Handbook Of Process Chromatography

Author : Gunter Jagschies,Gail K. Sofer,Lars Hagel
Publisher : Elsevier
Page : 382 pages
File Size : 53,8 Mb
Release : 2007-12-08
Category : Science
ISBN : 0080554512

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Handbook of Process Chromatography by Gunter Jagschies,Gail K. Sofer,Lars Hagel Pdf

This book will update the original edition published in 1997. Since the publication of the first edition, the biotechnology and biologics industries have gained extensive knowledge and experience in downstream processing using chromatography and other technologies associated with recovery and purification unit operations. This book will tie that experience together for the next generation of readers. Updates include: - sources and productivity - types of products made today - experiences in clinical and licensed products - economics - current status of validation - illustrations and tables - automated column packing - automated systems New topics include: - the use of disposables - multiproduct versus dedicated production - design principles for chromatography media and filters - ultrafiltration principles and optimization - risk assessments - characterization studies - design space - platform technologies - process analytical technologies (PATs) - biogenerics - comparability assessments Key Features: - new approaches to process optimiaztion - use of patform technologies - applying risk assessment to process design

Author : Gail Sofer
Publisher : Unknown
Page : 128 pages
File Size : 44,9 Mb
Release : 1997
Category : Chromatographic analysis
ISBN : OCLC:643203707

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Handbook of Process Chromatography by Gail Sofer Pdf

Author : Gail K. Sofer,L. E.E. Nystrom
Publisher : Academic Press
Page : 89 pages
File Size : 53,9 Mb
Release : 2015-09-02
Category : Science
ISBN : 9781483289175

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Process Chromatography by Gail K. Sofer,L. E.E. Nystrom Pdf

Research and development into biological products for therapeutic use has increased dramatically over the last 10 years. With this, strict regulatory requirements have been imposed by authorities such as the U.S. Food & Drug Administration, so that today validation has become a key issue in the biopharmaceutical industry.This concise book addresses validation issues in the chromatography of biotherapeutics. It covers process design, qualification and validation, including an overview of analytical techniques commonly used in the validation of processes. A concluding section comments on product changeover and presents four case studies.

Author : Gail K. Sofer,Lars Hagel
Publisher : Academic Press
Page : 410 pages
File Size : 47,8 Mb
Release : 1997-06-24
Category : Medical
ISBN : STANFORD:36105019357438

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Handbook of Process Chromatography by Gail K. Sofer,Lars Hagel Pdf

With examples from companies with establised processes and approved biotherapeutics, this pack considers the entire scope of process chromatography, including scale-up, regulatory issues, equipment, evaluation studies, scheduling and cost effectiveness.

Author : Ronald W. Rousseau
Publisher : John Wiley & Sons
Page : 1028 pages
File Size : 40,8 Mb
Release : 1987-05-13
Category : Technology & Engineering
ISBN : 047189558X

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Handbook of Separation Process Technology by Ronald W. Rousseau Pdf

Surveys the selection, design, and operation of most of the industrially important separation processes. Discusses the underlying principles on which the processes are based, and provides illustrative examples of the use of the processes in a modern context. Features thorough treatment of newer separation processes based on membranes, adsorption, chromatography, ion exchange, and chemical complexation. Includes a review of historically important separation processes such as distillation, absorption, extraction, leaching, and crystallization and considers these techniques in light of recent developments affecting them.

Author : Donald A Wellings
Publisher : Elsevier
Page : 176 pages
File Size : 54,5 Mb
Release : 2011-04-18
Category : Technology & Engineering
ISBN : 0080458858

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A Practical Handbook of Preparative HPLC by Donald A Wellings Pdf

This book is a distillation of twenty years of practical experience of the high pressure liquid chromatography (HPLC) process. Deliberately steering clear of complex theoretical aspects, this book concentrates on the everyday problems associated with the technique, making it perfect for frequent use in the laboratory and for those in the pharmaceutical, agrochemical and biotechnology industries for the analysis and purification of drugs, small molecules, proteins and DNA. This book... •Provides practical, hands-on advice based on years of experience •Will help ensure optimal design, equipment and separation results for your particular task •Presents system layouts from laboratory to process scale •Will help you to devise or improve record-keeping and documentation systems ·Provides practical, hands-on advice based on years of experience ·Will help ensure optimal design, equipment and separation results for your particular task ·Presents system layouts from laboratory to process scale ·Will help you to devise or improve record-keeping and documentation systems

