Pathology Of Septic Shock

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Oxford Textbook of Critical Care

Webb
Oxford Textbook of Critical Care Book PDF

Author : Webb
Publisher : Oxford University Press
Page : 1961 pages
File Size : 43,9 Mb
Release : 2020-01-10
Category : Medical
ISBN : 9780198855439

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Oxford Textbook of Critical Care by Webb Pdf

Now in paperback, the second edition of the Oxford Textbook of Critical Care is a comprehensive multi-disciplinary text covering all aspects of adult intensive care management. Uniquely this text takes a problem-orientated approach providing a key resource for daily clinical issues in the intensive care unit. The text is organized into short topics allowing readers to rapidly access authoritative information on specific clinical problems. Each topic refers to basic physiological principles and provides up-to-date treatment advice supported by references to the most vital literature. Where international differences exist in clinical practice, authors cover alternative views. Key messages summarise each topic in order to aid quick review and decision making. Edited and written by an international group of recognized experts from many disciplines, the second edition of the Oxford Textbook of Critical Careprovides an up-to-date reference that is relevant for intensive care units and emergency departments globally. This volume is the definitive text for all health care providers, including physicians, nurses, respiratory therapists, and other allied health professionals who take care of critically ill patients.

Pathophysiology of Shock, Sepsis, and Organ Failure

Günther Schlag,Heinz Redl
Pathophysiology of Shock Sepsis and Organ Failure Book PDF

Author : Günther Schlag,Heinz Redl
Publisher : Springer Science & Business Media
Page : 1180 pages
File Size : 55,6 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9783642767364

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Pathophysiology of Shock, Sepsis, and Organ Failure by Günther Schlag,Heinz Redl Pdf

In this book current knowledge of the pathophysiology of shock, sepsis and multi organ failure is presented. The rapid progress which has been made and the results achieved in intensive care medicine are based on sound basic research, which is duly reflected in these chapters. Multiorgan failure is the foremost cause of postoperative and posttraumatic death and many complex mechanisms are involved. Only with a good foundation of basic research can abnormalities in the physiological, biochemical, and morphological course of shock be recognized and the necessary conclusions for treatment drawn. Therapy must proceed from profound knowledge of the multi variant physiological events in order to influence shock, sepsis and organ failure. Although numerous possibilities for therapy have arisen from pharmaceutical research in recent years, they are beyond the scope of this book and are not discussed here. To gain a better understanding of the pathophysiological events it was necessary to examine and to describe different models that simulate and reproduce these events. Here we describe the causative agents (shock) and the consequences (sepsis, organ failure) in two main sections, divided on the basis of their pathophysiology.

Pathology of Septic Shock

Ernst T. Rietschel,Hermann Wagner
Pathology of Septic Shock Book PDF

Author : Ernst T. Rietschel,Hermann Wagner
Publisher : Springer
Page : 321 pages
File Size : 45,9 Mb
Release : 2011-12-22
Category : Medical
ISBN : 3642801870

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Pathology of Septic Shock by Ernst T. Rietschel,Hermann Wagner Pdf

Severe sepsis and septic shock are the most serious compli cations of bacterial infections. Both gram-positive and gram negative bacteria can trigger these extreme inflammatory re sponses and, by so doing, cause substantial morbidity and mortality. In the United States alone, over 400 000 patients suffer from septicaemia each year, and approximately 100 000 of these patients die despite optimal intensive care and modern antimicrobial therapy. These dramatic figures have prompted intensive research to define the bacterial and host factors involved in the septic response. Scientists from many disciplines, including chem istry, physics, biology, medical microbiology, immunology, and pharmacology, have worked closely with clinicians to achieve rapid and profound progress. To translate this newly acquired knowledge into clinical practice, clinical trials have also been performed to evaluate numerous new therapeutic drugs. The disappointing results from these trials have underscored a major lesson, namely, that sepsis constitutes an extremely complex syndrome and that basic and clinical research must be greatly intensified in order to illuminate its molecular mechan isms. At this stage, the editors of the present volume of Current Topics in Microbiology and Immunology considered it would be rewarding to compile a volume summarizing our present basic and clinical knowledge on sepsis. Our particular gratitude extends to those international experts who have followed our invitation and elaborated on particular areas of the basic and clinical aspects of this field.

