Hydrogen Sulfide And Its Therapeutic Applications

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Hydrogen Sulfide and its Therapeutic Applications

Hideo Kimura
Hydrogen Sulfide and its Therapeutic Applications Book PDF

Author : Hideo Kimura
Publisher : Springer Science & Business Media
Page : 213 pages
File Size : 51,5 Mb
Release : 2013-09-02
Category : Science
ISBN : 9783709115503

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Hydrogen Sulfide and its Therapeutic Applications by Hideo Kimura Pdf

The metabolism of sulfur especially by sulfurtransferases had been intensively studied in mid 1900’s. Three enzymes, cystathionine β–synthase (CBS), cystathionine γ–lyase (CSE) and 3-mercaptopyruvate sulfurtransferase (3MST) were found to have the capacity to produce H2S in vitro. However, H2S was recognized simply as a by-product of the metabolic pathways or as a marker for evaluating the activity of enzymes rather than as a physiological active molecule. In the late 1980’s relatively high concentrations of sulfide were measured in the brain that led to the successive studies of identifying the physiological functions of H2S. Recently, the steady-state concentrations of H2S have been re-evaluated and found to be much less than that initially measured. However, despite these differences, such re-evaluations served to further confirm the existence of H2S in mammalian tissues. H2S is produced in almost every organ and plays various roles such as neuromodulation, vasodilation, insulin release, inflammation, angiogenesis and cytoprotection. The unregulated production of H2S and improper responses of target molecules are involved in the pathogenesis of various diseases. This book focuses on these topics as well as on the recent progress in the biology and the therapeutic development of this molecule.

Hydrogen Sulfide

Michael D. Pluth
Hydrogen Sulfide Book PDF

Author : Michael D. Pluth
Publisher : John Wiley & Sons
Page : 596 pages
File Size : 40,8 Mb
Release : 2022-09-21
Category : Science
ISBN : 9781119799870

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Hydrogen Sulfide by Michael D. Pluth Pdf

HYDROGEN SULFIDE Covers H2S interactions, methods of detection and delivery in biological environments, and a wide range of applications Research on hydrogen sulfide (H2S) spans diverse disciplines including chemistry, biology, and physiology. In recent years, new materials and approaches have been developed to deliver H2S and related reactive sulfur species in various clinical contexts. Although many biological pathways involving H2S are complex, all are governed by fundamental chemical interactions between reactive sulfur species and other molecular entities. Hydrogen Sulfide: Chemical Biology Basics, Detection Methods, Therapeutic Applications, and Case Studies provides the foundation required for understanding the fundamental chemical biology of H2S while highlighting the compound’s therapeutic potential and medicinal applications. This book covers key aspects of H2S chemical biology, including the fundamental chemistry of reactive sulfur species; the measurement, detection, and delivery of H2S in biological environments; and the therapeutic and medicinal uses of exogenous H2S delivery in various pharmacologically relevant systems. Throughout the text, editor Michael Pluth and chapter contributors discuss the opportunities and future of the multidisciplinary field. Provides approaches for delivering H2S with relevance to biological and therapeutic applications Describes complex interactions of H2S with bioinorganic complexes and reactive sulfur, nitrogen, and oxygen species Summarizes advances in available tools to detect, measure, and modulate H2S levels in biological environments, such as real-time methods for H2S fluorescence imaging in live cell and animal systems Helps readers understand known systems and make connections to new and undiscovered pathways and mechanisms of action Includes in-depth case studies of different systems in which H2S plays an important role Hydrogen Sulfide: Chemical Biology Basics, Detection Methods, Therapeutic Applications, and Case Studies is an important source of current knowledge for researchers, academics, graduate students, and industrial scientists in the fields of redox biology, hydrogen sulfide research, and medicinal chemistry of small biological molecules.

