Insight On Genotoxicity

Author : Shiv Shankar Shukla,Ravindra Kumar Pandey,Bina Gidwani,Gunjan Kalyani
Publisher : CRC Press
Page : 164 pages
File Size : 48,6 Mb
Release : 2020-10-14
Category : Science
ISBN : 9781000197310

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Insight on Genotoxicity by Shiv Shankar Shukla,Ravindra Kumar Pandey,Bina Gidwani,Gunjan Kalyani Pdf

Genetic toxicology is considered to be an important assessment tool as there is genetic impact of artificial chemicals. Insight on Genotoxicity discusses testing, mechanism, prediction, and bioindicator of genotoxicity taking into consideration recent advances in nano-engineered particles. Corollary of DNA dent is also discussed in detail taking into consideration the impact of ICH guidelines on genotoxicity testing, which is important for drug discovery innovation and development. Perspective review of genotoxicity evaluation in phytopharmaceuticals has been mentioned along with the prevention of genotoxicity in brief viewpoint. Salient Features Presents methods, standard protocols, and guidelines for genotoxicity testing Examines the impact of ICH Guidelines on genetic toxicity testing which is a regulatory requirement for drug discovery and development Defines appropriate strategies about advances in in vivo genotoxicity testing which have been listed along with progress and prospects Discusses advancement in the high-throughput approaches for genotoxicity testing Details computational prediction of genotoxicity with consideration of mutagenicity, chromosomal damage caused and strategies for computational prediction in drug development

Author : Marcelo Larramendy,Sonia Soloneski
Publisher : BoD – Books on Demand
Page : 124 pages
File Size : 55,8 Mb
Release : 2018-07-11
Category : Medical
ISBN : 9781789234183

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Genotoxicity by Marcelo Larramendy,Sonia Soloneski Pdf

This book is designed to provide an overview of the different genotoxicants and their effects on living organisms, including humans. The contributions made by the specialists in this field of research are gratefully acknowledged. We hope that the information presented in this book will meet the expectations and needs of all those interested in the different aspects of the genotoxicity field. The publication of this book is of great importance to those scientists, pharmacologists, physicians and veterinarians, as well as engineers, teachers, graduate students and administrators of environmental programmes, who make use of these investigations to understand both the basic and applied genotoxic aspects of known and new xenobiotics, and to guide them in their future investigations.

Author : Sonia Soloneski
Publisher : BoD – Books on Demand
Page : 241 pages
File Size : 51,5 Mb
Release : 2014-02-20
Category : Medical
ISBN : 9789535112174

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Pesticides by Sonia Soloneski Pdf

The edited book Pesticides - Toxic Aspects contains an overview of attractive researchers of pesticide toxicology that covers the hazardous effects of common chemical pesticide agents employed every day in our agricultural practices. The combination of experimental and theoretical pesticide investigations of current interest will make this book of significance to researchers, scientists, engineers, and graduate students who make use of those different investigations to understand the toxic aspects of pesticides. We hope that this book will continue to meet the expectations and needs of all interested in different aspects of pesticide toxicity.

Author : Ashutosh Kumar,Vasily N. Dobrovolsky,Alok Dhawan,Rishi Shanker
Publisher : Academic Press
Page : 350 pages
File Size : 45,5 Mb
Release : 2017-09-26
Category : Science
ISBN : 9780128092606

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Mutagenicity: Assays and Applications by Ashutosh Kumar,Vasily N. Dobrovolsky,Alok Dhawan,Rishi Shanker Pdf

Mutagenicity: Assays and Applications presents an extensive examination of the detection, assessment and future of mutagenicity, particularly as it concerns human health and the environment. Chapters focused on specific types of mutagens or testing methods for their detection collectively explore the current state of human and environmental mutagenesis, future perspectives and regulatory needs. The test procedures for measuring mutagenicity, their advantages and limitations are described with practical and procedural detail, along with their presentation and data processing aspects. It is an essential reference covering the breadth and depth of the field of mutagenicity studies and regulation. By providing both important introductory material and practical assays and applications, this book is useful to graduate students, academic and industry researchers and regulators at various stages of their careers, leading to improved risk assessment and regulation. Presents an up-to-date and in-depth review of the current state of mutagenesis research Draws upon the combined experience and expertise of an international group of highly respected editors and chapter authors Provides an introduction to the concept of mutagenesis with particular consideration given to novel chemicals and materials

