Lipid Metabolism In The Normoxic And Ischaemic Heart

Author : H. Stam,G.J. van der Vusse
Publisher : Springer Science & Business Media
Page : 274 pages
File Size : 46,8 Mb
Release : 2013-03-14
Category : Medical
ISBN : 9783662083901

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Lipid metabolism in the normoxic and ischaemic heart by H. Stam,G.J. van der Vusse Pdf

Scientific progress with respect to the important role of various lipids in myocardial function and the dearrangements of lipid metabolism underlying ischaemic heart disease(s) has been con siderable in recent years. In 1986 alone, an overall number ofl 044 full papers covering the topics "Lipids-Heart-Heart Disease", have been published in a variety of biochemistry, physiology, pharmacology and cardiology journals (source: Index Medicus). They have broadened our in sight into the molecular basis of myocardial lipidology and the lipido-chemical basis of car diology in health and disease, and have narrowed the gap between promising pharmacological intervention in experimental animals and clinical treatment of patients suffering from an ischaemic heart. Furthermore, they illustrate the fundamental significance of the product of the union between basic and clinical science. The rapid development of knowledge in the "Lipids-Heart-Heart Disease" triad prompted us to organize the International Symposium on Lipid Metabolism in the Normoxic and lschaemic Heart, held in Rotterdam (The Netherlands) on September 22 and 23, 1986. This meeting was a coproject of the Department of Biochemistry I (Medical Faculty, Erasmus University Rotter dam) and the Department of Physiology (Medical Faculty, University of Limburg) and was held under the auspices of the GerritJan Mulder Foundation (named after a famous Rotterdam physi cian and chemist who lived from 1802-1880) whom we thank for their co-operation. The present volume is a compendium of invited papers and contributions selected from the posters presented during the symposium.

Author : H. Stam,G. J. van der Vusse
Publisher : Springer Verlag
Page : 269 pages
File Size : 52,9 Mb
Release : 1987
Category : Coronary heart disease
ISBN : 0387912916

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Lipid Metabolism in the Normoxic and Ischaemic Heart by H. Stam,G. J. van der Vusse Pdf

Author : Ger J. van der Vusse
Publisher : Springer Science & Business Media
Page : 210 pages
File Size : 47,8 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9781461316114

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Lipid Metabolism in Normoxic and Ischemic Heart by Ger J. van der Vusse Pdf

During recent decades, bewildering progress has occurred in the field of Molecular and Cellular Biochemistry. Progress has been extraordinarily rapid primarily because of the challenge for finding solutions to a wide variety of diseases and the availability of new techniques for monitoring biochemical processes. This has resulted in a voluminous and complex literature in the field of biochemical medicine so that there is a clear need for the synthesis and analysis of the continuing expansion of valuable data. It was thus considered appropriate to initiate a new series of monographs, each dedicated to a specialized area of investigation, encompassing molecular and cellular processes in health and disease. Most of the biochemical scientists have devoted their energies in understanding the fundamentals of biochemistry and indeed impressive advances have been made in the past. However, the full potential for explanation has been hampered by the concept of universality of biochemical reactions occurring in the cell. In view of the fact that each organ in the body performs a distinct function, it is now beginning to be realized that each cell type is unique in its need to survive and perform its specific function. Accordingly, the aspect of individualty is receiving increased attention for revealing new avenues in the study of pathophysiology of cellular abnormalities.

Author : Ger J. van der Vusse,Hans Stam
Publisher : Springer Science & Business Media
Page : 197 pages
File Size : 47,7 Mb
Release : 2012-12-06
Category : Science
ISBN : 9781461535140

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Lipid Metabolism in the Healthy and Disease Heart by Ger J. van der Vusse,Hans Stam Pdf

Proceedings of the Third International Symposium on Lipid Metabolism in the Normoxic and Ischemic Heart, September 9 & 10, 1991, Rotterdam, The Netherlands

Author : R. Ferrari
Publisher : Springer Science & Business Media
Page : 337 pages
File Size : 53,8 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9781468448658

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Myocardial Ischemia and Lipid Metabolism by R. Ferrari Pdf

