Iron And Human Disease

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Iron and Human Disease

R.B. Lauffer
Iron and Human Disease Book PDF

Author : R.B. Lauffer
Publisher : CRC Press
Page : 550 pages
File Size : 42,9 Mb
Release : 2018-01-18
Category : Medical
ISBN : 9781351082341

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Iron and Human Disease by R.B. Lauffer Pdf

Iron and Human Disease is the first book to cover the three key aspects of human iron metabolism: the accumulation of iron in adults, iron as a limiting factor for tumor and infectious cell growth, and iron as a catalyst for oxygen free radical production. The book describes the hypotheses and findings related to the role of iron in cardiovascular disease (including reperfusion injury), cancer, aging, and autoimmune and neurodegenerative diseases. Other topics covered include the molecular biology and biochemistry of iron, the general principles governing iron balance, iron in the immune system and acute phase response, and new preventive and therapeutic strategies. Iron and Human Disease will be a useful reference for biomedical investigators, physicians, nutritionists, and public health officials.

Iron Metabolism in Health and Disease

Jeremy H. Brock
Iron Metabolism in Health and Disease Book PDF

Author : Jeremy H. Brock
Publisher : Bailliere Tindall Limited
Page : 512 pages
File Size : 42,8 Mb
Release : 1994
Category : Ferritin
ISBN : UOM:39015034242746

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Iron Metabolism in Health and Disease by Jeremy H. Brock Pdf

An overview of human iron metabolism. This book reviews the metabolic importance of iron in evolution, the physiology and biochemistry of internal iron exchange, iron absorption and iron storage, the molecular regulation of cellular iron homeostasis and aspects of iron and disease.

Brain Iron Metabolism and CNS Diseases

Yan-Zhong Chang
Brain Iron Metabolism and CNS Diseases Book PDF

Author : Yan-Zhong Chang
Publisher : Springer Nature
Page : 194 pages
File Size : 51,6 Mb
Release : 2019-08-27
Category : Medical
ISBN : 9789811395895

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Brain Iron Metabolism and CNS Diseases by Yan-Zhong Chang Pdf

This book focuses on advances in our understanding of the regulatory mechanisms of brain iron uptake, iron homeostasis and iron metabolism in the pathophysiology and pharmacology of CNS disease models. Dysregulation of brain iron homeostasis can lead to severe pathological changes in the neural system. Iron deficiency can slow down the development of the neural system and cause language and motion disorders, while iron overload is closely related to neurodegenerative diseases. Although some current books include chapters on iron metabolism and certain neurodegenerative diseases, this is the first systematic summary of the latest discoveries regarding brain iron metabolism and CNS diseases. By providing novel and thought-provoking insights into the mechanisms and physiological significance of brain iron metabolism and related diseases, the book stimulates further new research directions. It helps graduate students and researchers gain an overall picture of brain iron metabolism and the pathogenesis of neurodegenerative diseases, and also offers pharmaceutical companies inspiration for new treatment strategies for CNS diseases.

Iron as Therapeutic Targets in Human Diseases

Paolo Arosio,Maura Poli,Raffaella Gozzelino
Iron as Therapeutic Targets in Human Diseases Book PDF

Author : Paolo Arosio,Maura Poli,Raffaella Gozzelino
Publisher : MDPI
Page : 472 pages
File Size : 44,9 Mb
Release : 2020-02-11
Category : Science
ISBN : 9783039280827

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Iron as Therapeutic Targets in Human Diseases by Paolo Arosio,Maura Poli,Raffaella Gozzelino Pdf

Iron is an essential element for almost all organisms, a cofactor playing a crucial role in a number of vital functions, including oxygen transport, DNA synthesis, and respiration. However, its ability to exchange electrons renders excess iron potentially toxic, since it is capable of catalyzing the formation of highly poisonous free radicals. As a consequence, iron homeostasis is tightly controlled by sophisticated mechanisms that have been partially elucidated. Because of its biological importance, numerous disorders have been recently linked to the deregulation of iron homeostasis, which include not only the typical disorders of iron overload and deficiency but also cancer and neurodegenerative diseases. This leads iron metabolism to become an interesting therapeutic target for novel pharmacological treatments against these diseases. Several therapies are currently under development for hematological disorders, while other are being considered for different pathologies. The therapeutic targeting under study includes the hepcidin/ferroportin axis for the regulation of systemic iron homeostasis, complex cytosolic machineries for the regulation of the intracellular iron status and its association with oxidative damage, and reagents exploiting proteins of iron metabolism such as ferritin and transferrin receptor. A promising potential target is a recently described form of programmed cell death named ferroptosis, in which the role of iron is essential but not completely clarified. This Special Issue has the aim to summarize the state-of-the-art, and the latest findings published in the iron field, as well as to elucidate future directions.

