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Author : Jorge H. Crosa,Alexandra R. Mey,Shelley M. Payne
Publisher : Unknown
Page : 499 pages
File Size : 46,8 Mb
Release : 2004
Category : Iron
ISBN : 1555816541
Author : Ranjan Chakraborty,Volkmar Braun,Klaus Hantke,Pierre Cornelis
Publisher : Springer Science & Business Media
Page : 98 pages
File Size : 44,9 Mb
Release : 2013-02-02
Category : Science
ISBN : 9789400760882
Iron is essential for the growth of most bacteria because it serves as a cofactor for vital enzymes and for the components of the electron transport chain. Moreover, Iron plays an important role in bacterial pathogenicity; in fact, the iron transport systems in bacteria works as target for designing novel antibiotics. Because iron is not soluble under aerobic conditions, bacteria have had to find ways to overcome iron deficiency. One of them is producing an iron-chelating small organic molecule called siderophore. Indeed, most bacteria and fungi produce structurally and chemically diverse siderophores which are transported back to the cytoplasm using complex energy dependent transport systems. Escherichia coli and Pseudomonas were the first ones to be tested; however, nowadays iron transport systems have been investigated in many other bacteria. Iron Uptake in Bacteria with Emphasis on E. coli and Pseudomonas reviews the recent advancements in the field of iron transport systems in bacteria. Chapter 1 is dedicated to Dr. Dick van der Helm’s contribution to the field of siderophore biology. It then describes and discusses the structural advances in the components and the mechanism of siderophore mediated iron transport systems in E.coli. Chapter 2 details the variety of iron transport and iron regulatory systems of both gram negative and gram positive bacteria. Finally, chapter 3 describes the iron transport systems of Pseudomonas. This book is aimed at researchers in the fields of iron metabolism in multiple organisms, and to those who are interested in studying iron transport systems of bacteria. It appeals also to scientists researching structure and function relationship of proteins.
Author : Günther Winkelmann,Dick Van der Helm,J. B. Neilands
Publisher : Wiley-VCH
Page : 568 pages
File Size : 49,5 Mb
Release : 1987
Category : Science
ISBN : UOM:39015012639533
This first comprehensive treatise on iron transport in bacteria, fungi, plants, and animals summarizes the current state of knowledge on the subject.
Author : Jorge H. Crosa,Shelley M. Payne
Publisher : Amer Society for Microbiology
Page : 499 pages
File Size : 54,7 Mb
Release : 2004
Category : Medical
ISBN : 1555812929
provides an up–to–date survey of iron transport systems in bacteria; details iron transport and its regulation in E.colias a prototype for iron transport systems in gram–negative bacteria; includes chapters on the major gram–negative, gram–positive and acid–fast bacterial pathogens – their iron transport systems and the roles of these systems in virulence; presents structural studies of siderophores, heme carriers, and iron transport proteins; discusses the ecology of siderophores and potential therapeutic uses of siderophores.
Author : J. B. Neilands
Publisher : Academic Press
Page : 616 pages
File Size : 42,9 Mb
Release : 2014-06-28
Category : Science
ISBN : 9781483274812
Microbial Iron Metabolism: A Comprehensive Treatise provides a comprehensive treatment of microbial iron metabolism. It aims to contribute to an increased understanding of the path of iron in microbial species and, eventually, in the plant and animal. The book is organized into five parts. Part I describes some features of iron and its function in the microbial world. These include a historical sketch of the recognition of the importance of iron in cellular physiology; a description of certain physical properties of ferrous and ferric ions; and a list of various known biocoordination derivatives grouped by ligand atom. Metabolism under iron-limited conditions is also examined. Part II presents studies on iron transport, biosynthesis, and storage in microorganisms. Part III examines iron enzymes and proteins, including ferredoxin, rubredoxin, nitrogenase, and hydrogenase. Part IV deals with reactions of inorganic substrates. Part V presents a study on the role of bacterial iron metabolism in infection and immunity.
