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The Role of Iron in Bacterial Pathogenesis by Susu M Zughaier,Pierre Cornelis Pdf
The collection of articles published in this eBook represent different facets of the interactions between pathogens and their host concerning the battle for iron. Pathogens have developed different strategies to acquire iron from their host. These include the production of siderophores, heme acquisition and ferrous iron uptake.
The Role of Iron in Bacterial Pathogenesis by Anonim Pdf
The collection of articles published in this eBook represent different facets of the interactions between pathogens and their host concerning the battle for iron. Pathogens have developed different strategies to acquire iron from their host. These include the production of siderophores, heme acquisition and ferrous iron uptake.
Iron Uptake in Bacteria with Emphasis on E. coli and Pseudomonas by Ranjan Chakraborty,Volkmar Braun,Klaus Hantke,Pierre Cornelis Pdf
Iron is essential for the growth of most bacteria because it serves as a cofactor for vital enzymes and for the components of the electron transport chain. Moreover, Iron plays an important role in bacterial pathogenicity; in fact, the iron transport systems in bacteria works as target for designing novel antibiotics. Because iron is not soluble under aerobic conditions, bacteria have had to find ways to overcome iron deficiency. One of them is producing an iron-chelating small organic molecule called siderophore. Indeed, most bacteria and fungi produce structurally and chemically diverse siderophores which are transported back to the cytoplasm using complex energy dependent transport systems. Escherichia coli and Pseudomonas were the first ones to be tested; however, nowadays iron transport systems have been investigated in many other bacteria. Iron Uptake in Bacteria with Emphasis on E. coli and Pseudomonas reviews the recent advancements in the field of iron transport systems in bacteria. Chapter 1 is dedicated to Dr. Dick van der Helm’s contribution to the field of siderophore biology. It then describes and discusses the structural advances in the components and the mechanism of siderophore mediated iron transport systems in E.coli. Chapter 2 details the variety of iron transport and iron regulatory systems of both gram negative and gram positive bacteria. Finally, chapter 3 describes the iron transport systems of Pseudomonas. This book is aimed at researchers in the fields of iron metabolism in multiple organisms, and to those who are interested in studying iron transport systems of bacteria. It appeals also to scientists researching structure and function relationship of proteins.
Institute of Medicine,Committee on Military Nutrition Research
Author : Institute of Medicine,Committee on Military Nutrition Research Publisher : National Academies Press Page : 722 pages File Size : 46,5 Mb Release : 1999-05-13 Category : Medical ISBN : 9780309173186
Military Strategies for Sustainment of Nutrition and Immune Function in the Field by Institute of Medicine,Committee on Military Nutrition Research Pdf
Every aspect of immune function and host defense is dependent upon a proper supply and balance of nutrients. Severe malnutrition can cause significant alteration in immune response, but even subclinical deficits may be associated with an impaired immune response, and an increased risk of infection. Infectious diseases have accounted for more off-duty days during major wars than combat wounds or nonbattle injuries. Combined stressors may reduce the normal ability of soldiers to resist pathogens, increase their susceptibility to biological warfare agents, and reduce the effectiveness of vaccines intended to protect them. There is also a concern with the inappropriate use of dietary supplements. This book, one of a series, examines the impact of various types of stressors and the role of specific dietary nutrients in maintaining immune function of military personnel in the field. It reviews the impact of compromised nutrition status on immune function; the interaction of health, exercise, and stress (both physical and psychological) in immune function; and the role of nutritional supplements and newer biotechnology methods reported to enhance immune function. The first part of the book contains the committee's workshop summary and evaluation of ongoing research by Army scientists on immune status in special forces troops, responses to the Army's questions, conclusions, and recommendations. The rest of the book contains papers contributed by workshop speakers, grouped under such broad topics as an introduction to what is known about immune function, the assessment of immune function, the effect of nutrition, and the relation between the many and varied stresses encountered by military personnel and their effect on health.
Established almost 30 years ago, Methods in Microbiology is the most prestigious series devoted to techniques and methodology in the field. Now totally revamped, revitalized, with a new format and expanded scope, Methods in Microbiology will continue to provide you with tried and tested, cutting-edge protocols to directly benefit your research. Focuses on the methods most useful for the microbiologist interested in the way in which bacteria cause disease Includes section devoted to 'Approaches to characterising pathogenic mechanisms' by Stanley Falkow Covers safety aspects, detection, identification and speciation Includes techniques for the study of host interactions and reactions in animals and plants Describes biochemical and molecular genetic approaches Essential methods for gene expression and analysis Covers strategies and problems for disease control
Second Edition Iron and Infection Molecular, Physiological and Clinical Aspects Edited by J J Bullen University of Miami School of Medicine, USA, and E Griffiths World Health Organization, Geneva, Switzerland This revised edition covers major new advances made during the past decade on the role of iron in infection. These issues are of fundamental importance for understanding bacterial pathogenesis and resistance to infection, and are particularly relevant to present day circumstances in view of the progressive failure of antibiotics to control clinical infections. Topics covered are: * Iron in biological systems * Iron proteins * The iron uptake systems of pathogenic organisms * Iron as a regulatory signal * Molecular genetics of iron transport as a component of virulence * Iron and the immune system * Iron binding proteins and host defence * Clinical and physiological aspects * Future prospects Sepsis is a global problem which requires urgent investigation, and this second edition of Iron and Infection will be essential reading for clinical microbiologists and infectious disease specialists.