Sepsis Management in Resource-limited Settings

Arjen M. Dondorp,Martin W. Dünser,Marcus J. Schultz
Sepsis Management in Resource limited Settings Book PDF

Author : Arjen M. Dondorp,Martin W. Dünser,Marcus J. Schultz
Publisher : Springer
Page : 216 pages
File Size : 53,5 Mb
Release : 2019-02-08
Category : Medical
ISBN : 9783030031435

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Sepsis Management in Resource-limited Settings by Arjen M. Dondorp,Martin W. Dünser,Marcus J. Schultz Pdf

This book is open access under a CC BY 4.0 license. It constitutes a unique source of knowledge and guidance for all healthcare workers who care for patients with sepsis and septic shock in resource-limited settings. More than eighty percent of the worldwide deaths related to sepsis occur in resource-limited settings in low and middle-income countries. Current international sepsis guidelines cannot be implemented without adaptations towards these settings, mainly because of the difference in local resources and a different spectrum of infectious diseases causing sepsis. This prompted members of the Global Intensive Care working group of the European Society of Intensive Care Medicine (ESICM) and the Mahidol-Oxford Tropical Medicine Research Unit (MORU, Bangkok, Thailand) - among which the Editors – to develop with an international group of experts a comprehensive set of recommendations for the management of sepsis in resource-limited settings. Recommendations are based on both current scientific evidence and clinical experience of clinicians working in resource-limited settings. The book includes an overview chapter outlining the current challenges and future directions of sepsis management as well as general recommendations on the structure and organization of intensive care services in resource-limited settings. Specific recommendations on the recognition and management of patients with sepsis and septic shock in these settings are grouped into seven chapters. The book provides evidence-based practical guidance for doctors in low and middle income countries treating patients with sepsis, and highlights areas for further research and discussion.

Essentials of Shock Management

Gil Joon Suh
Essentials of Shock Management Book PDF

Author : Gil Joon Suh
Publisher : Springer
Page : 147 pages
File Size : 44,9 Mb
Release : 2018-11-30
Category : Medical
ISBN : 9789811054068

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Essentials of Shock Management by Gil Joon Suh Pdf

This book is designed to offer the reader first-rate guidance on shock management in the real world. Comprehensive, evidence-based, and up-to-date instruction is provided on optimal care of patients with different types of shock – septic, hemorrhagic, cardiogenic, anaphylactic, and obstructive – at all stages from initial response through to ICU admission. As well as management, the coverage encompasses pathophysiology, clinical presentation, diagnosis, and emerging trends. A further key feature is the use of a scenario-based approach to present a series of cases based on real-life experiences. Here, a narrative style and Q&A form are employed to vividly convey scenarios that may be encountered in clinical practice and to elucidate decision making in complex circumstances. When readers experience difficulty in answering the questions, the earlier sections can be consulted to identify the correct response. This book will be of great value for all health care professionals. In particular, it will be very helpful for novice or inexperienced practitioners in emergency medicine, critical care medicine, and traumatology.

Septic Shock

George H. Sakorafas,Adelais G. Tsiotou
Septic Shock Book PDF

Author : George H. Sakorafas,Adelais G. Tsiotou
Publisher : Nova Publishers
Page : 128 pages
File Size : 51,8 Mb
Release : 2005
Category : Septic shock
ISBN : 159454168X

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Septic Shock by George H. Sakorafas,Adelais G. Tsiotou Pdf

Sepsis is one of the most frequent complications in the surgical patient and one of the leading causes of mortality in intensive care units. During the past two decades, a great deal has been learned about surgical bacteriology, antibiotic prophylaxis, supportive management, and the host response to microbial invasion. Sepsis can be caused by infection with gram-negative bacteria, gram-positive bacteria, fungi (and particularly Candida), or viruses. Sepsis may also occur in the absence of detectable bacterial invasion, and in these cases, microbial toxins, particularly gram-negative bacterial endotoxin (lipopolysaccharide, LPS), and endogenous cytokine production have been implicated as initiators and mediators. Although activation of the immune system during microbial invasion is generally protective, septic shock develops in a significant number of patients as a consequence of a poorly regulated immune response to the offending organism. Sepsis can be presented with a spectrum of severity. Septic shock represents the most severe form of host response to infection. The aim of this monograph is to summarise the currently available data regarding epidemiology, pathogenesis, and optimal management of septic shock, with a particular emphasis on the role of source control in sepsis. Emerging therapies for septic shock are also discussed.

