Iron Uptake In Bacteria With Emphasis On E Coli And Pseudomonas

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Iron Uptake in Bacteria with Emphasis on E. coli and Pseudomonas

Ranjan Chakraborty,Volkmar Braun,Klaus Hantke,Pierre Cornelis
Iron Uptake in Bacteria with Emphasis on E coli and Pseudomonas Book PDF

Author : Ranjan Chakraborty,Volkmar Braun,Klaus Hantke,Pierre Cornelis
Publisher : Springer Science & Business Media
Page : 98 pages
File Size : 40,8 Mb
Release : 2013-02-02
Category : Science
ISBN : 9789400760882

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Iron Uptake in Bacteria with Emphasis on E. coli and Pseudomonas by Ranjan Chakraborty,Volkmar Braun,Klaus Hantke,Pierre Cornelis Pdf

Iron is essential for the growth of most bacteria because it serves as a cofactor for vital enzymes and for the components of the electron transport chain. Moreover, Iron plays an important role in bacterial pathogenicity; in fact, the iron transport systems in bacteria works as target for designing novel antibiotics. Because iron is not soluble under aerobic conditions, bacteria have had to find ways to overcome iron deficiency. One of them is producing an iron-chelating small organic molecule called siderophore. Indeed, most bacteria and fungi produce structurally and chemically diverse siderophores which are transported back to the cytoplasm using complex energy dependent transport systems. Escherichia coli and Pseudomonas were the first ones to be tested; however, nowadays iron transport systems have been investigated in many other bacteria. Iron Uptake in Bacteria with Emphasis on E. coli and Pseudomonas reviews the recent advancements in the field of iron transport systems in bacteria. Chapter 1 is dedicated to Dr. Dick van der Helm’s contribution to the field of siderophore biology. It then describes and discusses the structural advances in the components and the mechanism of siderophore mediated iron transport systems in E.coli. Chapter 2 details the variety of iron transport and iron regulatory systems of both gram negative and gram positive bacteria. Finally, chapter 3 describes the iron transport systems of Pseudomonas. This book is aimed at researchers in the fields of iron metabolism in multiple organisms, and to those who are interested in studying iron transport systems of bacteria. It appeals also to scientists researching structure and function relationship of proteins.

Iron Transport in Bacteria

Jorge H. Crosa,Shelley M. Payne
Iron Transport in Bacteria Book PDF

Author : Jorge H. Crosa,Shelley M. Payne
Publisher : Amer Society for Microbiology
Page : 499 pages
File Size : 40,9 Mb
Release : 2004
Category : Medical
ISBN : 1555812929

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Iron Transport in Bacteria by Jorge H. Crosa,Shelley M. Payne Pdf

provides an up–to–date survey of iron transport systems in bacteria; details iron transport and its regulation in E.colias a prototype for iron transport systems in gram–negative bacteria; includes chapters on the major gram–negative, gram–positive and acid–fast bacterial pathogens – their iron transport systems and the roles of these systems in virulence; presents structural studies of siderophores, heme carriers, and iron transport proteins; discusses the ecology of siderophores and potential therapeutic uses of siderophores.

Transition Metals in Microbial Metabolism

Gunther Winkelmann
Transition Metals in Microbial Metabolism Book PDF

Author : Gunther Winkelmann
Publisher : CRC Press
Page : 516 pages
File Size : 47,5 Mb
Release : 2022-02-15
Category : Medical
ISBN : 9781000445718

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Transition Metals in Microbial Metabolism by Gunther Winkelmann Pdf

The key role played by iron, as well as other transition metals, in microbial metabolism is investigated in this volume. Topics covered include: iron chelation and siderophores; receptor-mediated bacterial iron transport; and the nitogenases.