Chemistry, Biochemistry and Pharmacology of Hydrogen Sulfide

Philip K. Moore,Matt Whiteman
Chemistry Biochemistry and Pharmacology of Hydrogen Sulfide Book PDF

Author : Philip K. Moore,Matt Whiteman
Publisher : Springer
Page : 395 pages
File Size : 41,8 Mb
Release : 2015-07-10
Category : Medical
ISBN : 9783319181448

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Chemistry, Biochemistry and Pharmacology of Hydrogen Sulfide by Philip K. Moore,Matt Whiteman Pdf

This book puts hydrogen sulfide in context with other gaseous mediators such as nitric oxide and carbon monoxide, reviews the available mechanisms for its biosynthesis and describes its physiological and pathophysiological roles in a wide variety of disease states. Hydrogen sulfide has recently been discovered to be a naturally occurring gaseous mediator in the body. Over a relatively short period of time this evanescent gas has been revealed to play key roles in a range of physiological processes including control of blood vessel caliber and hence blood pressure and in the regulation of nerve function both in the brain and the periphery. Disorders concerning the biosynthesis or activity of hydrogen sulfide may also predispose the body to disease states such as inflammation, cardiovascular and neurological disorders. Interest in this novel gas has been high in recent years and many research groups worldwide have described its individual biological effects. Moreover, medicinal chemists are beginning to synthesize novel organic molecules that release this gas at defined rates with a view to exploiting these new compounds for therapeutic benefit.

Hydrogen Sulfide in Kidney Diseases

George J. Dugbartey,Alp Sener
Hydrogen Sulfide in Kidney Diseases Book PDF

Author : George J. Dugbartey,Alp Sener
Publisher : Springer Nature
Page : 235 pages
File Size : 48,7 Mb
Release : 2023-12-23
Category : Medical
ISBN : 9783031440410

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Hydrogen Sulfide in Kidney Diseases by George J. Dugbartey,Alp Sener Pdf

This book will be the first book that presents the beneficial effects of hydrogen sulfide in the treatment of various kidney pathologies. Hydrogen sulfide (H2S), a gas with a distinctive smell of rotten eggs, was known for over three centuries for its toxicity and death at high concentrations especially among agricultural and industrial workers. This is due to its ability to reversibly antagonize complex IV of the mitochondrial electron transport chain. However, studies over the past two decades have shown that H2S has risen above its historic notorious label and has received significant experimental attention as an endogenously produced gaseous signaling molecule that plays an important role in cellular homeostasis and influences a myriad of physiological and pathological processes at low concentrations. Its production is enzymatically regulated and has specific molecular targets. Several recent in vitro and in vivo studies have demonstrated that at low micromolar concentrations, H2S exhibits important therapeutic characteristics that target multiple molecular pathways and thereby preventing the development and progression of several pathologies. This beneficial effect of H2S suggests that it may meet the demand for alternative and/or additional therapeutic agents against various renal pathologies in which reduced levels of renal and plasma H2S were observed. Interestingly, while the distribution of H2S-producing enzymes is tissue-specific, they are abundantly expressed in the glomeruli and in the brush border and cytoplasm of epithelial cells of the renal tubules and in the peritubular capillaries. This makes the kidney a rich source of endogenous H2S production. From pre-clinical and clinical perspectives, this book is topical and timely, and seeks to lay the foundation for future clinical applications of H2S in nephrology.

Hydrogen Sulfide in Redox Biology

Anonim
Hydrogen Sulfide in Redox Biology Book PDF

Author : Anonim
Publisher : Academic Press
Page : 344 pages
File Size : 48,6 Mb
Release : 2015-02-25
Category : Science
ISBN : 9780128016237

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Hydrogen Sulfide in Redox Biology by Anonim Pdf

