Mathematical Modeling And Computational Predictions In Oncoimmunology

Author : Vladimir A. Kuznetsov,Heiko Enderling,Mark Chaplain
Publisher : Frontiers Media SA
Page : 121 pages
File Size : 47,7 Mb
Release : 2024-06-06
Category : Medical
ISBN : 9782832550069

Get Book

Mathematical Modeling and Computational Predictions in Oncoimmunology by Vladimir A. Kuznetsov,Heiko Enderling,Mark Chaplain Pdf

Cancer is a complex adaptive dynamic system that causes both local and systemic failures in the patient. Cancer is caused by a number of gain-of-function and loss-of-function events, that lead to cells proliferating without control by the host organism over time. In cancer, the immune system modulates cancer cell population heterogeneity and plays a crucial role in disease outcomes. The immune system itself also generates multiple clones of different cell types, with some clones proliferating quickly and maturing into effector cells. By creating regulatory signals and their networks, and generating effector cells and molecules, the immune system recognizes and kills abnormal cells. Anti-cancer immune mechanisms are realized as multi-layer, nonlinear cellular and molecular interactions. A number of factors determine the outcome of immune system-tumor interactions, including cancer-associated antigens, immune cells, and host organisms.

Author : Dominik Wodarz,Natalia L. Komarova
Publisher : World Scientific
Page : 268 pages
File Size : 47,5 Mb
Release : 2005
Category : Science
ISBN : 9789812560278

Get Book

Computational Biology of Cancer by Dominik Wodarz,Natalia L. Komarova Pdf

- Provides an introduction to computational methods in cancer biology - Follows a multi-disciplinary approach

Author : Vittorio Cristini,Eugene Koay,Zhihui Wang
Publisher : CRC Press
Page : 303 pages
File Size : 45,6 Mb
Release : 2017-06-26
Category : Mathematics
ISBN : 9781315356884

Get Book

An Introduction to Physical Oncology by Vittorio Cristini,Eugene Koay,Zhihui Wang Pdf

Physical oncology has the potential to revolutionize cancer research and treatment. The fundamental rationale behind this approach is that physical processes, such as transport mechanisms for drug molecules within tissue and forces exchanged by cancer cells with tissue, may play an equally important role as biological processes in influencing progression and treatment outcome. This book introduces the emerging field of physical oncology to a general audience, with a focus on recent breakthroughs that help in the design and discovery of more effective cancer treatments. It describes how novel mathematical models of physical transport processes incorporate patient tissue and imaging data routinely produced in the clinic to predict the efficacy of many cancer treatment approaches, including chemotherapy and radiation therapy. By helping to identify which therapies would be most beneficial for an individual patient, and quantifying their effects prior to actual implementation in the clinic, physical oncology allows doctors to design treatment regimens customized to each patient’s clinical needs, significantly altering the current clinical approach to cancer treatment and improving the outcomes for patients.

Author : Suhrit Dey,Charlie Dey
Publisher : Springer Nature
Page : 377 pages
File Size : 42,6 Mb
Release : 2022-03-25
Category : Computers
ISBN : 9789811660771

Get Book

Mathematical and Computational Studies on Progress, Prognosis, Prevention and Panacea of Breast Cancer by Suhrit Dey,Charlie Dey Pdf

This book’s aim is to study the mathematical and computational models to analyze the progress, prognosis, prevention, and panacea of breast cancer. The book discusses application of Markov chains and transient mappings, Charlie–Simpson numerical algorithm, models represented by nonlinear reaction–diffusion-type partial differential equations, and related techniques. The book also attempts to design mathematical model of targeted strategic treatments by using Skilled Killer Drugs (SKD1 and SKD2) to suggest the improvisation of future cancer treatments. Both graduate students and researchers of computational biology and oncologists will benefit by studying this book. Researchers of cancer studies and biological sciences will also find this work helpful.