Author : Institute of Medicine,Committee on Military Nutrition Research
Publisher : National Academies Press
Page : 722 pages
File Size : 41,6 Mb
Release : 1999-05-13
Category : Medical
ISBN : 9780309173186
Every aspect of immune function and host defense is dependent upon a proper supply and balance of nutrients. Severe malnutrition can cause significant alteration in immune response, but even subclinical deficits may be associated with an impaired immune response, and an increased risk of infection. Infectious diseases have accounted for more off-duty days during major wars than combat wounds or nonbattle injuries. Combined stressors may reduce the normal ability of soldiers to resist pathogens, increase their susceptibility to biological warfare agents, and reduce the effectiveness of vaccines intended to protect them. There is also a concern with the inappropriate use of dietary supplements. This book, one of a series, examines the impact of various types of stressors and the role of specific dietary nutrients in maintaining immune function of military personnel in the field. It reviews the impact of compromised nutrition status on immune function; the interaction of health, exercise, and stress (both physical and psychological) in immune function; and the role of nutritional supplements and newer biotechnology methods reported to enhance immune function. The first part of the book contains the committee's workshop summary and evaluation of ongoing research by Army scientists on immune status in special forces troops, responses to the Army's questions, conclusions, and recommendations. The rest of the book contains papers contributed by workshop speakers, grouped under such broad topics as an introduction to what is known about immune function, the assessment of immune function, the effect of nutrition, and the relation between the many and varied stresses encountered by military personnel and their effect on health.
Author : Günther Winkelmann
Publisher : John Wiley & Sons
Page : 501 pages
File Size : 55,9 Mb
Release : 2008-01-08
Category : Science
ISBN : 9783527612727
Transport of molecules across the cell membrane is a fundamental process of all living organisms. It is essential for understanding growth, development, nutrition as well as uptake and excretion of exogenous or synthesized molecules. Microbes respresent general and basic functional systems where many transport processes have been studied on a molecular basis. Knowledge of the microbial transport processes will provide new perspectives to treatments by inhibitors, drugs, antibiotics, vitamins, growth promotion compounds, activators and toxic compunds of various kinds.
Author : Kalyani Dhusia,Kalpana Raja,Pramod Ramteke
Publisher : Springer Nature
Page : 220 pages
File Size : 44,8 Mb
Release : 2021-02-08
Category : Science
ISBN : 9783030530778
In the past few decades, it has been realized through research that fungal siderophores epitomize the uptake of iron as well as other essential elements like zinc, magnesium, copper, nickel and arsenic. Understanding the chemical structures of different fungal siderophores and the membrane receptors involved in uptake of mineral ions has opened new areas for research. In this edited volume, recent research is presented on fungal siderophores in one comprehensive volume to provide researchers a strong base for future research. Siderophores are the low molecular weight, high affinity iron-chelating compounds produced by bacteria and fungi. They are responsible for transporting iron across the cell membrane. Fungi produce a range of hydroxamate siderophores involved in the uptake of essential elements in almost all microorganisms and plants. In recent years, siderophores have been used in molecular imaging applications to visualize and understand cellular functions, which thus provide an opportunity to identify new drug targets. Therefore, knowledge of fungal siderophores has become vital in current research. Siderophores have received much attention in recent years because of their potential roles and applications in various research areas. Their significance in these applications is because siderophores have the ability to bind a variety of metals in addition to iron, and they have a wide range of chemical structures and specific properties. For instance, siderophores function as biocontrols, biosensors, and bioremediation and chelation agents, in addition to their important role in weathering soil minerals and enhancing plant growth. This book focuses on siderophores with the following significant points. It discusses leading, state-of-the-art research in all possible areas on fungal siderophores. The contributors are well-known and recognized authorities in the field of fungal siderophores. It discusses a projection of practical applications of fungal siderophores in various domains. This is the first book exclusively on fungal siderophores. In this comprehensive, edited volume, we show leading research on fungal siderophores and provide the most recent knowledge of researchers' work on siderophores. This book presents in-depth knowledge on siderophores to researchers working in areas of health sciences, microbiology, plant sciences, biotechnology, and bioinformatics.
Author : J. J. Bullen,E. Griffiths
Publisher : Unknown
Page : 356 pages
File Size : 50,6 Mb
Release : 1987-05-11
Category : Medical
ISBN : UOM:39015011764159
The first book to present an integrated account of the role of iron in microbial pathogenicity and in clinical infection. Describes advances in biochemistry, microbiology, molecular genetics, and clinical science and identifies gaps in present knowledge. Encompasses bacterial, fungal, and protozoal pathogens and discusses recent discoveries that show the importance of iron uptake mechanisms to malignant and other rapidly proliferating cells. Considers the significance of recent developments to the design and use of new vaccines and to the therapeutic measures used in treating infections.