These new volumes of Methods in Enzymology (554 and 555) on Hydrogen Sulfide Signaling continue the legacy established by previous volumes on another gasotransmitter, nitric oxide (Methods in Enzymology volumes 359, 396, 440, and 441), with quality chapters authored by leaders in the field of hydrogen sulfide research. These volumes of Methods in Enzymology were designed as a compendium for hydrogen sulfide detection methods, the pharmacological activity of hydrogen sulfide donors, the redox biochemistry of hydrogen sulfide and its metabolism in mammalian tissues, the mechanisms inherent in hydrogen sulfide cell signaling and transcriptional pathways, and cell signaling in specific systems, such as cardiovascular and nervous system as well as its function in inflammatory responses. Two chapters are also devoted to hydrogen sulfide in plants and a newcomer, molecular hydrogen, its function as a novel antioxidant. Continues the legacy of this premier serial with quality chapters on hydrogen sulfide research authored by leaders in the field Covers conventional and new hydrogen sulfide detection methods Covers the pharmacological activity of hydrogen sulfide donors Contains chapters on important topics on hydrogen sulfide modulation of cell signaling and transcriptional pathways, and the the role of hydrogen sulfide in the cardiovascular and nervous systems and in inflammation

Advances in Hydrogen Sulfide Biology

Yi-Chun Zhu
Advances in Hydrogen Sulfide Biology Book PDF

Author : Yi-Chun Zhu
Publisher : Springer Nature
Page : 242 pages
File Size : 51,8 Mb
Release : 2021-07-24
Category : Medical
ISBN : 9789811609916

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Advances in Hydrogen Sulfide Biology by Yi-Chun Zhu Pdf

Hydrogen sulfide (H2S) has emerged as an important gas signalling molecule in a series of organs/tissues, on the diseases of which it plays protective roles, such as proangiogenic effects in ischemic tissues, antiapoptotic effects in the cardiomyocytes, regularization of fatal arrhythmia in myocardial infarction, amelioration of inflammation in autoimmune diseases, modification of neuronal transmission, increase in sodium excretion from the kidney, and amelioration of insulin resistance, etc. This book focuses on the effect of hydrogen sulfide in cardiovascular system, immune system, nervous system, kidney, as well as on the metabolism of glucose and lipids and regulation of ion channels and so on. This book also provides the advances in the understanding of endogenous H2S metabolism and H2S protein targets, as well as H2S donors. It will benefit researchers in both academics and industry working on the underlying mechanism of H2S field and the future of translational medicine of H2S.

Chemistry of Biologically Potent Natural Products and Synthetic Compounds

Shahid Ul-Islam,Javid Ahmad Banday
Chemistry of Biologically Potent Natural Products and Synthetic Compounds Book PDF

Author : Shahid Ul-Islam,Javid Ahmad Banday
Publisher : John Wiley & Sons
Page : 434 pages
File Size : 42,9 Mb
Release : 2021-06-29
Category : Science
ISBN : 9781119640349

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Chemistry of Biologically Potent Natural Products and Synthetic Compounds by Shahid Ul-Islam,Javid Ahmad Banday Pdf

In view of their promising biological and pharmaceutical activities, natural product inspired and heterocyclic compounds have recently gained a reputation in the field of medicinal chemistry. Over the past decades, intensive research efforts have been ongoing to understand the synthesis, biochemistry and engineering involved in their preparation and action mechanisms. Several novel natural product derivatives, heterocyclic and other synthetic compounds, have been reported to have shown interesting biological activities including anticancer, antimicrobial, anti-inflammatory, anti-glycemic, anti-allergy and antiviral etc. Chemistry of Biologically Potent Natural Products and Synthetic Compounds provides up-to-date information on new developments and most recent medicinal applications of the natural products and derivatives, as well as the chemistry and synthesis of heterocyclic and other related compounds.