Author : Namrata Tomar
Publisher : Humana
Page : 409 pages
File Size : 48,7 Mb
Release : 2021-03-26
Category : Medical
ISBN : 1071603914

Get Book

Immunoinformatics by Namrata Tomar Pdf

This book covers a wide range of diverse immunoinformatics research topics, involving tools and databases of potential epitope prediction, HLA gene analysis, MHC characterizing, in silico vaccine design, mathematical modeling of host-pathogen interactions, and network analysis of immune system data. In that way, this fully updated volume explores the enormous value of computational tools and models in immunology research. Written for the highly successful Methods in Molecular Biology series, chapters include the kind of key insights and detailed implementation advice to encourage successful results in the lab. Authoritative and practical, Immunoinformatics, Third Edition serves as an ideal guide for scientists working at the intersection of bioinformatics, mathematical modelling, and statistics for the study of immune systems biology.

Author : Regina Padmanabhan,Nader Meskin,Ala-Eddin Al Moustafa
Publisher : Springer
Page : 256 pages
File Size : 41,5 Mb
Release : 2021-11-02
Category : Technology & Engineering
ISBN : 981158642X

Get Book

Mathematical Models of Cancer and Different Therapies by Regina Padmanabhan,Nader Meskin,Ala-Eddin Al Moustafa Pdf

This book provides a unified framework for various currently available mathematical models that are used to analyze progression and regression in cancer development, and to predict its dynamics with respect to therapeutic interventions. Accurate and reliable model representations of cancer dynamics are milestones in the field of cancer research. Mathematical modeling approaches are becoming increasingly common in cancer research, as these quantitative approaches can help to validate hypotheses concerning cancer dynamics and thus elucidate the complexly interlaced mechanisms involved. Even though the related conceptual and technical information is growing at an exponential rate, the application of said information and realization of useful healthcare devices are lagging behind. In order to remedy this discrepancy, more interdisciplinary research works and course curricula need to be introduced in academic, industrial, and clinical organizations alike. To that end, this book reformulates most of the existing mathematical models as special cases of a general model, allowing readers to easily get an overall idea of cancer dynamics and its modeling. Moreover, the book will help bridge the gap between biologists and engineers, as it brings together cancer dynamics, the main steps involved in mathematical modeling, and control strategies developed for cancer management. This also allows readers in both medical and engineering fields to compare and contrast all the therapy-based models developed to date using a single source, and to identify unexplored research directions.

Author : Raluca Eftimie,Dumitru Trucu
Publisher : World Scientific Publishing Europe Limited
Page : 0 pages
File Size : 48,9 Mb
Release : 2024-06-14
Category : Mathematics
ISBN : 1800614373

Get Book

Modelling and Computational Approaches for Multi-Scale Phenomena in Cancer Research: From Cancer Evolution to Cancer Treatment by Raluca Eftimie,Dumitru Trucu Pdf

Cancer development and progression is the result of biological phenomena that occur across multiple temporal and spatial scales. Recent years have seen a flurry of multi-scale mathematical models developed to generate and test new biological hypotheses related to cancer development, progression, and various treatment approaches. This led to the development of new computational and analytical approaches aimed at investigating these multiscale models.This review volume summarises some of the current state of the art related to the modelling, experimental investigation and data assimilation for multiscale phenomena during cancer development, evolution and treatment, as well as computational and analytical investigation of the multi-scale models developed to reproduce the biological phenomena. The book also identifies the experimental and theoretical open problems that will have to be addressed in the near future in order to advance this field. Modelling and Computational Approaches for Multi-scale Phenomena in Cancer Research is an excellent resource for both early career and advanced researchers.

