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Involvement Of Blood Brain Barrier Efficacy Neurovascular Coupling And Angiogenesis In The Healthy And Diseased Brain Book in PDF, ePub and Kindle version is available to download in english. Read online anytime anywhere directly from your device. Click on the download button below to get a free pdf file of Involvement Of Blood Brain Barrier Efficacy Neurovascular Coupling And Angiogenesis In The Healthy And Diseased Brain book. This book definitely worth reading, it is an incredibly well-written.
Author : Jean-luc Morel,Daniela Carnevale,Fabrice Dabertrand,Clotilde Lecrux
Publisher : Frontiers Media SA
Page : 292 pages
File Size : 53,7 Mb
Release : 2021-12-30
Category : Science
ISBN : 9782889718917
Author : Katerina Dorovini-Zis
Publisher : CRC Press
Page : 394 pages
File Size : 42,5 Mb
Release : 2015-10-21
Category : Medical
ISBN : 9781498727099
Located at the interface between blood and the brain, the blood-brain barrier is a dynamic permeability barrier formed by a continuous layer of specialized endothelial cells endowed with important permeability, transport, and regulatory functions that both protect the internal milieu of the brain and allow essential nutrients to be transported into the brain. Abnormalities of the blood-brain barrier are increasingly recognized as a key component in the pathogenesis of a range of primary diseases of the brain and the secondary involvement of the brain from pathological processes in other organs. In The Blood-Brain Barrier in Health and Disease, Volume 2, international experts present comprehensive reviews and research accounts on blood-brain barrier dysfunction in infectious and inflammatory diseases, cerebrovascular diseases, stroke, trauma, vitamin deficiency, exposure to neurotoxicants, primary and metastatic brain tumors, and neurodegenerative diseases. This book is intended to serve as a guide and reference to basic and advanced information for researchers, students, and clinicians interested in this fast-expanding field and stimulate further research well into the future.
Author : Katerina Dorovini-Zis
Publisher : CRC Press
Page : 0 pages
File Size : 48,8 Mb
Release : 2015-10-15
Category : Medical
ISBN : 1498727085
Located at the interface between blood and the brain, the blood-brain barrier is a dynamic permeability barrier formed by a continuous layer of specialized endothelial cells endowed with important permeability, transport, and regulatory functions that both protect the internal milieu of the brain and allow essential nutrients to be transported into the brain. Abnormalities of the blood-brain barrier are increasingly recognized as a key component in the pathogenesis of a range of primary diseases of the brain and the secondary involvement of the brain from pathological processes in other organs. In The Blood-Brain Barrier in Health and Disease, Volume 2, international experts present comprehensive reviews and research accounts on blood-brain barrier dysfunction in infectious and inflammatory diseases, cerebrovascular diseases, stroke, trauma, vitamin deficiency, exposure to neurotoxicants, primary and metastatic brain tumors, and neurodegenerative diseases. This book is intended to serve as a guide and reference to basic and advanced information for researchers, students, and clinicians interested in this fast-expanding field and stimulate further research well into the future.
Author : Kason Benson
Publisher : American Medical Publishers
Page : 0 pages
File Size : 42,6 Mb
Release : 2023-09-26
Category : Medical
ISBN : 9798887404936
The blood-brain barrier (BBB) is responsible for the movement of ions, molecules, and cells between the blood and the CNS. This barrier is essential for providing the right environment for healthy neuronal function and also for protecting the CNS from injury and disease. The BBB is made up of three biological components of the brain microvasculature: brain endothelial cells (BECs), astrocyte end-feet, and pericytes (PCs). BECs are essential components of the BBB, responsible for protecting the brain from pathogens while also limiting the flow of circulatory factors. Astrocytes, which are five times the number of neurons in the CNS, provide simple structural and nutritional support for neurons and also contribute to the composition of the BBB. Pericytes play an essential role in angiogenesis, vascular remodeling, vascular tone, and BBB development. Several neurologic diseases such as stroke and neuroinflammatory disorders are affected by the BBB dysfunction. This book presents researches and studies performed by internationally acclaimed experts on the role of blood-brain barrier. It will serve as a valuable source of reference for graduate and post graduate students.
Author : Roy Bicknell
Publisher : Cambridge University Press
Page : 156 pages
File Size : 49,8 Mb
Release : 1996-09-28
Category : Science
ISBN : 0521559901
The aim of the Handbooks in Practical Animal Cell Biology is to provide practical workbooks for those involved in primary cell culture. Each volume addresses a different cell lineage, and contains an introductory section followed by individual chapters on the culture of specific differentiated cell types. The authors of each chapter are leading researchers in their fields and use their first-hand experience to present reliable techniques in a clear and thorough manner. Endothelial Cell Culture contains chapters on endothelial cells derived from 1) lung, 2) bone marrow, 3) brain, 4) mammary glands, 5) skin, 6) adipose tissue, 7) female reproductive system, and 8) synovium.
