Inhibitors Of Molecular Chaperones As Therapeutic Agents

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Inhibitors of Molecular Chaperones as Therapeutic Agents

Timothy D. Machajewski,Zhenhai Gao,David P. Rotella
Inhibitors of Molecular Chaperones as Therapeutic Agents Book PDF

Author : Timothy D. Machajewski,Zhenhai Gao,David P. Rotella
Publisher : Royal Society of Chemistry
Page : 443 pages
File Size : 52,7 Mb
Release : 2014
Category : Medical
ISBN : 9781849736664

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Inhibitors of Molecular Chaperones as Therapeutic Agents by Timothy D. Machajewski,Zhenhai Gao,David P. Rotella Pdf

This book aims to provide a comprehensive examination of the field of molecular chaperone inhibition and its application to pharmaceutical research. With several small molecule inhibitors in oncology clinical development, there is clearly intense interest in the chaperones as a molecular target. Filling a significant gap in the market by providing a detailed comparison of discovery programs across the industry, this text will find broad interest among researchers in the field of molecular chaperone pharmaceutical research, oncology research, and medicinal chemistry. Arranged into three main sections the book covers structure and function, small molecule inhibitors and concludes with a section discussing clinical perspectives. With specific chapters covering the discovery of key molecules such as, BIIB028, STA-9090, Serenex Hsp90 inhibitor, NVP-AUY922 and NVP-HSP990, this comprehensive text will be an essential treatise for researchers working in academia and industry.

HSF1 and Molecular Chaperones in Biology and Cancer

Marc Laurence Mendillo,David Pincus,Ruth Scherz-Shouval
HSF1 and Molecular Chaperones in Biology and Cancer Book PDF

Author : Marc Laurence Mendillo,David Pincus,Ruth Scherz-Shouval
Publisher : Springer Nature
Page : 185 pages
File Size : 41,5 Mb
Release : 2020-04-15
Category : Medical
ISBN : 9783030402044

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HSF1 and Molecular Chaperones in Biology and Cancer by Marc Laurence Mendillo,David Pincus,Ruth Scherz-Shouval Pdf

Protein homeostasis, or “Proteostasis”, lies at the heart of human health and disease. From the folding of single polypeptide chains into functional proteins, to the regulation of intracellular signaling pathways, to the secreted signals that coordinate cells in tissues and throughout the body, the proteostasis network operates to support cell health and physiological fitness. However, cancer cells also hijack the proteostasis network and many of these same processes to sustain the growth and spread of tumors. The chapters in this book are written by world experts in the many facets of the proteostasis network. They describe cutting-edge insights into the structure and function of the major chaperone and degradation systems in healthy cells and how these systems are co-opted in cancer cells and the cells of the tumor microenvironment. The chapters also cover therapeutic interventions such as the FDA-approved proteasome inhibitors Velcade and Krypolis as well as other therapies currently under clinical investigation to disarm the ability of the proteostasis network to support malignancy. This compendium is the first of its kind and aims to serve as a reference manual for active investigators and a primer for newcomers to the field. This book is dedicated to the memory of Susan Lindquist, a pioneer of the proteostasis field and a champion of the power of basic scientific inquiry to unlock the mechanisms of human disease. The chapter “Reflections and Outlook on Targeting HSP90, HSP70 and HSF1 in Cancer: A Personal Perspective” is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.

Molecular Chaperones in Health and Disease

Matthias Gaestel
Molecular Chaperones in Health and Disease Book PDF

Author : Matthias Gaestel
Publisher : Springer Science & Business Media
Page : 464 pages
File Size : 47,9 Mb
Release : 2005-09-27
Category : Science
ISBN : 3540258752

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Molecular Chaperones in Health and Disease by Matthias Gaestel Pdf

Molecular chaperones are involved in a wide variety of essential cellular processes in living cells. A subset of molecular chaperones have been initially described as heat shock proteins protecting cells from stress damage by keeping cellular proteins in a folding competent state and preventing them from irreversible aggregation. Later it became obvious that molecular chaperones are also expressed constitutively in the cell and are involved in complex processes such as protein synthesis, intracellular protein transport, post-translational modification and secretion of proteins as well as receptor signalling. Hence, it is not surprising that molecular chaperones are implicated in the pathogenesis of many relevant diseases and could be regarded as potential pharmacological targets. Starting with the analysis of the mode of action of chaperones at the molecular, cellular and organismic level, this book will then describe specific aspects where modulation of chaperone action could be of pharmacological and therapeutic interest.

