Host Defense Dysfunction In Trauma Shock And Sepsis

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Host Defense Dysfunction in Trauma, Shock and Sepsis

Eugen Faist,Jonathan L. Meakins,Friedrich W. Schildberg
Host Defense Dysfunction in Trauma Shock and Sepsis Book PDF

Author : Eugen Faist,Jonathan L. Meakins,Friedrich W. Schildberg
Publisher : Springer Science & Business Media
Page : 1219 pages
File Size : 49,7 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9783642774058

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Host Defense Dysfunction in Trauma, Shock and Sepsis by Eugen Faist,Jonathan L. Meakins,Friedrich W. Schildberg Pdf

This book presents a unique overview of all aspects of host defense alterations under stressful conditions. It is based on the most important contributions given at the "2nd International Congress on the Immune Consequences of Trauma, Shock, and Sepsis-Mechanisms and Therapeutic Approaches," which was held in Munich under the auspices of the most distinguished scientific societies involved in this field (Society of Critical Care Medicine, European Society of Intensive Care Medicine, Societe Internationale de Chirurgie, Surgical Infection Society, Surgical Infection Society Europe, European Society for Surgical Research, International Society for Burn Injury, American Association for the Surgery of Trauma, and National Institutes of Health). Since the first conference of this kind in 1988, new information from basic studies and clinical trials has provided exciting and novel insights into the immune dysfunctions accom panying trauma, shock, and sepsis. The volume is divided into 18 parts presenting the structural background of trauma-induced alterations of immune and imflammatory mechanisms as well as the currently discussed therapeutic interventions designed to restore or maintain normal host defenses following major injury. Introducing the general theme of the book is a summary of the essential keystones of trauma and sepsis-related immune deficits. Discussions of the progress in trauma care brought through better understanding of the cell biology of injury and of the major clinical factors that influence host defense integrity in operative medicine provide a setting for understanding the wide array of detailed information that is presented thereafter.

Host Defense Dysfunctions in Trauma, Shock, and Sepsis

Eugen Faist,Jonathan L. Meakins,Friedrich W. Schildberg
Host Defense Dysfunctions in Trauma Shock and Sepsis Book PDF

Author : Eugen Faist,Jonathan L. Meakins,Friedrich W. Schildberg
Publisher : Berlin : Springer-Verlag
Page : 1330 pages
File Size : 46,9 Mb
Release : 1993
Category : Medical
ISBN : UOM:39015029526319

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Host Defense Dysfunctions in Trauma, Shock, and Sepsis by Eugen Faist,Jonathan L. Meakins,Friedrich W. Schildberg Pdf

This book presents a unique overview of all aspects of host defense alterations under stressful conditions. It is based on the most important contributions given at the "2nd International Congress on the Immune Consequences of Trauma, Shock, and Sepsis-Mechanisms and Therapeutic Approaches," which was held in Munich under the auspices of the most distinguished scientific societies involved in this field (Society of Critical Care Medicine, European Society of Intensive Care Medicine, Societe Internationale de Chirurgie, Surgical Infection Society, Surgical Infection Society Europe, European Society for Surgical Research, International Society for Burn Injury, American Association for the Surgery of Trauma, and National Institutes of Health). Since the first conference of this kind in 1988, new information from basic studies and clinical trials has provided exciting and novel insights into the immune dysfunctions accom panying trauma, shock, and sepsis. The volume is divided into 18 parts presenting the structural background of trauma-induced alterations of immune and imflammatory mechanisms as well as the currently discussed therapeutic interventions designed to restore or maintain normal host defenses following major injury. Introducing the general theme of the book is a summary of the essential keystones of trauma and sepsis-related immune deficits. Discussions of the progress in trauma care brought through better understanding of the cell biology of injury and of the major clinical factors that influence host defense integrity in operative medicine provide a setting for understanding the wide array of detailed information that is presented thereafter.

