Handbook Of Reagents For Organic Synthesis Reagents For High Throughput Solid Phase And Solution Phase Organic Synthesis

Author : Jonathan A. Ellman
Publisher : Wiley
Page : 392 pages
File Size : 55,7 Mb
Release : 2005-05-20
Category : Science
ISBN : 047086298X

Get Book

Handbook of Reagents for Organic Synthesis, Reagents for High-Throughput Solid-Phase and Solution-Phase Organic Synthesis by Jonathan A. Ellman Pdf

Since its discovery in 1963 by R. B. Merrifield, solid-phase synthesis, or polymer-supported synthesis, has become an essential technique with its wide use in the synthesis of peptides and other oligomers. Solid-Phase Reactions provides extensive and comprehensive information on this form of synthesis in a format ideal for those working in the laboratory. As part of the Handbook of Reagents in Organic Synthesis Series, this new addition extends the wealth of information available to the chemist at the bench. All content has been expertly collected and presented by an internationally recognised and respected editorial board led by Professor Peter Wipf.

Author : Kevin Burgess
Publisher : John Wiley & Sons
Page : 294 pages
File Size : 49,5 Mb
Release : 2004-04-05
Category : Science
ISBN : 9780471458456

Get Book

Solid-Phase Organic Synthesis by Kevin Burgess Pdf

Solid-Phase Organic Synthesis Edited by Kevin Burgess, Texas A & M University Efficient, high-throughput chemistry is now the focus of many research laboratories. Solid-phase organic syntheses are central to many of these combinatorial and parallel screening methodologies. Consequently, they have been a major scientific theme of the 1990s and promise to remain prominent for the first part of the new millennium. Indeed, a bewildering number of papers have entered the literature on this topic; some report minor modifications enabling transformation of solution-phase methods to a solid support, while others report major innovations. Solid-Phase Organic Synthesis collects, highlights, and critiques some of the key developments in the field. Leading practitioners explain different perspectives on diverse aspects of the area. Specific topics covered include: * Syntheses of guanidines * Palladium-catalyzed C-C bond forming reactions * S_nAr reactions for the formation of heterocycles * Sequence-specific arylalkyne oligomers * Resin-supported capture agents and other reagents * Synthesis on pins * Monitoring of supported reactions using IR * Solid-phase syntheses of natural product derivatives Of related interest . Combinatorial Chemistry and Molecular Diversity in Drug Discovery Eric M. Gordon and James F. Kerwin 1998 (0-471-15518-7) 544 pp. Combinatorial Chemistry Synthesis and Application Stephen R. Wilson and Anthony W. Czarnik 1997 (0-471-12687-X) 288 pp.

Author : Perry G. Wang
Publisher : CRC Press
Page : 432 pages
File Size : 47,8 Mb
Release : 2008-08-20
Category : Medical
ISBN : 9781420059540

Get Book

High-Throughput Analysis in the Pharmaceutical Industry by Perry G. Wang Pdf

The introduction of combinatorial chemistry technology has increased the amount of compounds generated in a year from 50 to 2000. Conventional analytical approaches simply cannot keep up. These circumstances have caused drug discovery to take on the shape of a bottleneck, like traffic through a toll booth. In order to break the bottleneck, a corres

Author : Anonim
Publisher : Unknown
Page : 402 pages
File Size : 51,5 Mb
Release : 1999
Category : Chemical tests and reagents
ISBN : CHI:70670685

Get Book

Handbook of Reagents for Organic Synthesis by Anonim Pdf

Author : André B. Charette
Publisher : John Wiley & Sons
Page : 824 pages
File Size : 55,5 Mb
Release : 2015-07-15
Category : Science
ISBN : 9781118726556

Get Book

Handbook of Reagents for Organic Synthesis by André B. Charette Pdf

Heteroarenes are among the most prevalent structural units in natural products, pharmaceuticals, agrochemicals, and other compounds of scientific or commercial interest. In the last decade, a broad range of novel synthetic methods has been developed to not only facilitate construction of the heteroarene motif, but to enable its modification through direct C–H functionalization. This Handbook describes 117 key reagents for selective heteroarene functionalization reactions, including both traditional and transition metal-catalyzed C–H functionalization. Since these reactions typically involve one heteroarene, a coupling partner and a catalyst, the handbook not only focuses on the catalyst itself but also contains other key reaction species. All the information compiled in this volume is also available in electronic format on Wiley Online Library. The 117 reagents represented here are but a small fraction of the ca. 5,000 reagents available in the electronic Encyclopedia of Reagents for Organic Synthesis (e-EROS). e-EROS offers various search interfaces to locate reagents of interest, including chemical structure, substructure and reactions search modes. e-EROS is updated regularly with new and updated entries.

