Mass Spectrometry In Chemical Biology

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Mass Spectrometry in Chemical Biology

Norberto Peporine Lopes,Ricardo Roberto da Silva
Mass Spectrometry in Chemical Biology Book PDF

Author : Norberto Peporine Lopes,Ricardo Roberto da Silva
Publisher : Royal Society of Chemistry
Page : 312 pages
File Size : 44,7 Mb
Release : 2017-11-22
Category : Science
ISBN : 9781782625278

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Mass Spectrometry in Chemical Biology by Norberto Peporine Lopes,Ricardo Roberto da Silva Pdf

Mass spectrometry is one of the most widespread technologies in chemistry and has been increasingly used in biology with the rise of omics sciences. This book summarizes some important methodological approaches in mass spectrometry and applications in the field of chemical biology. The core chapters build on basic concepts introduced in the opening chapter and explore established fields such as high throughput screening, proteomics and metabolomics. Emerging applications of mass spectrometry in elucidating biosynthetic pathways, enzyme mechanisms and protein-protein interactions are then presented. Connections between these diverse research fields are highlighted throughout. The book concludes with a discussion of databases and future perspectives. This book will be a useful tool to early chemical biology researchers wishing to incorporate mass spectrometry as a tool in their research.

Mass Spectrometry in Biomolecular Sciences

Richard M. Caprioli,A. Malorni,G. Sindona
Mass Spectrometry in Biomolecular Sciences Book PDF

Author : Richard M. Caprioli,A. Malorni,G. Sindona
Publisher : Springer Science & Business Media
Page : 531 pages
File Size : 49,9 Mb
Release : 2012-12-06
Category : Science
ISBN : 9789400902176

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Mass Spectrometry in Biomolecular Sciences by Richard M. Caprioli,A. Malorni,G. Sindona Pdf

Mass Spectrometry in the Biological Sciences covers the most recent technological and applied developments in the area, including both ionization techniques and ion analysis. It introduces and reviews some of the newer ionization methods, describes the major instrumentation involved in mass analysis, and presents the scope of the technology in biology, medicine, and environmental science. Specific examples are given for a number of topics. It also deals with recent achievements in the on-line combination of separation techniques such as gas chromatography, liquid chromatography, and supercritical fluid technology.

Mass Spectrometry in Structural Biology and Biophysics

Igor A. Kaltashov,Stephen J. Eyles
Mass Spectrometry in Structural Biology and Biophysics Book PDF

Author : Igor A. Kaltashov,Stephen J. Eyles
Publisher : John Wiley & Sons
Page : 312 pages
File Size : 41,6 Mb
Release : 2012-04-03
Category : Science
ISBN : 9780470937792

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Mass Spectrometry in Structural Biology and Biophysics by Igor A. Kaltashov,Stephen J. Eyles Pdf

The definitive guide to mass spectrometry techniques in biology and biophysics The use of mass spectrometry (MS) to study the architecture and dynamics of proteins is increasingly common within the biophysical community, and Mass Spectrometry in Structural Biology and Biophysics: Architecture, Dynamics, and Interaction of Biomolecules, Second Edition provides readers with detailed, systematic coverage of the current state of the art. Offering an unrivalled overview of modern MS-based armamentarium that can be used to solve the most challenging problems in biophysics, structural biology, and biopharmaceuticals, the book is a practical guide to understanding the role of MS techniques in biophysical research. Designed to meet the needs of both academic and industrial researchers, it makes mass spectrometry accessible to professionals in a range of fields, including biopharmaceuticals. This new edition has been significantly expanded and updated to include the most recent experimental methodologies and techniques, MS applications in biophysics and structural biology, methods for studying higher order structure and dynamics of proteins, an examination of other biopolymers and synthetic polymers, such as nucleic acids and oligosaccharides, and much more. Featuring high-quality illustrations that illuminate the concepts described in the text, as well as extensive references that enable the reader to pursue further study, Mass Spectrometry in Structural Biology and Biophysics is an indispensable resource for researchers and graduate students working in biophysics, structural biology, protein chemistry, and related fields.