Heat Shock Proteins in Cancer

Stuart K. Calderwood,Michael Y. Sherman,Daniel R. Ciocca
Heat Shock Proteins in Cancer Book PDF

Author : Stuart K. Calderwood,Michael Y. Sherman,Daniel R. Ciocca
Publisher : Springer Science & Business Media
Page : 400 pages
File Size : 42,7 Mb
Release : 2007-09-09
Category : Medical
ISBN : 9781402064012

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Heat Shock Proteins in Cancer by Stuart K. Calderwood,Michael Y. Sherman,Daniel R. Ciocca Pdf

Heat shock proteins are emerging as important molecules in the development of cancer and as key targets in cancer therapy. These proteins enhance the growth of cancer cells and protect tumors from treatments such as drugs or surgery. However, new drugs have recently been developed particularly those targeting heat shock protein 90. As heat shock protein 90 functions to stabilize many of the oncogenes and growth promoting proteins in cancer cells, such drugs have broad specificity in many types of cancer cell and offer the possibility of evading the development of resistance through point mutation or use of compensatory pathways. Heat shock proteins have a further property that makes them tempting targets in cancer immunotherapy. These proteins have the ability to induce an inflammatory response when released in tumors and to carry tumor antigens to antigen presenting cells. They have thus become important components of anticancer vaccines. Overall, heat shock proteins are important new targets in molecular cancer therapy and can be approached in a number of contrasting approaches to therapy.

The Molecular Chaperones Interaction Networks in Protein Folding and Degradation

Walid A. Houry
The Molecular Chaperones Interaction Networks in Protein Folding and Degradation Book PDF

Author : Walid A. Houry
Publisher : Springer
Page : 485 pages
File Size : 42,7 Mb
Release : 2014-09-01
Category : Science
ISBN : 9781493911301

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The Molecular Chaperones Interaction Networks in Protein Folding and Degradation by Walid A. Houry Pdf

Molecular chaperones are a fundamental group of proteins that have been identified only relatively recently. They are key components of a protein quality machinery in the cell which insures that the folding process of any newly-synthesized polypeptide chain results in the formation of a properly folded protein and that the folded protein is maintained in an active conformation throughout its functional lifetime. Molecular chaperones have been shown to play essential roles in cell viability under both normal and stress conditions. Chaperones can also assist in the unfolding and degradation of misfolded proteins and in disaggregating preformed protein aggregates. Chaperones are also involved in other cellular functions including protein translocation across membranes, vesicle fusion events, and protein secretion. In recent years, tremendous advances have been made in our understanding of the biology, biochemistry, and biophysics of function of molecular chaperones. In addition, recent technical developments in the fields of proteomics and genomics allowed us to obtain a global view of chaperone interaction networks. Finally, there is now a growing interest in the role of molecular chaperones in diseases. This book will provide a comprehensive analysis of the structure and function of the diverse systems of molecular chaperones and their role in cell stress responses and in diseases from a global network perspective. ​

Heat Shock Protein Inhibitors

Shelli R. McAlpine,Adrienne Lesley Edkins
Heat Shock Protein Inhibitors Book PDF

Author : Shelli R. McAlpine,Adrienne Lesley Edkins
Publisher : Springer
Page : 238 pages
File Size : 40,7 Mb
Release : 2016-05-23
Category : Science
ISBN : 9783319326078

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Heat Shock Protein Inhibitors by Shelli R. McAlpine,Adrienne Lesley Edkins Pdf

Medicinal chemistry is both science and art. The science of medicinal chemistry offers mankind one of its best hopes for improving the quality of life. The art of medicinal chemistry continues to challenge its practitioners with the need for both intuition and experience to discover new drugs. Hence sharing the experience of drug research is uniquely beneficial to the field of medicinal chemistry. Drug research requires interdisciplinary team-work at the interface between chemistry, biology and medicine. Therefore, the topic-related series Topics in Medicinal Chemistry covers all relevant aspects of drug research, e.g. pathobiochemistry of diseases, identification and validation of (emerging) drug targets, structural biology, drugability of targets, drug design approaches, chemogenomics, synthetic chemistry including combinatorial methods, bioorganic chemistry, natural compounds, high-throughput screening, pharmacological in vitro and in vivo investigations, drug-receptor interactions on the molecular level, structure-activity relationships, drug absorption, distribution, metabolism, elimination, toxicology and pharmacogenomics. In general, special volumes are edited by well known guest editors.