W. Arber,W. Braun,F. Cramer,R. Haas,W. Henle,P. H. Hofschneider,N. K. Jerne,P. Koldovský,H. Koprowski,O. Maaløe,R. Rott,H. G. Schweiger,M. Sela,L. Syru?ek,P. K. Vogt,E. Wecker
Author : W. Arber,W. Braun,F. Cramer,R. Haas,W. Henle,P. H. Hofschneider,N. K. Jerne,P. Koldovský,H. Koprowski,O. Maaløe,R. Rott,H. G. Schweiger,M. Sela,L. Syru?ek,P. K. Vogt,E. Wecker Publisher : Springer Science & Business Media Page : 242 pages File Size : 46,9 Mb Release : 2013-03-08 Category : Medical ISBN : 9783642461699
Current Topics in Microbiology and Immunology by W. Arber,W. Braun,F. Cramer,R. Haas,W. Henle,P. H. Hofschneider,N. K. Jerne,P. Koldovský,H. Koprowski,O. Maaløe,R. Rott,H. G. Schweiger,M. Sela,L. Syru?ek,P. K. Vogt,E. Wecker Pdf
Iron Uptake and Homeostasis in Microorganisms by Pierre Cornelis,Simon C. Andrews Pdf
In this book, an international team of authors presents a comprehensive collection of reviews on iron uptake and metabolism in various microorganisms including rhizobia, Bordetella, Shigella, E. coli, Erwinia, Vibrio, Aeromonas, Francisella, Bacteroides, Campylobacter, cyanobacteria, Bacillus, staphylococci and yeasts. An entire chapter is dedicated to siderophores and another to heme uptake. The volume provides an expert and timely summary of current knowledge, with a focus on molecular and genetic aspects, and highlights some of the most exciting recent developments. Aimed at research scient.
Molecular Basis of Bacterial Pathogenesis by Barbara H. Iglewski Pdf
Molecular Basis of Bacterial Pathogenesis focuses on the molecular mechanism of disease associated with bacterial pathogens. Topics covered include the population genetics of bacterial pathogenesis; environmental modulation of gene expression in gram-negative pathogens; and bacterial invasion and intracellular growth. Bacterial toxins are also discussed. This volume is comprised of 20 chapters and begins with an overview of pathogenesis, paying particular attention to common elements and genetic mechanisms of regulation. The discovery that many bacterial pathogens are clonal, with individual clones often having a greater virulence than others, is then considered. The next section deals with the regulation of synthesis of surface components and their role in colonization of the host and/or evasion of the host immune defense systems; antigenic variation and its role in evasion of the host immune response; and the role of iron acquisition systems in the colonization of the host. Subsequent chapters explore the invasion and intracellular growth of facultative and obligate intracellular parasites. The last section is devoted to studies on the role of bacterial toxic products in pathogenesis. Bacterial lipopolysaccharides (endotoxins) and exotoxins are described. This book should be of interest to molecular biologists, physiologists, clinical specialists, pathologists, and geneticists.
Iron Transport in Bacteria by Jorge H. Crosa,Shelley M. Payne Pdf
provides an up–to–date survey of iron transport systems in bacteria; details iron transport and its regulation in E.colias a prototype for iron transport systems in gram–negative bacteria; includes chapters on the major gram–negative, gram–positive and acid–fast bacterial pathogens – their iron transport systems and the roles of these systems in virulence; presents structural studies of siderophores, heme carriers, and iron transport proteins; discusses the ecology of siderophores and potential therapeutic uses of siderophores.
Microbial Siderophores by Ajit Varma,S.B. Chincholkar Pdf
In response to low iron availability in the environment most microorganisms synthesize iron chelators, called siderophores. Bacteria and fungi produce a broad range of structurally diverse siderophores, all of which show a very high affinity for ferric ions. This book presents an up-to-date overview of the chemistry, biology and biotechnology of these iron chelators. Coverage ranges from an introductory chapter to siderotyping to applications in human and plant health.
Transition Metals in Microbial Metabolism by Gunther Winkelmann Pdf
The key role played by iron, as well as other transition metals, in microbial metabolism is investigated in this volume. Topics covered include: iron chelation and siderophores; receptor-mediated bacterial iron transport; and the nitogenases.