Author : Tomislav Rovis
Publisher : John Wiley & Sons
Page : 816 pages
File Size : 41,8 Mb
Release : 2016-10-20
Category : Science
ISBN : 9781119061014

Get Book

Handbook of Reagents for Organic Synthesis by Tomislav Rovis Pdf

Spurred by the desire to make chemistry a sustainable and "greener" technology, the field of organocatalysis has grown to become one of the most important areas in synthetic organic chemistry. Organic catalysts can often replace potentially toxic metal catalysts and allow reactions to proceed under mild reaction conditions, thereby saving energy costs and rendering chemical processes inherently safer. More importantly perhaps, organocatalysis offers a complementary reactivity in many instances leading to increased versatility.This Handbook describes 126 key reagents for organocatalytic reactions and will be especially useful for professionals in the area of sustainable chemistry, medicinal research, as well as synthetic organic chemists working in academia and the pharmaceutical industry. All the information compiled in this volume is also available in electronic format on Wiley Online Library. The 126 reagents represented here are but a small fraction of the ca. 5,000 reagents available in the electronic Encyclopedia of Reagents for Organic Synthesis (e-EROS). e-EROS offers various search interfaces to locate reagents of interest, including chemical structure, substructure and reactions search modes. e-EROS is updated regularly with new and updated entries.

Author : Leo A. Paquette
Publisher : John Wiley & Sons
Page : 618 pages
File Size : 49,7 Mb
Release : 2003-08-01
Category : Science
ISBN : 0470856254

Get Book

Chiral Reagents for Asymmetric Synthesis by Leo A. Paquette Pdf

Derived from the renowned, Encyclopedia of Reagents for Organic Synthesis (EROS), the related editors have created a new handbook which focuses on chiral reagents used in asymmetric synthesis and is designed for the chemist at the bench. This new handbook follows the same format as the Encyclopedia, including an introduction and an alphabetical arrangement of the reagents. As chiral reagents are the key for the successful asymmetric synthesis, choosing the right reagents is essential, in this handy reference the editors give details on how to prepare, store and use the reagents as well as providing key reactions to demonstrate where reagents have been successfully used. Comprehensive information on 226 reagents Covers 64 reagents which were not included in EROS All information in one easy to use volume – at an affordable price All reagents included will be added to e-EROS – please visit the site where you can gain access to over 50,000 reactions and 3,800 of the most frequently consulted reagents. Visit: www.interscience.wiley.com/eros

Author : Philip L. Fuchs
Publisher : John Wiley & Sons
Page : 816 pages
File Size : 47,6 Mb
Release : 2013-05-30
Category : Technology & Engineering
ISBN : 9781118636138

Get Book

Reagents for Silicon-Mediated Organic Synthesis by Philip L. Fuchs Pdf

Over the last three decades the importance of organosiliconchemistry has greatly increased because it has opened a number ofnew synthetic strategies. Silicon reagents are usually low-cost,versatile and allow a wide range of reactions. This is the firstHandbook to compile essential Silicon containing reagents and makesuse of the leading reagent database e-EROS. Another hotvolume in the series Handbooks of Reagents for OrganicSynthesis, this is a must-have resource for all syntheticchemists working in drug development and medicinal chemistry. For the selection the Editor focussed on three key syntheticapproaches with the greatest impact: 1. Use of silicon as a 'temporary tether' by unifying a reactivepair of functional groups and taking advantage of theirtemplate-biased intramolecular cyclization. 2. The specific use of the silane functionality as a heterot-butyl group, often colloquially referred to as the use ofsilicon as a 'fat proton'. 3. The use of the Brook rearrangement as an 'anion relaystratagem'. A new feature in this Handbook is the reagent finder, analphabetically organized lookup table arranged by organicfunctionality and specific structure of the silicon atom to whichit is bound.

Author : David Crich
Publisher : John Wiley & Sons
Page : 1874 pages
File Size : 45,8 Mb
Release : 2013-05-30
Category : Science
ISBN : 9781118634899

Get Book

Reagents for Radical and Radical Ion Chemistry by David Crich Pdf

Radicals and radical ions are important intermediates with wide use in organic synthesis. The first book to concentrate on reagents for the creation and use of radicals and radical ions, this new volume in the Handbooks of Reagents for Organic Synthesis series compiles articles taken from the e-eros database, on reagents for use in radical and radical chemistry, to help the chemist in the lab choose the right reagents. Reflecting the enormous growth of radical chemistry over the past ten years, this is an essential guide for all synthetic chemists.

Author : Gary A. Molander
Publisher : John Wiley & Sons
Page : 1749 pages
File Size : 49,6 Mb
Release : 2013-05-30
Category : Science
ISBN : 9781118643433

Get Book

Catalyst Components for Coupling Reactions by Gary A. Molander Pdf

The long awaited Handbook for all synthetic chemists working on coupling reactions, compiling all major catalyst components in use in the area. Consists of a compilation of articles taken from the EROS database, with the inclusion of about 20 newly commissioned catalysts/pre-catalysts/ligands that have made an impact in this area of synthetic organic chemistry. Includes catalyst systems used in Heck, Kumada-Tamao-Corriu, Suzuki-Miyaura, Hiyama-Hatanaka, Negishi, Migita-Kosugi-Stille, Buchwald-Hartwig, and Tsuji-Trost coupling reactions.