Iron Metabolism

Robert Crichton
Iron Metabolism Book PDF

Author : Robert Crichton
Publisher : John Wiley & Sons
Page : 576 pages
File Size : 52,5 Mb
Release : 2016-03-31
Category : Medical
ISBN : 9781118925621

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Iron Metabolism by Robert Crichton Pdf

Iron is indispensable for the growth, development and well-being of almost all living organisms. Biological systems from bacteria, fungi and plants to humans have evolved systems for the uptake, utilisation, storage and homeostasis of iron. Its importance for microbial growth makes its uptake systems a natural target for pathogenic microorganisms and parasites. Uniquely, humans suffer from both iron deficiency and iron overload, while the capacity of iron to generate highly reactive free radicals, causing oxidative stress, is associated with a wide range of human pathologies, including many neurodegenerative diseases. Whereas some essential metal ions like copper and zinc are closely linked with iron metabolism, toxic metals like aluminium and cadmium can interfere with iron metabolism. Finally, iron metabolism and homeostasis are key targets for the development of new drugs for human health. The 4th edition of Iron Metabolism is written in a lively style by one of the leaders in the field, presented in colour and covers the latest discoveries in this exciting area. It will be essential reading for researchers and students in biochemistry, molecular biology, microbiology, cell biology, nutrition and medical sciences. Other interested groups include biological inorganic chemists with an interest in iron metabolism, health professionals with an interest in diseases of iron metabolism, or of diseases in which iron uptake systems are involved (eg. microbial and fungal infections, cancer, neurodegenerative disorders), and researchers in the pharmaceutical industry interested in developing novel drugs targeting iron metabolism/homeostasis.

Metal Ions in Biological Systems

Astrid Sigel,Helmut Sigel
Metal Ions in Biological Systems Book PDF

Author : Astrid Sigel,Helmut Sigel
Publisher : CRC Press
Page : 826 pages
File Size : 48,6 Mb
Release : 1998-01-09
Category : Science
ISBN : 0824799844

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Metal Ions in Biological Systems by Astrid Sigel,Helmut Sigel Pdf

"Volume 35 covers the biological cycling of iron in oceans; the transport of iron in microorganisms, fungi, and plants; the roles and properties of siderophores; the regulation of iron transport and uptake in animals, plants, and microorganisms, and more. "

Microbial Transport Systems

Günther Winkelmann
Microbial Transport Systems Book PDF

Author : Günther Winkelmann
Publisher : John Wiley & Sons
Page : 501 pages
File Size : 46,8 Mb
Release : 2008-01-08
Category : Science
ISBN : 9783527612727

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Microbial Transport Systems by Günther Winkelmann Pdf

Transport of molecules across the cell membrane is a fundamental process of all living organisms. It is essential for understanding growth, development, nutrition as well as uptake and excretion of exogenous or synthesized molecules. Microbes respresent general and basic functional systems where many transport processes have been studied on a molecular basis. Knowledge of the microbial transport processes will provide new perspectives to treatments by inhibitors, drugs, antibiotics, vitamins, growth promotion compounds, activators and toxic compunds of various kinds.

Iron Uptake and Homeostasis in Microorganisms

Pierre Cornelis,Simon C. Andrews
Iron Uptake and Homeostasis in Microorganisms Book PDF

Author : Pierre Cornelis,Simon C. Andrews
Publisher : Unknown
Page : 128 pages
File Size : 49,8 Mb
Release : 2010
Category : Electronic
ISBN : 1912530821

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Iron Uptake and Homeostasis in Microorganisms by Pierre Cornelis,Simon C. Andrews Pdf

In this book, an international team of authors presents a comprehensive collection of reviews on iron uptake and metabolism in various microorganisms including rhizobia, Bordetella, Shigella, E. coli, Erwinia, Vibrio, Aeromonas, Francisella, Bacteroides, Campylobacter, cyanobacteria, Bacillus, staphylococci and yeasts. An entire chapter is dedicated to siderophores and another to heme uptake. The volume provides an expert and timely summary of current knowledge, with a focus on molecular and genetic aspects, and highlights some of the most exciting recent developments. Aimed at research scient.