Selected Topics in Mass Spectrometry in the Biomolecular Sciences

Richard M. Caprioli,A. Malorni,G. Sindona
Selected Topics in Mass Spectrometry in the Biomolecular Sciences Book PDF

Author : Richard M. Caprioli,A. Malorni,G. Sindona
Publisher : Springer Science & Business Media
Page : 589 pages
File Size : 55,9 Mb
Release : 2012-12-06
Category : Science
ISBN : 9789401151658

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Selected Topics in Mass Spectrometry in the Biomolecular Sciences by Richard M. Caprioli,A. Malorni,G. Sindona Pdf

Many fundamental aspects of the methods used in mass spectrometry are here presented by outstanding scientists, with reference to very recent developments. The principles and applications of electrospray, ion spray and MALDI ionization technique are presented, together with optimised GC/MS interfacing systems and tools for quantitative analysis. A comprehensive treatment of modern instrumentation for mass analysis and detection is also included. The major part of the book deals with bioanalytical applications to peptides, proteins, oligonucleotides, polysaccharides, lipids and plant metabolites. Several papers are devoted to the evaluation of adduct formation between DNA and carcinogens. Environmental applications are also included, with examples of some specific cases. Fundamentals and applications are treated with the same degree of depth: the first two parts of the book therefore provide a basis for the understanding of the biomolecular applications section. Audience: Ideal for advanced graduate students of chemistry who have learned some basic mass spectrometry. Also useful for Ph.D. students in chemistry, biology and medicine. Of value to researchers in academic and industrial laboratories.

Mass Spectrometry

Marek Smoluch,Giuseppe Grasso,Piotr Suder,Jerzy Silberring
Mass Spectrometry Book PDF

Author : Marek Smoluch,Giuseppe Grasso,Piotr Suder,Jerzy Silberring
Publisher : John Wiley & Sons
Page : 448 pages
File Size : 43,7 Mb
Release : 2019-06-17
Category : Science
ISBN : 9781119377337

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Mass Spectrometry by Marek Smoluch,Giuseppe Grasso,Piotr Suder,Jerzy Silberring Pdf

Provides a comprehensive description of mass spectrometry basics, applications, and perspectives Mass spectrometry is a modern analytical technique, allowing for fast and ultrasensitive detection and identification of chemical species. It can serve for analysis of narcotics, counterfeit medicines, components of explosives, but also in clinical chemistry, forensic research and anti-doping analysis, for identification of clinically relevant molecules as biomarkers of various diseases. This book describes everything readers need to know about mass spectrometry—from the instrumentation to the theory and applications. It looks at all aspects of mass spectrometry, including inorganic, organic, forensic, and biological MS (paying special attention to various methodologies and data interpretation). It also contains a list of key terms for easier and faster understanding of the material by newcomers to the subject and test questions to assist lecturers. Knowing how crucial it is for young researchers to fully understand both the power of mass spectrometry and the importance of other complementary methodologies, Mass Spectrometry: An Applied Approach teaches that it should be used in conjunction with other techniques such as NMR, pharmacological tests, structural identification, molecular biology, in order to reveal the true function(s) of the identified molecule. Provides a description of mass spectrometry basics, applications and perspectives of the technique Oriented to a broad audience with limited or basic knowledge in mass spectrometry instrumentation, theory, and its applications in order to enhance their competence in this field Covers all aspects of mass spectrometry, including inorganic, organic, forensic, and biological MS with special attention to application of various methodologies and data interpretation Includes a list of key terms, and test questions, for easier and faster understanding of the material Mass Spectrometry: An Applied Approach is highly recommended for advanced students, young scientists, and anyone involved in a field that utilizes the technique.

Mass Spectrometry in Biology & Medicine

A.L. Burlingame,Steven A. Carr,Michael A. Baldwin
Mass Spectrometry in Biology Medicine Book PDF

Author : A.L. Burlingame,Steven A. Carr,Michael A. Baldwin
Publisher : Springer Science & Business Media
Page : 576 pages
File Size : 41,8 Mb
Release : 1999-09-14
Category : Science
ISBN : 9781592597192

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Mass Spectrometry in Biology & Medicine by A.L. Burlingame,Steven A. Carr,Michael A. Baldwin Pdf

Leading practitioners detail revolutionary new spectrometric techniques for the identification and covalent structural characterization of macromolecules, proteins, glycoconjugates, and nucleic acids. Based on the Fourth International Symposium on Mass Spectrometry in the Health and Life Sciences held in San Francisco in 1998, this invaluable book contains tested strategies for solving many significant biomedical research problems. The techniques use mass spectrometry, automated computer processing of spectral information, and gene, protein, and EST databases for genomic and proteomic correlations. Mass Spectrometry in Biology and Medicine offers a unique opportunity to explore and apply these new techniques of mass spectrometry that are revolutionizing the identification and structural characterization of proteins, carbohydrates, and nucleic acids.

