Hormone Action And Signal Transduction In Endocrine Physiology And Disease
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Hormone Action and Signal Transduction in Endocrine Physiology and Disease by László Hunyady,Tamas Balla Pdf
This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.
Author : Vincent Goffin,Paul A. Kelly Publisher : Springer Science & Business Media Page : 340 pages File Size : 41,9 Mb Release : 2013-03-09 Category : Medical ISBN : 9781475736007
Hormone Signaling by Vincent Goffin,Paul A. Kelly Pdf
Multicellular organisms require a means of intracellular communication to organize and develop the complex body plan that occurs during embryogenesis and then for cell and organ systems to access and respond to an ever changing environmental milieu. Mediators of this constant exchange of information are growth factors, neurotransmmitters, peptide and protein hormones which bind to cell surface receptors and transduce their signals from the extracellular space to the intracellular compartment. Via multiple signaling pathways, receptors of this general class affect growth, development and differentiation. Smaller hydrophobic signaling molecules, such as steroids and non-steroid hormones, vitamins and metabolic mediators interact with a large family of nuclear receptors. These receptors function as transcription factors affecting gene expression, to regulate the multiple aspects of animal and human physiology, including development, reproduction and homeostasis. The aim of this book is to cover various aspects of intracellular signaling involving hormone receptors.
Hormonal Signaling and Postembryonic Development by Jamshed Rustom Tata Pdf
This monograph combines two very active research areas: that of cell signaling with that of the postembryonic development of organisms into their adult phenotype. The first part concentrates on hormone actions, signal transduction and the hormone regulation of transcription, whereas the second part discusses postembryonic development as a function of hormonal signaling. Over 10,000 original research articles, reviews, and conference papers were screened for this book.
Principles of Endocrinology and Hormone Action by Antonino Belfiore,Derek LeRoith Pdf
This volume provides comprehensive coverage of the current knowledge of the physiology of the endocrine system and hormone synthesis and release, transport, and action at the molecular and cellular levels. It presents essential as well as in-depth information of value to both medical students and specialists in Endocrinology, Gynecology, Pediatrics, and Internal Medicine. Although it is well established that the endocrine system regulates essential functions involved in growth, reproduction, and homeostasis, it is increasingly being recognized that this complex regulatory system comprises not only hormones secreted by the classic endocrine glands but also hormones and regulatory factors produced by many organs, and involves extensive crosstalk with the neural and immune system. At the same time, our knowledge of the molecular basis of hormone action has greatly improved. Understanding this complexity of endocrine physiology is crucial to prevent endocrine disorders, to improve the sensitivity of our diagnostic tools, and to provide the rationale for pharmacological, immunological, or genetic interventions. It is such understanding that this book is designed to foster.
Endocrinology by Leslie J. DeGroot,J. Larry Jameson Pdf
ENDOCRINOLOGY, 4th Edition gives a complete, authoritative, up-to-date analysis of endocrine disease and basic endocrine physiology from internationally known and respected editors and authors. Every aspect of endocrinology is covered in significant detail by an authority in the field. A clinical focus emphasizes diagnosis and therapy, with a brand new section on diagnostic methods and the pharmaceutical therapies used in treatment.
Post-transcriptional Mechanisms in Endocrine Regulation by K.M.J. Menon, PhD,Aaron Goldstrohm, PhD Pdf
This book examines how post-transcriptional mechanisms control endocrine function. This includes newly identified regulatory mechanisms involved in hormone biosynthesis, control of hormone receptors and the outputs of hormone mediated signal transduction. Chapters address endocrine hormones including protein peptide/peptide, steroid, and non-steroidal hormones. The impacts of these mechanisms on disease and health are covered, providing a novel update to the scientific literature. Post-transcriptional regulatory mechanisms play an essential role in controlling dynamic gene expression. The outcome of this regulation includes control of the amount, timing, and location of protein expression. Regulation is mediated by cis-acting RNA sequences and structures and transacting RNA binding proteins and non-coding RNAs, including microRNAs. Recent advances in characterization of these regulatory factors have revealed enormous regulatory potential.
Hormonal Signaling and Postembryonic Development by Jamshed Rustom Tata Pdf
This monograph combines two very active research areas: that of cell signaling with that of the postembryonic development of organisms into their adult phenotype. The first part concentrates on hormone actions, signal transduction and the hormone regulation of transcription, whereas the second part discusses postembryonic development as a function of hormonal signaling. Over 10,000 original research articles, reviews, and conference papers were screened for this book.
Now in paperback, the second edition of the Oxford Textbook of Critical Care is a comprehensive multi-disciplinary text covering all aspects of adult intensive care management. Uniquely this text takes a problem-orientated approach providing a key resource for daily clinical issues in the intensive care unit. The text is organized into short topics allowing readers to rapidly access authoritative information on specific clinical problems. Each topic refers to basic physiological principles and provides up-to-date treatment advice supported by references to the most vital literature. Where international differences exist in clinical practice, authors cover alternative views. Key messages summarise each topic in order to aid quick review and decision making. Edited and written by an international group of recognized experts from many disciplines, the second edition of the Oxford Textbook of Critical Careprovides an up-to-date reference that is relevant for intensive care units and emergency departments globally. This volume is the definitive text for all health care providers, including physicians, nurses, respiratory therapists, and other allied health professionals who take care of critically ill patients.