Military Strategies for Sustainment of Nutrition and Immune Function in the Field

Institute of Medicine,Committee on Military Nutrition Research
Military Strategies for Sustainment of Nutrition and Immune Function in the Field Book PDF

Author : Institute of Medicine,Committee on Military Nutrition Research
Publisher : National Academies Press
Page : 722 pages
File Size : 52,8 Mb
Release : 1999-05-13
Category : Medical
ISBN : 9780309173186

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Military Strategies for Sustainment of Nutrition and Immune Function in the Field by Institute of Medicine,Committee on Military Nutrition Research Pdf

Every aspect of immune function and host defense is dependent upon a proper supply and balance of nutrients. Severe malnutrition can cause significant alteration in immune response, but even subclinical deficits may be associated with an impaired immune response, and an increased risk of infection. Infectious diseases have accounted for more off-duty days during major wars than combat wounds or nonbattle injuries. Combined stressors may reduce the normal ability of soldiers to resist pathogens, increase their susceptibility to biological warfare agents, and reduce the effectiveness of vaccines intended to protect them. There is also a concern with the inappropriate use of dietary supplements. This book, one of a series, examines the impact of various types of stressors and the role of specific dietary nutrients in maintaining immune function of military personnel in the field. It reviews the impact of compromised nutrition status on immune function; the interaction of health, exercise, and stress (both physical and psychological) in immune function; and the role of nutritional supplements and newer biotechnology methods reported to enhance immune function. The first part of the book contains the committee's workshop summary and evaluation of ongoing research by Army scientists on immune status in special forces troops, responses to the Army's questions, conclusions, and recommendations. The rest of the book contains papers contributed by workshop speakers, grouped under such broad topics as an introduction to what is known about immune function, the assessment of immune function, the effect of nutrition, and the relation between the many and varied stresses encountered by military personnel and their effect on health.

Microbial Siderophores

Ajit Varma,S.B. Chincholkar
Microbial Siderophores Book PDF

Author : Ajit Varma,S.B. Chincholkar
Publisher : Springer Science & Business Media
Page : 255 pages
File Size : 51,7 Mb
Release : 2007-07-04
Category : Science
ISBN : 9783540711605

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Microbial Siderophores by Ajit Varma,S.B. Chincholkar Pdf

In response to low iron availability in the environment most microorganisms synthesize iron chelators, called siderophores. Bacteria and fungi produce a broad range of structurally diverse siderophores, all of which show a very high affinity for ferric ions. This book presents an up-to-date overview of the chemistry, biology and biotechnology of these iron chelators. Coverage ranges from an introductory chapter to siderotyping to applications in human and plant health.

Fungal Siderophores

Kalyani Dhusia,Kalpana Raja,Pramod Ramteke
Fungal Siderophores Book PDF

Author : Kalyani Dhusia,Kalpana Raja,Pramod Ramteke
Publisher : Springer Nature
Page : 220 pages
File Size : 48,7 Mb
Release : 2021-02-08
Category : Science
ISBN : 9783030530778

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Fungal Siderophores by Kalyani Dhusia,Kalpana Raja,Pramod Ramteke Pdf

In the past few decades, it has been realized through research that fungal siderophores epitomize the uptake of iron as well as other essential elements like zinc, magnesium, copper, nickel and arsenic. Understanding the chemical structures of different fungal siderophores and the membrane receptors involved in uptake of mineral ions has opened new areas for research. In this edited volume, recent research is presented on fungal siderophores in one comprehensive volume to provide researchers a strong base for future research. Siderophores are the low molecular weight, high affinity iron-chelating compounds produced by bacteria and fungi. They are responsible for transporting iron across the cell membrane. Fungi produce a range of hydroxamate siderophores involved in the uptake of essential elements in almost all microorganisms and plants. In recent years, siderophores have been used in molecular imaging applications to visualize and understand cellular functions, which thus provide an opportunity to identify new drug targets. Therefore, knowledge of fungal siderophores has become vital in current research. Siderophores have received much attention in recent years because of their potential roles and applications in various research areas. Their significance in these applications is because siderophores have the ability to bind a variety of metals in addition to iron, and they have a wide range of chemical structures and specific properties. For instance, siderophores function as biocontrols, biosensors, and bioremediation and chelation agents, in addition to their important role in weathering soil minerals and enhancing plant growth. This book focuses on siderophores with the following significant points. It discusses leading, state-of-the-art research in all possible areas on fungal siderophores. The contributors are well-known and recognized authorities in the field of fungal siderophores. It discusses a projection of practical applications of fungal siderophores in various domains. This is the first book exclusively on fungal siderophores. In this comprehensive, edited volume, we show leading research on fungal siderophores and provide the most recent knowledge of researchers' work on siderophores. This book presents in-depth knowledge on siderophores to researchers working in areas of health sciences, microbiology, plant sciences, biotechnology, and bioinformatics.

