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Lewis Acids and Selectivity in Organic Synthesis by M. Santelli,J.-M. Pons Pdf
Lewis acids provide inexpensive access to elaborated molecules obtained with high selectivities (regio-, stereo-, and enantioselectivity). Lewis Acids and Selectivity in Organic Synthesis is the first book to deal with these new and promising roles of Lewis acids. The book begins with general considerations on Lewis acids and a description of Lewis acid-carbonyl complexes, which are involved in most of the reactions described: ene reactions, allylsilane and allyltin addition to carbonyl compounds, addition of nucleophiles to acetals, conjugated addition of allylsilanes and allyltins to unsaturated carbonyl compounds (Sakurai reaction), and Diels-Alder reaction. Subsequent chapters examine these issue in detail, with special attention given to the way Lewis acids induce diastereo- and enantioselectivity. The extensive use of schemes (approximately 1000) ensures rapid visual uptake of the information. Lewis Acids and Selectivity in Organic Synthesis serves as a valuable source of information for all who face the challenge of selectivity in organic synthesis.
Selectivities in Lewis Acid Promoted Reactions by Dieter Schinzer Pdf
The ASI workshop on "Selectivities in Lewis Acid Promoted Reactions" held in the Emmantina-Hotel in Athens-Glyfada, Greece, October 2-7, 1988 was held to bring some light into the darkness of Lewis acid induced processes. As such the workshop reflects some current trends in organic synthesis, where Lewis acids are becoming a powerful tool in many different modern reactions, e.g. Diels-Alder reactions, Ene reactions, Sakurai reactions, and in general silicon and tin chemistry. The objective of this meeting was to bring together most of the world experts in the field to discuss the major reactions promoted by Lewis acids. Organic synthesis will play a major role in this book connected with some fundamental mechanistic work on allylsilane and -tin chemistry. Both natural product synthesis and unnatural molecules are presented in the chapters. The book presents all the 15 invited lectures and the contributions of 15 posters. I am confident that the material presented in this book will stimulate the chemistry, which has been discussed on our meeting, around the world. The meeting and the book were only possible through a grant of the NATO Scientific Affairs Devision and financial support by the following companies: Kali Chemie (Hannover, W-Germany), E. Merck (Darmstadt, W-Germany), Sandoz (Basel, Switzerland), Schering (Berlin, W-Germany).
Lewis Base Catalysis in Organic Synthesis by Edwin Vedejs,Scott E. Denmark Pdf
This three-volume set represents the first comprehensive coverage of the rapidly expanding field of Lewis base catalysis that has attracted enormous attention in recent years. Lewis base catalysis is a conceptually novel paradigm that encompasses an extremely wide variety of preparatively useful transformations and is particularly effective for enantioselectively constructing new stereogenic centers. As electron-pair donors, Lewis bases can influence the rate and stereochemical course of myriad synthetic organic reactions. The book presents the conceptual/mechanistic principles that underlie Lewis base catalysis, and then builds upon that foundation with a thorough presentation of many different reaction types. And last but not least, the editors, Prof. Edwin Vedejs and Prof. Scott E. Denmark, are without doubt the leaders in this emerging field and have compiled high quality contributions from an impressive collection of international experts.
Lewis Base Catalysis in Organic Synthesis, 3 Volume Set by Edwin Vedejs,Scott E. Denmark Pdf
This three-volume set represents the first comprehensive coverage of the rapidly expanding field of Lewis base catalysis that has attracted enormous attention in recent years. Lewis base catalysis is a conceptually novel paradigm that encompasses an extremely wide variety of preparatively useful transformations and is particularly effective for enantioselectively constructing new stereogenic centers. As electron-pair donors, Lewis bases can influence the rate and stereochemical course of myriad synthetic organic reactions. The book presents the conceptual/mechanistic principles that underlie Lewis base catalysis, and then builds upon that foundation with a thorough presentation of many different reaction types. And last but not least, the editors, Prof. Edwin Vedejs and Prof. Scott E. Denmark, are without doubt the leaders in this emerging field and have compiled high quality contributions from an impressive collection of international experts.