Structure and Action of Molecular Chaperones

Lila M Gierasch,Arthur L Horwich,Christine Slingsby,Sue Wickner,David Agard
Structure and Action of Molecular Chaperones Book PDF

Author : Lila M Gierasch,Arthur L Horwich,Christine Slingsby,Sue Wickner,David Agard
Publisher : World Scientific
Page : 128 pages
File Size : 49,7 Mb
Release : 2016-08-08
Category : Science
ISBN : 9789814749343

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Structure and Action of Molecular Chaperones by Lila M Gierasch,Arthur L Horwich,Christine Slingsby,Sue Wickner,David Agard Pdf

This unique volume reviews the beautiful architectures and varying mechanical actions of the set of specialized cellular proteins called molecular chaperones, which provide essential kinetic assistance to processes of protein folding and unfolding in the cell. Ranging from multisubunit ring-shaped chaperonin and Hsp100 machines that use their central cavities to bind and compartmentalize action on proteins, to machines that use other topologies of recognition — binding cellular proteins in an archway or at the surface of a "clamp" or at the surface of a globular assembly — the structures show us the ways and means the cell has devised to assist its major effectors, proteins, to reach and maintain their unique active forms, as well as, when required, to disrupt protein structure in order to remodel or degrade. Each type of chaperone is beautifully illustrated by X-ray and EM structure determinations at near- atomic level resolution and described by a leader in the study of the respective family. The beauty of what Mother Nature has devised to accomplish essential assisting actions for proteins in vivo is fully appreciable.

Molecular Chaperones

Sophie Jackson
Molecular Chaperones Book PDF

Author : Sophie Jackson
Publisher : Springer
Page : 274 pages
File Size : 41,8 Mb
Release : 2012-12-15
Category : Science
ISBN : 9783642345524

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Molecular Chaperones by Sophie Jackson Pdf

Assisting Oxidative Protein Folding: How Do Protein Disulphide-Isomerases Couple Conformational and Chemical Processes in Protein Folding?, by A. Katrine Wallis and Robert B. Freedman Peptide Bond cis/trans Isomerases: A Biocatalysis Perspective of Conformational Dynamics in Proteins, by Cordelia Schiene-Fischer, Tobias Aumüller and Gunter Fischer Small Heat-Shock Proteins: Paramedics of the Cell, by Gillian R. Hilton, Hadi Lioe, Florian Stengel, Andrew J. Baldwin und Justin L. P. Benesch Allostery in the Hsp70 Chaperone Proteins, by Erik R. P. Zuiderweg, Eric B. Bertelsen, Aikaterini Rousaki, Matthias P. Mayer, Jason E. Gestwicki and Atta Ahmad Hsp90: Structure and Function, by Sophie E. Jackson Extracellular Chaperones, by Rebecca A. Dabbs, Amy R. Wyatt, Justin J. Yerbury, Heath Ecroyd and Mark R. Wilson

211 Medical Therapies In The World PART-2

Brijpal Singh Chouhan
211 Medical Therapies In The World PART 2 Book PDF

Author : Brijpal Singh Chouhan
Publisher : Brijpal Singh Chouhan
Page : 165 pages
File Size : 47,5 Mb
Release : 2020-02-24
Category : Health & Fitness
ISBN : 8210379456XXX

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211 Medical Therapies In The World PART-2 by Brijpal Singh Chouhan Pdf

