Human Exposure To Pollutants Via Dermal Absorption And Inhalation

Author : Mihalis Lazaridis,Ian Colbeck
Publisher : Springer Science & Business Media
Page : 313 pages
File Size : 48,7 Mb
Release : 2010-03-22
Category : Science
ISBN : 9789048186631

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Human Exposure to Pollutants via Dermal Absorption and Inhalation by Mihalis Lazaridis,Ian Colbeck Pdf

Estimates of the air pollution health impact play a crucial role in environmental protection. These estimates require accurate data on the pollutant exposure and dose to the population as well as the dose–response relationships to calculate the health impact. From an air quality manager’s perspective there is concern about the validity and accuracy of these calculations. There is a need for information and possible ways to adjust the assessment. One important topic for air quality managers is to understand the relative cont- bution of sources to the total exposure. These sources may be coming from both different outdoor sources from sectors such as transport, industry and energy ind- tries, and from a number of indoor sources, such as heating, ventilation and indoor activities as well as out-gassing from building material and furniture. Indoor air quality is now drawing the attention of policy makers. The basic right to, and importance of, healthy indoor air was emphasized by the World Health Organization as early as 2000 and several countries have described target conc- trations for various pollutants. The WHO Air Quality Guidelines 2005 rec- mended the development of specific guidelines for indoor air quality and these are expected to be published soon. Indoor air pollutants have not been as extensively monitored as outdoor air pollutants and the evidence base for contributions to health effects needs to be strengthened.

Author : Wayne R. Ott,Anne C. Steinemann,Lance A. Wallace
Publisher : CRC Press
Page : 554 pages
File Size : 52,5 Mb
Release : 2006-10-26
Category : Medical
ISBN : 9781420012637

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Exposure Analysis by Wayne R. Ott,Anne C. Steinemann,Lance A. Wallace Pdf

Written by experts, Exposure Analysis is the first complete resource in the emerging scientific discipline of exposure analysis. A comprehensive source on the environmental pollutants that affect human health, the book discusses human exposure through pathways including air, food, water, dermal absorption, and, for children, non-food ingesti

Author : Stephen S Olin
Publisher : CRC Press
Page : 247 pages
File Size : 47,6 Mb
Release : 2020-08-18
Category : Medical
ISBN : 9781000102642

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Exposure to Contaminants in Drinking Water by Stephen S Olin Pdf

Exposure to Contaminants in Drinking Water: Estimating Uptake through the Skin and by Inhalation examines the current state of science in this field by identifying and reviewing the available information resources; evaluating various models and approaches; and demonstrating the feasibility of developing estimates of the distribution of absorbed doses of contaminants in drinking water through contact with the skin and by inhalation. This book, the product of a fifteen-member expert working group convened by the Risk Science Institute of the International Life Sciences Institute under a cooperative agreement with the U.S. Environmental Protection Agency's Office of Water, includes contributions from experts in exposure modeling and measurement; water chemistry; time-activity patterns; dermal and respiratory uptake; and the use of probability distributions in characterizing exposures.

Author : Rhoda G.M. Wang
Publisher : CRC Press
Page : 543 pages
File Size : 50,9 Mb
Release : 2020-08-26
Category : Technology & Engineering
ISBN : 9781000104943

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Water Contamination and Health by Rhoda G.M. Wang Pdf

This volume examines every potential means of exposure to water contaminants, provides in-depth discussions on toxicology, and explains up-to-date techniques for evaluating human health risk. It develops a methodology for assessing the cumulative absorbed dose of contaminants through all routes of exposure, including ingestion, inhalation and dermal. Federal and state efforts to monitor and treat water are examined.

Author : Anonim
Publisher : World Health Organization
Page : 488 pages
File Size : 43,7 Mb
Release : 2010
Category : House & Home
ISBN : UCBK:C105261333

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WHO Guidelines for Indoor Air Quality by Anonim Pdf

This book presents WHO guidelines for the protection of public health from risks due to a number of chemicals commonly present in indoor air. The substances considered in this review, i.e. benzene, carbon monoxide, formaldehyde, naphthalene, nitrogen dioxide, polycyclic aromatic hydrocarbons (especially benzo[a]pyrene), radon, trichloroethylene and tetrachloroethylene, have indoor sources, are known in respect of their hazardousness to health and are often found indoors in concentrations of health concern. The guidelines are targeted at public health professionals involved in preventing health risks of environmental exposures, as well as specialists and authorities involved in the design and use of buildings, indoor materials and products. They provide a scientific basis for legally enforceable standards.