Host Defense Dysfunction in Trauma, Shock, and Sepsis

Eugen Faist,Jonathan L. Meakins,Friedrich W. Schildberg
Host Defense Dysfunction in Trauma Shock and Sepsis Book PDF

Author : Eugen Faist,Jonathan L. Meakins,Friedrich W. Schildberg
Publisher : Berlin : Springer-Verlag
Page : 1296 pages
File Size : 50,7 Mb
Release : 1993
Category : Immunosuppression
ISBN : 3540553290

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Host Defense Dysfunction in Trauma, Shock, and Sepsis by Eugen Faist,Jonathan L. Meakins,Friedrich W. Schildberg Pdf

This book contains a unique overview of the sequence of steps of host defense impairment that result from injury and lead to multiple organ dysfunction syndrome. The crucial alterations of immune and inflammatory mechanisms as they are seen during ischemia, during inter- mediate inflammatory phases, and in states of bacterial sepsis are described in detail. The role of endotoxin, its mechanisms of action, and potential counterregulatory strategies to neutralize endotoxin in order to protect from shock are discussed, as there are major etiologic factors leading to organ failure such as hepatic cellular injury and bacterial translocation. Cytokines, as the central mediators in acute phase states and the modulation of cytokine action are then evaluated carefully. In the discussion of the clinical aspects of multiple organ failure, the antibiotic interactions with host defenses, the augmentation of immunoreactivity with special nutrients and the newest insights into the regulation of wound repair are elucidated. The final sections of this book deal with therapeutic immunomodulatory approaches for the prevention ofinfections and with interventional strategies in the therapy of septic shock.

The Brain and Host Defense

Anonim
The Brain and Host Defense Book PDF

Author : Anonim
Publisher : Elsevier
Page : 358 pages
File Size : 49,8 Mb
Release : 2009-12-24
Category : Science
ISBN : 0444535454

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The Brain and Host Defense by Anonim Pdf

It is now well recognized that the brain, and especially the hypothalamus, plays an important role in the regulation of immune reactions and inflammation. This book aims to review our current state of knowledge of this important field. Key historical findings are presented, and the reciprocal interactions between the brain and the immune system are examined. Particular emphasis is placed on inflammation, a critical host defense reaction that serves as an effector response for both the adaptive and innate immune systems. Mechanisms implicated in brain defense, as well as in more general host defense, are discussed. The regulatory influences of the brain on inflammatory responses are included with particular reference to the role of the hypothalamus, which is also the main director the hormonal regulation of immune/inflammatory. Gender-related differences in immune responsiveness, circadian modulator of immune responses, and evidence that behavioral conditioning (e.g. reward) of immune responses is possible are used as examples to reinforce the notion that the neuroendocrine system exerts a fundamental and complex regulatory influence on the immune system. * Presents timely issues such as immunological aspects of the blood-brain-barrier and the role of inflammatory mediators in the evolution of strokes and degenerative diseases * Includes analysis of the role of the brain in the adaptive responses to disease * Evaluates the argument that further knowledge of the influence of the brain on the immune system will provide new insights to the pathophysiology infectious and autoimmune diseases

Immunology and Its Impact on Infections in Surgery

Rainer Engemann,Rene Holzheimer,A. Thiede
Immunology and Its Impact on Infections in Surgery Book PDF

Author : Rainer Engemann,Rene Holzheimer,A. Thiede
Publisher : Springer Science & Business Media
Page : 266 pages
File Size : 42,7 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9783642790799

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Immunology and Its Impact on Infections in Surgery by Rainer Engemann,Rene Holzheimer,A. Thiede Pdf

In this book, the recent developments in immunology and the impact on the treatment of infections in critical care and in surgery are presented, also describing how cellular immunology influences clinical treatment. This information helps in understanding the pathogenesis of infections in surgery and critical care. The impact of a standard treatment such as antibiotic therapy is evaluated and possible future therapy modalities outlined. This book will be of interest to clinicians and immunologists as scientists of both specialties have contributed to the book.