Lewis Acids in Organic Synthesis by Hisashi Yamamoto Pdf
VOLUME 2. Sb(III) and Sb(V) Lewis Acids (K. Ishihara). Copper Lewis Acids in Organic Synthesis (M. Sibi & G. Cook). Ag(I), Au(I) Lewis Acids (A. Yanagisawa). Transition Metal Lewis Acids: From Vanadium to Platinum (E. Kündig & C. Saudan). Titanium(IV) Lewis Acids (H. Urabe & F. Sato). Chiral Ti(IV) Lewis Acids (K. Mikami & M. Terada). Hf-Centered Lewis Acids in Organic Chemistry (K. Suzuki & S. Yamanoi). Zirconium Lewis Acids (R. Hara & T. Takahashi). Sc(III) Lewis Acids (S. Kobayashi). Lanthanide Lewis Acids Catalysis (M. Shibasaki, et al.). Polymer-Supported Metal Lewis Acids (S. Itsuno). Index.
Selectivity in Organic Synthesis by Robert S. Ward Pdf
Selectivity is an important part of organic synthesis. The whole basis of organic chemistry, and especially organic synthesis, depends upon the selectivity which can be achieved in organic reactions. This concise textbook describes the strategies which can be adopted to improve selectivity, and the reactions which have been specially designed to afford high selectivity. The book illustrates the range of processes to which these principles can be applied and the high degree of selectivity which can be achieved. Selectivity in Organic Synthesis provides a solid introduction to this subject, focusing on the key areas and applications. Selectivity in Organic Synthesis features: * A concise introduction to selectivity in organic chemistry. * Lucidly written text including many carefully chosen examples and applications. * Numerous problems along with their solutions to help and encourage the reader. Suitable for organic chemistry students taking a course on organic synthesis or asymmetric synthesis in the 3rd or final year of an undergraduate chemistry course or in the first year of a postgraduate course.
The series Topics in Organometallic Chemistry presents critical overviews of research results in organometallic chemistry. As our understanding of organometallic structure, properties and mechanisms increases, new ways are opened for the design of organometallic compounds and reactions tailored to the needs of such diverse areas as organic synthesis, medical research, biology and materials science. Thus the scope of coverage includes a broad range of topics of pure and applied organometallic chemistry, where new breakthroughs are being achieved that are of significance to a larger scientific audience. The individual volumes of Topics in Organometallic Chemistry are thematic. Review articles are generally invited by the volume editors. All chapters from Topics in Organometallic Chemistry are published OnlineFirst with an individual DOI. In references, Topics in Organometallic Chemistry is abbreviated as Top Organomet Chem and cited as a journal
A clear and comprehensive laboratory manual providing step-by-step protocols for using Lewis acid reagents to catalyze organic synthesis processes. After an examination of the synthetic utility of bulky aluminum reagents as Lewis acid receptors, the manual covers the following reagents, protocols, and processes: Boron; Magnesium (II) and other alkali and alkaline earth metals; Zinc (II); Chiral titanium complexes for enantioselective catalysis; Tin Lewis acid; Silicon (IV); Silver and gold; Zr- and Hf-centered Lewis acid in organic synthesis; Scandium (III) and yttrium (III); Lanthanides (III); and other transition metal reagents. Also covered are Lewis acid-assisted anionic polymerizations for synthesis of polymers with controlled molecular weights. Lewis Acid Chemistry: A Practical Approach, a volume in the Oxford Practical Approach Series in Chemistry will prove a handy addition to the professional libraries of organic chemists in research and industry.