Author : Anonim
Publisher : Academic Press
Page : 880 pages
File Size : 49,7 Mb
Release : 2009-11-11
Category : Science
ISBN : 0123757274

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Handbook of Methods and Instrumentation in Separation Science by Anonim Pdf

Handbook of Methods and Instrumentation in Separation Science, Volume 1 provides concise overviews and summaries of the main methods used for separation. It is based on the Encyclopedia of Separation Science. The handbook focuses on the principles of methods and instrumentation. It provides general concepts concerning the subject matter; it does not present specific procedures. This volume discusses the separation processes including affinity methods, analytical ultracentrifugation, centrifugation, chromatography, and use of decanter centrifuge and dye. Each methodology is defined and compared with other separation processes. It also provides specific techniques, principles, and theories concerning each process. Furthermore, the handbook presents the applications, benefits, and validation of the processes described in this book. This handbook is an excellent reference for biomedical researchers, environmental and production chemists, flavor and fragrance technologists, food and beverage technologists, academic and industrial librarians, and nuclear researchers. Students and novices will also find this handbook useful for practice and learning. One-stop source for information on separation methods General overviews for quick orientation Ease of use for finding results fast Expert coverage of major separation methods Coverage of techniques for all sizes of samples, pico-level to kilo-level

Author : E. Goldberg
Publisher : Springer Science & Business Media
Page : 745 pages
File Size : 54,6 Mb
Release : 2012-12-06
Category : Science
ISBN : 9789400915633

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Handbook of Downstream Processing by E. Goldberg Pdf

The last two decades have seen a phenomenal growth of the field of genetic or biochemical engineering and have witnessed the development and ultimately marketing of a variety of products-typically through the manipulation and growth of different types of microorganisms, followed by the recovery and purification of the associated products. The engineers and biotechnologists who are involved in the full-scale process design of such facilities must be familiar with the variety of unit operations and equipment and the applicable regulatory requirements. This book describes current commercial practice and will be useful to those engineers working in this field in the design, construction and operation of pharmaceutical and biotechnology plants. It will be of help to the chemical or pharmaceutical engineer who is developing a plant design and who faces issues such as: Should the process be batch or continuous or a combination of batch and continuous? How should the optimum process design be developed? Should one employ a new revolutionary separation which could be potentially difficult to validate or use accepted technology which involves less risk? Should the process be run with ingredients formulated from water for injection, deionized water, or even filtered tap water? Should any of the separations be run in cold rooms or in glycol jacketed lines to minimize microbial growth where sterilization is not possible? Should the process equipment and lines be designed to be sterilized in-place, cleaned-in-place, or should every piece be broken down, cleaned and autoclaved after every turn?

Author : Anurag Rathore,Ajoy Velayudhan
Publisher : CRC Press
Page : 368 pages
File Size : 41,7 Mb
Release : 2002-09-26
Category : Medical
ISBN : 0203909283

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Scale-Up and Optimization in Preparative Chromatography by Anurag Rathore,Ajoy Velayudhan Pdf

Presenting guidelines to predict and improve separation system performance, this book contains numerous case studies illustrating the practice of scale-up principles in process development. It offers solutions to limitations that occur in real-world purification schemes; methods to model, optimize, and characterize nonlinear separation processes; d

Author : Chi-san Wu
Publisher : Academic Press
Page : 664 pages
File Size : 52,9 Mb
Release : 1999
Category : Science
ISBN : 9780127655550

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Column Handbook for Size Exclusion Chromatography by Chi-san Wu Pdf

The column is the heart of a chromatographic system. For the first time, complete and authoritative information on columns for size exclusion and gel filtration chromatography is available in a single volume containing contributions from every major manufacturer worldwide and many renowned column users. This comprehensive handbook covers the technology, characterization, application, evaluation, maintenance, and quality control of commercial analytical and preparative columns for SEC, GFC, and two closely related techniques, hydrodynamic chromatography and high osmotic pressure chromatography. Experienced column users discuss various applications in organic and aqueous mobile phases for synthetic and biopolymers, small solutes, biopharmaceutical therapeutics, and high-temperature SEC.