This ebook is written for knowledge and educational purpose. First of all thanks to you that you are interested about to know owesome Cultures like Medical Therapies by this ebook. So we are providing to you all about therepies were existed or now exist all over world. Although we have tried our best that all information and content of this ebook is true and correct. But if some information is not correct then we would not responsible for that and we are very sorry for that information. This is second Part of 211 Medical Therapies in The World (Part-2) Ebook Series, because there have more and much therapies in the world. We can say that you would not listened name of maximus therapies. For your ease we are divided some therapies in every some parts. So we are providing this Ebook Series in three parts. Therapy is the attempted remediation of a health problem, usually following a diagnosis. In the medical field, it is usually synonymous with treatment. Among psychologists and other mental health professionals, including psychiatrists, psychiatric nurse practitioners and clinical social workers, the term may refer specifically to psychotherapy (sometimes dubbed 'talking therapy'). The English word therapy comes via Latin therapia from and literally means "curing" or "healing". As a rule, each therapy has indications and contraindications. The words care, therapy, treatment and intervention overlap in a semantic field, and thus they can be synonymous depending on context. Moving rightward through that order, the connotative level of holism decreases and the level of specificity (to concrete instances) increases. Thus, in health care contexts (where its senses are always non-count), the word care tends to imply a broad idea of everything done to protect or improve someone's health (for example, as in the terms preventive care and primary care, which connote ongoing action), although it sometimes implies a narrower idea (for example, in the simplest cases of wound care or post anesthesia care, a few particular steps are sufficient, and the patient's interaction with that provider is soon finished).

Protein Misfolding in Neurodegenerative Diseases

Robert D. E. Sewell
Protein Misfolding in Neurodegenerative Diseases Book PDF

Author : Robert D. E. Sewell
Publisher : CRC Press
Page : 592 pages
File Size : 47,9 Mb
Release : 2007-12-03
Category : Science
ISBN : 1420007149

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Protein Misfolding in Neurodegenerative Diseases by Robert D. E. Sewell Pdf

Research focused on protein folding, misfolding, and aggregation is leading to major advances across biochemistry and medicine. The elucidation of a folding code is proving to be of extreme importance in the postgenomic era, where a number of orphan genes have been identified for which no clear function has yet been established. This research is starting to shed light on the molecular and biochemical basis of a number of neurodegenerative diseases of dramatic impact. Protein Misfolding in Neurodegenerative Diseases: Mechanisms and Therapeutic Strategies addresses key issues concerning protein misfolding and aggregation in neurodegenerative diseases. Building on recent developments, including the recognition of protein misfolding as both a marker and a causal agent, the text presents the work of those who are actively pursuing more effective treatments, as well as preventative measures, and a possible cure. These include the use of molecular chaperones to control misfolding and novel pharmaceuticals, as well as the potential role of various inhibitors and NSAIDS. A Comprehensive Multifaceted Examination of the Complex Causal Agents Implicated in Protein Misfolding Divided into five sections, this groundbreaking text provides up-to-date accounts for Alzheimer’s, Parkinson’s, Huntington’s, Amyotrophic Lateral Sclerosis and Transmissible Spongiform Encephalitis. It also explores the highly likelihood that multiple factors, including oxidative stress, play a role in these complex diseases.

Emerging Drugs and Targets for Multiple Sclerosis

Ana Martinez
Emerging Drugs and Targets for Multiple Sclerosis Book PDF

Author : Ana Martinez
Publisher : Royal Society of Chemistry
Page : 350 pages
File Size : 51,9 Mb
Release : 2019-06-28
Category : Science
ISBN : 9781788014502

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Emerging Drugs and Targets for Multiple Sclerosis by Ana Martinez Pdf

Multiple sclerosis (MS) is a complex disease with a presumed autoimmune aetiology and few current effective treatments. Disease modifying therapies focus on the altering the natural course of relapsing and remitting MS, targeting the inflammatory response. Other targets involve tacking the cause of the disease – demyelination of axons through remyelination therapies. Due to several recent breakthroughs in the understanding of the pathophysiology of MS new targets for remyelination and immunomodulation are rapidly emerging. This book provides a comprehensive overview of drug discovery and development for the molecular basis of the disease, from new targets to drugs currently in clinical development, cellular and animal disease models to biomarkers for diagnosis and assessment in clinical trials. Emerging Drugs and Targets for Multiple Sclerosis is an ideal reference for any student or researcher interested in drug development for neurodegenerative diseases, autoimmune diseases and MS in particular.