Pathology of Septic Shock

Ernst T. Rietschel,Hermann Wagner
Pathology of Septic Shock Book PDF

Author : Ernst T. Rietschel,Hermann Wagner
Publisher : Springer Science & Business Media
Page : 325 pages
File Size : 43,7 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9783642801860

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Pathology of Septic Shock by Ernst T. Rietschel,Hermann Wagner Pdf

Severe sepsis and septic shock are the most serious compli cations of bacterial infections. Both gram-positive and gram negative bacteria can trigger these extreme inflammatory re sponses and, by so doing, cause substantial morbidity and mortality. In the United States alone, over 400 000 patients suffer from septicaemia each year, and approximately 100 000 of these patients die despite optimal intensive care and modern antimicrobial therapy. These dramatic figures have prompted intensive research to define the bacterial and host factors involved in the septic response. Scientists from many disciplines, including chem istry, physics, biology, medical microbiology, immunology, and pharmacology, have worked closely with clinicians to achieve rapid and profound progress. To translate this newly acquired knowledge into clinical practice, clinical trials have also been performed to evaluate numerous new therapeutic drugs. The disappointing results from these trials have underscored a major lesson, namely, that sepsis constitutes an extremely complex syndrome and that basic and clinical research must be greatly intensified in order to illuminate its molecular mechan isms. At this stage, the editors of the present volume of Current Topics in Microbiology and Immunology considered it would be rewarding to compile a volume summarizing our present basic and clinical knowledge on sepsis. Our particular gratitude extends to those international experts who have followed our invitation and elaborated on particular areas of the basic and clinical aspects of this field.

Multiple Organ Failure

Arthur E. Baue,Eugen Faist,Donald Fry
Multiple Organ Failure Book PDF

Author : Arthur E. Baue,Eugen Faist,Donald Fry
Publisher : Springer Science & Business Media
Page : 712 pages
File Size : 50,9 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9781461212225

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Multiple Organ Failure by Arthur E. Baue,Eugen Faist,Donald Fry Pdf

Inflammation in itself is not to be considered as a disease . . . and in disease, where it can alter the diseased mode of action, it likewise leads to a cure; but where it cannot accomplish that solitary purpose . . . it does mischief - John Hunter, A Treatise on the Blood, ITfIlammation, and Gunshot Woundr (London, 1794)1 As we reached the millennium, we recognized the gap between our scientific knowledge of biologic processes and our more limited clinical capabilities in the care of patients. Our science is strong. Molecular biology is powerful, but our therapy to help patients is weaker and more limited. For this reason, this book focuses on the problems of multiple organ failure (MOF), multiple organ dysfunction syndrome (MODS), and systemic inflammatory response syndrome is, patients who have severe injuries; require major, (SIRS) in high-risk patients, that overwhelming operations; or have serious illnesses requiring intensive care; patients who have diseases elsewhere, in other organs or systems, that limit their capabilities to survive a new insult; and patients who are elderly or at high risk for sepsis or other complications. These are the patients who need our help. They need the advances in science, in molecular biology, immunology, pathophysiology, biochemistry, genetics, high technology, and other areas of maximum support at the bedside. These advances could potentially have the greatest impact on improving patient care.

The Sepsis Text

Jean-Louis Vincent,Jean Carlet,Steven M. Opal
The Sepsis Text Book PDF

Author : Jean-Louis Vincent,Jean Carlet,Steven M. Opal
Publisher : Springer Science & Business Media
Page : 848 pages
File Size : 53,7 Mb
Release : 2007-05-08
Category : Medical
ISBN : 9780306476648

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The Sepsis Text by Jean-Louis Vincent,Jean Carlet,Steven M. Opal Pdf

This textbook is written at the dawn of a new era in the management of sepsis. Recent achievements in the clinical management of septic shock are the culmination of decades of basic and applied research by innovative researchers and clinical investigators worldwide. The contributing authors to this book have spearheaded much of this research and the Editors have endeavored to create a textbook that is comprehensive in nature while maintaining a specific focus upon the multitude of work that constitutes the spectrum of sepsis research including: pathophysiology; monitoring systems; general support; microbial aspects; complications; and anti-sepsis therapies.

