Methods Of Therapeutic Drug Monitoring Including Pharmacogenetics

Author : Georg Hempel
Publisher : Elsevier
Page : 380 pages
File Size : 45,5 Mb
Release : 2019-10-17
Category : Science
ISBN : 9780444640673

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Methods of Therapeutic Drug Monitoring Including Pharmacogenetics by Georg Hempel Pdf

Methods of Therapeutic Drug Monitoring Including Pharmacogenetics, Second Edition, Volume Seven in the Handbook of Analytical Separations series, covers all aspects of drug monitoring, including laboratory work, pharmacokinetic analysis and clinical aspects, thus enabling readers from different fields to understand the whole process of therapeutic drug monitoring and how to avoid common pitfalls. The book contains analytical techniques for the quantification of drugs, along with pharmacogenetic and pharmacogenomic methods. Also included are updates on sample preparation, including dried blood spot technology and microextraction methods. In addition, the book includes new drugs, such as tyrosine kinase inhibitors and the monitoring of immunosuppressant drugs. Presents a unique, interdisciplinary approach that appeals to a wide range of users Written by authors from international labs, providing a global perspective that can be applied in various regulatory environments Features additional therapeutic drugs to reflect the rising number of immunocompromised patients Includes a new mass spectroscopic methods chapter to capture the frequent use in TDM and the improved availability of LC-MS across laboratories

Author : Amitava Dasgupta
Publisher : Academic Press
Page : 469 pages
File Size : 55,5 Mb
Release : 2012-06-07
Category : Medical
ISBN : 9780123854681

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Therapeutic Drug Monitoring by Amitava Dasgupta Pdf

Therapeutic Drug Monitoring: Newer Drugs and Biomarkers features timely topics such as the monitoring of classical and newer drugs, pharmacogenomics and the application of biomarkers in therapeutic drug monitoring. This reference also discusses the limitations of current commercially available immunoassays for therapeutic monitoring. It presents new and sophisticated techniques used for proper determination of blood levels and the clinical utility of therapeutic drug monitoring of contemporary drugs. Written by leading international experts and geared toward clinical pathologists, toxicologists, clinical chemists, laboratory professionals and physicians, this book is an essential resource on the current practice of therapeutic drug monitoring in improving patient safety. Includes both the technical and clinical issues associated with therapeutic drug monitoring Discusses the utility of therapeutic drug monitoring of newer drugs such as antiretroviral agents, anticonvulsants, antidepressants etc. Provides up-to-date information on issues in pharmacogenomics and personalized medicine with emphasis on therapy with warfarin, certain anticancer drugs and antidepressants Covers important content on the limitations of commercially available immunoassays (chemical tests) for therapeutic drug monitoring and additional analytical techniques

Author : William Clarke,Amitava Dasgupta
Publisher : Elsevier
Page : 376 pages
File Size : 48,9 Mb
Release : 2016-07-21
Category : Medical
ISBN : 9780128020524

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Clinical Challenges in Therapeutic Drug Monitoring by William Clarke,Amitava Dasgupta Pdf

Clinical Challenges in Therapeutic Drug Monitoring: Special Populations, Physiological Conditions and Pharmacogenomics focuses on critical issues in therapeutic drug monitoring including special requirements of therapeutic drug monitoring important to special populations (infants and children, pregnant women, elderly patients, and obese patients). The book also covers issues of free drug monitoring and common interferences in using immunoassays for therapeutic drug monitoring. This book is essential reading for any clinician, fellow, or trainee who wants to gain greater insight into the process of therapeutic drug monitoring for individual dosage adjustment and avoiding drug toxicity for certain drugs within a narrow therapeutic window. The book is written specifically for busy clinicians, fellows, and trainees who order therapeutic drug monitoring and need to get more familiar with testing methodologies, issues of interferences, and interpretation of results in certain patient populations. Offers busy clinicians, pathologists, and trainees a concise resource on the key aspects and critical issues in therapeutic drug monitoring Focuses on patient populations such as infants and children, pregnant women, elderly patients, and obese patients, who have special requirements in therapeutic drug monitoring Explores special topics in therapeutic drug monitoring including free drug monitoring and common immunoassay interference Explains how individual dosage adjustments can prevent drug toxicity for certain drugs within a narrow therapeutic window