Author : Miriam Christine Poirier
Publisher : World Scientific
Page : 392 pages
File Size : 41,8 Mb
Release : 2018-09-28
Category : Medical
ISBN : 9789813237216

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Carcinogens, Dna Damage And Cancer Risk: Mechanisms Of Chemical Carcinogenesis by Miriam Christine Poirier Pdf

As chemical exposures and cancer rates increase worldwide, there is a need for students, researchers, public health professionals, and physicians to understand the mechanisms connecting exposure with human cancer risk. This new book is an essential reference, as well as introduction to the field of chemical carcinogenesis, with particular focus on DNA damage as a critical link between exposure and disease, and emphasis on biomarkers associated with cancer risk in humans. In addition to DNA damage, related topics covered include metabolism of selected chemical carcinogens, exposure-induced epigenetic changes, cancer-associated mutations and reduction of DNA damage and cancer risk by chemoprevention. The book is designed to be a comprehensive guide to basic principles, a teaching tool for academics, and a map for the development of protective mechanisms to reduce human cancer risk.

Author : Albert P. Li
Publisher : CRC Press
Page : 508 pages
File Size : 44,7 Mb
Release : 1991-03-27
Category : Medical
ISBN : 0849388155

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Genetic Toxicology by Albert P. Li Pdf

Genetic Toxicology is a comprehensive book covering the historical perspective of genetic toxicology; basic mechanisms of mutations and chromosomal effects; health consequences of genetic damage, including cancer and inheritable mutations; properties of physical, chemical, and biological mutagens; risk assessment of human exposure to genotoxicants; and the current position of some government regulatory agencies in the United States on the issues of genetic toxicology. The book will be a useful reference for students and researchers in toxicology, genetics, cancer biology, and medicine who are interested in the basic and applied principles of genetic toxicology. It will also benefit industrial toxicologists, products registration specialists, and government regulatory specialists with responsibility for the safety evaluation of industrial and environmental agents.

Author : Russell S Thomas,Michael D Waters
Publisher : Royal Society of Chemistry
Page : 524 pages
File Size : 45,9 Mb
Release : 2016-06-16
Category : Medical
ISBN : 9781782624059

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Toxicogenomics in Predictive Carcinogenicity by Russell S Thomas,Michael D Waters Pdf

Research over the past decade has demonstrated that TGx methods of various types can be used to discriminate modes of mutagenesis as a function of dose. TGx can quickly inform safety evaluation regarding potential mechanisms of conventional outcomes and can provide essential dose-response information. This can then be used to ascertain the sequence of key events in a putative mode of action as may apply in quantitative cancer risk assessment. With the increasing complexity of research in mode of action investigations it is important to gain a better understand of approaches to data integration and health risk assessment. Furthermore, it is essential to consider how novel test systems and newer methods and approaches may be used in future to gain a better understanding of mechanisms. Toxicogenomics in Predictive Carcinogenicity describes toxicogenomics methods in predictive carcinogenicity testing, mode of action and safety evaluation, and cancer risk assessment. It illustrates these methods using case studies that have yielded significant new information on compounds and classes of compounds that have proven difficult to evaluate using conventional methods alone. This book additionally covers current and potential toxicogenomic research using stem cells as well as new bioinformatics methods for drug discovery and environmental toxicology. This publication is an indispensable tool for postgraduates, academics and industrialists working in biochemistry, genomics, carcinogenesis, pathology, pharmaceuticals, food technology, bioinformatics, risk assessment and environmental toxicology.

Author : Alok Dhawan,Mahima Bajpayee
Publisher : Humana
Page : 0 pages
File Size : 50,7 Mb
Release : 2016-08-23
Category : Medical
ISBN : 1493963023

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Genotoxicity Assessment by Alok Dhawan,Mahima Bajpayee Pdf

Genetic toxicology is recognized by geneticists and researchers concerned with the genetic impact of man-made chemicals. In Genotoxicity Assessment: Methods and Protocols, expert researchers in the field provide comprehensive genetic toxicology protocols. These include in vitro and in vivo protocols on mutation assays, cytogenetic techniques, and primary DNA damage, assays in alternate to animal models, and updated ICH guidelines. Written in the highly successful Methods in Molecular Biology series format, the chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step and readily reproducible laboratory protocols, as well as key tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Genotoxicity Assessment: Methods and Protocols seeks to aid research students and scientists working in regulatory toxicology as well as biomedical, biochemical and pharmaceutical sciences.