Stress and Environmental Regulation of Gene Expression and Adaptation in Bacteria

Frans J. de Bruijn
Stress and Environmental Regulation of Gene Expression and Adaptation in Bacteria Book PDF

Author : Frans J. de Bruijn
Publisher : John Wiley & Sons
Page : 1472 pages
File Size : 40,9 Mb
Release : 2016-07-13
Category : Science
ISBN : 9781119004899

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Stress and Environmental Regulation of Gene Expression and Adaptation in Bacteria by Frans J. de Bruijn Pdf

Bacteria in various habitats are subject to continuously changing environmental conditions, such as nutrient deprivation, heat and cold stress, UV radiation, oxidative stress, dessication, acid stress, nitrosative stress, cell envelope stress, heavy metal exposure, osmotic stress, and others. In order to survive, they have to respond to these conditions by adapting their physiology through sometimes drastic changes in gene expression. In addition they may adapt by changing their morphology, forming biofilms, fruiting bodies or spores, filaments, Viable But Not Culturable (VBNC) cells or moving away from stress compounds via chemotaxis. Changes in gene expression constitute the main component of the bacterial response to stress and environmental changes, and involve a myriad of different mechanisms, including (alternative) sigma factors, bi- or tri-component regulatory systems, small non-coding RNA’s, chaperones, CHRIS-Cas systems, DNA repair, toxin-antitoxin systems, the stringent response, efflux pumps, alarmones, and modulation of the cell envelope or membranes, to name a few. Many regulatory elements are conserved in different bacteria; however there are endless variations on the theme and novel elements of gene regulation in bacteria inhabiting particular environments are constantly being discovered. Especially in (pathogenic) bacteria colonizing the human body a plethora of bacterial responses to innate stresses such as pH, reactive nitrogen and oxygen species and antibiotic stress are being described. An attempt is made to not only cover model systems but give a broad overview of the stress-responsive regulatory systems in a variety of bacteria, including medically important bacteria, where elucidation of certain aspects of these systems could lead to treatment strategies of the pathogens. Many of the regulatory systems being uncovered are specific, but there is also considerable “cross-talk” between different circuits. Stress and Environmental Regulation of Gene Expression and Adaptation in Bacteria is a comprehensive two-volume work bringing together both review and original research articles on key topics in stress and environmental control of gene expression in bacteria. Volume One contains key overview chapters, as well as content on one/two/three component regulatory systems and stress responses, sigma factors and stress responses, small non-coding RNAs and stress responses, toxin-antitoxin systems and stress responses, stringent response to stress, responses to UV irradiation, SOS and double stranded systems repair systems and stress, adaptation to both oxidative and osmotic stress, and desiccation tolerance and drought stress. Volume Two covers heat shock responses, chaperonins and stress, cold shock responses, adaptation to acid stress, nitrosative stress, and envelope stress, as well as iron homeostasis, metal resistance, quorum sensing, chemotaxis and biofilm formation, and viable but not culturable (VBNC) cells. Covering the full breadth of current stress and environmental control of gene expression studies and expanding it towards future advances in the field, these two volumes are a one-stop reference for (non) medical molecular geneticists interested in gene regulation under stress.

Microbial Life History

Steven A. Frank
Microbial Life History Book PDF

Author : Steven A. Frank
Publisher : Princeton University Press
Page : 400 pages
File Size : 54,5 Mb
Release : 2022-08-16
Category : Science
ISBN : 9780691231198

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Microbial Life History by Steven A. Frank Pdf

