Human Population Genomics

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Human Population Genomics

Kirk E. Lohmueller,Rasmus Nielsen
Human Population Genomics Book PDF

Author : Kirk E. Lohmueller,Rasmus Nielsen
Publisher : Springer Nature
Page : 236 pages
File Size : 47,6 Mb
Release : 2021-03-13
Category : Science
ISBN : 9783030616465

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Human Population Genomics by Kirk E. Lohmueller,Rasmus Nielsen Pdf

This textbook provides a concise introduction and useful overview of the field of human population genomics, making the highly technical and contemporary aspects more accessible to students and researchers from various fields. Over the past decade, there has been a deluge of genetic variation data from the entire genome of individuals from many populations. These data have allowed an unprecedented look at human history and how natural selection has impacted humans during this journey. Simultaneously, there have been increased efforts to determine how genetic variation affects complex traits in humans. Due to technological and methodological advances, progress has been made at determining the architecture of complex traits. Split in three parts, the book starts with the basics, followed by more advanced and current research. The first part provides an introduction to essential concepts in population genetics, which are relevant for any organism. The second part covers the genetics of complex traits in humans. The third part focuses on applying these techniques and concepts to genetic variation data to learn about demographic history and natural selection in humans. This new textbook aims to serve as a gateway to modern human population genetics research for those new to the field. It provides an indispensable resource for students, researchers and practitioners from disparate areas of expertise.

Human Population Genetics and Genomics

Alan R. Templeton
Human Population Genetics and Genomics Book PDF

Author : Alan R. Templeton
Publisher : Academic Press
Page : 498 pages
File Size : 44,7 Mb
Release : 2018-11-08
Category : Science
ISBN : 9780123860262

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Human Population Genetics and Genomics by Alan R. Templeton Pdf

Human Population Genetics and Genomics provides researchers/students with knowledge on population genetics and relevant statistical approaches to help them become more effective users of modern genetic, genomic and statistical tools. In-depth chapters offer thorough discussions of systems of mating, genetic drift, gene flow and subdivided populations, human population history, genotype and phenotype, detecting selection, units and targets of natural selection, adaptation to temporally and spatially variable environments, selection in age-structured populations, and genomics and society. As human genetics and genomics research often employs tools and approaches derived from population genetics, this book helps users understand the basic principles of these tools. In addition, studies often employ statistical approaches and analysis, so an understanding of basic statistical theory is also needed. Comprehensively explains the use of population genetics and genomics in medical applications and research Discusses the relevance of population genetics and genomics to major social issues, including race and the dangers of modern eugenics proposals Provides an overview of how population genetics and genomics helps us understand where we came from as a species and how we evolved into who we are now

Population Genomics

Om P. Rajora
Population Genomics Book PDF

Author : Om P. Rajora
Publisher : Springer
Page : 822 pages
File Size : 48,8 Mb
Release : 2019-01-07
Category : Science
ISBN : 9783030045890

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Population Genomics by Om P. Rajora Pdf

Population genomics has revolutionized various disciplines of biology including population, evolutionary, ecological and conservation genetics, plant and animal breeding, human health, medicine and pharmacology by allowing to address novel and long-standing questions with unprecedented power and accuracy. It employs large-scale or genome-wide genetic information and bioinformatics to address various fundamental and applied aspects in biology and related disciplines, and provides a comprehensive genome-wide perspective and new insights that were not possible before. These advances have become possible due to the development of new and low-cost sequencing and genotyping technologies and novel statistical approaches and software, bioinformatics tools, and models. Population genomics is tremendously advancing our understanding the roles of evolutionary processes, such as mutation, genetic drift, gene flow, and natural selection, in shaping up genetic variation at individual loci and across the genome and populations; improving the assessment of population genetic parameters or processes such as adaptive evolution, effective population size, gene flow, admixture, inbreeding and outbreeding depression, demography, and biogeography; resolving evolutionary histories and phylogenetic relationships of extant, ancient and extinct species; understanding the genomic basis of fitness, adaptation, speciation, complex ecological and economically important traits, and disease and insect resistance; facilitating forensics, genetic medicine and pharmacology; delineating conservation genetic units; and understanding the genetic effects of resource management practices, and assisting conservation and sustainable management of genetic resources. This Population Genomics book discusses the concepts, approaches, applications and promises of population genomics in addressing most of the above fundamental and applied crucial aspects in a variety of organisms from microorganisms to humans. The book provides insights into a range of emerging population genomics topics including population epigenomics, landscape genomics, seascape genomics, paleogenomics, ecological and evolutionary genomics, biogeography, demography, speciation, admixture, colonization and invasion, genomic selection, and plant and animal domestication. This book fills a vacuum in the field and is expected to become a primary reference in Population Genomics world-wide.