Over the past years, the thrust of research in cardiology has been toward an understanding of the engineering of the heart as a pump that transports blood to the various organs of the body. More recently, the fields of biochemistry and biophysics have come to influence heart research. The modern cardiologist can no longer pretend to understand, for example, what is happening to the patient with myocardial infarction or ischemia without understanding the principles of molecular biology. The structure and function of the heart are therefore central themes of cardiological research and practice, which incorporate knowledge and discoveries from diverse disciplines. The importance of lipid metabolism in the myocardium has become clearly understood. In the well-oxygenated heart, fatty acids are the preferred substrates. The fact that the heart derives most of its energy from the oxidation of lipids, which represent the larg est energy store of the body, is logical for an organ that must work throughout our lifetime. There are, however, several lines of evidence that during ischemia, lipids may. be harmful to the heart. High levels of free fatty acids in the serum have been suggested to play a role in causing life-threatening arryhthmias and damage in the ischemic heart. The molecular basis for these effects remains poorly understood, and several possible mechanisms for these harm ful effects have been suggested.

Author : Ger J Van Der Vusse
Publisher : Unknown
Page : 228 pages
File Size : 54,5 Mb
Release : 1989-11-30
Category : Electronic
ISBN : 146131612X

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Lipid Metabolism in Normoxic and Ischemic Heart by Ger J Van Der Vusse Pdf

Author : Robert J. Moffatt,Bryant Stamford
Publisher : CRC Press
Page : 376 pages
File Size : 42,6 Mb
Release : 2005-12-15
Category : Medical
ISBN : 9781420038422

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Lipid Metabolism and Health by Robert J. Moffatt,Bryant Stamford Pdf

That a relation exists between lipids/lipoproteins and coronary artery disease is no longer an arguable point. However, the complexities associated with this relationship, and the number of factors that can impact and alter circumstances and clinical status, are many and diverse. Consequently, this relationship continues to receive a great deal of focus from researchers. Lipid Metabolism and Health, in presenting the latest statement from those positioned on the cutting edge in this arena, provides an overview and historical perspective of the evolution of serum lipids and lipoproteins. It traces their development from a mere curiosity to their acceptance as an established and major coronary artery disease (CAD) risk factor, and, ultimately, to their becoming the subject of clinical guidelines. Considerable attention is focused on the fundamentals, beginning with a chapter on basic lipidology, and progresses through such topics as lipid/lipoprotein metabolism, and the biology of atherosclerosis. Additional topics include methodologies for measuring lipoproteins, clinical strategies used to manage unhealthy lipid levels, and discussion of important influential factors such as obesity, diabetes and metabolic syndrome, diet/nutrition, exercise, cigarette smoking and environmental tobacco smoke, and age, as well as gender, race, and other heredity factors. Qualified and recognized experts in their specific fields of study were recruited by the editors to contribute chapters. They include top researchers in, nutrition, pharmacology, exercise science, and several areas of clinical medicine including cardiology, kinesiology, and immunology. Lipid Metabolism and Health provides a useful scientific and educational tool for researchers, clinicians, academicians, and students seeking a timely and bona fide source of information on the relationship between lipids and health.

Author : Anonim
Publisher : Unknown
Page : 1828 pages
File Size : 51,9 Mb
Release : 1997
Category : Medicine
ISBN : OSU:32436010520193

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Cumulated Index Medicus by Anonim Pdf

Author : National Library of Medicine (U.S.)
Publisher : Unknown
Page : 1128 pages
File Size : 42,5 Mb
Release : 1990
Category : Medicine
ISBN : MINN:31951D00422786D

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National Library of Medicine Current Catalog by National Library of Medicine (U.S.) Pdf

Author : E.M. Vaughan Williams,T.J. Campbell
Publisher : Springer Science & Business Media
Page : 671 pages
File Size : 48,8 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9783642736667

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Antiarrhythmic Drugs by E.M. Vaughan Williams,T.J. Campbell Pdf

The development of a new antiarrhythmic drug involves many people with disparate skills. The organic chemist who makes it is guided not only by the structure-action relations of previous compounds, but by anticipation of a requirement for a particular type of action. In fact several of the best-known antiarrhythmics, including lidocaine, mexiletine, amiodarone and verapamil, were originally synthesized for other purposes. Physicians have to determine whether the new drug works, and pharma cologists how it works. For some years I have believed that there was room for a work which could be understood by all these groups and which could enlighten each about the point of view of the others. Thus when I was invited by Springer-Verlag to prepare a volume in their series Handbook of Experimental Pharmacology, I already had a firm conception of what its form should be. In any multi-author work there are two objectives which cannot always readily be reconciled. The first is to select topics which would relate to each other in a coherent manner. to give a logical and orderly shape to the volume as a whole. The second is to offer authors the greatest possible freedom to express themselves as they wish. When the general design was complete, prospective contributors were invited to write specific chapters, being provided with a complete list of their coauthors and chosen topics, so that they could avoid overlap.

