Innate Lymphoid Cell Development Migration And Function

Author : Paula Licona-Limón,Jorge Henao-Mejia,José Carlos Crispín
Publisher : Frontiers Media SA
Page : 144 pages
File Size : 44,8 Mb
Release : 2023-10-23
Category : Medical
ISBN : 9782832536704

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Innate Lymphoid Cell Development, Migration, and Function by Paula Licona-Limón,Jorge Henao-Mejia,José Carlos Crispín Pdf

Cell lineages derived from common lymphoid progenitors (CLPs) play a critical role in antigen recognition, acute and long term protection against pathogens, and maintenance of immune homeostasis. CLPs give rise to adaptive immune cells that bear unique antigen receptors and to innate immune cells that perform non-redundant roles, particularly during early effector responses, by facilitating local immunity and shaping the ensuing adaptive response. Recent discoveries indicate that innate lymphoid cells (ILCs) exert essential modulatory effects in normal and pathological responses. Because adaptive and innate lymphoid cells share transcription factors, cytokines, and molecular surface markers, it is essential to dissect the contribution of innate lymphoid cell subsets to immune tolerance, maintenance of tissue homeostasis and during the development of inflammatory responses. In this research topic we will focus on the functional diversity and individual roles that the variety of innate lymphoid cell subsets perform in steady state as well as in different pathological conditions including infection and autoimmunity. This will contribute to the generation of a more comprehensive and integrated view of how these cells interact with the environment, collaborate with other cells and regulate tissue homeostasis and immunity in a context-dependent manner. We welcome Original Research, Review, and Mini-review articles related to, but not limited to the following topics: 1. Innate lymphoid cell development and migration 2. Characterization and identification of signals controlling innate lymphoid differentiation and function 3. Molecular interactions between innate lymphoid cells and other immune and non-immune subsets 4. Role of ILCs in tissue homeostasis 5. Role of ILCs in pathology We acknowledge the initiation and support of this Research Topic by the International Union of Immunological Societies (IUIS). We hereby state publicly that the IUIS has had no editorial input in articles included in this Research Topic, thus ensuring that all aspects of this Research Topic are evaluated objectively, unbiased by any specific policy or opinion of the IUIS.

Author : Alan J. Husband
Publisher : Springer
Page : 224 pages
File Size : 42,7 Mb
Release : 1988
Category : Science
ISBN : UOM:39015012578277

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MIGRATION & HOMING LYMPHOID CELL by Alan J. Husband Pdf

This comprehensive set is crucial to the basic understanding of the immune system and is an essential component of the design and implementation of improved immunization strategies. Contains au-thoritative reviews of cell migration research and addresses the is-sues of lymphocyte recirculation leading to inductive interactions, and the subsequent migration and homing of effector cells gener-ated from these responses. Systemic migration of cells from the central and peripheral lymphoid organs, the dichotomy of behavior between systemic and mucosal lymphoid cell pools, and explana-tions sought for mechanisms mediating selectivity of migration and homing are covered. This set is of interest to problem oriented sci-entists.

Author : Kenneth Murphy,Paul Travers,Mark Walport,Peter Walter
Publisher : Garland Science
Page : 128 pages
File Size : 46,6 Mb
Release : 2010-06-22
Category : Medical
ISBN : 0815344570

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Janeway's Immunobiology by Kenneth Murphy,Paul Travers,Mark Walport,Peter Walter Pdf

The Janeway's Immunobiology CD-ROM, Immunobiology Interactive, is included with each book, and can be purchased separately. It contains animations and videos with voiceover narration, as well as the figures from the text for presentation purposes.

Author : Jessica Borger,Joanna Kirman,Graham Le Gros
Publisher : Frontiers Media SA
Page : 191 pages
File Size : 46,6 Mb
Release : 2020-08-06
Category : Electronic
ISBN : 9782889639250

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The Role of Innate Lymphoid Cells in Mucosal Immunity by Jessica Borger,Joanna Kirman,Graham Le Gros Pdf

We acknowledge the initiation and support of this Research Topic by the InternationalUnion of Immunological Societies (IUIS). We hereby state publicly that the IUIS hashad no editorial input in articles included in this Research Topic, thus ensuring that allaspects of this Research Topic are evaluated objectively, unbiased by any specific policyor opinion of the IUIS.