Iron Chelation Therapy

Chaim Hershko
Iron Chelation Therapy Book PDF

Author : Chaim Hershko
Publisher : Springer Science & Business Media
Page : 275 pages
File Size : 41,6 Mb
Release : 2012-12-06
Category : Science
ISBN : 9781461505938

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Iron Chelation Therapy by Chaim Hershko Pdf

Within the last few years, iron research has yielded exciting new insights into the under standing of normal iron homeostasis. However, normal iron physiology offers little protec tion from the toxic effects of pathological iron accumulation, because nature did not equip us with effective mechanisms of iron excretion. Excess iron may be effectively removed by phlebotomy in hereditary hemochromatosis, but this method cannot be applied to chronic anemias associated with iron overload. In these diseases, iron chelating therapy is the only method available for preventing early death caused mainly by myocardial and hepatic iron toxicity. Iron chelating therapy has changed the quality of life and life expectancy of thalassemic patients. However, the high cost and rigorous requirements of deferoxamine therapy, and the significant toxicity of deferiprone underline the need for the continued development of new and improved orally effective iron chelators. Such development, and the evolution of improved strategies of iron chelating therapy require better understanding of the pathophysiology of iron toxicity and the mechanism of action of iron chelating drugs. The timeliness of the present volume is underlined by several significant develop ments in recent years. New insights have been gained into the molecular basis of aberrant iron handling in hereditary disorders and the pathophysiology of iron overload (Chapters 1-5).

Iron Physiology and Pathophysiology in Humans

Gregory J. Anderson,Gordon D. McLaren
Iron Physiology and Pathophysiology in Humans Book PDF

Author : Gregory J. Anderson,Gordon D. McLaren
Publisher : Springer Science & Business Media
Page : 705 pages
File Size : 51,6 Mb
Release : 2012-01-14
Category : Medical
ISBN : 9781603274852

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Iron Physiology and Pathophysiology in Humans by Gregory J. Anderson,Gordon D. McLaren Pdf

Iron Physiology and Pathophysiology in Humans provides health professionals in many areas of research and practice with the most up-to-date and well-referenced volume on the importance of iron as a nutrient and its role in health and disease. This important new volume is the benchmark in the complex area of interrelationships between the essentiality of iron, its functions throughout the body, including its critical role in erythropoiesis, the biochemistry and clinical relevance of iron-containing enzymes and other molecules involved in iron absorption, transport and metabolism, he importance of optimal iron status on immune function, and links between iron and the liver, heart, brain and other organs. Moreover, the interactions between genetic and environmental factors and the numerous co-morbidities seen with both iron deficiency and iron overload in at risk populations are clearly delineated so that students as well as practitioners can better understand the complexities of these interactions. Key features of the volume include an in-depth index and recommendations and practice guidelines are included in relevant chapters. The volume contains more than 100 detailed tables and informative figures and up-to-date references that provide the reader with excellent sources of information about the critical role of iron nutrition, optimal iron status and the adverse clinical consequences of altered iron homeostasis. Iron Physiology and Pathophysiology in Humans is an excellent new text as well as the most authoritative resource in the field.

Iron as Therapeutic Targets in Human Diseases

Paolo Arosio,Maura Poli,Raffaella Gozzelino
Iron as Therapeutic Targets in Human Diseases Book PDF

Author : Paolo Arosio,Maura Poli,Raffaella Gozzelino
Publisher : MDPI
Page : 440 pages
File Size : 48,8 Mb
Release : 2020-02-11
Category : Science
ISBN : 9783039281145

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Iron as Therapeutic Targets in Human Diseases by Paolo Arosio,Maura Poli,Raffaella Gozzelino Pdf