Endocrinology by P. Michael Conn,Shlomo Melmed Pdf
Leading scientists and clinicians create a concise yet comprehensive encyclopedia of the latest scientific and clinical knowledge covering the entire spectrum of endocrinology-from mammalian cells, plants, and insects to animal models and human disease. Their book illuminates the scientific principles underlying all aspects of hormone secretion and hormone action and leads the reader toward a full understanding of the pathogenesis of human endocrine disease. It will be indispensable to physicians and scientists as well as to students who need a high-quality, up-to-date critical survey and reference to endocrinology today.
Handbook of Hormones by Hironori Ando,Kazuyoshi Ukena,Shinji Nagata Pdf
Handbook of Hormones: Comparative Endocrinology for Basic and Clinical Research, Second Edition presents a catalog of fundamental information on the structure and function of hormones from basic biology to clinical use, offering a rapid way to obtain specific facts about the chemical and molecular characteristics of hormones, their receptors, signaling pathways, and the biological activities they regulate. The book's stellar editorial board, affiliated with the Japan Society for Comparative Endocrinology, brings together authors that present a compelling structure of each hormone with a consistent presentation that provides a primer surrounding the plethora of hormones that now exist. Comparative endocrinology continues to rapidly expand and new information about hormones is being produced almost daily, making it important to stay up-to-date. Hormone, paracrine, and autocrine factors have been identified as key players in a range of different systems, including immune, musculoskeletal and cardiovascular. Frontiers between disciplines are being blurred and many scientists in fields other than endocrinology are interested in hormones. Scientists now have the unprecedented opportunity to look from invertebrates to vertebrate and identify novel regulatory factors and understand their function and how they determine an organism’s physiology and survival. Presents hormones in groups according to their origin so that readers can easily understand their inter-relation Includes 47 new hormones, such as neuropeptides, cytokines, growth hormones, biogenic amines and amino acids that are important for cell to cell communication via endocrine, paracrine and neurotransmitter signaling Summarizes the current knowledge of hormone evolution based on comparative genome resources, such as synteny, genome sequence and comprehensive phylogeny Covers a wide range of information on hormones, from basic information on structure and function across vertebrate and invertebrate phyla to clinical applications Collates key information on 259 hormones and 47 groups/families
Provides a comprehensive treatment of human hormones viewed in the light of modern theories of hormone action and in the context of current understanding of cellular architecture and organ physiology.
The newly revised and updated Hormones, Second Edition provides a comprehensive treatment of human hormones, viewed in light of modern theories of hormone action and in the context of current understanding of subcellular and cellular architecture and classical organ physiology. Each chapter presents a physiological description of the hormone system under consideration, followed by a listing of the mode-of-action of the hormone. This book includes significant advances in the molecular biology of receptors, hormones, and studies of hormone action that have transpired over the past five years. The text updates the material on enzymes related to steroid metabolism and new hormone systems, as well as providing a new chapter on hormones and cancer. Key Features * Completely updates the material, covering new discoveries and significant advances since the First Edition was published in 1987 * Contains new information regarding steroid hormones, the role of hormones in cancer, and a comprehensive introductory chapter * Presents an overview of virtually all important hormones * Provides detailed physiological, cellular, and molecular descriptions of classical human endocrine systems * Streamlines the presentation of the First Edition, making the book easier to use and read
Molecular Endocrinology examines basic principles in molecular endocrinology using selected examples. It looks at the molecular aspects of hormone action, from hormone-receptor interactions to second messenger generation, gene induction, and post-transcriptional control. It also explores the regulation of nuclear receptors and membrane receptors, the nontranscriptional effects of hormones, the modifications of histone and nonhistone protein, the molecular evolution of the endocrine system, and the molecular bases of endocrinopathies. Organized into five sections comprised of 16 chapters, this book begins with a brief summary of general endocrinology and then discusses the basic characteristics of hormones and their regulation, illustrated by the hormonal control of calcium metabolism. It explains other major endocrine systems, including the hypothalamus, pituitary gland, and thyroid gland. The remainder of the text focuses on receptors and how to determine their number and affinity; the structure, function, and metabolism of nuclear and membrane receptors; the mechanisms for the regulation of receptor activity; the major second messengers, such as cyclic nucleotides, and how they can directly affect cellular processes; the role of phospholipids in signal transduction; mediators such as polyamines, oligosaccharides, and the cytoskeleton; the mechanisms by which hormones and their second messengers affect gene expression; and the hormonal control of various post-transcriptional events. This book will be of interest to biologists and those working in the field of molecular endocrinology.
This concise overview of hormone biological actions introduces basic science principles and their relevance in the clinical expression of disease. Each chapter incorporates a wealth of pedagogical aids including: study questions, learning objectives, and clinical examples.