Author : Larry L. Barton,Javier Abadia
Publisher : Springer Science & Business Media
Page : 500 pages
File Size : 41,9 Mb
Release : 2007-08-20
Category : Medical
ISBN : 1402066236
This book provides a comprehensive review on the status of iron nutrition in plants. It contains updated reviews of most relevant issues involving Fe in plants and combines research on molecular biology with physiological studies of plant-iron nutrition. It also covers molecular aspects of iron uptake and storage in Arabidopsis and transmembrane movement and translocation of iron in plants. This book should serve to stimulate continued exploration in the field.
Author : Robert Donald Perry
Publisher : Unknown
Page : 182 pages
File Size : 43,8 Mb
Release : 1975
Category : Iron in the body
ISBN : MSU:31293031038494
Author : Markus Geisler,Kees Venema
Publisher : Springer Science & Business Media
Page : 388 pages
File Size : 44,6 Mb
Release : 2010-10-17
Category : Science
ISBN : 9783642143694
Due to their sessile lifestyle, plants need to efficiently adapt to changing environmental conditions during their life cycle. Nutrient acquisition from the soil has to be able to adapt to considerable fluctuations in concentrations to ensure adequate distribution between tissues, cells and organelles. The storage and retrieval of nutrients, metabolites or toxic substances in vacuoles plays an important part in cellular homeostasis in plants. The long-range transport and maintenance of turgor is critically dependent on the availability of water and rate of evaporation, while at the same time photosynthetic products have to be transported to all plant parts. As a result plants contain a large number of ATP-dependent pumps and secondary transporters that, in order to adapt to the changing environment, need to be regulated by a complex network of sensing and signaling mechanisms. Plants share many basic elements of signal transduction with animals, but also contain plant-specific signaling molecules and mechanisms. In this volume, the role of transporters and pumps in the regulation of movement, long-range transport and compartmentalization of water, solutes, nutrients and classical signaling molecules is highlighted, and the function, regulation and membrane-transporter interaction and their roles in plant signaling controlling plant physiology and development are discussed.
Author : Jose M. Arguello,Svetlana Lutsenko,José M. Argüello
Publisher : Academic Press
Page : 478 pages
File Size : 44,9 Mb
Release : 2012-10-25
Category : Science
ISBN : 9780123943903
This volume of Current Topics in Membranes focuses on metal transmembrane transporters and pumps, a recently discovered family of membrane proteins with many important roles in the physiology of living organisms. The book summarizes the most recent advances in the field of metal ion transport and provides a broad overview of the major classes of transporters involved in homeostasis of heavy metals. Various families of the transporters and metal specificities are discussed with the focus on the structural and mechanistic aspects of their function and regulation. The reader will access information obtained through a variety of approaches ranging from X-ray crystallography to cell biology and bioinformatics, which have been applied to transporters identified in diverse biological systems, such as pathogenic bacteria, plants, humans and others. Field is cutting-edge and a lot of the information is new to research community Wide breadth of topic coverage Contributors of high renown and expertise
Author : Douglas Templeton
Publisher : CRC Press
Page : 926 pages
File Size : 43,8 Mb
Release : 2002-01-23
Category : Science
ISBN : 9780824744175
This text analyzes the molecular mechanisms, chemical behaviour and regulation of iron transport in biological systems and offers novel methods for the assessment of iron transport across biological membranes. It details the characteristics and consequences of iron deficiency and excess to prevent diseases affecting major organ structures and promote bodily iron homeostasis.
Author : Lucia Banci
Publisher : Springer Science & Business Media
Page : 642 pages
File Size : 42,8 Mb
Release : 2013-04-18
Category : Science
ISBN : 9789400755611
Metallomics and the Cell provides in an authoritative and timely manner in 16 stimulating chapters, written by 37 internationally recognized experts from 9 nations, and supported by more than 3000 references, several tables, and 110 illustrations, mostly in color, a most up-to-date view of the "metallomes" which, as defined in the "omics" world, describe the entire set of biomolecules that interact with or are affected by each metal ion. The most relevant tools for visualizing metal ions in the cell and the most suitable bioinformatic tools for browsing genomes to identify metal-binding proteins are also presented. Thus, MILS-12 is of relevance for structural and systems biology, inorganic biological chemistry, genetics, medicine, diagnostics, as well as teaching, etc.