Author : Walter Gottlieb Land
Publisher : Springer
Page : 870 pages
File Size : 52,7 Mb
Release : 2018-10-09
Category : Medical
ISBN : 9783319786551

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Damage-Associated Molecular Patterns in Human Diseases by Walter Gottlieb Land Pdf

This book presents current understanding of the importance of modern immunology in the etiopathogenesis of human diseases and explores how this understanding is impacting on diagnosis, prognosis, treatment, and prophylaxis. As the core of modern immunology, the “danger/injury model” is introduced and addressed throughout the book. Volume I of the book describes the network of damage-associated molecular pattern molecules (DAMPs) and examines the central role of DAMPs in cellular stress responses and associated regulated cell death, the promotion and resolution of inflammation, the activation of innate lymphoid cells and unconventional T cells, the stimulation of adaptive immunity, and tissue repair. The significance of DAMPs in a wide range of human diseases will then be explored in Volume II of the book, with discussion of the implications of injury-induced innate immunity for present and future treatments. This book is written for professionals from all medical and paramedical disciplines who are interested in the introduction of innovative data from immunity and inflammation research into clinical practice. The readership will include practitioners and clinicians such as hematologists, rheumatologists, traumatologists, oncologists, intensive care anesthetists, endocrinologists such as diabetologists, psychiatrists, neurologists, pharmacists, and transplantologists.

Author : Gheorghita Isvoranu
Publisher : BoD – Books on Demand
Page : 194 pages
File Size : 44,6 Mb
Release : 2017-07-12
Category : Medical
ISBN : 9789535133438

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Lymphocyte Updates by Gheorghita Isvoranu Pdf

This book represents a synergic effort of an international team of specialists in immunology to expand the scientific achievements in the field of lymphocytes. It offers important and specific updated information to researchers, students, teachers, and medical professionals. Moreover, considering the remarkable dynamics of immunology and immunotherapy, this book "Lymphocyte Updates - Cancer, Autoimmunity, and Infection" aims to represent a significant source of concise scientific data and advancement of knowledge in this field. The chapters offer new insights into the latest scientific progress on lymphocyte roles in protective immunity, as well as their involvement in pathogenesis of various disorders.

Author : G. Hartmann,H. Wagner
Publisher : Karger Medical and Scientific Publishers
Page : 140 pages
File Size : 47,9 Mb
Release : 2013-06-05
Category : Medical
ISBN : 9783318023480

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Innate Immunity: Resistance and Disease-Promoting Principles by G. Hartmann,H. Wagner Pdf

Our understanding of the complex innate immune response is increasing rapidly. Its role in the protection against viral or bacterial pathogens is essential for the survival of an organism. However, it is equally important to avoid unregulated inflammation because innate immune responses can cause or promote chronic autoinflammatory diseases such as gout, atherosclerosis, type 2 diabetes or certain aspects of the metabolic syndrome. In this book leading international experts in the field of innate immunity share their findings, define the ‚state of the art‘ in this field and evaluate how insight into the molecular basis of these diseases could help in the design of new therapies. A tremendous amount of work on the innate immune response has been done over the last fifteen years, culminating in the 2011 Nobel Prize in Physiology/Medicine awarded for the discoveries of Toll genes in immunity in flies, membrane-bound Toll-like receptors in mammals, and dendritic cells as initiators of adaptive immunity.

Author : R. Lee Reinhardt
Publisher : Humana
Page : 0 pages
File Size : 44,6 Mb
Release : 2018-06-29
Category : Medical
ISBN : 1493978950

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Type 2 Immunity by R. Lee Reinhardt Pdf

This book provides researchers the opportunity to investigate type-2-associated diseases in their laboratories. Beginning with chapters describing various models of type-2 immunity, the volume then continues by detailing cellular protocols designed to identify, characterize, and assess the function of key adaptive and innate immune cells involved in type-2 inflammation; approaches to isolate and evaluate specific cellular subsets at the genetic, epigenetic, and molecular level; protocols to assess type-2 immunity and its relationship to organismal and metabolic systems (ex. Microbiome). This book concludes with a section that explores the use of primary human cells in evaluating relevance to the clinic. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Vital and authoritative, Type 2 Immunity: Methods and Protocols aims to provide a broad network of methods that can be used to develop a hypothesis and investigate its potential from bench to beside.

Author : Pedro A. de Alarcón,Eric J. Werner,Robert D. Christensen,Martha C. Sola-Visner
Publisher : Cambridge University Press
Page : 501 pages
File Size : 40,8 Mb
Release : 2021-02-18
Category : Medical
ISBN : 9781108488983

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Neonatal Hematology by Pedro A. de Alarcón,Eric J. Werner,Robert D. Christensen,Martha C. Sola-Visner Pdf

An essential guide to the pathogenesis, diagnosis and management of hematologic problems in the neonate, covering erythrocyte disorders, leukocyte disorders, immunologic disorders and hemostatic disorders. Guidance is practical, including blood test interpretation, advice on transfusions and reference ranges for hematological values.