Controversies in Acute Kidney Injury

John A. Kellum,C. Ronco,J. L. Vincent
Controversies in Acute Kidney Injury Book PDF

Author : John A. Kellum,C. Ronco,J. L. Vincent
Publisher : Karger Medical and Scientific Publishers
Page : 267 pages
File Size : 48,8 Mb
Release : 2011
Category : Medical
ISBN : 9783805598101

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Controversies in Acute Kidney Injury by John A. Kellum,C. Ronco,J. L. Vincent Pdf

A timely update Acute kidney injury (AKI) is a serious and as yet incompletely understood disorder in which sudden impairment of kidney function occurs secondary to one or more of a variety of underlying conditions. This disorder is very common in (elderly) ICU patients and is associated with very high mortality. Many of those who survive suffer from permanent kidney failure and other long-term morbidities, which may include cardiovascular disease and immune dysfunction. Epidemiologic evidence suggests that AKI is not a single disease, but a syndrome comprised of multiple, often coexisting, etiologies. Being usually part of multiorgan failure syndrome, it calls for multiple organ support therapy. The publication at hand contains sections on prerenal azotemia syndromes, dying of' or with' AKI, pathophysiology of sepsis- induced acute kidney injury, developments in prevention / treatment / rehabilitation, and renal support. Reporting the latest recommendations from experts, it provides valuable information for those that are interested in understanding the disorder and its treatment options.

Obstetric and Intrapartum Emergencies

Edwin Chandraharan,Sabaratnam Arulkumaran
Obstetric and Intrapartum Emergencies Book PDF

Author : Edwin Chandraharan,Sabaratnam Arulkumaran
Publisher : Cambridge University Press
Page : 295 pages
File Size : 49,9 Mb
Release : 2012-10-11
Category : Medical
ISBN : 9781139788601

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Obstetric and Intrapartum Emergencies by Edwin Chandraharan,Sabaratnam Arulkumaran Pdf

Every day, approximately 1000 women die from preventable causes related to pregnancy and childbirth, most of which result from common treatable complications, such as haemorrhage, infections, pre-eclampsia and obstructed labour, which have not been recognized in time or treated properly. Every unborn child also faces risk of stillbirth, birth trauma, oxygen deprivation and neonatal death or long-term brain damage during birthing. Obstetric and Intrapartum Emergencies: A Practical Guide to Management is written by a wide variety of obstetric experts in developing and developed countries and provides an easy-to-use guide to recognize and treat perinatal emergencies before it is too late. The text includes learning tools such as 'Key Pearls' and 'Key Pitfalls', a section on managing emergencies in a low-resource setting and contains detailed illustrations throughout. This book is a practical and invaluable guide for obstetricians, neonatologists, midwives, medical students and the wider perinatal team.

Sepsis

Konrad Reinhart,Klaus Eyrich,Charles Sprung
Sepsis Book PDF

Author : Konrad Reinhart,Klaus Eyrich,Charles Sprung
Publisher : Springer Science & Business Media
Page : 573 pages
File Size : 53,5 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9783642850363

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Sepsis by Konrad Reinhart,Klaus Eyrich,Charles Sprung Pdf

The comprehensive coverage of the incidence, etiology, pathophysiology, definition, and therapy of sepsis and septic shock gives you the knowledge you need to keep up with modern therapeutic strategies. The authors are either basic scientists or clinical researchers whose goal is to present the newest aspects of their work in comprehensible language. They clearly show the new perspectives that are emerging in the treatment of sepsis and septic shock.

Handbook of Sepsis

W. Joost Wiersinga,Christopher W. Seymour
Handbook of Sepsis Book PDF

Author : W. Joost Wiersinga,Christopher W. Seymour
Publisher : Springer
Page : 267 pages
File Size : 42,5 Mb
Release : 2018-04-13
Category : Medical
ISBN : 9783319735061

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Handbook of Sepsis by W. Joost Wiersinga,Christopher W. Seymour Pdf

This practically oriented book provides an up-to-date overview of all significant aspects of the pathogenesis of sepsis and its management, including within the intensive care unit. Readers will find information on the involvement of the coagulation and endocrine systems during sepsis and on the use of biomarkers to diagnose sepsis and allow early intervention. International clinical practice guidelines for the management of sepsis are presented, and individual chapters focus on aspects such as fluid resuscitation, vasopressor therapy, response to multiorgan failure, antimicrobial therapy, and adjunctive immunotherapy. The closing section looks forward to the coming decade, discussing novel trial designs, sepsis in low- and middle-income countries, and emerging management approaches. The book is internatio nal in scope, with contributions from leading experts worldwide. It will be of value to residents and professionals/practitioners in the fields of infectious diseases and internal medicine, as well as to GPs and medical students.