Genomic Diversity

Surinder Singh Papiha,Ranjan Deka,Ranajit Chakraborty
Genomic Diversity Book PDF

Author : Surinder Singh Papiha,Ranjan Deka,Ranajit Chakraborty
Publisher : Springer Science & Business Media
Page : 246 pages
File Size : 55,8 Mb
Release : 2012-12-06
Category : Social Science
ISBN : 9781461542636

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Genomic Diversity by Surinder Singh Papiha,Ranjan Deka,Ranajit Chakraborty Pdf

One of the major themes of human population genetics is assaying genetic variation in human populations. The ultimate goal of this objective is to understand the extent of genetic diversity and the use of this knowledge to reconstruct our evolutionary history. The discipline had undergone a revolutionary transition with the advent of molecular techniques in the 1980s. With this shift, statistical methods have also been developed to perceive the biological and molecular basis of human genetic variation. Using the new perspectives gained during the above transition, this volume describes the applications of molecular markers spanning the autosomal, Y-chromosomal and mitochondrial genome in the analysis of human diversity in contemporary populations. This is the first reference book of its kind to bring together data from these diverse sets of markers for understanding evolutionary histories and relationships of modern humans in a single volume.

The Genetics of Human Populations

Luigi Luca Cavalli-Sforza,Walter Fred Bodmer
The Genetics of Human Populations Book PDF

Author : Luigi Luca Cavalli-Sforza,Walter Fred Bodmer
Publisher : Courier Corporation
Page : 994 pages
File Size : 46,9 Mb
Release : 1999-01-01
Category : Science
ISBN : 9780486406930

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The Genetics of Human Populations by Luigi Luca Cavalli-Sforza,Walter Fred Bodmer Pdf

Comprehensive, advanced treatment of nature and source of inherited characteristics, with treatment of mathematical techniques. Mendelian populations, mutations, polymorphisms, genetic demography, much more. Emphasizes interpretation of data in relation to theoretical models.

Evaluating Human Genetic Diversity

National Research Council,Division on Earth and Life Studies,Commission on Life Sciences,Committee on Human Genome Diversity
Evaluating Human Genetic Diversity Book PDF

Author : National Research Council,Division on Earth and Life Studies,Commission on Life Sciences,Committee on Human Genome Diversity
Publisher : National Academies Press
Page : 101 pages
File Size : 53,6 Mb
Release : 1998-01-19
Category : Science
ISBN : 9780309184748

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Evaluating Human Genetic Diversity by National Research Council,Division on Earth and Life Studies,Commission on Life Sciences,Committee on Human Genome Diversity Pdf

This book assesses the scientific value and merit of research on human genetic differencesâ€"including a collection of DNA samples that represents the whole of human genetic diversityâ€"and the ethical, organizational, and policy issues surrounding such research. Evaluating Human Genetic Diversity discusses the potential uses of such collection, such as providing insight into human evolution and origins and serving as a springboard for important medical research. It also addresses issues of confidentiality and individual privacy for participants in genetic diversity research studies.

Population Genomics: Marine Organisms

Marjorie F. Oleksiak,Om P. Rajora
Population Genomics Marine Organisms Book PDF

Author : Marjorie F. Oleksiak,Om P. Rajora
Publisher : Springer Nature
Page : 458 pages
File Size : 46,6 Mb
Release : 2019-12-31
Category : Science
ISBN : 9783030379360

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Population Genomics: Marine Organisms by Marjorie F. Oleksiak,Om P. Rajora Pdf

Population genomics has provided unprecedented opportunities to unravel the mysteries of marine organisms in the oceans' depths. The world's oceans, which make up 70% of our planet, encompass diverse habitats and host numerous unexplored populations and species. Population genomics studies of marine organisms are rapidly emerging and have the potential to transform our understanding of marine populations, species, and ecosystems, providing insights into how these organisms are evolving and how they respond to different stimuli and environments. This knowledge is critical for understanding the fundamental aspects of marine life, how marine organisms will respond to environmental changes, and how we can better protect and preserve marine biodiversity and resources. This book brings together leading experts in the field to address critical aspects of fundamental and applied research in marine species and share their research and insights crucial for understanding marine ecosystem diversity and function. It also discusses the challenges, opportunities and future perspectives of marine population genomics.