Disease-Modifying Targets in Neurodegenerative Disorders

Veerle Baekelandt,Evy Lobbestael
Disease Modifying Targets in Neurodegenerative Disorders Book PDF

Author : Veerle Baekelandt,Evy Lobbestael
Publisher : Academic Press
Page : 324 pages
File Size : 48,8 Mb
Release : 2017-03-31
Category : Medical
ISBN : 9780128052662

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Disease-Modifying Targets in Neurodegenerative Disorders by Veerle Baekelandt,Evy Lobbestael Pdf

Disease-Modifying Targets in Neurodegenerative Disorders: Paving the Way for Disease-Modifying Therapies examines specific neurodegenerative disorders in comprehensive chapters written by experts in the respective fields. Each chapter contains a summary of the disease management field, subsequently elaborating on the molecular mechanisms and promising new targets for disease-modifying therapies. This overview is ideal for neuroscientists, biomedical researchers, medical doctors, and caregivers, not only providing readers with a summary of the way patients are treated today, but also offering a glance at the future of neurodegenerative disorder treatment. Provides a comprehensive overview of how key proteins in neurodegenerative disorders can be used as targets to modify disease progress Summarizes how patients are treated today, providing a glance at future disease management Includes intelligible and informative information that is perfect for non-specialists, medical practitioners, and scientists Written and peer reviewed by outstanding scientists in their respective fields

Protein Degradation with New Chemical Modalities

Hilmar Weinmann,Craig Crews
Protein Degradation with New Chemical Modalities Book PDF

Author : Hilmar Weinmann,Craig Crews
Publisher : Royal Society of Chemistry
Page : 382 pages
File Size : 52,9 Mb
Release : 2020-10-07
Category : Medical
ISBN : 9781839160776

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Protein Degradation with New Chemical Modalities by Hilmar Weinmann,Craig Crews Pdf

Targeting protein degradation using small molecules is one of the most exciting small-molecule therapeutic strategies in decades and a rapidly growing area of research. In particular, the development of proteolysis targeting chimera (PROTACs) as potential drugs capable of recruiting target proteins to the cellular quality control machinery for elimination has opened new avenues to address traditionally ‘difficult to target’ proteins. This book provides a comprehensive overview from the leading academic and industrial experts on recent developments, scope and limitations in this dynamically growing research area; an ideal reference work for researchers in drug discovery and chemical biology as well as advanced students.

Protein–Protein Interaction Regulators

Siddhartha Roy,Haian Fu
Protein Protein Interaction Regulators Book PDF

Author : Siddhartha Roy,Haian Fu
Publisher : Royal Society of Chemistry
Page : 399 pages
File Size : 44,5 Mb
Release : 2020-12-15
Category : Science
ISBN : 9781788011877

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Protein–Protein Interaction Regulators by Siddhartha Roy,Haian Fu Pdf

New genomic information has revealed the crucial role that protein-protein interactions (PPIs) play in regulating numerous cellular functions. Aberrant forms of these interactions are common in numerous diseases and thus PPIs have emerged as a vast class of critical drug targets. Despite the importance of PPIs in biology, it has been extremely challenging to convert targets into therapeutics and targeting PPIs had long been considered a very difficult task. However, over the past decade the field has advanced with increasing growth in the number of successful PPI regulators. Protein-Protein Interaction Regulators surveys the latest advances in the structural understanding of PPIs as well as recent developments in modulator discovery.

Molecular Chaperones—Advances in Research and Application: 2013 Edition

Anonim
Molecular Chaperones Advances in Research and Application 2013 Edition Book PDF

Author : Anonim
Publisher : ScholarlyEditions
Page : 224 pages
File Size : 42,5 Mb
Release : 2013-06-21
Category : Science
ISBN : 9781481689939

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Molecular Chaperones—Advances in Research and Application: 2013 Edition by Anonim Pdf

Molecular Chaperones—Advances in Research and Application: 2013 Edition is a ScholarlyEditions™ book that delivers timely, authoritative, and comprehensive information about Histone Chaperones. The editors have built Molecular Chaperones—Advances in Research and Application: 2013 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Histone Chaperones in this book to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Molecular Chaperones—Advances in Research and Application: 2013 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.