Mechanisms Of Cell Death Ii

Author : International Cell Death Society. Conference
Publisher : Unknown
Page : 238 pages
File Size : 48,9 Mb
Release : 2000
Category : Science
ISBN : 1573313203

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Mechanisms of Cell Death II by International Cell Death Society. Conference Pdf

Cell death and apoptosis are increasingly recognized as critical in normal development disease and ageing. The contributors to this volume, among the most prominent in the field, review: the known types of cell death; the means by which the methodologies affect the interpretations; the role of cell death genes when cells are not dying; how cells interpret signals and why the response differs according to the physiology of the cell; the roles of proteases other than caspases; and the importance of phagocytosis in cell death and its measurement. Proceedings of a May 2000 conference.

Author : Zahra Zakeri,Richard A. Lockshin,Luis Benitez-Bribiesca
Publisher : Unknown
Page : 236 pages
File Size : 47,7 Mb
Release : 1999
Category : Science
ISBN : STANFORD:36105024897386

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Mechanisms of Cell Death by Zahra Zakeri,Richard A. Lockshin,Luis Benitez-Bribiesca Pdf

Contains papers from a July 1998 conference held at the Queens College Campus of the City University of New York. Papers are arranged in sections on mechanisms and general considerations, programmed (developmental) cell death, and cell death and pathological and clinical situations. Specific topics

Author : Douglas R. Green
Publisher : Unknown
Page : 250 pages
File Size : 55,9 Mb
Release : 2018-09-30
Category : Science
ISBN : 1621822141

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Cell Death by Douglas R. Green Pdf

One million cells in our bodies die every second--they commit suicide by a mechanism known as apoptosis. Apoptosis is essential for survival of the body as a whole and has critical roles in various developmental processes and the immune system. In Cell Death, Douglas Green provides a clear and comprehensive view of apoptosis and other cell death mechanisms. Taking a bottom-up approach, he starts with the enzymes that perform the execution process (a family of proteases termed caspases) and examines their cellular targets and the ways in which they are activated. He then looks at the molecular machinery that links signals that cause cell death to caspases, emphasizing the importance of the BCL-2 family of proteins and the role of cytochrome c released from mitochondria. The final stage of the process, phagocytic removal of dead or dying cells, is also covered. Green outlines the roles of apoptosis and death mechanisms such as necrosis in embryogenesis, neuronal selection, and the development of self-tolerance in the immune system. In addition, he explains how cell death defends the body against cancer and traces the evolutionary origins of the apoptosis machinery back over a billion years. This new edition contains critical new information on recent exciting advances in the field, such as new forms for cell death and important insights into the mechanisms and control of apoptosis. The book is thus of great use to all biologists interested in how cells function in the context of multicellular organisms and will appeal to everyone from undergraduates encountering the topic for the first time to researchers actively working in the field.

Author : Diaqing Liao
Publisher : Academic Press
Page : 298 pages
File Size : 41,8 Mb
Release : 2021-10-26
Category : Science
ISBN : 9780128142097

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Mechanisms of Cell Death and Opportunities for Therapeutic Development by Diaqing Liao Pdf

Mechanisms of Cell Death and Opportunities for Therapeutic Development, volume four in the Perspectives in Translational Cell Biology series, offers content for professors, students and researchers across basic and translational biology. The book covers fundamental mechanisms, ranging from different forms of cell death and drug development, to efforts for treating disease, providing a valuable resource for readers interested in understanding cell death and relevant translational research. The book's editor, Diaqing Liao, has over twenty years’ experience teaching topics of cell death. Provides a comprehensive overview of current knowledge on the process of apoptosis, its potential role in health and disease, and a discussion of potential alternative forms, such as autophagy Covers fundamental mechanisms and relevant translational research

Author : Zahra Zakeri,Richard A. Lockshin,Luis Benitez-Bribiesca
Publisher : Unknown
Page : 128 pages
File Size : 50,7 Mb
Release : 2001
Category : Electronic
ISBN : OCLC:757460776

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Mechanisms of Cell Death by Zahra Zakeri,Richard A. Lockshin,Luis Benitez-Bribiesca Pdf

Author : Kazuwa Nakao,Nagahiro Minato,Shinji Uemoto
Publisher : Springer
Page : 330 pages
File Size : 44,6 Mb
Release : 2015-10-13
Category : Science
ISBN : 9784431556510

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Innovative Medicine by Kazuwa Nakao,Nagahiro Minato,Shinji Uemoto Pdf

This book is devoted to innovative medicine, comprising the proceedings of the Uehara Memorial Foundation Symposium 2014. It remains extremely rare for the findings of basic research to be developed into clinical applications, and it takes a long time for the process to be achieved. The task of advancing the development of basic research into clinical reality lies with translational science, yet the field seems to struggle to find a way to move forward. To create innovative medical technology, many steps need to be taken: development and analysis of optimal animal models of human diseases, elucidation of genomic and epidemiological data, and establishment of “proof of concept”. There is also considerable demand for progress in drug research, new surgical procedures, and new clinical devices and equipment. While the original research target may be rare diseases, it is also important to apply those findings more broadly to common diseases. The book covers a wide range of topics and is organized into three complementary parts. The first part is basic research for innovative medicine, the second is translational research for innovative medicine, and the third is new technology for innovative medicine. This book helps to understand innovative medicine and to make progress in its realization.