Chiral Lewis Acids in Organic Synthesis by Jacek Mlynarski Pdf
A complete overview covering the application of metal-based chiral Lewis acids from all parts of the periodic table, the Author emphasizes the most recent contributions to the field as well as prominent direction of development. The book discusses the design of chiral complexes as well as a wide spectrum of reactions promoted by various chiral Lewis acids, including water-compatible acids as well as the most important applications in the chemical and pharmaceutical industries. A must-have for catalytic and organic chemists working in the field, both in academia and industry, as well as pharmaceutical and medicinal chemists.
The Essential Guide to Lewis Acids by Oliver M. Sandes Pdf
Lewis acids have been utilized to activate molecules, whether it be the generation of a simple Lewis acid-base adduct or the coordination and activation of a substrate molecule in a catalytic transformation. When designing new Lewis acids, a synthetic chemist has to consider the properties of the Lewis acid. As such, this compilation describes the methods used in measuring Lewis acid strength, including a ladder diagram comparing the Lewis acid strength of both main group and metal-based Lewis acids. Since carboxylic acid derivatives are commercially available, non-toxic, cheap and normally stable to air and moisture, carboxylic acid derivatives are ideal reactants for synthetic strategy. The decarboxylative coupling reaction is discussed as one of the most important tools for organic synthesis, and remarkable progress has been made in this field. In conclusion, the authors highlight recent advances achieved in the development of processes for esters production from glycerol and terpenic alcohols in metal salts-catalyzed reactions, using acetic acid as the carbonylic reactant. The effects of main reaction parameters such as concentration, temperature and reactants stoichiometry are assessed. A comparison with traditional acid catalysts used in these reactions is also performed.
Chiral Lewis Acids in Organic Synthesis by Jacek Mlynarski Pdf
A complete overview covering the application of metal-based chiral Lewis acids from all parts of the periodic table, the Author emphasizes the most recent contributions to the field as well as prominent direction of development. The book discusses the design of chiral complexes as well as a wide spectrum of reactions promoted by various chiral Lewis acids, including water-compatible acids as well as the most important applications in the chemical and pharmaceutical industries. A must-have for catalytic and organic chemists working in the field, both in academia and industry, as well as pharmaceutical and medicinal chemists.
Current Trends in Organic Synthesis by Carlo Scolastico,Francesco Nicotra Pdf
The last two decades have seen a rapid growth in the synthetic processing of both simple and complex molecules, aimed at meeting the needs of society in all aspects of life. Many efforts have been devoted to the development of new biologically active compounds, new materials with innovative properties such as bio-compatibility, new catalysts that allow highly selective transformations, and technologies that facilitate the synthetic pro cesses. This book is a compendium of recent progress in all these aspects of synthetic chemistry. It collects the lectures of the XII International Conference on Organic Synthesis, held in Venice from June 28 to July 2, 1998, in which the present state of art of this discipline has been reported. The topics covered include: combinatorial chemistry, new synthetic methods, stereo selective synthesis, metal-mediated synthesis, and target oriented synthesis. The book collects the contributions, in the mentioned topics, of 43 scientists from 19 different countries. The contributions presented in the Conference as plenary lectures are reported in the first section of the book. Particular attention has been dedicated to combinatorial chemistry, a new and promising methodology for the synthesis of libraries of pharmaco logically interesting compounds in order to allow the automatic pharmacological screening of thousands of compounds. The Conference has dedicated to combinatorial chemistry a mini-symposium in which scientists from academy and companies have described the current trends of this very new technology.
Cycloaddition Reactions in Organic Synthesis by W. Carruthers Pdf
Demonstrates the wide scope of cycloaddition reactions, including the Diels-Alder reaction, the ene reaction, 1,3-dipolar cycloadditions and [2+2] cycloadditions in organic synthesis. The author, a leading exponent of the subject, illustrates the ways in which they can be employed in the synthesis of a wide range of carbocyclic and heterocyclic compounds, including a variety of natural products of various types. Special attention is given to intramolecular reactions, which often provide a rapid and efficient route to polycyclic compounds, and to the stereochemistry of the reactions, including recent and developing work on enantioselective synthesis.