Blood Substitutes

Robert M. Winslow,Kim D. Vandegriff,Marcos Intaglietta
Blood Substitutes Book PDF

Author : Robert M. Winslow,Kim D. Vandegriff,Marcos Intaglietta
Publisher : Springer Science & Business Media
Page : 219 pages
File Size : 55,7 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9781461241140

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Blood Substitutes by Robert M. Winslow,Kim D. Vandegriff,Marcos Intaglietta Pdf

This book is not a "proceedings" volume. Rather the chapters are essays by experts in the field of blood substitutes, invited by the editors to con tribute to the 1996 "Current Issues in Blood Substitutes Research and Development" course given in San Diego, March 18-21. The contributors were selected because of their expertise in areas deemed by the editors to be critical to the advancement of the field. The course, as in past years, is heavily influenced by feedback from par ticipants, and by research in this and related fields. In addition to the didactic lectures (for which these chapters are the foundation), the course also offers the opportunity for presentation of research reports, progress reports from the various companies currently commercializing products, and round table discussions of selected subjects. Thus, we are grateful to past participants for their helpful comments. Production of a book, especially on a short timeline, is not an easy feat.

Yearbook of Intensive Care and Emergency Medicine 2000

Prof. Jean-Louis Vincent
Yearbook of Intensive Care and Emergency Medicine 2000 Book PDF

Author : Prof. Jean-Louis Vincent
Publisher : Springer Science & Business Media
Page : 859 pages
File Size : 50,7 Mb
Release : 2013-11-11
Category : Medical
ISBN : 9783662134559

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Yearbook of Intensive Care and Emergency Medicine 2000 by Prof. Jean-Louis Vincent Pdf

The Yearbook compiles the most recent, widespread developments of experimental and clinical research and practice in one comprehensive reference book. The chapters are written by well recognized experts in their field of intensive care and emergency medicine. It is addressed to everyone involved in internal medicine, anesthesia, surgery, pediatrics, intensive care and emergency medicine. (With approximately 90 contributions.)

Growth Factors and Wound Healing

Thomas R. Ziegler,Glenn F. Pierce,David N. Herndon
Growth Factors and Wound Healing Book PDF

Author : Thomas R. Ziegler,Glenn F. Pierce,David N. Herndon
Publisher : Springer Science & Business Media
Page : 374 pages
File Size : 46,7 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9781461218760

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Growth Factors and Wound Healing by Thomas R. Ziegler,Glenn F. Pierce,David N. Herndon Pdf

The aim of this symposium was to provide basic and clinical investigators with the latest information on the biology of wound healing and tissue repair. Written and edited by eminent experts in the field, the papers cover the general concepts of wound healing; the role of nutrients; endogenous growth factors; clinical applications of growth hormone and IGF-1 therapy; and clinical applications of peptide growth factors.

Cytokines in Severe Sepsis and Septic Shock

H. Redl,Günther Schlag
Cytokines in Severe Sepsis and Septic Shock Book PDF

Author : H. Redl,Günther Schlag
Publisher : Springer Science & Business Media
Page : 398 pages
File Size : 52,6 Mb
Release : 1998-11
Category : Health & Fitness
ISBN : 3764358777

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Cytokines in Severe Sepsis and Septic Shock by H. Redl,Günther Schlag Pdf

