutedwater. Finally, Part IV looks at new frontiers and includeschapters on genetic engineering, microalgae as platforms forrecombinant proteins, bioactive chemicals, heterotrophicproduction, microalgae as gene-delivery systems for expressingmosquitocidal toxins and the enhancement of marine productivity forclimate stabilization and food security. Handbook of Microalgal Culture is an essential purchasefor all phycologists and also those researching aquatic systems,aquaculture and plant sciences. There is also much of great use toresearchers and those involved in product formulation withinpharmaceutical, nutrition and food companies. Libraries in alluniversities and research establishments teaching and researchingin chemistry, biological and pharmaceutical sciences, food sciencesand nutrition, and aquaculture will need copies of this book ontheir shelves. Amos Richmond is at the Blaustein Institute for DesertResearch, Ben-Gurion University of the Negev, Israel.

Author : Giorgio Carta,Alois Jungbauer
Publisher : John Wiley & Sons
Page : 440 pages
File Size : 41,6 Mb
Release : 2020-06-02
Category : Science
ISBN : 9783527346660

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Protein Chromatography by Giorgio Carta,Alois Jungbauer Pdf

An all-in-one practical guide on how to efficiently use chromatographic separation methods Based on a training course that teaches the theoretical as well as practical aspects of protein bioseparation to bioprocess professionals, this fully updated and revised new edition offers comprehensive coverage of continuous chromatography and provides readers with many relevant examples from the biopharmaceutical industry. Divided into two large parts, Protein Chromatography: Process Development and Scale-Up, Second Edition presents all the necessary knowledge for effective process development in chromatographic bioseparation, both on small and large scale. The first part introduces chromatographic theory, including process design principles, to enable the reader to rationalize the set-up of a bioseparation process. The second part illustrates by way of case studies and sample protocols how the theory learned in the first part may be applied to real-life problems. Chapters look at: Downstream Processing of Biotechnology Products; Chromatography Media; Laboratory and Process Columns and Equipment; Adsorption Equilibrium; Rate Processes; and Dynamics of Chromatography Columns. The book closes with chapters on: Effects of Dispersion and Rate Processes on Column Performance; Gradient Elution Chromatography; and Chromatographic Column Design and Optimization. -Presents the most pertinent examples from the biopharmaceutical industry, including monoclonal antibodies -Provides an overview of the field along with design tools and examples illustrating the advantages of continuous processing in biopharmaceutical productions -Focuses on process development and large-scale bioseparation tasks, making it an ideal guide for the professional bioengineer in the biotech and pharma industries -Offers field-tested information based on decades of training courses for biotech and chemical engineers in Europe and the U.S. Protein Chromatography: Process Development and Scale-Up, Second Edition will appeal to biotechnologists, analytical chemists, chromatographers, chemical engineers, pharmaceutical industry, biotechnological industry, and biochemists.

Author : Pau Loke Show,Chien Wei Ooi,Tau Chuan Ling
Publisher : CRC Press
Page : 186 pages
File Size : 41,7 Mb
Release : 2019-06-13
Category : Medical
ISBN : 9780429882517

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Bioprocess Engineering by Pau Loke Show,Chien Wei Ooi,Tau Chuan Ling Pdf

Bioprocess Engineering: Downstream Processing is the first book to present the principles of bioprocess engineering, focusing on downstream bioprocessing. It aims to provide the latest bioprocess technology and explain process analysis from an engineering point of view, using worked examples related to biological systems. This book introduces the commonly used technologies for downstream processing of biobased products. The covered topics include centrifugation, filtration, membrane separation, reverse osmosis, chromatography, biosorption, liquid-liquid separation, and drying. The basic principles and mechanism of separation are covered in each of the topics, wherein the engineering concept and design are emphasized. This book is aimed at bioprocess engineers and professionals who wish to perform downstream processing for their feedstock, as well as students.