Author : Nelson Durán,Silvia S. Guterres,Oswaldo L. Alves
Publisher : Springer Science & Business Media
Page : 415 pages
File Size : 55,8 Mb
Release : 2013-10-25
Category : Medical
ISBN : 9781461489931

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Nanotoxicology by Nelson Durán,Silvia S. Guterres,Oswaldo L. Alves Pdf

This book takes a systematic approach to nanotoxicology and the developing risk factors associated with nanosized particles during manufacture and use of nanotechnology. Beginning with a detailed introduction to engineered nanostructures, the first part of the book presents concepts and definitions of nanomaterials from quantum dots to graphene to fullerenes, with detailed discussion of functionalization, stability, and medical and biological applications. The second part critically examines methodologies used to assess cytotoxicity and genotoxicity. Coverage includes interactions with blood (erythrocytes), combinatorial and microarray techniques, cellular mechanisms, and ecotoxicology assessments. Part three describes cases studies both in vitro and in vivo for specific nanomaterials including solid lipid nanoparticles and nanostructured lipid carriers and metallic nanoparticles and metallic oxides. New information is also presented on toxicological aspects of poloxamers and polymeric nanoparticles as drug carriers as well as size effects on cytotoxicity and genotoxicity. Didactic aspects are emphasized in all chapters, making the book suitable for a broad audience ranging from advanced undergraduate and graduate students to researchers in academia and industry. In all, Nanotoxicology: Materials, Methodologies, and Assessments will provide comprehensive insight into biological and environmental interactions with nanostructures. Provides an introduction to nanostructures actually in use Describes cyto- and genotoxicity methodologies, and assesses their performance in comparison to common toxicity assays Discusses the relation of cytotoxicity and genotoxicity to ecotoxicity Presents a range of applications, from biogenic silver nanoparticles to poloxamers as drug-delivery systems, reflecting the expanding applications of nanotechnology

Author : Valérie Fessard,Fabrice Nesslany
Publisher : MDPI
Page : 188 pages
File Size : 44,9 Mb
Release : 2021-03-24
Category : Medical
ISBN : 9783036501123

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From Basic Research to New Tools and Challenges for the Genotoxicity Testing of Nanomaterials by Valérie Fessard,Fabrice Nesslany Pdf

This Special Issue presents studies on the genotoxicity of nanomaterials. Although nanomaterials provide multiple benefits in a wide range of applications, challenges remain in addressing strong concerns about their risks to the environment and human health. As a result of inconsistencies among published results and diverging conclusions, the understanding of nanomaterial exposure and toxicity remains unclear. Determining whether these materials cause DNA damage—the first step in carcinogenesis—must be a priority in testing. In this book, readers will find recent publications on the genotoxic response to a broad range of nanomaterials, the impact of physico-chemical characteristics, safe-by-design and new developed tools.

Author : Sonia Soloneski,Marcelo L. Larramendy
Publisher : Unknown
Page : 128 pages
File Size : 49,9 Mb
Release : 2021
Category : DNA repair
ISBN : 1839621672

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Genotoxicity and Mutagenicity by Sonia Soloneski,Marcelo L. Larramendy Pdf

Author : Wai Nang Choy
Publisher : CRC Press
Page : 405 pages
File Size : 42,7 Mb
Release : 2001-08-31
Category : Medical
ISBN : 9780824745226

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Genetic Toxicology and Cancer Risk Assessment by Wai Nang Choy Pdf