Author : Manmeet Ahluwalia,Philippe Metellus,Riccardo Soffietti
Publisher : Springer Nature
Page : 421 pages
File Size : 40,9 Mb
Release : 2019-11-05
Category : Medical
ISBN : 9783030234171
This book provides a comprehensive overview of brain metastases, from the molecular biology aspects to therapeutic management and perspectives. Due to the increasing incidence of these tumors and the urgent need to effectively control brain metastatic diseases in these patients, new therapeutic strategies have emerged in recent years. The volume discusses all these innovative approaches combined with new surgical techniques (fluorescence, functional mapping, integrated navigation), novel radiation therapy techniques (stereotactic radiosurgery) and new systemic treatment approaches such as targeted- and immunotherapy. These combination strategies represent a new therapeutic model in brain metastatic patients in which each medical practitioner (neurosurgeon, neurologist, medical oncologist, radiation oncologist) plays a pivotal role in defining the optimal treatment in a multidisciplinary approach. Written by recognized experts in the field, this book is a valuable tool for neurosurgeons, neuro-oncologists, neuroradiologists, medical oncologists, radiation oncologists, cognitive therapists, basic scientists and students working in the area of brain tumors.
Author : Amanda Tivnan
Publisher : Springer
Page : 260 pages
File Size : 50,6 Mb
Release : 2016-11-26
Category : Medical
ISBN : 9783319465050
This volume will bring together a review of research being carried out by international experts in this field, detailing treatment and research approaches in several forms of malignant brain tumors. These include glioblastoma (GBM), a highly aggressive and fatal form of astrocytoma which accounts for 80% of newly diagnosed brain tumor patients per year, and meningioma, of which 10% are malignant and extremely resistant to targeted therapies. The volume will also include a discussion of methods to overcome blood-brain barrier exclusion for more efficient targeted drug delivery in all forms of brain cancer treatment. The volume will include information on the repurposing of drugs in an attempt to circumvent drug resistance, use of small molecule inhibitors in GBM treatment, mechanisms of secondary brain metastasis, drug resistance, and state-of-the-art imaging of targeted therapies.
Author : Gert Fricker,Melanie Ott,Anne Mahringer
Publisher : Springer
Page : 163 pages
File Size : 55,7 Mb
Release : 2014-10-24
Category : Science
ISBN : 9783662437872
Medicinal chemistry is both science and art. The science of medicinal chemistry offers mankind one of its best hopes for improving the quality of life. The art of medicinal chemistry continues to challenge its practitioners with the need for both intuition and experience to discover new drugs. Hence sharing the experience of drug research is uniquely beneficial to the field of medicinal chemistry. Drug research requires interdisciplinary team-work at the interface between chemistry, biology and medicine. Therefore, the topic-related series Topics in Medicinal Chemistry covers all relevant aspects of drug research, e.g. pathobiochemistry of diseases, identification and validation of (emerging) drug targets, structural biology, drugability of targets, drug design approaches, chemogenomics, synthetic chemistry including combinatorial methods, bioorganic chemistry, natural compounds, high-throughput screening, pharmacological in vitro and in vivo investigations, drug-receptor interactions on the molecular level, structure-activity relationships, drug absorption, distribution, metabolism, elimination, toxicology and pharmacogenomics. In general, special volumes are edited by well known guest editors.
Author : Luisa L. Rocha,Alberto Lazarowski,Esper A. Cavalheiro
Publisher : Springer Nature
Page : 598 pages
File Size : 49,8 Mb
Release : 2023-08-29
Category : Medical
ISBN : 9783031365263
This new edition of Pharmacoresistance in Epilepsy addresses all issues relating to drug-resistance in epilepsy, including studies in patients as well in experimental models and presents the basis for an understanding of recent developments in the pathogenesis and treatment of this condition. Important issues associated with drug-resistant epilepsy are reviewed and updated, such as abnormalities in inhibitory mechanisms, neurotoxicity and changes the immune system associated with this disorder, and the development of drug-resistance as consequence of chronic exposure to antiseizure-medications. Considering that a major obstacle is that epilepsy associated with drug-resistance cannot be controlled with the traditional antiseizure medications, specific chapters describe therapeutic strategies to prevent or reduce the progression of the disease with complementary medical therapies, such as transcranial focal stimulation to promote neuroprotection. Pharmacoresistance in Epilepsy is a valuable resource for anyone working in the field, whether studying epilepsy in the lab or treating it in an office.