W. Arber,W. Henle,P. H. Hofschneider,J. H. Humphrey,N. K. Jerne,P. Koldovský,H. Koprowski,O. Maaløe,R. Rott,H. G. Schweiger,M. Sela,L. Syru?ek,P. K. Vogt
Author : W. Arber,W. Henle,P. H. Hofschneider,J. H. Humphrey,N. K. Jerne,P. Koldovský,H. Koprowski,O. Maaløe,R. Rott,H. G. Schweiger,M. Sela,L. Syru?ek,P. K. Vogt Publisher : Springer Page : 0 pages File Size : 45,5 Mb Release : 2011-11-11 Category : Medical ISBN : 3642661033
Current Topics in Microbiology and Immunology / Ergebnisse der Mikrobiologie und Immunitätsforschung by W. Arber,W. Henle,P. H. Hofschneider,J. H. Humphrey,N. K. Jerne,P. Koldovský,H. Koprowski,O. Maaløe,R. Rott,H. G. Schweiger,M. Sela,L. Syru?ek,P. K. Vogt Pdf
The processes involved in herpesvirus replication, latency, and oncogenic transformation, have, in general, been rather poorly defined. A primary reason for this is the size and complexity of the herpesvirus genome. Undoubtedly, a better understanding of the functions of the viral genome in infected and transformed cells will be achieved through studies with temperature-sensitive (ts) mutants of herpesviruses since, theoretically, any essential gene function can be affected by mutants of this type. A. The Herpesviruses A consideration of the genetic analysis of members of the herpesvirus group necessitates a description, albeit brief, of the properties of the group and, most importantly, of their genetic material. The herpesviruses comprise a group of relatively large (100-150 nm), enveloped viruses. The envelope surrounds an icosahedral capsid enclosing a core which contains double stranded DNA (ROIZMAN, 1969). The group is thus defined on the basis of a common virion morphology. In addition to a common structure, members of the group share a number of biological properties such as a similar replicative cycle, the ability to cause latent and chronic infections, and the ability to induce antigenic modifications of infected cell membranes. Several herpes viruses have been associated recently with malignancies in man and animals (KLEIN, 1972). Herpesviruses are ubiquitous and have been described in over 30 different species (HUNT and MELENDEZ, 1969; WILDY, 1971; FARLEY et aI. , 1972; KAZAMA and SCHORNSTEIN, 1972; NAHMIAS et aI. , 1972; ROlZMAN et aI. , 1973). Their widespread occurrence in nature suggests a common ancestor.
Indira T. Kudva,Nancy A. Cornick,Paul J. Plummer,Qijing Zhang,Tracy L. Nicholson,John P. Bannantine,Bryan H. Bellaire
Author : Indira T. Kudva,Nancy A. Cornick,Paul J. Plummer,Qijing Zhang,Tracy L. Nicholson,John P. Bannantine,Bryan H. Bellaire Publisher : John Wiley & Sons Page : 871 pages File Size : 44,9 Mb Release : 2020-07-10 Category : Medical ISBN : 9781555819286
Virulence Mechanisms of Bacterial Pathogens by Indira T. Kudva,Nancy A. Cornick,Paul J. Plummer,Qijing Zhang,Tracy L. Nicholson,John P. Bannantine,Bryan H. Bellaire Pdf
Ground-breaking overview of an enduring topic Despite the use of antibiotics, bacterial diseases continue to be a critical issue in public health, and bacterial pathogenesis remains a tantalizing problem for research microbiologists. This new edition of Virulence Mechanisms of Bacterial Pathogens broadly covers the knowledge base surrounding this topic and presents recently unraveled bacterial virulence strategies and cutting-edge therapies. A team of editors, led by USDA scientist Indira Kudva, compiled perspectives from experts to explain the wide variety of mechanisms through which bacterial pathogens cause disease: the host interface, host cell enslavement, and bacterial communication, secretion, defenses, and persistence. A collection of reviews on targeted therapies rounds out the seven sections of this unique book. The new edition provides insights into some of the most recent advances in the area of bacterial pathogenesis, including how metabolism shapes the host-pathogen interface interactions across species and genera mechanisms of the secretion systems evasion, survival, and persistence mechanisms new therapies targeting various adaptive and virulence mechanisms of bacterial pathogens Written to promote discussion, extrapolation, exploration, and multidimensional thinking, Virulence Mechanisms of Bacterial Pathogens serves as a textbook for graduate courses on bacterial pathogenesis and a resource for specialists in bacterial pathogenicity, such as molecular biologists, physician scientists, infectious disease clinicians, dental scientists, veterinarians, molecular biologists, industry researchers, and technicians.
Stress Response in Pathogenic Bacteria by Stephen P. Kidd Pdf
The ability of pathogenic bacteria to adapt to various chemical, biochemical and physical conditions within the human host and their ability to respond to stresses generated in these environments is a central feature of infectious diseases and the outcome of bacterial infection. This book covers the key aspects of this rapidly developing field, including the generation of stresses by the host immune system, bacterial response to reactive chemicals, and adaptation to environmental conditions of anatomical niches such as the gut, mouth and urogenital tract. It also addresses the increasing importance of different metal ions in the pathogenesis and survival of specific bacteria. With chapters by active research experts in the field, the book provides a comprehensive outline of the current understanding of this field, the latest developments and where future research is likely to be directed.