Ion Mobility-Mass Spectrometry

Alison E Ashcroft,Frank Sobott
Ion Mobility Mass Spectrometry Book PDF

Author : Alison E Ashcroft,Frank Sobott
Publisher : Royal Society of Chemistry
Page : 547 pages
File Size : 45,8 Mb
Release : 2021-11-11
Category : Science
ISBN : 9781839162893

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Ion Mobility-Mass Spectrometry by Alison E Ashcroft,Frank Sobott Pdf

Over the last decade, the use of ion mobility separation in combination with mass spectrometry analysis has developed significantly. This technique adds a unique extra dimension enabling the in-depth analysis of a wide range of complex samples in the areas of the chemical and biological sciences. Providing a comprehensive guide to the technique, each chapter is written by an internationally recognised expert and with numerous different commercial platforms to choose from, this book will help the end users understand the practicalities of using different instruments for different ion mobility purposes. The first section provides a detailed account of the fundamentals behind the technique and the current range of available instrumentation. The second section focusses on the wide range of applications that have benefitted from ion mobility – mass spectrometry and includes topics taken from current research in the pharmaceutical, metabolomics, glycomics, and structural molecular biology fields. The book is primarily aimed at researchers, appealing to practising chemists and biochemists, as well as those in the pharmaceutical and medical fields.

Mass Spectrometry in the Biological Sciences

A. L. Burlingame,Steven A. Carr
Mass Spectrometry in the Biological Sciences Book PDF

Author : A. L. Burlingame,Steven A. Carr
Publisher : Springer Science & Business Media
Page : 569 pages
File Size : 46,9 Mb
Release : 2012-12-06
Category : Science
ISBN : 9781461202295

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Mass Spectrometry in the Biological Sciences by A. L. Burlingame,Steven A. Carr Pdf

Leading practitioners describe in detail advanced methods of mass spectrometry used in structural characterization of biomacromolecules of both natural and recombinant origin. They demonstrate by example how these methodologies can solve a wide array of real-world problems in protein biochemistry, immunology, and glycobiology, as well as for human bacterial pathogens, lipids, and nucleic acids. The book offers a unique opportunity to learn these techniques that are revolutionizing the field. Its authoritative assessment in the context of how to solve important and challenging problems in bioscience and medicine ensures a competitive advantage for today's researchers.

Biological Mass Spectrometry

T. Matsuo
Biological Mass Spectrometry Book PDF

Author : T. Matsuo
Publisher : Unknown
Page : 698 pages
File Size : 53,6 Mb
Release : 1994-05-10
Category : Science
ISBN : UOM:39015037845560

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Biological Mass Spectrometry by T. Matsuo Pdf

Prominent active researchers present comprehensive reviews of modern biological mass spectrometry (BMS) including an excellent introduction to the instrumentation and applications currently being implemented. Profiles such recent techniques as ESI, MALDI, LC/MS, Ion-Trap and FT/ICR. Contains specific applications to proteins, drugs and natural products. Features practical guidance for problem solving within the biological sciences. Provides a detailed record of BMS in the early 90s which will serve as a reference in years to come.

Mass Spectrometry of Biological Materials

Barbara S. Larsen,Charles N. McEwen
Mass Spectrometry of Biological Materials Book PDF

Author : Barbara S. Larsen,Charles N. McEwen
Publisher : CRC Press
Page : 488 pages
File Size : 44,7 Mb
Release : 1998-03-02
Category : Science
ISBN : 9781482269987

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Mass Spectrometry of Biological Materials by Barbara S. Larsen,Charles N. McEwen Pdf

Second Edition provides up-to-the-minute discussions on the application of mass spectrometry to the biological sciences. Shows how and why experiments are performed and furnishes details to facilitate duplication of results.

Mass Spectrometry in Biophysics

Igor A. Kaltashov,Stephen J. Eyles
Mass Spectrometry in Biophysics Book PDF

Author : Igor A. Kaltashov,Stephen J. Eyles
Publisher : John Wiley & Sons
Page : 320 pages
File Size : 54,9 Mb
Release : 2005-05-06
Category : Science
ISBN : 9780471705161

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Mass Spectrometry in Biophysics by Igor A. Kaltashov,Stephen J. Eyles Pdf

The first systematic summary of biophysical mass spectrometrytechniques Recent advances in mass spectrometry (MS) have pushed the frontiersof analytical chemistry into the biophysical laboratory. As aresult, the biophysical community's acceptance of MS-based methods,used to study protein higher-order structure and dynamics, hasaccelerated the expansion of biophysical MS. Despite this growing trend, until now no single text has presentedthe full array of MS-based experimental techniques and strategiesfor biophysics. Mass Spectrometry in Biophysics expertly closesthis gap in the literature. Covering the theoretical background and technical aspects of eachmethod, this much-needed reference offers an unparalleled overviewof the current state of biophysical MS. Mass Spectrometry inBiophysics begins with a helpful discussion of general biophysicalconcepts and MS-related techniques. Subsequent chaptersaddress: * Modern spectrometric hardware * High-order structure and dynamics as probed by various MS-basedmethods * Techniques used to study structure and behavior of non-nativeprotein states that become populated under denaturingconditions * Kinetic aspects of protein folding and enzyme catalysis * MS-based methods used to extract quantitative information onprotein-ligand interactions * Relation of MS-based techniques to other experimental tools * Biomolecular properties in the gas phase Fully referenced and containing a helpful appendix on the physicsof electrospray mass spectrometry, Mass Spectrometry in Biophysicsalso offers a compelling look at the current challenges facingbiomolecular MS and the potential applications that will likelyshape its future.