This book deals with the central role of cytokines in the generalized inflammatory response of the host as the consequence of severe infection/endotoxin action. International specialists cover several aspects in 20 chapters starting with the agents responsible (endotoxin, superantigens) and recognition during cytokine induction. Further chapters deal with the signal transduction cascade, its modulation due to sex or genetic polymorphism, and the possibilities and problems in detection (including surrogate markers). Major targets of actions are covered in the chapters on coagulation-/fibrinolysis, adherence molecules, vasoactive factors, apoptosis and metabolism. As not all actions of cytokines are beneficial, several chapters deal with the prevention of induction, modulation of the cytokine generation or scavenging cytokines including gene therapy approaches. Models are necessary for obtaining pathophysiological information and for testing therapeutic approaches, and thus all chapters deal with experimental models as well as clinical trials. The reasons why these have failed so far are the subject of the final chapter.

Red Blood Cell Substitutes

Alan Rudolph
Red Blood Cell Substitutes Book PDF

Author : Alan Rudolph
Publisher : CRC Press
Page : 512 pages
File Size : 55,6 Mb
Release : 1997-09-05
Category : Medical
ISBN : 0824700589

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Red Blood Cell Substitutes by Alan Rudolph Pdf

Presents an up-to-date treatment of research strategies, clinical and commercial developments, and regulatory and economic issues pertaining to the formulation of effective and safe red blood cell substitutes. The text examines regulatory and socioeconomic aspects of blood substitute products, and global tranfusion practices from the perspective of blood banks and the US Food and Drug Administrations. It also includes the mechanisms of action and consequences of blood substitute administration.

Immune Consequences of Trauma, Shock, and Sepsis

Eugen Faist,John L. Ninnemann,Douglas R. Green
Immune Consequences of Trauma Shock and Sepsis Book PDF

Author : Eugen Faist,John L. Ninnemann,Douglas R. Green
Publisher : Springer Science & Business Media
Page : 563 pages
File Size : 51,6 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9783642734687

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Immune Consequences of Trauma, Shock, and Sepsis by Eugen Faist,John L. Ninnemann,Douglas R. Green Pdf

Sepsis and infection are the major enemies of the intensive care patient in whom immunological defenses are severely impaired. This major problem is thefocus of attention in this book, based on the presentation of the First International Congress on the Immune Consequences of Trauma, Shock, and Sepsis, which is one of the first attempts to exchange ideas on the state-of-the-art in this area of immunology. Both basic and clinical research, including new centres of attention, are described. The growing role of immunology in medicine opens new avenues to the under- standing of trauma and sepsis and will allow the design of novel therapeutic approaches.

The Physiological Genomics of the Critically Ill Mouse

Can Ince
The Physiological Genomics of the Critically Ill Mouse Book PDF

Author : Can Ince
Publisher : Springer Science & Business Media
Page : 555 pages
File Size : 43,6 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9781461504832

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The Physiological Genomics of the Critically Ill Mouse by Can Ince Pdf

The physiological genomics of the cardiovascular system studies the relationship between gene and physiological (dys)function. It is a rapidly developing area of research and distinguishes itself from other areas of molecular medicine by its highly integrative nature. In this multi disciplinarian area of the physiological sciences, there is interaction between gene structure and physiological cardiovascular function as well as interactions between the different organs and their physiological compartments. The mouse has played a central role in the study of genomics due to the detailed knowledge of the mouse genome and the wide availability of genetically modified mice. In the past, the mouse had mainly been used in the area of immunology and molecular biology, and physiological interest in the mouse was scarce. As more insight has come into the structural genomics of the mouse, however, it has become increasingly important to understand the relation between gene and physiological function. With this in mind we have been organizing the Amsterdam Mouse Symposia to bring together different disciplines interested in the molecular basis of cardiovascular function (see J. of Clinical and Exp. Pharmacology and rd Physiology (2002) 29:A69-AI02 for the proceedings of the 3 Amsterdam Mouse Symposium and Basic Research in Cardiology (2000) 95:492-535 for nd the proceedings of the 2 symposium).