Health Professionals for a New Century

Anonim
Health Professionals for a New Century Book PDF

Author : Anonim
Publisher : Harvard School of Public Health, Frangois-Xavier Bagnoud Cen
Page : 95 pages
File Size : 42,5 Mb
Release : 2011
Category : Medical
ISBN : 0674061489

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Health Professionals for a New Century by Anonim Pdf

One hundred years ago a series of seminal documents, starting with the Flexner Report of 1910, sparked an enormous burst of energy to harness the power of science to transform higher education in health. Professional education, however, has not been able to keep pace with the challenges of the 21st century. A new generation of reforms is needed to meet the demands of health systems in an interdependent world. The report of the Commission on the Education of Health Professionals for the 21st Century, a global independent initiative consisting of 20 leaders from diverse disciplinary backgrounds and institutional affiliations, articulates a fresh vision and recommends renewed actions. Building on a rich legacy of educational reforms during the past century, the Commission's findings and recommendations adopt a global and multi-professional perspective using a systems approach to analyze education and health, with a focus on institutional and instructional reforms.

Heparanase

Israel Vlodavsky,Ralph D. Sanderson,Neta Ilan
Heparanase Book PDF

Author : Israel Vlodavsky,Ralph D. Sanderson,Neta Ilan
Publisher : Springer Nature
Page : 871 pages
File Size : 43,5 Mb
Release : 2020-04-09
Category : Medical
ISBN : 9783030345211

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Heparanase by Israel Vlodavsky,Ralph D. Sanderson,Neta Ilan Pdf

Written by internationally recognized leaders in Heparanase biology, the book’s eight chapters offer an opportunity for scientists, clinicians and advanced students in cell biology, tumor biology and oncology to obtain a comprehensive understanding of Heparanase’s multifaceted activities in cancer, inflammation, diabetes and other diseases, as well as its related clinical applications. Proteases and their involvement in cancer progression have been well addressed and documented; however, the emerging premise presented within this book is that Heparanase is a master regulator of aggressive cancer phenotypes and crosstalk with the tumor microenvironment. This endoglycosidase contributes to tumor-mediated remodeling of the extracellular matrix and cell surfaces, augmenting the bioavailability of pro-tumorigenic and pro-inflammatory growth factors and cytokines that are bound to Heparan sulfate. Compelling evidence ties Heparanase with all steps of tumor progression including tumor initiation, growth, angiogenesis, metastasis, and chemoresistance, supporting the notion that Heparanase is an important contributor to the poor outcome of cancer patients and a validated target for therapy. Unlike Heparanase, heparanase-2, a close homolog of Heparanase, lacks enzymatic activity, inhibits Heparanase, and regulates selected genes that promote normal differentiation and tumor suppression. Written by internationally recognized leaders in Heparanase biology, this volume presents a comprehensive understanding of Heparanase’s multifaceted activities in cancer, inflammation, diabetes and other diseases, as well as its related clinical applications to scientists, clinicians and advanced students in cell biology, tumor biology and oncology.

Pathophysiology of Shock, Sepsis, and Organ Failure

Günther Schlag,Heinz Redl
Pathophysiology of Shock Sepsis and Organ Failure Book PDF

Author : Günther Schlag,Heinz Redl
Publisher : Springer
Page : 1165 pages
File Size : 53,5 Mb
Release : 1993-05-17
Category : Medical
ISBN : 354054223X

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Pathophysiology of Shock, Sepsis, and Organ Failure by Günther Schlag,Heinz Redl Pdf

In this book current knowledge of the pathophysiology of shock, sepsis and multi organ failure is presented. The rapid progress which has been made and the results achieved in intensive care medicine are based on sound basic research, which is duly reflected in these chapters. Multiorgan failure is the foremost cause of postoperative and posttraumatic death and many complex mechanisms are involved. Only with a good foundation of basic research can abnormalities in the physiological, biochemical, and morphological course of shock be recognized and the necessary conclusions for treatment drawn. Therapy must proceed from profound knowledge of the multi variant physiological events in order to influence shock, sepsis and organ failure. Although numerous possibilities for therapy have arisen from pharmaceutical research in recent years, they are beyond the scope of this book and are not discussed here. To gain a better understanding of the pathophysiological events it was necessary to examine and to describe different models that simulate and reproduce these events. Here we describe the causative agents (shock) and the consequences (sepsis, organ failure) in two main sections, divided on the basis of their pathophysiology.