Advancements of Mass Spectrometry in Biomedical Research

Alisa G. Woods,Costel C. Darie
Advancements of Mass Spectrometry in Biomedical Research Book PDF

Author : Alisa G. Woods,Costel C. Darie
Publisher : Springer
Page : 813 pages
File Size : 46,8 Mb
Release : 2019-07-25
Category : Science
ISBN : 9783030159504

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Advancements of Mass Spectrometry in Biomedical Research by Alisa G. Woods,Costel C. Darie Pdf

This volume explores the use of mass spectrometry for biomedical applications. Chapters focus on specific therapeutic areas such as oncology, infectious disease, and psychiatry. Additional chapters focus on methodology, technologies and instrumentation, as well as on analysis of protein-protein interactions, protein quantitation, and protein post-translational modifications. Various omics fields such as proteomics, metabolomics, glycomics, lipidomics, and adductomics are also covered. Applications of mass spectrometry in biotechnological and pharmaceutical industry are also discussed. This volume provides readers with a comprehensive and informative manual that will allow them to appreciate mass spectrometry and proteomic research, but also to initiate and improve their own work. This book acts as a technical guide as well as a conceptual guide to the newest information in this exciting field.

Detection of Chemical, Biological, Radiological and Nuclear Agents for the Prevention of Terrorism

Joseph Banoub
Detection of Chemical Biological Radiological and Nuclear Agents for the Prevention of Terrorism Book PDF

Author : Joseph Banoub
Publisher : Springer
Page : 291 pages
File Size : 52,9 Mb
Release : 2014-11-03
Category : Science
ISBN : 9789401792387

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Detection of Chemical, Biological, Radiological and Nuclear Agents for the Prevention of Terrorism by Joseph Banoub Pdf

This NATO-ASI installment is designed to provide an advanced overview for doctoral and post-doctoral candidates of the state-of-the-art technologies for bio-detection. The main objective of the work aims at providing readers with the latest developments necessary to successfully understand the CBRN Agents and their associated biotechnologies. The core methods focused on are mass spectrometry (including chromatographic and electrophoretic separation) and comparisons to spectroscopic, immunological and molecular analysis of chemical, biological and nuclear agents.

Mass Spectrometry

Jürgen H Gross
Mass Spectrometry Book PDF

Author : Jürgen H Gross
Publisher : Springer
Page : 753 pages
File Size : 46,9 Mb
Release : 2011-01-19
Category : Science
ISBN : 9783642107115

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Mass Spectrometry by Jürgen H Gross Pdf

This book offers a balanced mixture of practice-oriented information and theoretical background as well as numerous references, clear illustrations, and useful data tables. Problems and solutions are accessible via a special website. This new edition has been completely revised and extended; it now includes three new chapters on tandem mass spectrometry, interfaces for sampling at atmospheric pressure, and inorganic mass spectrometry.

Toxic Chemical and Biological Agents

Giovanni Sindona,Joseph H. Banoub,Maria Luisa Di Gioia
Toxic Chemical and Biological Agents Book PDF

Author : Giovanni Sindona,Joseph H. Banoub,Maria Luisa Di Gioia
Publisher : Springer Nature
Page : 282 pages
File Size : 47,7 Mb
Release : 2020-10-19
Category : Science
ISBN : 9789402420418

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Toxic Chemical and Biological Agents by Giovanni Sindona,Joseph H. Banoub,Maria Luisa Di Gioia Pdf

This book critically assesses the current state of knowledge on new and important detection technologies, e.g. mass spectrometry, tandem mass spectrometry, biosensor detection and tissue imaging, in connection with toxic chemical and biological agents. In general, the main topics discussed concern the risks and consequences of chemical and biological agents for human health in general, with special emphasis on all biochemical and metabolic pathways including the reproductive system. The exposome, genetic risks and the environment, various health hazard agents, risk assessment, environmental assessment and preparedness, and analysis of sub-lethal effects at the molecular level are also discussed. In closing, the book provides comprehensive information on the diagnosis of exposure, and on health concerns related to toxic chemical and biological agents.