Author : Rhoda G.M. Wang,James B. Knaak,Howard I. Maibach
Publisher : CRC Press
Page : 544 pages
File Size : 43,7 Mb
Release : 2017-11-22
Category : Medical
ISBN : 9781351361743

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Health Risk Assessment Dermal and Inhalation Exposure and Absorption of Toxicants by Rhoda G.M. Wang,James B. Knaak,Howard I. Maibach Pdf

Health Risk Assessment is a comprehensive reference focusing on dermal absorption, cholinesterase inhibition, adverse reproductive effects, and carcinogenicity. The book features contributions from over 40 top scientists and covers topics such as PBPK modeling, cytochrome P-450 metabolism in skin, percutaneous absorption, adverse effects, new skin models, and the role of epidemiology in assessing the hazards of toxicants. Health Risk Assessment is essential for toxicologists, environmental chemists, pharmacologists, risk assessors, and managers working in industrial, pesticide, and pharmaceutical development. The book will also benefit individuals in environmental, regulatory, and registration affairs, as well as academicians and students.

Author : National Research Council,Division on Earth and Life Studies,Board on Environmental Studies and Toxicology,Committee on Contaminated Drinking Water at Camp Lejeune
Publisher : National Academies Press
Page : 338 pages
File Size : 51,6 Mb
Release : 2009-09-06
Category : Medical
ISBN : 9780309136990

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Contaminated Water Supplies at Camp Lejeune by National Research Council,Division on Earth and Life Studies,Board on Environmental Studies and Toxicology,Committee on Contaminated Drinking Water at Camp Lejeune Pdf

In the early 1980s, two water-supply systems on the Marine Corps Base Camp Lejeune in North Carolina were found to be contaminated with the industrial solvents trichloroethylene (TCE) and perchloroethylene (PCE). The water systems were supplied by the Tarawa Terrace and Hadnot Point watertreatment plants, which served enlisted-family housing, barracks for unmarried service personnel, base administrative offices, schools, and recreational areas. The Hadnot Point water system also served the base hospital and an industrial area and supplied water to housing on the Holcomb Boulevard water system (full-time until 1972 and periodically thereafter). This book examines what is known about the contamination of the water supplies at Camp Lejeune and whether the contamination can be linked to any adverse health outcomes in former residents and workers at the base.

Author : National Academies of Sciences, Engineering, and Medicine,Division on Earth and Life Studies,Board on Environmental Studies and Toxicology,Committee on Assessing Toxicologic Risks to Human Subjects Used in Controlled Exposure Studies of Environmental Pollutants
Publisher : National Academies Press
Page : 159 pages
File Size : 45,9 Mb
Release : 2017-05-10
Category : Science
ISBN : 9780309452496

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Controlled Human Inhalation-Exposure Studies at EPA by National Academies of Sciences, Engineering, and Medicine,Division on Earth and Life Studies,Board on Environmental Studies and Toxicology,Committee on Assessing Toxicologic Risks to Human Subjects Used in Controlled Exposure Studies of Environmental Pollutants Pdf

The U.S. Environmental Protection Agency (EPA) has a mission and regulatory responsibility to protect human health and the environment. EPA's pursuit of that goal includes a variety of research activities involving human subjects, such as epidemiologic studies and surveys. Those research activities also involve studies of individuals who volunteer to be exposed to air pollutants intentionally in controlled laboratory settings so that measurements can be made of transient and reversible biomarker or physiologic responses to those exposures that can indicate pathways of toxicity and mechanisms of air-pollution responses. The results of those controlled human inhalation exposure (CHIE) studies, also referred to as human clinical studies or human challenge studies, are used to inform policy decisions and help establish or revise standards to protect public health and improve air quality. Controlled Human Inhalation-Exposure Studies at EPA addresses scientific issues and provides guidance on the conduct of CHIE studies. This report assesses the utility of CHIE studies to inform and reduce uncertainties in setting air-pollution standards to protect public health and assess whether continuation of such studies is warranted. It also evaluates the potential health risks to test subjects who participated in recent studies of air pollutants at EPA's clinical research facility.

Author : Douglas J. Crawford-Brown
Publisher : Springer Science & Business Media
Page : 228 pages
File Size : 51,5 Mb
Release : 1997-04-30
Category : Technology & Engineering
ISBN : 079239898X

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Theoretical and Mathematical Foundations of Human Health Risk Analysis by Douglas J. Crawford-Brown Pdf

Scientists and regulators have struggled to define the role of theory, experiments, models and common sense in risk analysis. This situation has been made worse by the isolation of theory from modeling, of experimentation from theory, and of practical action from basic science. This book arises from efforts at regulatory agencies and industries to bring more science into health risk analysis so that society may better use limited resources to improve public health. This book covers: the characterization of exposure to pollutants and other sources of risk; the movement of pollutants into the body via inhalation; ingestion, dermal absorption, and exposures to radiation; the movement of a pollutant as it cascades through the tissues and organs of the body; and the development of principles and models for dose-response modeling. The book shows how an understanding of the biological, chemical, and physical properties of the environment and of the human body can guide the selection of mathematical models, and how these models can aid in estimating risks. Included in the book are models covering the full range of topics in human health risk analysis: exposure assessment, rates of intake, deposition and uptake by organs, absorption across membranes, biokinetics, dosimetry, and dose-response. The reader will gain from the book a better understanding of how environmental health science, as applied in risk analysis, can be used to create a more rational basis for the improvement of public health.