Redox Biochemistry

Ruma Banerjee
Redox Biochemistry Book PDF

Author : Ruma Banerjee
Publisher : John Wiley & Sons
Page : 350 pages
File Size : 46,7 Mb
Release : 2007-12-04
Category : Science
ISBN : 0470177322

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Redox Biochemistry by Ruma Banerjee Pdf

This is the premier, single-source reference on redox biochemistry, a rapidly emerging field. This reference presents the basic principles and includes detailed chapters focusing on various aspects of five primary areas of redox biochemistry: antioxidant molecules and redox cofactors; antioxidant enzymes; redox regulation of physiological processes; pathological processes related to redox; and specialized methods. This is a go-to resource for professionals in pharmaceuticals, medicine, immunology, nutrition, and environmental fields and an excellent text for upper-level students.

Review of Submarine Escape Action Levels for Selected Chemicals

National Research Council,Division on Earth and Life Studies,Board on Environmental Studies and Toxicology,Committee on Toxicology,Subcommittee on Submarine Escape Action Levels
Review of Submarine Escape Action Levels for Selected Chemicals Book PDF

Author : National Research Council,Division on Earth and Life Studies,Board on Environmental Studies and Toxicology,Committee on Toxicology,Subcommittee on Submarine Escape Action Levels
Publisher : National Academies Press
Page : 310 pages
File Size : 41,5 Mb
Release : 2002-02-04
Category : Nature
ISBN : 9780309182683

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Review of Submarine Escape Action Levels for Selected Chemicals by National Research Council,Division on Earth and Life Studies,Board on Environmental Studies and Toxicology,Committee on Toxicology,Subcommittee on Submarine Escape Action Levels Pdf

On-board fires can occur on submarines after events such as collision or explosion. These fires expose crew members to toxic concentrations of combustion products such as ammonia, carbon monoxide, hydrogen chloride, and hydrogen sulfide. Exposure to these substances at high concentrations may cause toxic effects to the respiratory and central nervous system; leading possible to death. T protect crew members on disabled submarines, scientists at the U.S. Navy Health Research Center's Toxicology Detachment have proposed two exposure levels, called submarine escape action level (SEAL) 1 and SEAL 2, for each substance. SEAL 1 is the maximum concentration of a gas in a disabled submarine below which healthy submariners can be exposed for up to 10 days without encountering irreversible health effects while SEAL 2 the maximum concentration of a gas in below which healthy submariners can be exposed for up to 24 hours without experiencing irreversible health effects. SEAL 1 and SEAL 2 will not impair the functions of the respiratory system and central nervous system to the extent of impairing the ability of crew members in a disabled submarine to escape, be rescued, or perform specific tasks. Hoping to better protect the safety of submariners, the chief of the Bureau of Medicine and Surgery requested that the National Research Council (NRC) review the available toxicologic and epidemiologic data on eight gases that are likely to be produced in a disabled submarine and to evaluate independently the scientific validity of the Navy's proposed SEALs for those gases. The NRC assigned the task to the Committee on Toxicology's (COT's) Subcommittee on Submarine Escape Action Levels. The specific task of the subcommittee was to review the toxicologic, epidemiologic, and related data on ammonia, carbon monoxide, chlorine, hydrogen chloride, hydrogen cyanide, hydrogen sulfide, nitrogen dioxide, and sulfur dioxide in order to validate the Navy's proposed SEALs. The subcommittee also considered the implications of exposures at hyperbaric conditions and potential interactions between the eight gases. Review of Submarine Escape Action Levels for Selected Chemicals presents the subcommittee's findings after evaluation human data from experimental, occupational, and epidemiologic studies; data from accident reports; and experimental-animal data. The evaluations focused primarily on high-concentration inhalation exposure studies. The subcommittee's recommended SEALs are based solely on scientific data relevant to health effects. The report includes the recommendations for each gas as determined by the subcommittee as well as the Navy's original instructions for these substances.