Author : Yufang Shi,John A. Cidlowski,David W. Scott,Jia-Rui Wu,Yun Bo Shi
Publisher : Springer Science & Business Media
Page : 229 pages
File Size : 46,9 Mb
Release : 2013-06-29
Category : Medical
ISBN : 9781475758900

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Molecular Mechanisms of Programmed Cell Death by Yufang Shi,John A. Cidlowski,David W. Scott,Jia-Rui Wu,Yun Bo Shi Pdf

The 2002 Nobel Prize in Physiology or Medicine was awarded to Sydney Brenner, H. Robert Horvitz, and John E. Sulston for their seminal discoveries concerning "genetic regulation of organ development and programmed cell death." This clearly marked the prime importance of understanding the molecular mechanisms controlling cell death. The 1 st International Symposium on Programmed Cell Death was held in the Shanghai Science Center of the Chinese Academy of Sciences on September 8-12, 1996. A number of key issues in apoptosis were discussed at the meeting, and progress in major areas of apopto sis research was summarized by expert participants at the meeting and published by Plenum Publishing Corporation as a book entitled Programmed Cell Death. In the last six years, we have witnessed a real explosion in our knowledge on how cells undergo apoptosis, thereby participating in various developmental and pathophysiological processes. At this ever exciting time, we organized the 2nd International Symposium on Programmed Cell Death.

Author : Roya Khosravi-Far,Eileen White
Publisher : Springer Science & Business Media
Page : 356 pages
File Size : 49,9 Mb
Release : 2007-12-29
Category : Medical
ISBN : 9781402065545

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Programmed Cell Death in Cancer Progression and Therapy by Roya Khosravi-Far,Eileen White Pdf

Programmed cell death (PCD) plays pivotal roles in tumor progression, cancer therapeutics and resistance of tumor cells to therapy. This book examines the mechanisms involved in mediating and regulating PCD in cancer. It also provides a detailed indication of the utility of PCD in cancer therapy. The book features chapters on the current and future of RNA interference in therapeutics and Pathways involved in Stem Cell Survival and Death.

Author : Rakesh Srivastava
Publisher : Springer Science & Business Media
Page : 402 pages
File Size : 45,7 Mb
Release : 2007-11-05
Category : Science
ISBN : 9781597451994

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Apoptosis, Cell Signaling, and Human Diseases by Rakesh Srivastava Pdf

Apoptosis, Cell Signaling, and Human Diseases: Molecular Mechanisms, Volumes 1 and 2, present a concise synthesis of recent developments in the understanding of both cell survival and apoptotic pathways. Particular attention is given to apoptosis in human diseases, such as different forms of cancer. These comprehensive volumes integrate the most innovative and current findings. The contributors are at the forefront of scientific discovery.

Author : Sharad Kumar
Publisher : Springer Science & Business Media
Page : 276 pages
File Size : 52,7 Mb
Release : 1998-11-05
Category : Science
ISBN : 3540646248

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Apoptosis: Mechanisms and Role in Disease by Sharad Kumar Pdf

This volume deals with many of the recent advances made in uncovering the molecular and cellular basis of apoptosis and elaborates on how this accumulating knowledge is helping us to understand the significance of apoptosis in pathogenesis of diseases arising from inappropriate cell death. Further, mechanistic aspects of cell death and role of apoptosis in disease is covered.

Author : Robert C. Bast, Jr.,Carlo M. Croce,William N. Hait,Waun Ki Hong,Donald W. Kufe,Martine Piccart-Gebhart,Raphael E. Pollock,Ralph R. Weichselbaum,Hongyang Wang,James F. Holland
Publisher : John Wiley & Sons
Page : 2008 pages
File Size : 54,8 Mb
Release : 2017-03-10
Category : Medical
ISBN : 9781119000846

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Holland-Frei Cancer Medicine by Robert C. Bast, Jr.,Carlo M. Croce,William N. Hait,Waun Ki Hong,Donald W. Kufe,Martine Piccart-Gebhart,Raphael E. Pollock,Ralph R. Weichselbaum,Hongyang Wang,James F. Holland Pdf

Holland-Frei Cancer Medicine, Ninth Edition, offers a balanced view of the most current knowledge of cancer science and clinical oncology practice. This all-new edition is the consummate reference source for medical oncologists, radiation oncologists, internists, surgical oncologists, and others who treat cancer patients. A translational perspective throughout, integrating cancer biology with cancer management providing an in depth understanding of the disease An emphasis on multidisciplinary, research-driven patient care to improve outcomes and optimal use of all appropriate therapies Cutting-edge coverage of personalized cancer care, including molecular diagnostics and therapeutics Concise, readable, clinically relevant text with algorithms, guidelines and insight into the use of both conventional and novel drugs Includes free access to the Wiley Digital Edition providing search across the book, the full reference list with web links, illustrations and photographs, and post-publication updates