Author : Srikanth Ramaswamy,Francisco F. De-Miguel,Chiayu Chiu,Inaki-Carril Mundinano,Nilesh Bhailalbhai Patel,Luis Lemus,Leonor Teles-Grilo Ruivo,Yoshiyuki Kubota,Matteo Feurra,Jimena Andersen,Mubarak H. Syed,Johanna Jackson,Catarina Osorio,Yves A. Dauvilliers,Alison Jane Canty,Pierre J. Magistretti,Toru Takahata
Publisher : Frontiers Media SA
Page : 347 pages
File Size : 45,7 Mb
Release : 2022-02-24
Category : Science
ISBN : 9782889745128
Author : Derek J. Chadwick,Jamie A. Goode
Publisher : John Wiley & Sons
Page : 260 pages
File Size : 48,9 Mb
Release : 2007-08-20
Category : Science
ISBN : 9780470319420
The formation of blood vessels is an essential aspect of embryogenesis in vertebrates. It is a central feature of numerous post-embryonic processes, including tissue and organ growth and regeneration. It is also part of the pathology of tumour formation and certain inflammatory conditions. In recent years, comprehension of the molecular genetics of blood vessel formation has progressed enormously and studies in vertebrate model systems, especially the mouse and the zebrafish, have identified a common set of molecules and processes that are conserved throughout vertebrate embryogenesis while, in addition, highlighting aspects that may differ between different animal groups. The discovery in the past decade of the crucial role of new blood vessel formation for the development of cancers has generated great interest in angiogenesis (the formation of new blood vessels from pre-existing ones), with its major implications for potential cancer-control strategies. In addition, there are numerous situations where therapeutic treatments either require or would be assisted by vasculogenesis (the de novo formation of blood vessels). In particular, post-stroke therapies could include treatments that stimulate neovascularization of the affected tissues. The development of such treatments, however, requires thoroughly understanding the developmental properties of endothelial cells and the basic biology of blood vessel formation. While there are many books on angiogenesis, this unique book focuses on exactly this basic biology and explores blood vessel formation in connection with tissue development in a range of animal models. It includes detailed discussions of relevant cell biology, genetics and embryogenesis of blood vessel formation and presents insights into the cross-talk between developing blood vessels and other tissues. With contributions from vascular biologists, cell biologists and developmental biologists, a comprehensive and highly interdisciplinary volume is the outcome.
Author : K. Michael Welch
Publisher : Academic Press
Page : 855 pages
File Size : 50,7 Mb
Release : 1997-04-24
Category : Medical
ISBN : 9780127431703
Primer on Cerebrovascular Diseases is a handy reference source for scientists, students, and physicians needing reliable, up-to-date information on basic mechanisms, physiology, pathophysiology, and medical issues related to brain vasculature. The book consists of short, specific chapters written by international experts on cerebral vasculature, and presents the information in a comprehensive and easily accessible manner. The book also contains valuable information on practical applications of basic research. Presents topics in a comprehensive and accessible format Written by international authorities on cerebral vasculature Provides practical applications for researchers
Author : Peter Fecci,Priscilla Brastianos,Gavin P. Dunn,Ganesh Rao
Publisher : Frontiers Media SA
Page : 150 pages
File Size : 42,9 Mb
Release : 2022-11-22
Category : Medical
ISBN : 9782832506721
Author : Anonim
Publisher : Academic Press
Page : 336 pages
File Size : 55,8 Mb
Release : 2010-12-16
Category : Science
ISBN : 0123850622
Cardiovascular disease remains a major cause of death and disability in developed countries and, increasingly so, in the developing world. Presented in this volume of Advances in Pharmacology are some of the most promising possibilities for treating large numbers of individuals afflicted with these conditions. Contains up-to-date reviews of the most important emerging cardiovascular therapies written by world leaders in the field
Author : Anonim
Publisher : Elsevier
Page : 298 pages
File Size : 51,5 Mb
Release : 2016-04-26
Category : Science
ISBN : 9780444637062
New Horizons in Neurovascular Coupling: A Bridge Between Brain Circulation and Neural Plasticity is the latest volume in the Progress in Brain Research series that focuses on new trends and developments in neurovascular coupling. This established international series examines major areas of basic and clinical research within the neurosciences, as well as popular and emerging subfields. This volume takes an integrated approach to review and summarize some of the most recent progress reported on the connection between brain circulation and neural plasticity. Explores new trends and developments in basic and clinical research in the neurovascular coupling subfield of neuroscience Uses an integrated approach to review and summarize recent progress Emphasizes potential applications in a clinical setting Enhances the literature of neuroscience by further expanding the established, ongoing international series Progress in Brain Research