Iron is an essential element for almost all organisms, a cofactor playing a crucial role in a number of vital functions, including oxygen transport, DNA synthesis, and respiration. However, its ability to exchange electrons renders excess iron potentially toxic, since it is capable of catalyzing the formation of highly poisonous free radicals. As a consequence, iron homeostasis is tightly controlled by sophisticated mechanisms that have been partially elucidated. Because of its biological importance, numerous disorders have been recently linked to the deregulation of iron homeostasis, which include not only the typical disorders of iron overload and deficiency but also cancer and neurodegenerative diseases. This leads iron metabolism to become an interesting therapeutic target for novel pharmacological treatments against these diseases. Several therapies are currently under development for hematological disorders, while other are being considered for different pathologies. The therapeutic targeting under study includes the hepcidin/ferroportin axis for the regulation of systemic iron homeostasis, complex cytosolic machineries for the regulation of the intracellular iron status and its association with oxidative damage, and reagents exploiting proteins of iron metabolism such as ferritin and transferrin receptor. A promising potential target is a recently described form of programmed cell death named ferroptosis, in which the role of iron is essential but not completely clarified. This Special Issue has the aim to summarize the state-of-the-art, and the latest findings published in the iron field, as well as to elucidate future directions.

Iron Physiology and Pathophysiology in Humans

Gregory J. Anderson,Gordon D. McLaren
Iron Physiology and Pathophysiology in Humans Book PDF

Author : Gregory J. Anderson,Gordon D. McLaren
Publisher : Springer Science & Business Media
Page : 705 pages
File Size : 41,8 Mb
Release : 2012-01-16
Category : Medical
ISBN : 9781603274845

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Iron Physiology and Pathophysiology in Humans by Gregory J. Anderson,Gordon D. McLaren Pdf

Iron Physiology and Pathophysiology in Humans provides health professionals in many areas of research and practice with the most up-to-date and well-referenced volume on the importance of iron as a nutrient and its role in health and disease. This important new volume is the benchmark in the complex area of interrelationships between the essentiality of iron, its functions throughout the body, including its critical role in erythropoiesis, the biochemistry and clinical relevance of iron-containing enzymes and other molecules involved in iron absorption, transport and metabolism, he importance of optimal iron status on immune function, and links between iron and the liver, heart, brain and other organs. Moreover, the interactions between genetic and environmental factors and the numerous co-morbidities seen with both iron deficiency and iron overload in at risk populations are clearly delineated so that students as well as practitioners can better understand the complexities of these interactions. Key features of the volume include an in-depth index and recommendations and practice guidelines are included in relevant chapters. The volume contains more than 100 detailed tables and informative figures and up-to-date references that provide the reader with excellent sources of information about the critical role of iron nutrition, optimal iron status and the adverse clinical consequences of altered iron homeostasis. Iron Physiology and Pathophysiology in Humans is an excellent new text as well as the most authoritative resource in the field.

Iron Deficiency and Overload

Shlomo Yehuda,David I. Mostofsky
Iron Deficiency and Overload Book PDF

Author : Shlomo Yehuda,David I. Mostofsky
Publisher : Springer Science & Business Media
Page : 377 pages
File Size : 51,7 Mb
Release : 2010-03-10
Category : Medical
ISBN : 9781597454629

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Iron Deficiency and Overload by Shlomo Yehuda,David I. Mostofsky Pdf

Iron deficiency is ever-present among all populations throughout the world irrespective of race, culture, or ethnic background. Even with the latest advances in medicine, improved nutrition, and the ready availability of cheap oral iron, there is still no satisfactory explanation for the widespread occurrence of iron deficiency or for the absence of an effective treatment. Iron Deficiency and Overload: From Biology to Clinical Medicine is an important new text that provides a timely review of the latest science concerning iron metabolism as well as practical, data-driven options to manage at-risk populations with the best accepted therapeutic nutritional interventions. Chapter topics reflect the excitement in current theoretical development and laboratory activity in this area. The distinguished authors address their presentations to professionals and graduate students who need to be better informed about the concepts, methodologies, and current status of the field. Iron Deficiency and Overload: From Biology to Clinical Medicine is an essential text that presents a sampling of the major issues in iron research, from the most basic research level to human applications.

Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc

Institute of Medicine,Food and Nutrition Board,Standing Committee on the Scientific Evaluation of Dietary Reference Intakes,Subcommittee of Interpretation and Uses of Dietary Reference Intakes,Subcommittee on Upper Reference Levels of Nutrients,Panel on Micronutrients
Dietary Reference Intakes for Vitamin A Vitamin K Arsenic Boron Chromium Copper Iodine Iron Manganese Molybdenum Nickel Silicon Vanadium and Zinc Book PDF

Author : Institute of Medicine,Food and Nutrition Board,Standing Committee on the Scientific Evaluation of Dietary Reference Intakes,Subcommittee of Interpretation and Uses of Dietary Reference Intakes,Subcommittee on Upper Reference Levels of Nutrients,Panel on Micronutrients
Publisher : National Academies Press
Page : 804 pages
File Size : 51,7 Mb
Release : 2002-07-19
Category : Medical
ISBN : 0309072794