Author : Doron Levy,George Bebis,Russell C. Rockne,Ernesto Augusto Bueno Da Fonseca Lima,Katharina Jahn,Panayiotis V. Benos
Publisher : Frontiers Media SA
Page : 337 pages
File Size : 51,9 Mb
Release : 2022-05-05
Category : Science
ISBN : 9782889741786

Get Book

Advances in Mathematical and Computational Oncology by Doron Levy,George Bebis,Russell C. Rockne,Ernesto Augusto Bueno Da Fonseca Lima,Katharina Jahn,Panayiotis V. Benos Pdf

Author : Beata Ujvari,Benjamin Roche,Frederic Thomas
Publisher : Academic Press
Page : 290 pages
File Size : 54,7 Mb
Release : 2017-02-08
Category : Medical
ISBN : 9780128043806

Get Book

Ecology and Evolution of Cancer by Beata Ujvari,Benjamin Roche,Frederic Thomas Pdf

Ecology and Evolution of Cancer is a timely work outlining ideas that not only represent a substantial and original contribution to the fields of evolution, ecology, and cancer, but also goes beyond by connecting the interfaces of these disciplines. This work engages the expertise of a multidisciplinary research team to collate and review the latest knowledge and developments in this exciting research field. The evolutionary perspective of cancer has gained significant international recognition and interest, which is fully understandable given that somatic cellular selection and evolution are elegant explanations for carcinogenesis. Cancer is now generally accepted to be an evolutionary and ecological process with complex interactions between tumor cells and their environment sharing many similarities with organismal evolution. As a critical contribution to this field of research the book is important and relevant for the applications of evolutionary biology to understand the origin of cancers, to control neoplastic progression, and to prevent therapeutic failures. Covers all aspects of the evolution of cancer, appealing to researchers seeking to understand its origins and effects of treatments on its progression, as well as to lecturers in evolutionary medicine Functions as both an introduction to cancer and evolution and a review of the current research on this burgeoning, exciting field, presented by an international group of leading editors and contributors Improves understanding of the origin and the evolution of cancer, aiding efforts to determine how this disease interferes with biotic interactions that govern ecosystems Highlights research that intends to apply evolutionary principles to help predict emergence and metastatic progression with the aim of improving therapies

Author : George Bebis,Dinler Amaral Antunes,Ken Chen,Mohammad Kohandel,Kathleen Wilkie,Mamoru Kato,Jinzhuang Dou
Publisher : Frontiers Media SA
Page : 374 pages
File Size : 53,6 Mb
Release : 2023-10-25
Category : Medical
ISBN : 9782832536643

Get Book

Advances in mathematical and computational oncology, volume III by George Bebis,Dinler Amaral Antunes,Ken Chen,Mohammad Kohandel,Kathleen Wilkie,Mamoru Kato,Jinzhuang Dou Pdf

Author : Emmanuel Barillot,Laurence Calzone,Philippe Hupe,Jean-Philippe Vert,Andrei Zinovyev
Publisher : CRC Press
Page : 463 pages
File Size : 40,9 Mb
Release : 2012-08-25
Category : Science
ISBN : 9781439831441

Get Book

Computational Systems Biology of Cancer by Emmanuel Barillot,Laurence Calzone,Philippe Hupe,Jean-Philippe Vert,Andrei Zinovyev Pdf

The future of cancer research and the development of new therapeutic strategies rely on our ability to convert biological and clinical questions into mathematical models—integrating our knowledge of tumour progression mechanisms with the tsunami of information brought by high-throughput technologies such as microarrays and next-generation sequencing. Offering promising insights on how to defeat cancer, the emerging field of systems biology captures the complexity of biological phenomena using mathematical and computational tools. Novel Approaches to Fighting Cancer Drawn from the authors’ decade-long work in the cancer computational systems biology laboratory at Institut Curie (Paris, France), Computational Systems Biology of Cancer explains how to apply computational systems biology approaches to cancer research. The authors provide proven techniques and tools for cancer bioinformatics and systems biology research. Effectively Use Algorithmic Methods and Bioinformatics Tools in Real Biological Applications Suitable for readers in both the computational and life sciences, this self-contained guide assumes very limited background in biology, mathematics, and computer science. It explores how computational systems biology can help fight cancer in three essential aspects: Categorising tumours Finding new targets Designing improved and tailored therapeutic strategies Each chapter introduces a problem, presents applicable concepts and state-of-the-art methods, describes existing tools, illustrates applications using real cases, lists publically available data and software, and includes references to further reading. Some chapters also contain exercises. Figures from the text and scripts/data for reproducing a breast cancer data analysis are available at www.cancer-systems-biology.net.