Population Genomics: Wildlife

Paul A. Hohenlohe,Om P. Rajora
Population Genomics Wildlife Book PDF

Author : Paul A. Hohenlohe,Om P. Rajora
Publisher : Springer Nature
Page : 559 pages
File Size : 44,6 Mb
Release : 2020-12-09
Category : Science
ISBN : 9783030634896

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Population Genomics: Wildlife by Paul A. Hohenlohe,Om P. Rajora Pdf

Population genomics is revolutionizing wildlife biology, conservation, and management by providing key and novel insights into genetic, population and landscape-level processes in wildlife, with unprecedented power and accuracy. This pioneering book presents the advances and potential of population genomics in wildlife, outlining key population genomics concepts and questions in wildlife biology, population genomics approaches that are specifically applicable to wildlife, and application of population genomics in wildlife population and evolutionary biology, ecology, adaptation and conservation and management. It is important for students, researchers, and wildlife professionals to understand the growing set of population genomics tools that can address issues from delineation of wildlife populations to assessing their capacity to adapt to environmental change. This book brings together leading experts in wildlife population genomics to discuss the key areas of the field, as well as challenges, opportunities and future prospects of wildlife population genomics.

Paleogenomics

Charlotte Lindqvist,Om P. Rajora
Paleogenomics Book PDF

Author : Charlotte Lindqvist,Om P. Rajora
Publisher : Springer
Page : 427 pages
File Size : 42,8 Mb
Release : 2019-01-07
Category : Science
ISBN : 9783030047535

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Paleogenomics by Charlotte Lindqvist,Om P. Rajora Pdf

Advances in genome-scale DNA sequencing technologies have revolutionized genetic research on ancient organisms, extinct species, and past environments. When it is recoverable after hundreds or thousands of years of unintended preservation, “ancient DNA” (or aDNA) is often highly degraded, necessitating specialized handling and analytical approaches. Paleogenomics defines the field of reconstructing and analyzing the genomes of historic or long-dead organisms, most often through comparison with modern representatives of the same or similar species. The opportunity to isolate and study paleogenomes has radically transformed many fields, spanning biology, anthropology, agriculture, and medicine. Examples include understanding evolutionary relationships of extinct species known only from fossils, the domestication of plants and animals, and the evolution and geographical spread of certain pathogens. This pioneering book presents a snapshot view of the history, current status, and future prospects of paleogenomics, taking a broad viewpoint that covers a range of topics and organisms to provide an up-to-date status of the applications, challenges, and promise of the field. This book is intended for a variety of readerships, including upper-level undergraduate and graduate students, professionals and experts in the field, as well as anyone excited by the extraordinary insights that paleogenomics offers.

Human Population Genetics

P.P. Majumder
Human Population Genetics Book PDF

Author : P.P. Majumder
Publisher : Springer Science & Business Media
Page : 348 pages
File Size : 40,5 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9781461529705

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Human Population Genetics by P.P. Majumder Pdf

J. B. S. Haldane, R. A. Fisher and Sewall Wright simultaneously, and largely independently, laid the foundations of population genetics and the mathematical theory of evolution. Hal dane was born on November 5, 1892. Although he primarily worked at the University College London (UCL), in 1957 he resigned from the UCL and joined the Indian Statistical Institute, Calcutta (India) as a Research Professor. In celebration of his birth centenary, the Indian Statistical Institute organized an International Conference on Human Genetics from 15 to 19 December, 1992. The prime motive in holding this Conference was to bring together a group of scientists - geneticists, anthropologists, clinicians and statisticians - to evaluate the impact of Haldane's contributions to various areas of human genetics, and also to review recent developments in the subject. Session and lecture themes were so chosen that they covered areas theoretical and applied, classical and emerging. Speakers were then identified and invited to deliver lectures on these themes. Manuscripts of all invited presentations and a selected number of contributed presentations were considered for inclusion in this Proceed ings Volume. Each manuscript was reviewed by at least one Conference participant, which resulted in revision of several manuscripts and rejection of some. This volume is a collection of the manuscripts which have been 'accepted' after the review-process. The Conference began with the "J. B. S. Haldane Centenary Lecture" delivered by C. R. Rao.