Author : National Research Council,Commission on Life Sciences,Board on Environmental Studies and Toxicology,Committee on Health Effects of Waste Incineration
Publisher : National Academies Press
Page : 336 pages
File Size : 45,8 Mb
Release : 2000-10-21
Category : Science
ISBN : 9780309063715

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Waste Incineration and Public Health by National Research Council,Commission on Life Sciences,Board on Environmental Studies and Toxicology,Committee on Health Effects of Waste Incineration Pdf

Incineration has been used widely for waste disposal, including household, hazardous, and medical wasteâ€"but there is increasing public concern over the benefits of combusting the waste versus the health risk from pollutants emitted during combustion. Waste Incineration and Public Health informs the emerging debate with the most up-to-date information available on incineration, pollution, and human healthâ€"along with expert conclusions and recommendations for further research and improvement of such areas as risk communication. The committee provides details on: Processes involved in incineration and how contaminants are released. Environmental dynamics of contaminants and routes of human exposure. Tools and approaches for assessing possible human health effects. Scientific concerns pertinent to future regulatory actions. The book also examines some of the social, psychological, and economic factors that affect the communities where incineration takes place and addresses the problem of uncertainty and variation in predicting the health effects of incineration processes.

Author : Rebecca Susan Bladon
Publisher : Unknown
Page : 430 pages
File Size : 46,7 Mb
Release : 2006
Category : Electronic
ISBN : CORNELL:31924105543213

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Pathways of Human Exposure to Environmental Pollutants by Rebecca Susan Bladon Pdf

Author : National Research Council (U.S.). Board on Environmental Studies and Toxicology. Committee on Advances in Assessing Human Exposure to Airborne Pollutants
Publisher : Routledge
Page : 348 pages
File Size : 54,9 Mb
Release : 1991-01-15
Category : Medical
ISBN : NAP:15205

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Human Exposure Assessment for Airborne Pollutants by National Research Council (U.S.). Board on Environmental Studies and Toxicology. Committee on Advances in Assessing Human Exposure to Airborne Pollutants Pdf

Most people in the United States spend far more time indoors than outdoors. Yet, many air pollution regulations and risk assessments focus on outdoor air. These often overlook contact with harmful contaminants that may be at their most dangerous concentrations indoors. A new book from the National Research Council explores the need for strategies to address indoor and outdoor exposures and examines the methods and tools available for finding out where and when significant exposures occur. The volume includes: A conceptual framework and common terminology that investigators from different disciplines can use to make more accurate assessments of human exposure to airborne contaminants. An update of important developments in assessing exposure to airborne contaminants: ambient air sampling and physical chemical measurements, biological markers, questionnaires, time-activity diaries, and modeling. A series of examples of how exposure assessments have been applied-properly and improperly-to public health issues and how the committee's suggested framework can be brought into practice. This volume will provide important insights to improve risk assessment, risk management, pollution control, and regulatory programs.

Author : Sponsored by The Health Effects Institute
Publisher : National Academies Press
Page : 703 pages
File Size : 53,9 Mb
Release : 1988-01-01
Category : Science
ISBN : 9780309037266

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Air Pollution, the Automobile, and Public Health by Sponsored by The Health Effects Institute Pdf

"The combination of scientific and institutional integrity represented by this book is unusual. It should be a model for future endeavors to help quantify environmental risk as a basis for good decisionmaking." â€"William D. Ruckelshaus, from the foreword. This volume, prepared under the auspices of the Health Effects Institute, an independent research organization created and funded jointly by the Environmental Protection Agency and the automobile industry, brings together experts on atmospheric exposure and on the biological effects of toxic substances to examine what is knownâ€"and not knownâ€"about the human health risks of automotive emissions.

Author : National Research Council,Division on Earth and Life Studies,Commission on Life Sciences,Board on Environmental Studies and Toxicology,Committee on National Monitoring of Human Tissues
Publisher : National Academies Press
Page : 224 pages
File Size : 47,6 Mb
Release : 1991-02-01
Category : Science
ISBN : 9780309044370

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Monitoring Human Tissues for Toxic Substances by National Research Council,Division on Earth and Life Studies,Commission on Life Sciences,Board on Environmental Studies and Toxicology,Committee on National Monitoring of Human Tissues Pdf

The National Human Monitoring Program (NHMP) identifies concentrations of specific chemicals in human tissues, including toxicologic testing and risk assessment determinations. This volume evaluates the current activities of the NHMP; identifies important scientific, technical, and programmatic issues; and makes recommendations regarding the design of the program and use of its products.

Author : Anonim
Publisher : Unknown
Page : 166 pages
File Size : 44,8 Mb
Release : 1990
Category : Silver
ISBN : UOM:39015032450432

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Toxicological Profile for Silver by Anonim Pdf