Author : João Manuel R. S. Tavares,Paulo Rui Fernandes
Publisher : Springer
Page : 0 pages
File Size : 53,9 Mb
Release : 2020-08-15
Category : Medical
ISBN : 3030230759

Get Book

New Developments on Computational Methods and Imaging in Biomechanics and Biomedical Engineering by João Manuel R. S. Tavares,Paulo Rui Fernandes Pdf

This book gathers selected, extended and revised contributions to the 15th International Symposium on Computer Methods in Biomechanics and Biomedical Engineering (CMBBE2018), and the 3rd Conference on Imaging and Visualization, which took place on 26-29 March, 2018, in Lisbon, Portugal. The respective chapters highlight cutting-edge methods, e.g. new algorithms, image analysis techniques, and multibody modeling methods; and new findings obtained by applying them in biological and/or medical contexts. Original numerical studies, Monte Carlo simulations, FEM analyses and reaction-diffusion models are described in detail, together with intriguing new applications. The book offers a timely source of information for biologists, engineers, applied mathematicians and clinical researchers working on multidisciplinary projects, and is also intended to foster closer collaboration between these groups.

Author : Christine E. Engeland
Publisher : Humana
Page : 329 pages
File Size : 54,7 Mb
Release : 2020-09-19
Category : Medical
ISBN : 1493997963

Get Book

Oncolytic Viruses by Christine E. Engeland Pdf

This book aims to provide a guide for virologists, translational researchers, and clinicians in the field of cancer research by providing reference protocols and methodologies from vector development through clinical translation. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Oncolytic Viruses: Methods and Protocols aims to ensure successful results in the further study of this vital field.

Author : Jianmei Wu Leavenworth,Lewis Z. Shi,Xi Wang,Haiming Wei
Publisher : Frontiers Media SA
Page : 244 pages
File Size : 45,8 Mb
Release : 2022-02-22
Category : Medical
ISBN : 9782889744732

Get Book

Immune Cell Lineage Reprogramming in Cancer by Jianmei Wu Leavenworth,Lewis Z. Shi,Xi Wang,Haiming Wei Pdf

Topic Editor Dr. Lewis Shi received financial support from Varian Medical System, Inc. The other Topic Editors declare no competing interests with regard to the Research Topic subject.

Author : John A. Adam,Nicola Bellomo
Publisher : Springer Science & Business Media
Page : 357 pages
File Size : 52,9 Mb
Release : 2012-10-06
Category : Mathematics
ISBN : 9780817681197

Get Book

A Survey of Models for Tumor-Immune System Dynamics by John A. Adam,Nicola Bellomo Pdf

Mathematical Modeling and Immunology An enormous amount of human effort and economic resources has been directed in this century to the fight against cancer. The purpose, of course, has been to find strategies to overcome this hard, challenging and seemingly endless struggle. We can readily imagine that even greater efforts will be required in the next century. The hope is that ultimately humanity will be successful; success will have been achieved when it is possible to activate and control the immune system in its competition against neoplastic cells. Dealing with the above-mentioned problem requires the fullest pos sible cooperation among scientists working in different fields: biology, im munology, medicine, physics and, we believe, mathematics. Certainly, bi ologists and immunologists will make the greatest contribution to the re search. However, it is now increasingly recognized that mathematics and computer science may well able to make major contributions to such prob lems. We cannot expect mathematicians alone to solve fundamental prob lems in immunology and (in particular) cancer research, but valuable sup port, however modest, can be provided by mathematicians to the research aspirations of biologists and immunologists working in this field.