Author : Nikolaos E. Labrou,Evangelia G.. Chronopoulou,Farid Ataya
Publisher : Unknown
Page : 0 pages
File Size : 40,5 Mb
Release : 2018
Category : Proteins
ISBN : 1536143650

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Handbook on Protein Purification by Nikolaos E. Labrou,Evangelia G.. Chronopoulou,Farid Ataya Pdf

Proteins are important biomolecules that are vital for the cellular structure and function. They perform a vast array of functions within organisms, including the catalysis of metabolic reactions, DNA replication, response to stimuli, and transporting molecules from one location to another. The technological advances in the omics areas (e.g., genomics, transcriptomics, proteomics, metagenomics, etc.) have dramatically increased the rate of discovering new proteins. Some of them hold large opportunities for innovative research and the development of commercial products and applications. It is worth noting that the global protein ingredients market is poised to grow over the next decade to reach approximately 58.49 billion USD by 2022, with the protein therapeutics market valuing around USD 315.9 billion by 2025. Interestingly, about seventy monoclonal antibody products will be on the market by 2020 with a combined worldwide sales of about 125 billion USD.The most significant parameter for the successful commercial exploitation of proteins rely on the development of an efficient and effective isolation and purification technology, known as protein downstream processing. Downstream processing refers to the technology that involves the isolation and production of purified products from natural sources such as animal tissues, plant tissues, microorganisms or fermentation broth. The most important element of this technology is the high purification processes, most important of which is chromatography and in particular affinity chromatography.This book provides information on the resent developments of protein downstream processing and deals with the information gained over the last years from the application of protein purification technologies on different research areas. Each chapter gives key examples that cover a wide range of diverse scientific disciplines in order to provide the reader with a representative sample of the current status of the field. The present book would definitely be an ideal source of scientific information to the advanced students, junior researchers, and scientists involved in cellular and molecular biology, biochemistry, microbiology, biotechnology and other related areas.

Author : Venko N. Beschkov,Dragomir Yankov
Publisher : Walter de Gruyter GmbH & Co KG
Page : 211 pages
File Size : 50,7 Mb
Release : 2021-06-21
Category : Science
ISBN : 9783110574005

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Downstream Processing in Biotechnology by Venko N. Beschkov,Dragomir Yankov Pdf

The current book gives an excellent insight into downstream processing technology and explains how to establish a successful strategy for an efficient recovery, isolation and purification of biosynthetic products. In addition to the overview of purification steps and unit operations, the authors provide practical information on capital and operating costs related to downstream processing.

Author : Martin Koller
Publisher : CRC Press
Page : 453 pages
File Size : 54,7 Mb
Release : 2020-11-05
Category : Medical
ISBN : 9781000173574

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The Handbook of Polyhydroxyalkanoates by Martin Koller Pdf

The first volume of the "Handbook of Polyhydroxyalkanoates (PHA): Microbial Biosynthesis and Feedstocks" focusses on feedstock aspects, enzymology, metabolism and genetic engineering of PHA biosynthesis. It addresses better understanding the mechanisms of PHA biosynthesis in scientific terms and profiting from this understanding in order to enhance PHA biosynthesis in bio-technological terms and in terms of PHA microstructure. It further discusses making PHA competitive for outperforming established petrol-based plastics on industrial scale and obstacles for market penetration of PHA. Aimed at professionals and graduate students in Polymer (plastic) industry, wastewater treatment plants, food industry, biodiesel industry, this book Covers the intracellular on-goings in PHA-accumulating bacteria Assesses diverse feedstocks to be used as carbon source for PHA production including current knowledge on PHA biosynthesis starting from inexpensive waste feedstocks Summarizes recent relevant results dealing with PHA production from various organic by-products Presents the key elements to understand and fine-tune the microstructure and sequence-controlled molecular architecture of PHA co-polyesters Discusses the use of CO-rich syngas, sourced from various organic waste materials, for PHA biosynthesis

Author : D. J. Bell,P. Dunnill,K. Esser,E. Flaschel,M. Hoare,J. Holló,M.-R. Kula,Ch. Lang-Hinrichs,L. Nyeste,M. Pécs,B. Sevella,Ch. Wandrey
Publisher : Springer
Page : 212 pages
File Size : 41,8 Mb
Release : 1983-01-01
Category : Science
ISBN : 3662387948

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Downstream Processing by D. J. Bell,P. Dunnill,K. Esser,E. Flaschel,M. Hoare,J. Holló,M.-R. Kula,Ch. Lang-Hinrichs,L. Nyeste,M. Pécs,B. Sevella,Ch. Wandrey Pdf