Author : Johan Vereecke,P. P. van Bogaert,Fons Verdonck
Publisher : Leuven University Press
Page : 352 pages
File Size : 48,5 Mb
Release : 1990
Category : Medical
ISBN : 9061864070

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Ionic Currents and Ischemia by Johan Vereecke,P. P. van Bogaert,Fons Verdonck Pdf

Author : H.M. Piper
Publisher : Springer Science & Business Media
Page : 420 pages
File Size : 51,6 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9789400904750

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Pathophysiology of Severe Ischemic Myocardial Injury by H.M. Piper Pdf

In industrialized countries, ischemic heart disease is by far the most common organ-specific cause of death. The thrombotic occlusion of a coronary artery which had previously been severely altered by atherosclerosis, is the most frequent cause of ischemic deterioration of myocardial tissue, i. e. myocardial infarction. Death of the human individual occurs when myocardial ischemia causes a critical impairment of cardiac pump function. The failure of a heart with an ischemic area may be due to the amount and location of contractile tissue becoming paralyzed or even necrotic, or to arrhythmias provoked by the ischemic condition, or by a combination of both factors. Considerable progress has been made in the development of antiarrythmic therapy. Effective tools have been developed to reperfuse ischemic myocar dial tissue as soon as the patient reaches hospital. However, therapeutical principles for the ischemic-reperfused myocardium which would specifically interfere with the state of injury of the ischemic tissue at the onset of reperfusion, and avoid the apparent hazards of the reperfusion process itself, have yet to be established. But not only approved therapeutical concepts are lacking, the pathophysiology of myocardial cell injury in pro gressive ischemia and under reperfusion is in itself only partly understood.

Author : A.H. Maddy,J. Robin Harris
Publisher : Springer Science & Business Media
Page : 424 pages
File Size : 52,9 Mb
Release : 2013-11-11
Category : Science
ISBN : 9781461524014

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Membrane Biogenesis by A.H. Maddy,J. Robin Harris Pdf

Scientific reviews are now of two complementary types: short, very up-to-date articles, as are found in the Trends series, and the more traditional longer re views, which are more comprehensive but take longer to publish. The Subcellu lar Biochemistry series belongs to the latter category where a number of reviews on a broad topic are collected together in the one volume. It has been the aim of this volume to summarize the present state of knowledge of membrane assembly. It is appreciated that some relevant topics have not been included, and an editor's selection is restricted by the many calls on potential authors who are unable to meet all requests made to them. The absence of a discussion of the roles of lipids is," however, a reflection of the fact that a recent volume in this series, edited by Dr. H. 1. Hilderson, has been devoted to this subject (Vol. 16, Intracellular Transfer of Lipid Molecules), and readers are recommended to this source.

Author : A. Lee Carter
Publisher : CRC Press
Page : 278 pages
File Size : 46,7 Mb
Release : 1991-12-19
Category : Medical
ISBN : 0849301866

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Current Concepts in Carnitine Research by A. Lee Carter Pdf

Current Concepts in Carnitine Research is based on the proceedings of a symposium on carnitine research presented by the School of Medicine, Medical College of Georgia, April 20-21, 1991. The book is intended to introduce areas of carnitine research and explore key clinical and basic aspects of carnitine metabolism. The four major topics covered are carnitine and the heart; the structure, function, and regulation of carnitine palmitoyl transferase; functions of the short chain carnitine acyltransferase; and areas of carnitine research. This information is essential for physicians and biochemists studying intermediate metabolism, nutritionists involved in dietary nanuplication, and cardiology researchers, especially those studying cardiomyopathy.

Author : Santiago Grisolía,Vicente Felipo,Maria-Dolores Miñana
Publisher : Springer Science & Business Media
Page : 277 pages
File Size : 51,8 Mb
Release : 2013-03-08
Category : Medical
ISBN : 9781468458268

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Cirrhosis, Hepatic Encephalopathy, and Ammonium Toxicity by Santiago Grisolía,Vicente Felipo,Maria-Dolores Miñana Pdf

Proceedings of an international symposium held in Valencia, Spain, November 27--29, 1989