Author : Philip L. Fuchs
Publisher : John Wiley & Sons
Page : 2037 pages
File Size : 42,7 Mb
Release : 2013-07-29
Category : Science
ISBN : 9781118704844

Get Book

Catalytic Oxidation Reagents by Philip L. Fuchs Pdf

The Handbook is part of the Handbook of Reagents for Organic Chemistry series, aiming at collecting articles on a particular theme that individual researchers in academia or industry can use on a daily basis. The Handbook starts with a section discussing the most important aspects of heteroarene functionalization. The introduction is followed by the alphabetical listing of the most relevant reagents drawn from the EROS database. The Editor, André Charette from the University of Montreal, has selected 120 reagent descriptions, many of them updated with heteroarene-specific reactions for this Handbook. Following the standard format for EROS, each article contains an overview of the synthesis and physical properties of the reagents or catalyst, conditions for its storage, and purification methods. Given the importance of heteroarenes in biology and especially in medicinal chemistry, a Handbook that focuses exclusively on heteroarene functionalization has been long overdue. This Handbook will have a broad appeal to many individuals engaged in the area of medicinal chemistry, fine chemical synthesis and industrial-scale chemistry. Key features: Builds on the success of the previously published Handbooks of Reagents for Organic Synthesis Compares the numerous new C-H functionalization reactions that have been developed in the past decade Heteroarene functionalization is widely used in the development of pharmaceuticals and other bioactive compounds Contains listings of secondary reagents for which more information is available in the online edition

Author : Leo A. Paquette
Publisher : John Wiley & Sons
Page : 1957 pages
File Size : 51,8 Mb
Release : 2013-05-30
Category : Science
ISBN : 9781118634868

Get Book

Sulfur-Containing Reagents by Leo A. Paquette Pdf

There are a lot of books available about the chemistry and biology of sulfur. However, this is the first book with a compilation of all relevant Sulfur containing reagents. Synthetic chemists, most particularly in the medicinal and pharmaceutical chemists, are often called upon to prepare compounds that contain Sulfur as a key structural feature. In the past, this seemed to be a domain for specialists; today every synthetic chemist working in these area is expected to synthesize compounds containing sulfides, sulfates, sulfones, etc. This book offers an important source of information for the selection and handling of the right reagents.

Author : Takeshi Toru,Carsten Bolm
Publisher : John Wiley & Sons
Page : 448 pages
File Size : 41,5 Mb
Release : 2008-09-08
Category : Science
ISBN : 9783527623242

Get Book

Organosulfur Chemistry in Asymmetric Synthesis by Takeshi Toru,Carsten Bolm Pdf

In this first book to gather the information on this hot topic otherwise widely spread throughout the literature, experienced editors and top international authors cover everything the reader needs -- from the synthesis of chiral organosulfur compounds to applications and catalysis: * Asymmetric synthesis of chiral sulfinates and sulfoxides * Synthesis and use of chiral dithioacetal derivatives, ylids, chiral sulfoximines and sulfinamides * Use of chiral sulfoxides as ligands in catalysis * Asymmetric reactions of alpha-sulfenyl, alpha-sulfinyl and alpha-sulfonyl carbanions. As a result, readers will be able to improve their own performance in asymmetric synthesis.

Author : Irving Sucholeiki
Publisher : CRC Press
Page : 398 pages
File Size : 49,5 Mb
Release : 2001-02-22
Category : Science
ISBN : 1420056514

Get Book

High-Throughput Synthesis by Irving Sucholeiki Pdf

An exploration of high-throughput synthesis, this book presents a compilation of how-to methods, novel materials, and catalyst developments for creating a multitude of new compounds. Introductory sections are coupled with in-depth case studies clarifying theory through practice. The book emphasizes the potential for reproducing experiments in detail.

Author : Willi Bannwarth,Berthold Hinzen
Publisher : John Wiley & Sons
Page : 694 pages
File Size : 47,7 Mb
Release : 2006-05-12
Category : Science
ISBN : 9783527607389

Get Book

Combinatorial Chemistry by Willi Bannwarth,Berthold Hinzen Pdf

The new edition of this practice-oriented handbook features thoroughly updated contents, including recent developments in parallel synthesis. A new chapter on screening complements the overview of combinatorial strategy and synthetic methods. "Experimental details and complete reaction data [...] are a constant theme running through this work" (Angewandte Chemie) "Recommended to newcomers in the field of combinatorial chemical synthesis because of its broad scope" (Journal of the American Chemical Society)