Author : Malcolm Ronald Starkey,Hitesh Deshmukh,Nicholas W. Lukacs,Clare Margaret Lloyd
Publisher : Frontiers Media SA
Page : 166 pages
File Size : 47,7 Mb
Release : 2022-03-29
Category : Medical
ISBN : 9782889748129

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Pulmonary Innate Lymphoid Cells - Gatekeepers of Respiratory Health by Malcolm Ronald Starkey,Hitesh Deshmukh,Nicholas W. Lukacs,Clare Margaret Lloyd Pdf

Prof. Lukacs is the Co-Founder of Opsidio, LLC. The other Topic Editors declare no competing interests with regard to the Research Topic subject.

Author : Emanuela Marcenaro,Luigi D. Notarangelo,Jordan S. Orange,Eric Vivier
Publisher : Frontiers Media SA
Page : 245 pages
File Size : 53,9 Mb
Release : 2017-11-29
Category : Electronic book
ISBN : 9782889453504

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NK Cell Subsets in Health and Disease: New Developments by Emanuela Marcenaro,Luigi D. Notarangelo,Jordan S. Orange,Eric Vivier Pdf

Natural Killer (NK) cells were discovered ca 1975, as the first group of lymphoid cells that were neither T cells nor B cells. Since then, the dissection of the biology of NK cells has been growing exponentially with many seminal discoveries from the identification of MHC class I-specific inhibitory receptors to the discovery of receptor-ligand pairs involved in NK cell activation and to the manipulation of NK cells in cancer. In this research topic, we asked a group of thought leaders in NK cell biology to review recent advances in their origins and biology, and their roles in cancer, infection and inflammation. Together, these 25 articles provide a timely survey of NK cells as critical immunologic components of health and disease. They will hopefully prompt further dialogue and developments in basic and translational immunology.

Author : Anonim
Publisher : Academic Press
Page : 3161 pages
File Size : 46,5 Mb
Release : 2016-04-27
Category : Medical
ISBN : 9780080921525

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Encyclopedia of Immunobiology by Anonim Pdf

Encyclopedia of Immunobiology, Five Volume Set provides the largest integrated source of immunological knowledge currently available. It consists of broad ranging, validated summaries on all of the major topics in the field as written by a team of leading experts. The large number of topics covered is relevant to a wide range of scientists working on experimental and clinical immunology, microbiology, biochemistry, genetics, veterinary science, physiology, and hematology. The book is built in thematic sections that allow readers to rapidly navigate around related content. Specific sections focus on basic, applied, and clinical immunology. The structure of each section helps readers from a range of backgrounds gain important understanding of the subject. Contains tables, pictures, and multimedia features that enhance the learning process In-depth coverage allows readers from a range of backgrounds to benefit from the material Provides handy cross-referencing between articles to improve readability, including easy access from portable devices

Author : Charles N. Serhan,Peter A. Ward,Derek W. Gilroy
Publisher : Cambridge University Press
Page : 489 pages
File Size : 50,9 Mb
Release : 2010-04-26
Category : Medical
ISBN : 9780521887298

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Fundamentals of Inflammation by Charles N. Serhan,Peter A. Ward,Derek W. Gilroy Pdf

The acute inflammatory response is the body's first system of alarm signals that are directed toward containment and elimination of microbial invaders. Uncontrolled inflammation has emerged as a pathophysiologic basis for many widely occurring diseases in the general population. This book provides an introduction to the cell types, chemical mediators, and general mechanisms of the host's first response to invasion.

Author : Fritz Melchers
Publisher : Springer Science & Business Media
Page : 240 pages
File Size : 46,6 Mb
Release : 2000-09-04
Category : Medical
ISBN : 3540675698

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Lymphoid Organogenesis by Fritz Melchers Pdf

It has been clear for a long time that after transplantation of a lymphoid organ, hematopoietic stem cells can regenerate the compartments of the organ, provided that the rest of its architecture - the strome, the epithelia and the vessels - is intact. Ahead lies the even greater challenge to assemble also these other architectural elements of a lymphoid organ by transplanting stem cells. The workshop on lymphoid organogenesis was convened to review current knowledge of and experimental skills involved in this grand project to build a lymphoid organ from its individual cellular components.

Author : Carolina Jancic,Carmelo Luci,Rachel Golub
Publisher : Frontiers Media SA
Page : 206 pages
File Size : 54,9 Mb
Release : 2024-06-25
Category : Medical
ISBN : 9782832540862

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Innate Lymphoid Cells: Characterization and Classification by Carolina Jancic,Carmelo Luci,Rachel Golub Pdf