A powerful framework for understanding how natural selection shapes adaptation and biological design Design and diversity are the two great challenges in the study of life. Microbial Life History draws on the latest advances in microbiology to describe the fundamental forces of biological design and apply these evolutionary processes to a broad diversity of traits in microbial metabolism and biochemistry. Emphasizing how to formulate and test hypotheses of adaptation, Steven Frank provides a new foundation for exploring the evolutionary forces of design. He discusses the economic principles of marginal valuations, trade-offs, and payoffs in risky and random environments; the social aspects of conflict and cooperation; the demographic aspects of age and spatial heterogeneity; and the engineering control theory principles by which systems adjust to environments. Frank then applies these evolutionary principles to the biochemistry of microbial metabolism, providing the first comprehensive link between the forces that shape biological design and cellular energetics. Tracing how natural selection sculpts metabolism, Microbial Life History provides new perspectives on the life histories of organisms, from growth rate and survival to dispersal and defense against attack. Along the way, this incisive book addresses the conceptual and philosophical challenges confronting evolutionary biologists and other practitioners who study biological design and seek to apply its lessons.

The Role of Iron in Bacterial Pathogenesis

Susu M Zughaier,Pierre Cornelis
The Role of Iron in Bacterial Pathogenesis Book PDF

Author : Susu M Zughaier,Pierre Cornelis
Publisher : Frontiers Media SA
Page : 156 pages
File Size : 55,7 Mb
Release : 2018-12-27
Category : Electronic
ISBN : 9782889456628

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The Role of Iron in Bacterial Pathogenesis by Susu M Zughaier,Pierre Cornelis Pdf

The collection of articles published in this eBook represent different facets of the interactions between pathogens and their host concerning the battle for iron. Pathogens have developed different strategies to acquire iron from their host. These include the production of siderophores, heme acquisition and ferrous iron uptake.

Metal Transporters

Jose M. Arguello,Svetlana Lutsenko,José M. Argüello
Metal Transporters Book PDF

Author : Jose M. Arguello,Svetlana Lutsenko,José M. Argüello
Publisher : Academic Press
Page : 478 pages
File Size : 46,9 Mb
Release : 2012-10-25
Category : Science
ISBN : 9780123943903

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Metal Transporters by Jose M. Arguello,Svetlana Lutsenko,José M. Argüello Pdf

This volume of Current Topics in Membranes focuses on metal transmembrane transporters and pumps, a recently discovered family of membrane proteins with many important roles in the physiology of living organisms. The book summarizes the most recent advances in the field of metal ion transport and provides a broad overview of the major classes of transporters involved in homeostasis of heavy metals. Various families of the transporters and metal specificities are discussed with the focus on the structural and mechanistic aspects of their function and regulation. The reader will access information obtained through a variety of approaches ranging from X-ray crystallography to cell biology and bioinformatics, which have been applied to transporters identified in diverse biological systems, such as pathogenic bacteria, plants, humans and others. Field is cutting-edge and a lot of the information is new to research community Wide breadth of topic coverage Contributors of high renown and expertise

Lactoferrin

T. William Hutchens,Bo Lönnerdal,Sylvia V. Rumball
Lactoferrin Book PDF

Author : T. William Hutchens,Bo Lönnerdal,Sylvia V. Rumball
Publisher : Springer Science & Business Media
Page : 295 pages
File Size : 40,7 Mb
Release : 2012-12-06
Category : Science
ISBN : 9781461525486

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Lactoferrin by T. William Hutchens,Bo Lönnerdal,Sylvia V. Rumball Pdf

Lactoferrin is an intriguing protein with an interesting structure and several known or suggested biological activities. We feel that attention on this protein has been too limited and diffuse, partly because it has been "hidden" among other well-known iron-binding proteins such as hemoglobin, ferritin and transferrin, but also perhaps because its biological functions are so diverse. Investigators that focus on lactoferrin represent a wide variety of medical and scientific disciplines that do not usually come together. It was our intention to improve that situation with this symposium. In this book, experts from a variety of disciplines describe the present knowledge of the structural features of lactoferrin, its carbohydrate side chains and its capacity to bind different metal ions and anions. Several of the possible physiological functions of lactoferrin are described in detail, including the role of lactoferrin in bacterial killing, its involvement in growth and proliferation, in immune function and in iron absorption. Aspects of the molecular biology of lactoferrin and its specific interactions with different cell types are also included. Finally, as lactoferrin now has become commercially available in larger quantities, possible industrial applications are discussed. The book should give the interested reader a thorough insight into our present knowledge of lactoferrin.