Presents state-of-the-art regulatory cancer risk assessment models including a biologically based model for two-hit carcinogenesis and cell proliferation! This book comprehensively reviews the various roles of genetic toxicology in human cancer risk assessment conducted by United States and worldwide regulatory agencies-discussing hazard identification, dose-response relationships, exposure assessment, and current practices of risk characterization. Examines predictive values of mutagenicity tests, mechanisms of carcinogenesis, and conventional genotoxicity tests required by the International Conference on Harmonization and the Organization for Economic Cooperation and Development/Environmental Protection Agency guidelines! Comprised of contributions from prominent experts and risk assessors and including nearly 1200 references to facilitate further study, Genetic Toxicology and Cancer Risk Assessment reviews contemporary human cancer genetics as related to the mutagenic nature of carcinogenesis calculates acceptable exposure levels based on a carcinogenic threshold dose for nongenotoxic carcinogens reveals the rationale and methodology of quantitative estimation of human cancer risks using mathematical models discusses the threshold concept of carcinogenesis demonstrates how bacterial mutagenicity assays are the most reliable for predicting rodent carcinogens considers structural activity relationship (SAR) analysis of chemical carcinogenicity describes the emergence of the mouse lymphoma microwell and in vitro micronucleus assays illustrates the use of genetic biomarkers for dosimetry analysis and more! Linking human cancer genetics, mutagenicity assays, mechanisms of carcinogenesis, carcinogenic thresholds, molecular epidemiology, mathematical modeling, and quantitative cancer risk analysis, Genetic Toxicology and Cancer Risk Assessment is a must-have reference for toxicologists; oncologists; geneticists; biostatisticians; reproductive, developmental, cell, and molecular biologists; endocrinologists; biochemists; and upper-level undergraduate, graduate, and medical school students in these disciplines.

Author : Anonim
Publisher : Unknown
Page : 1576 pages
File Size : 51,7 Mb
Release : 2004
Category : Environmental health
ISBN : RUTGERS:39030033377435

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Environmental Health Perspectives by Anonim Pdf

Author : Darrell R. Boverhof,B. Bhaskar Gollapudi
Publisher : John Wiley & Sons
Page : 470 pages
File Size : 40,9 Mb
Release : 2011-10-11
Category : Science
ISBN : 9781118008980

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Applications of Toxicogenomics in Safety Evaluation and Risk Assessment by Darrell R. Boverhof,B. Bhaskar Gollapudi Pdf

This book provides a timely overview of toxicogenomics, with special emphasis on the practical applications of this technology to the risk assessment process. Introductory sections are followed by a series of chapters highlighting practical and systematic applications of toxicogenomics in informing the risk assessment process – including the areas of mutagenicity, carcinogenicity, endocrine toxicity, organ-specific toxicity, population monitoring, and ecotoxicology. The book concludes with approaches for the integration of this technology in safety evaluation studies, and an outlook on how toxicogenomics and complementary technologies can reframe the current risk assessment paradigm.

Author : Abdul Malik,Elisabeth Grohmann
Publisher : Springer Science & Business Media
Page : 613 pages
File Size : 40,9 Mb
Release : 2011-09-18
Category : Science
ISBN : 9789400715912

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Environmental Protection Strategies for Sustainable Development by Abdul Malik,Elisabeth Grohmann Pdf

The environment of our planet is degrading at an alarming rate because of non-sustainable urbanization, industrialization and agriculture. Unsustainable trends in relation to climate change and energy use, threats to public health, poverty and social exclusion, demographic pressure and ageing, management of natural resources, biodiversity loss, land use and transport still persist and new challenges are arising. Since these negative trends bring about a sense of urgency, short term action is required, whilst maintaining a longer term perspective. The main challenge is to gradually change our current unsustainable consumption and production patterns and the nonintegrated approach to policy-making. This book covers the broad area including potential of rhizospheric microorganisms in the sustainable plant development in anthropogenic polluted soils, bioremediation of pesticides from soil and waste water, toxic metals from soil, biological treatment of pulp and paper industry wastewater, sustainable solutions for agro processing waste management, solid waste management on climate change and human health, environmental impact of dyes and its remediation. Various methods for genotoxicity testing of environmental pollutants are also discussed and chapters on molecular detection of resistance and transfer genes in the environmental samples, biofilm formation by the environmental bacteria, biochemical attributes to assess soil ecosystem sustainability, application of rhizobacteria in biotechnology, role of peroxidases as a tool for the decolorization and removal of dyes and potential of biopesticides in sustainable agriculture. It offers a unique treatment of the subject, linking various protection strategies for sustainable development, describing the inter-relationships between the laboratory and field eco-toxicologist, the biotechnology consultant, environmental engineers and different international environmental regulatory and protection agencies.