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Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc by Institute of Medicine,Food and Nutrition Board,Standing Committee on the Scientific Evaluation of Dietary Reference Intakes,Subcommittee of Interpretation and Uses of Dietary Reference Intakes,Subcommittee on Upper Reference Levels of Nutrients,Panel on Micronutrients Pdf

This volume is the newest release in the authoritative series issued by the National Academy of Sciences on dietary reference intakes (DRIs). This series provides recommended intakes, such as Recommended Dietary Allowances (RDAs), for use in planning nutritionally adequate diets for individuals based on age and gender. In addition, a new reference intake, the Tolerable Upper Intake Level (UL), has also been established to assist an individual in knowing how much is "too much" of a nutrient. Based on the Institute of Medicine's review of the scientific literature regarding dietary micronutrients, recommendations have been formulated regarding vitamins A and K, iron, iodine, chromium, copper, manganese, molybdenum, zinc, and other potentially beneficial trace elements such as boron to determine the roles, if any, they play in health. The book also: Reviews selected components of food that may influence the bioavailability of these compounds. Develops estimates of dietary intake of these compounds that are compatible with good nutrition throughout the life span and that may decrease risk of chronic disease where data indicate they play a role. Determines Tolerable Upper Intake levels for each nutrient reviewed where adequate scientific data are available in specific population subgroups. Identifies research needed to improve knowledge of the role of these micronutrients in human health. This book will be important to professionals in nutrition research and education.

The Iron Disorders Institute Guide to Anemia

Cheryl Garrison
The Iron Disorders Institute Guide to Anemia Book PDF

Author : Cheryl Garrison
Publisher : Sourcebooks, Inc.
Page : 498 pages
File Size : 40,7 Mb
Release : 2009-06-01
Category : Health & Fitness
ISBN : 9781402247521

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The Iron Disorders Institute Guide to Anemia by Cheryl Garrison Pdf

Unravel the mysteries behind anemia's diverse forms, from iron deficiency anemia to hemolytic and aplastic anemia, and gain a deep understanding of their underlying mechanisms. Empower yourself with the treatments and prevention strategies, carefully curated by the Iron Disorders Institute. Inside these pages, you'll find: Comprehensive explanations of different types of anemia, their prevalence, and risk factors. An in-depth exploration of iron metabolism, absorption, and utilization in the body. Expert advice on diagnosing anemia accurately, distinguishing its various forms, and addressing related health concerns. Essential dietary guidelines and supplementation recommendations to combat iron deficiency and optimize iron levels. Practical tips on managing anemia-related symptoms, such as fatigue, weakness, and shortness of breath, to enhance your overall well-being. Empower yourself with the knowledge to promote healing, vitality, and a healthier life.

Interrelations between Essential Metal Ions and Human Diseases

Astrid Sigel,Helmut Sigel,Roland K.O. Sigel
Interrelations between Essential Metal Ions and Human Diseases Book PDF

Author : Astrid Sigel,Helmut Sigel,Roland K.O. Sigel
Publisher : Springer Science & Business Media
Page : 573 pages
File Size : 47,7 Mb
Release : 2014-01-27
Category : Science
ISBN : 9789400775008

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Interrelations between Essential Metal Ions and Human Diseases by Astrid Sigel,Helmut Sigel,Roland K.O. Sigel Pdf

MILS-13 provides an up-to-date review on the relationships between essential metals and human diseases, covering 13 metals and 3 metalloids: The bulk metals sodium, potassium, magnesium, and calcium, plus the trace elements manganese, iron, cobalt, copper, zinc, molybdenum, and selenium, all of which are essential for life. Also covered are chromium, vanadium, nickel, silicon, and arsenic, which have been proposed as being essential for humans in the 2nd half of the last century. However, if at all, they are needed only in ultra-trace amounts, and because of their prevalence in the environment, it has been difficult to prove whether or not they are required. In any case, all these elements are toxic in higher concentrations and therefore, transport and cellular concentrations of at least the essential ones, are tightly controlled; hence, their homeostasis and role for life, including deficiency or overload, and their links to illnesses, including cancer and neurological disorders, are thoroughly discussed. Indeed, it is an old wisdom that metals are indispensable for life. Therefore, Volume 13 provides in an authoritative and timely manner in 16 stimulating chapters, written by 29 internationally recognized experts from 7 nations, and supported by more than 2750 references, and over 20 tables and 80 illustrations, many in color, a most up-to-date view on the vibrant research area of the Interrelations between Essential Metal Ions and Human Diseases.