Author : Harold F. Giles Jr,Eldridge M. Mount III,John R. Wagner Jr.
Publisher : William Andrew
Page : 575 pages
File Size : 48,6 Mb
Release : 2004-12-31
Category : Technology & Engineering
ISBN : 9780815517115

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Extrusion by Harold F. Giles Jr,Eldridge M. Mount III,John R. Wagner Jr. Pdf

Why is it important to get to equilibrium and how long does it take? Are there problems running polypropylene profiles on a single screw extruder? Does the job involve compounding color concentrates on a corotating twin screw extruder? This unique reference work is designed to aid operators, engineers, and managers in quickly answering such practical day-to-day questions in extrusion processing. This comprehensive volume is divided into 7 Parts. It contains detailed reference data on such important operating conditions as temperatures, start-up procedures, shear rates, pressure drops, and safety. This reference is a practical guide to extrusion bringing together both the equipment and materials processing aspects. It provides basic and advanced topics about the thermoplastics processing in the extruder, for reference and training. Parts 1 û 3, emphasize the fundamentals, for operators and engineers, of polymeric materials extrusion processing in single and twin screw extruders. Parts 4 û 7 treat advanced topics including troubleshooting, auxiliary equipment, and coextrusion for operators, engineers, and managers. Extensive applications in Part 7 cover such contemporary areas as compounding, blown film, extrusion blow molding, coating, foam, and reprocessing. Each chapter includes review topics.

Author : Martin Killcross
Publisher : Elsevier
Page : 312 pages
File Size : 40,9 Mb
Release : 2011-09-27
Category : Technology & Engineering
ISBN : 9780080971759

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Chemical and Process Plant Commissioning Handbook by Martin Killcross Pdf

The Chemical and Process Plant Commissioning Handbook, winner of the 2012 Basil Brennan Medal from the Institution of Chemical Engineers, is a guide to converting a newly constructed plant or equipment into a fully integrated and operational process unit. Good commissioning is based on a disciplined, systematic and proven methodology and approach that achieve results in the safest, most efficient, cost effective and timely manner. The book is supported by detailed, proven and effective commission templates, plus extensive commissioning scenarios that enable the reader to learn the context of good commissioning practice from an experienced commissioning manager. It focuses on the critical safety assessment and inspection regimes necessary to ensure that new plants are compliant with OSHA and environmental requirements. Martin Killcross has brought together the theory of textbooks and technical information obtained from sales literature, in order to provide engineers with what they need to know before initiating talks with vendors regarding equipment selection. Unique information from a respected, global commissioning manager: delivers the know-how to succeed for anyone commissioning new plant or equipment Comes with online commissioning process templates that make this title a working tool kit as well as a key reference Extensive examples of successful commissioning processes with step-by-step guidance enable readers to understand the function and performance of the wide range of tasks required in the commissioning process

Author : Angelo Basile
Publisher : Elsevier
Page : 968 pages
File Size : 51,8 Mb
Release : 2013-04-04
Category : Technology & Engineering
ISBN : 9780857097347

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Handbook of Membrane Reactors by Angelo Basile Pdf

Membrane reactors are increasingly replacing conventional separation, process and conversion technologies across a wide range of applications. Exploiting advanced membrane materials, they offer enhanced efficiency, are very adaptable and have great economic potential. There has therefore been increasing interest in membrane reactors from both the scientific and industrial communities, stimulating research and development. The two volumes of the Handbook of membrane reactors draw on this research to provide an authoritative review of this important field. Volume 2 reviews reactor types and industrial applications, beginning in part one with a discussion of selected types of membrane reactor and integration of the technology with industrial processes. Part two goes on to explore the use of membrane reactors in chemical and large-scale hydrogen production from fossil fuels. Electrochemical devices and transport applications of membrane reactors are the focus of part three, before part four considers the use of membrane reactors in environmental engineering, biotechnology and medicine. Finally, the book concludes with a discussion of the economic aspects of membrane reactors. With its distinguished editor and international team of expert contributors, the two volumes of the Handbook of membrane reactors provide an authoritative guide for membrane reactor researchers and materials scientists, chemical and biochemical manufacturers, industrial separations and process engineers, and academics in this field. Discusses integration of membrane technology with industrial processes Explores the use of membrane reactors in chemical and large-scale hydrogen production from fossil fuels Considers electrochemical devices and transport applications of membrane reactors