Author : James A. Radosevich
Publisher : John Wiley & Sons
Page : 784 pages
File Size : 41,5 Mb
Release : 2018-09-18
Category : Science
ISBN : 9781119432357

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Apoptosis and Beyond by James A. Radosevich Pdf

These volumes teach readers to think beyond apoptosis and describes all of the known processes that cells can undergo which result in cell death This two-volume source on how cells dies is the first, comprehensive collection to cover all of the known processes that cells undergo when they die. It is also the only one of its kind to compare these processes. It seeks to enlighten those in the field about these many processes and to stimulate their thinking at looking at these pathways when their research system does not show signs of activation of the classic apoptotic pathway. In addition, it links activities like the molecular biology of one process (eg. Necrosis) to another process (eg. apoptosis) and contrasts those that are close to each. Volume 1 of Apoptosis and Beyond: The Many Ways Cells Die begins with a general view of the cytoplasmic and nuclear features of apoptosis. It then goes on to offer chapters on targeting the cell death mechanism; microbial programmed cell death; autophagy; cell injury, adaptation, and necrosis; necroptosis; ferroptosis; anoikis; pyronecrosis; and more. Volume 2 covers such subjects as phenoptosis; pyroptosis; hematopoiesis and eryptosis; cyclophilin d-dependent necrosis; and the role of phospholipase in cell death. Covers all known processes that dying cells undergo Provides extensive coverage of a topic not fully covered before Offers chapters written by top researchers in the field Provides activities that link and contrast processes to each other Apoptosis and Beyond: The Many Ways Cells Die will appeal to students and researchers/clinicians in cell biology, molecular biology, oncology, and tumor biology.

Author : Sudhir Gupta,J. John Cohen
Publisher : Springer Science & Business Media
Page : 268 pages
File Size : 41,6 Mb
Release : 2013-06-29
Category : Medical
ISBN : 9781489902740

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Mechanisms of Lymphocyte Activation and Immune Regulation VI by Sudhir Gupta,J. John Cohen Pdf

Since programmed cell death was first described in insects in 1964 and apoptosis was described in 1972, rapid progress has been made in understanding the basic mechanisms and genes regulating programmed cell death and apoptosis. In addition, defects in various genes regulating programmed cell death have been delineated in several experimental models of human diseases. This volume surveys various aspects of these rapidly developing areas of research in programmed cell death/apoptosis. This volume should be of interest to basic immunologists and molecular biologists. The volume begins with a historical perspective of cell death. The remainder of the volume is divided into four different parts. Part I deals with the signaling pathways in apoptosis, including cell cycle control of apoptosis, role of ceramide in apoptosis, role of antibody signaling, and biochemical regulation of apoptosis. The mechanisms for recognition of apoptotic lymphocytes by macrophages are also reviewed. Part II examines the role of various genes that regulate apoptosis, including the role ofFas, FasL, and other TNF family members in apoptosis and homeostatic regulation of immune response. Recently described splice variants and their influence on apoptosis are also reviewed, and the role of the members of the Bcl-2 family in apoptosis is discussed in detail. Part III reviews various aspects of apoptosis in B lymphocytes, including mechanisms that regulate apoptosis/survival of B lymphocytes and the regulation of Fas-mediated apoptosis in B lymphocytes.

Author : Richard A. Lockshin,Zahra Zakeri
Publisher : Wiley-Liss
Page : 578 pages
File Size : 42,6 Mb
Release : 2004
Category : Medical
ISBN : UOM:39015061138270

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When Cells Die II by Richard A. Lockshin,Zahra Zakeri Pdf

Offers the most thorough, cutting-edge coverage of the field of cell death since publication of the first edition. Leading international researchers present an up-to-date yet accessible survey ranging from the history of cell death science to its modern methodology. Extensively revised, this new edition features relavant discussions of: the impact of genomics and proteomics; gene therapy and pharmacogenetics; the role of mitochondria; caspase-independent and non-apoptotic cell death; and evolution of mechanisms.

Author : Shigekazu Nagata,Hiroyasu Nakano
Publisher : Springer
Page : 183 pages
File Size : 55,9 Mb
Release : 2017-04-07
Category : Medical
ISBN : 9783319239132

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Apoptotic and Non-apoptotic Cell Death by Shigekazu Nagata,Hiroyasu Nakano Pdf

This volume focuses on apoptotic and non-apoptotic programmed cell death, including necroptosis, pyroptosis, and ferroptosis, and presents recent findings in the field. It discusses the crucial role that apoptotic and non-apoptotic cell death play in various pathological conditions, such as skin diseases, inflammatory bowel diseases, and virus infections. Further, it highlights the mechanisms underlying the recognition and clearance of dead cells, and the subsequent biological responses triggered by phagocytosed macrophages and factors released from dying cells. Offering insights into cell death, it is a valuable resource for researchers and clinicians developing novel strategies to treat various diseases that are closely associated with cell death.