Iron Deficiency Anemia

Institute of Medicine,Committee on the Prevention, Detection, and Management of Iron Deficiency Anemia Among U.S. Children and Women of Childbearing Age
Iron Deficiency Anemia Book PDF

Author : Institute of Medicine,Committee on the Prevention, Detection, and Management of Iron Deficiency Anemia Among U.S. Children and Women of Childbearing Age
Publisher : National Academies Press
Page : 139 pages
File Size : 47,6 Mb
Release : 1994-02-01
Category : Medical
ISBN : 9780309049870

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Iron Deficiency Anemia by Institute of Medicine,Committee on the Prevention, Detection, and Management of Iron Deficiency Anemia Among U.S. Children and Women of Childbearing Age Pdf

This book summarizes information related to public health measures on the prevention, detection, and management of iron deficiency anemia. It presents draft guidelines and recommendations related to this area, as applicable in primary health care and public health clinic settings, and it formulates recommendations for research. This volume is intended both to provide a common frame of reference for health professionals in preventing and treating iron deficiency anemia and to enable the U.S. Centers for Disease Control and Prevention to prepare national guidelines and recommendations for the prevention and control of iron deficiency anemia.

Trace Elements and Iron in Human Metabolism

Ananda Prasad
Trace Elements and Iron in Human Metabolism Book PDF

Author : Ananda Prasad
Publisher : Springer
Page : 392 pages
File Size : 48,6 Mb
Release : 2013-03-17
Category : Medical
ISBN : 1468407953

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Trace Elements and Iron in Human Metabolism by Ananda Prasad Pdf

Each year, it becomes more apparent that trace elements play an important role in human metabolism. The concept is no longer new. The literature on the subject is voluminous. Dr. Prasad, who has been interested in this field for many years, has undertaken the enormous task of bringing our knowledge together in a comprehensive fashion. This monograph should prove very informative and extremely useful to everyone who is concemed with human disease and with the maintenance of good health. His coverage of the subject is broad. Because ofthe importance of iron, in addition to "trace" elements, in human metabolism and nutrition, a chapter dealing with iron has been included. Maxwell M. Wintrobe, M.D. vii PREFACE It has been known for several decades that many elements are present in living tissues, but it was not possible to measure their precise concentra tions until recently. They were therefore referred to as occurring in "trace" amounts, and this practice led to the use of the term "trace elements." Although techniques now available are such that virtually alI trace elements can be determined with reasonable accuracy, the designation "trace ele ments" remains in popular usage.

Iron as Therapeutic Targets in Human Diseases Volume 1

Paolo Arosio,Maura Poli,Raffaella Gozzelino
Iron as Therapeutic Targets in Human Diseases Volume 1 Book PDF

Author : Paolo Arosio,Maura Poli,Raffaella Gozzelino
Publisher : Unknown
Page : 472 pages
File Size : 44,7 Mb
Release : 2020
Category : Biochemistry
ISBN : 303928083X

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Iron as Therapeutic Targets in Human Diseases Volume 1 by Paolo Arosio,Maura Poli,Raffaella Gozzelino Pdf

Iron is an essential element for almost all organisms, a cofactor playing a crucial role in a number of vital functions, including oxygen transport, DNA synthesis, and respiration. However, its ability to exchange electrons renders excess iron potentially toxic, since it is capable of catalyzing the formation of highly poisonous free radicals. As a consequence, iron homeostasis is tightly controlled by sophisticated mechanisms that have been partially elucidated. Because of its biological importance, numerous disorders have been recently linked to the deregulation of iron homeostasis, which include not only the typical disorders of iron overload and deficiency but also cancer and neurodegenerative diseases. This leads iron metabolism to become an interesting therapeutic target for novel pharmacological treatments against these diseases. Several therapies are currently under development for hematological disorders, while other are being considered for different pathologies. The therapeutic targeting under study includes the hepcidin/ferroportin axis for the regulation of systemic iron homeostasis, complex cytosolic machineries for the regulation of the intracellular iron status and its association with oxidative damage, and reagents exploiting proteins of iron metabolism such as ferritin and transferrin receptor. A promising potential target is a recently described form of programmed cell death named ferroptosis, in which the role of iron is essential but not completely clarified. This Special Issue has the aim to summarize the state-of-the-art, and the latest findings published in the iron field, as well as to elucidate future directions.