Abdominal Sepsis

Massimo Sartelli,Matteo Bassetti,Ignacio Martin-Loeches
Abdominal Sepsis Book PDF

Author : Massimo Sartelli,Matteo Bassetti,Ignacio Martin-Loeches
Publisher : Springer
Page : 405 pages
File Size : 53,6 Mb
Release : 2018-03-20
Category : Medical
ISBN : 9783319597041

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Abdominal Sepsis by Massimo Sartelli,Matteo Bassetti,Ignacio Martin-Loeches Pdf

This book examines in detail the topic of sepsis, with a focus on intra-abdominal sepsis. Particular attention is devoted to source control in the management of the infection, antimicrobial therapy and sepsis support, which represent the cornerstones of treating patients with this problem. The importance of a multidisciplinary approach is highlighted not only by the instructive and informative sections on the acute manifestations of appendicitis, cholecystitis, and cholangitis, perforations and diverticulitis, Clostridium difficile infection and the role of candida in abdominal sepsis, but also by an extensive discussion of issues including antimicrobial resistance, damage control surgery, principles of antimicrobial therapy, hemodynamic support, adjunctive therapies, and thromboprophylaxis. Abdominal sepsis is the host’s systemic inflammatory response to intra-abdominal infections. It is associated with significant morbidity and mortality rates, and represents the second most common cause of sepsis-related mortality at intensive care units. Gathering contributions by authoritative experts from all around the world, this book will allow acute care surgeons, abdominal surgeons, intensive care clinicians, and students to broaden their understanding of intra-abdominal sepsis in daily clinical practice.

Autopsy Pathology: A Manual and Atlas

Andrew Connolly,Walter E. Finkbeiner,Philip C. Ursell,Richard L. Davis
Autopsy Pathology A Manual and Atlas Book PDF

Author : Andrew Connolly,Walter E. Finkbeiner,Philip C. Ursell,Richard L. Davis
Publisher : Elsevier Health Sciences
Page : 403 pages
File Size : 51,8 Mb
Release : 2015-09-23
Category : Medical
ISBN : 9780323287807

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Autopsy Pathology: A Manual and Atlas by Andrew Connolly,Walter E. Finkbeiner,Philip C. Ursell,Richard L. Davis Pdf

A mainstay for pathology residents, Autopsy Pathology is designed with a uniquely combined manual and atlas format that presents today's most complete coverage of performing, interpreting, and reporting post-mortem examinations. This lasting and useful medical reference book offers a practical, step-by-step approach to discussing not only the basics of the specialty, but the performance of specialized autopsy procedures as well. Material is divided into two sections for ease of use: a manual covering specific autopsy procedures, biosafety, generation of autopsy reports, preparation of death certificates, and other essential subjects; and an atlas, organized by organ system, which captures the appearance of the complete spectrum of autopsy findings. Offers expanded coverage of microscopic anatomy. Includes a chapter on performing special dissection procedures that may not be covered during a typical residency. Examines important techniques, such as autopsy photography and radiology, microscopic examination, supplemental laboratory studies, and other investigative approaches. Addresses the latest legal, social, and ethical issues relating to autopsies, as well as quality improvement and assurance. Presents more than 600 full-color photographs depicting common gross and microscopic autopsy findings for every part of the body. Correlates pathologic findings with their clinical causes to enhance diagnostic accuracy. Improved images in the Atlas section provide greater visual understanding. Additional online features include dissection videos demonstrating autopsy techniques; downloadable, commonly used forms for autopsy reports; and calculators for weights and measures. Expert Consult eBook version included with purchase. This enhanced eBook experience offers access to all of the text, figures, images, videos, forms, calculators, and references from the book on a variety of devices.