Introduction to Population Genetics

Richard Halliburton
Introduction to Population Genetics Book PDF

Author : Richard Halliburton
Publisher : Pearson
Page : 680 pages
File Size : 52,5 Mb
Release : 2004
Category : Juvenile Nonfiction
ISBN : UOM:39015058703573

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Introduction to Population Genetics by Richard Halliburton Pdf

Making the theory of population genetics relevant to readers, this book explains the related mathematics with a logical organization. It presents the quantitative aspects of population genetics, and employs examples of human genetics, medical evolution, human evolution, and endangered species. For an introduction to, and understanding of, population genetics.

Evolution of the Human Genome II

Naruya Saitou
Evolution of the Human Genome II Book PDF

Author : Naruya Saitou
Publisher : Springer Nature
Page : 260 pages
File Size : 52,7 Mb
Release : 2021-05-27
Category : Science
ISBN : 9784431569046

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Evolution of the Human Genome II by Naruya Saitou Pdf

This two-volume set provides a general overview of the evolution of the human genome; The first volume overviews the human genome with descriptions of important gene groups. This second volume provides up-to-date, concise yet ample knowledge on the genome evolution of modern humans. It comprises twelve chapters divided into two parts discussing “Non-neutral Evolution on Human Genes” (Part I) and “Evolution of Modern Human Populations” (Part II.) The most significant feature of this book is the continent-wise discussion of modern human dispersal using human genomic data in Part II. Recent results such as introgression of paleogenomes to modern humans, new methods such as computer simulation of global human dispersals, and new information on genes for humanness will be of particular interest to the readers. Since the euchromatin regions of the human genome was sequenced in 2003, a huge number of research papers were published on modern human evolution for a variety of populations. It is now time to summarize these achievements. This book stands out as the most comprehensive book on the modern human evolution, focusing on genomic points of view with a broad scope. Primary target audiences are researchers and graduate students in evolutionary biology.

Population Genetics and Microevolutionary Theory

Alan R. Templeton
Population Genetics and Microevolutionary Theory Book PDF

Author : Alan R. Templeton
Publisher : John Wiley & Sons
Page : 720 pages
File Size : 40,5 Mb
Release : 2006-09-29
Category : Science
ISBN : 9780470047217

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Population Genetics and Microevolutionary Theory by Alan R. Templeton Pdf

The advances made possible by the development of molecular techniques have in recent years revolutionized quantitative genetics and its relevance for population genetics. Population Genetics and Microevolutionary Theory takes a modern approach to population genetics, incorporating modern molecular biology, species-level evolutionary biology, and a thorough acknowledgment of quantitative genetics as the theoretical basis for population genetics. Logically organized into three main sections on population structure and history, genotype-phenotype interactions, and selection/adaptation Extensive use of real examples to illustrate concepts Written in a clear and accessible manner and devoid of complex mathematical equations Includes the author's introduction to background material as well as a conclusion for a handy overview of the field and its modern applications Each chapter ends with a set of review questions and answers Offers helpful general references and Internet links

Mapping and Sequencing the Human Genome

National Research Council,Division on Earth and Life Studies,Commission on Life Sciences,Committee on Mapping and Sequencing the Human Genome
Mapping and Sequencing the Human Genome Book PDF

Author : National Research Council,Division on Earth and Life Studies,Commission on Life Sciences,Committee on Mapping and Sequencing the Human Genome
Publisher : National Academies Press
Page : 128 pages
File Size : 45,8 Mb
Release : 1988-01-01
Category : Science
ISBN : 9780309038409

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Mapping and Sequencing the Human Genome by National Research Council,Division on Earth and Life Studies,Commission on Life Sciences,Committee on Mapping and Sequencing the Human Genome Pdf

There is growing enthusiasm in the scientific community about the prospect of mapping and sequencing the human genome, a monumental project that will have far-reaching consequences for medicine, biology, technology, and other fields. But how will such an effort be organized and funded? How will we develop the new technologies that are needed? What new legal, social, and ethical questions will be raised? Mapping and Sequencing the Human Genome is a blueprint for this proposed project. The authors offer a highly readable explanation of the technical aspects of genetic mapping and sequencing, and they recommend specific interim and long-range research goals, organizational strategies, and funding levels. They also outline some of the legal and social questions that might arise and urge their early consideration by policymakers.

Ancestors in Our Genome

Eugene E. Harris (Professor)
Ancestors in Our Genome Book PDF

Author : Eugene E. Harris (Professor)
Publisher : Oxford University Press, USA
Page : 249 pages
File Size : 53,8 Mb
Release : 2015
Category : Science
ISBN : 9780199978038

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Ancestors in Our Genome by Eugene E. Harris (Professor) Pdf

Geneticist Eugene Harris presents us with the complete and up-to-date account of the evolution of the human genome.