Heart and Toxins

Dr. Meenakshisundaram Sundaram Ramachandran
Heart and Toxins Book PDF

Author : Dr. Meenakshisundaram Sundaram Ramachandran
Publisher : Elsevier
Page : 668 pages
File Size : 50,5 Mb
Release : 2014-08-12
Category : Science
ISBN : 9780124165991

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Heart and Toxins by Dr. Meenakshisundaram Sundaram Ramachandran Pdf

The Heart and Toxins brings together global experts to provide the latest information and clinical trials that make the connection between genetic susceptibility, gene expression, and environmental factors in cardiovascular diseases. This unique reference, edited by renowned cardiologist Meenakshi Sundaram Ramachandran, solves the problem of managing multiple clinical cases of cardiovascular toxicity. It allows connections to be made between research, diagnosis, and treatment to avoid higher morbidity and mortality rates as a result of cardiovascular toxicity. Structured to bring together exploration into the epidemiology, molecular mechanism, pathogenesis, environmental factors and management in cardiovascular toxins” Included various topics on cardiovascular toxins such as plant, chemical, animal, nanomaterial and marine biology induced cardiac damage – which are new ideas discussed in detail Comprehensive chapters on the cardiovascular toxicity from drugs, radiotherapy and radiological imaging Enables you to manage multiple clinical cases of cardiovascular toxicity Outlined conclusions at the end of each chapter providing “key learning points” to help you organize the chapter’s details without losing insight

Tumor Microenvironment

Jacinta Serpa
Tumor Microenvironment Book PDF

Author : Jacinta Serpa
Publisher : Springer Nature
Page : 430 pages
File Size : 48,9 Mb
Release : 2020-03-04
Category : Medical
ISBN : 9783030340254

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Tumor Microenvironment by Jacinta Serpa Pdf

The way a cell undergoes malignant transformation should meet their capacity of surviving in the microenvironment of the organ where the cancer will develop. Metabolic adaptation is for sure one of the criteria that must be accomplished, driven by metabolic plasticity that allows the adaptation of cancer cells to the availability of energy and biomass sources that will sustain cell survival and proliferation. Each human organ has a particular microenvironment which depends on several cell types and in some cases also on symbiotic microorganisms. These biological partners are constantly sharing organic compounds and signaling molecules that will control mitogenesis, cell death and differentiation, accounting for the organ's function. Nevertheless, cancer cells are capable of taking advantage of this metabolic and signaling microenvironmental dynamics. In this book, we intend to present the different components of the microenvironment driving the metabolic fitness of cancer cells. The metabolic changes required for establishing a tumor in a given microenvironment and how these metabolic changes limit the response to drugs will generally be the major items addressed. It is important to mention not only aspects of the microenvironment that stimulate metabolic changes and that select better adapted tumor cells, but also how this regulation of cell plasticity is made. Thus, the signaling pathways that orchestrate and are orchestrated throughout this panoply of metabolic rearrangements will also be addressed in this book. The subjects will be presented from the conceptual point of view of the cross-cancer mechanisms and also particularizing some models that can be examples and enlightening within the different areas.

Advances in Metallodrugs

Shahid Ul-Islam,Athar Adil Hashmi,Salman Ahmad Khan
Advances in Metallodrugs Book PDF

Author : Shahid Ul-Islam,Athar Adil Hashmi,Salman Ahmad Khan
Publisher : John Wiley & Sons
Page : 432 pages
File Size : 47,5 Mb
Release : 2020-07-08
Category : Science
ISBN : 9781119640424

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Advances in Metallodrugs by Shahid Ul-Islam,Athar Adil Hashmi,Salman Ahmad Khan Pdf

This book is organized into 12 important chapters that focus on the progress made by metal-based drugs as anticancer, antibacterial, antiviral, anti-inflammatory, and anti-neurodegenerative agents, as well as highlights the application areas of newly discovered metallodrugs. It can prove beneficial for researchers, investigators and scientists whose work involves inorganic and coordination chemistry, medical science, pharmacy, biotechnology and biomedical engineering.