Author : Sarfaraz K. Niazi
Publisher : CRC Press
Page : 592 pages
File Size : 45,9 Mb
Release : 2002-08-15
Category : Medical
ISBN : 9781000611328

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Handbook of Biogeneric Therapeutic Proteins by Sarfaraz K. Niazi Pdf

More than 20 billion dollars worth of biopharmaceuticals are scheduled to go off-patent by 2006. Given the strong political impetus and the development of technological tools that can answer the questions regulatory authorities may raise, it is inevitable that the FDA and EMEA will allow biogeneric or biosimilar products. Even with all the regulato

Author : Chi-San Wu
Publisher : CRC Press
Page : 720 pages
File Size : 52,6 Mb
Release : 2003-11-04
Category : Science
ISBN : 9780203913321

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Handbook Of Size Exclusion Chromatography And Related Techniques by Chi-San Wu Pdf

Documenting critical advances in this rapidly evolving field, the Second Edition highlights the need for new applications and technologies that assist in the determination of molecular weight and molecular weight distributions of polymers in an accurate, efficient manner. This volume presents the latest findings from a international team of specialists and continues to inspire and extend practical applications of size exclusion chromatography (SEC). It includes six new chapters covering high-speed size exclusion chromatography, SEC of low molecular weight materials, and the extended family of techniques, from two-dimensional liquid chromatography to high osmotic pressure chromatography.

Author : Taylor & Francis Group
Publisher : Unknown
Page : 128 pages
File Size : 53,8 Mb
Release : 2019-07-20
Category : Electronic
ISBN : 0367340305

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Crc Handbook of Chromatography by Taylor & Francis Group Pdf

Author : Stefan Dübel,Janice M. Reichert
Publisher : John Wiley & Sons
Page : 2538 pages
File Size : 43,7 Mb
Release : 2014-12-03
Category : Science
ISBN : 9783527329373

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Handbook of Therapeutic Antibodies by Stefan Dübel,Janice M. Reichert Pdf

Still the most comprehensive reference source on the development, production and therapeutic application of antibodies, this second edition is thoroughly updated and now has 30% more content. Volume 1 covers selection and engineering strategies for new antibodies, while the second volume presents novel therapeutic concepts and antibodies in clinical study, as well as their potential. Volumes 3 and 4 feature detailed and specific information about each antibody approved for therapeutic purposes, including clinical data. This unique handbook concludes with a compendium of marketed monoclonal antibodies and an extensive index. Beyond providing current knowledge, the authors discuss emerging technologies, future developments, and intellectual property issues, such that this handbook meets the needs of academic researchers, decision makers in industry and healthcare professionals in the clinic.

Author : Giorgio Carta,Alois Jungbauer
Publisher : John Wiley & Sons
Page : 440 pages
File Size : 42,8 Mb
Release : 2020-06-02
Category : Science
ISBN : 9783527346660

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Protein Chromatography by Giorgio Carta,Alois Jungbauer Pdf

An all-in-one practical guide on how to efficiently use chromatographic separation methods Based on a training course that teaches the theoretical as well as practical aspects of protein bioseparation to bioprocess professionals, this fully updated and revised new edition offers comprehensive coverage of continuous chromatography and provides readers with many relevant examples from the biopharmaceutical industry. Divided into two large parts, Protein Chromatography: Process Development and Scale-Up, Second Edition presents all the necessary knowledge for effective process development in chromatographic bioseparation, both on small and large scale. The first part introduces chromatographic theory, including process design principles, to enable the reader to rationalize the set-up of a bioseparation process. The second part illustrates by way of case studies and sample protocols how the theory learned in the first part may be applied to real-life problems. Chapters look at: Downstream Processing of Biotechnology Products; Chromatography Media; Laboratory and Process Columns and Equipment; Adsorption Equilibrium; Rate Processes; and Dynamics of Chromatography Columns. The book closes with chapters on: Effects of Dispersion and Rate Processes on Column Performance; Gradient Elution Chromatography; and Chromatographic Column Design and Optimization. -Presents the most pertinent examples from the biopharmaceutical industry, including monoclonal antibodies -Provides an overview of the field along with design tools and examples illustrating the advantages of continuous processing in biopharmaceutical productions -Focuses on process development and large-scale bioseparation tasks, making it an ideal guide for the professional bioengineer in the biotech and pharma industries -Offers field-tested information based on decades of training courses for biotech and chemical engineers in Europe and the U.S. Protein Chromatography: Process Development and Scale-Up, Second Edition will appeal to biotechnologists, analytical chemists, chromatographers, chemical engineers, pharmaceutical industry, biotechnological industry, and biochemists.