Neuroprotection

Matilde Otero-Losada,Francisco Capani,Santiago Perez Lloret
Neuroprotection Book PDF

Author : Matilde Otero-Losada,Francisco Capani,Santiago Perez Lloret
Publisher : BoD – Books on Demand
Page : 350 pages
File Size : 52,6 Mb
Release : 2020-11-26
Category : Medical
ISBN : 9781838804398

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Neuroprotection by Matilde Otero-Losada,Francisco Capani,Santiago Perez Lloret Pdf

Neurological disease affects nearly 25%–30% of the world’s population, exerting enormous financial strain on the healthcare system. Estimated current costs are around $800 annual billion, and this number is expected to increase exponentially as the global population ages. As such, new and alternative neuroprotective strategies are urgently needed. This book examines some of the most promising approaches in neuroprotection as well as discusses current goals and prospects. Organized into three sections, chapters cover such topics as the use of cannabinoids, medicinal plants, and essential oils in Alzheimer’s and Parkinson’s; protein misfolding and the neuroprotective potential of vitamin E in cerebral ischemia; and potential new neurological treatments and their mechanisms of action.

Therapeutic Application of Nitric Oxide in Cancer and Inflammatory Disorders

Lucia Morbidelli,Benjamin Bonavida
Therapeutic Application of Nitric Oxide in Cancer and Inflammatory Disorders Book PDF

Author : Lucia Morbidelli,Benjamin Bonavida
Publisher : Academic Press
Page : 372 pages
File Size : 55,9 Mb
Release : 2019-02-09
Category : Medical
ISBN : 9780128172797

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Therapeutic Application of Nitric Oxide in Cancer and Inflammatory Disorders by Lucia Morbidelli,Benjamin Bonavida Pdf

Therapeutic Application of Nitric Oxide in Cancer and Inflammatory Disorders presents updated reviews on the chemistry, signaling, pre-clinical and clinical activities on the role of nitric oxide donors/inhibitors used alone and in combination with other therapeutic agents for the treatment of a variety of diseases. This book examines various studies related to the application of novel therapeutic NO (donors/inhibitors) compounds in the treatment of various cancers. These studies have been shown to exert significant therapeutic activities against various cancers and various inflammatory diseases such as rheumatoid arthritis, Crohn’s disease, allergies, and asthma, where no current effective therapies exist. Pathologies based on functional and structural vascular alterations are also taken into consideration. Edited and written by internationally renowned experts in the field of novel therapeutics for cancer, this book is a valuable source for cancer researchers, medical scientists, clinicians, clinical pharmacologists, and graduate students. Provides readers with a clear overview of the recent findings and references as well as summaries, significant molecular pathways, and conclusions Discusses new ideas proposed and makes suggestions for further investigations that will advance the field Presents introductory and summary information on the contributions of the field, all the findings of the studies discussed, and projects future goals for research

Vascular Effects of Hydrogen Sulfide

Jerzy Bełtowski
Vascular Effects of Hydrogen Sulfide Book PDF

Author : Jerzy Bełtowski
Publisher : Springer Nature
Page : 223 pages
File Size : 47,6 Mb
Release : 2019-05-30
Category : Science
ISBN : 9781493995288

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Vascular Effects of Hydrogen Sulfide by Jerzy Bełtowski Pdf

This book explores techniques for exploring hydrogen sulfide (H2S) and its effects on the vascular system through numerous experimental animal models and vascular preparations. Alterations of vascular H2S generation/signaling may be involved in the pathogenesis of systemic and pulmonary arterial hypertension, ischemic heart disease, ischemic stroke, preeclampsia, and erectile dysfunction, and H2S also serves as an attractive target for pharmacotherapy of cardiovascular diseases, as well as possible effects on cancer, wound healing, and diabetic retinopathy, among other pathologies. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Vascular Effects of Hydrogen Sulfide: Methods and Protocols is an ideal aid for scientists working to extend our knowledge in this valuable and wide-ranging field of study.