Author : Seth Kwabena Amponsah,Yashwant V. Pathak
Publisher : Springer Nature
Page : 384 pages
File Size : 41,7 Mb
Release : 2022-10-25
Category : Medical
ISBN : 9783031123986

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Recent Advances in Therapeutic Drug Monitoring and Clinical Toxicology by Seth Kwabena Amponsah,Yashwant V. Pathak Pdf

This book gives an overview of therapeutic drug monitoring (TDM) and its clinical application. It also highlights recent advances in toxicological studies, as they relate to therapeutic drug monitoring. This is one of the few books available on the market that covers TDM. Therapeutic drug monitoring (TDM) is a clinical decision-making tool that enables dosage regimen adjustments based on clinical and laboratory measurements. TDM not only involves the measuring of drug concentrations but also interpretation of the results. There is a strong correlation between drug concentrations in body fluids and outcome than between dose and outcome. The chapters include coverage of analytical techniques, pharmacokinetics, therapeutic indices, artificial intelligence and recent advances in toxicological studies. The book fills a gap in published literature and provides reliable information on; Analytical techniques in TDM and clinical toxicology TDM and pharmacokinetic studies TDM of drugs with narrow therapeutic indices Artificial intelligence in TDM and clinical toxicology Future directions and challenges

Author : Loralie J. Langman,Amitava Dasgupta
Publisher : John Wiley & Sons
Page : 400 pages
File Size : 40,6 Mb
Release : 2012-01-09
Category : Medical
ISBN : 9781119959588

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Pharmacogenomics in Clinical Therapeutics by Loralie J. Langman,Amitava Dasgupta Pdf

Pharmacogenomics is the basis of personalized medicine which will be the medicine of the future. Through both reducing the numbers of adverse drug reactions and improving the use of existing drugs in targeted populations, pharmacogenomics represents a real advance on traditional therapeutic drug monitoring. Pharmacogenomics in Clinical Therapeutics provides an introduction to the principles of pharmacogenomics before addressing the pharmacogenomic aspects of key therapeutic areas such as warfarin therapy, cancer chemotherapy, therapy with immunosuppressants, antiretroviral therapy, and psychoactive drugs. It also includes methods of pharmacogenomic testing and the pharmacogenomic aspects of drug–drug interactions. From a team of expert contributors, Pharmacogenomics in Clinical Therapeutics is a comprehensive overview of the current state of pharmacogenomics in pharmacotherapy for all clinicians, pharmacologists and clinical laboratory professionals. It is also a guide for practicing clinicians and health care professionals to the basic principles of pharmacogenomics, laboratory tests currently available to aid clinicians, and the future promise of this developing field.

Author : Q. Alan Xu,Timothy L. Madden
Publisher : John Wiley & Sons
Page : 913 pages
File Size : 44,6 Mb
Release : 2011-04-12
Category : Science
ISBN : 9780470922798

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Analytical Methods for Therapeutic Drug Monitoring and Toxicology by Q. Alan Xu,Timothy L. Madden Pdf

This book is a compilation of summarized analytical methods designed to serve the needs of pharmacologists, toxicologists, and other allied health professionals involved the development, use, or monitoring of pharmaceuticals. The summaries are structured monographs on 511 different drug entities detailing 964 different analytical methods, providing the reader with a thorough description of method validation. These analytical methods include not only high performance liquid chromatography (HPLC), but also gas chromatography (GC), immunoassay, electrophoresis, ultra performance liquid chromatography (UPLC) coupled with UV (UPLC-UV) detection and mass spectrometry (UPLC-MS/MS). With more detailed and complete summaries than sketchy and abbreviated formats used in the other books, this book provides a thorough description of method validation and results, as well as the operating parameters.

Author : Benjamin Gerson
Publisher : Unknown
Page : 231 pages
File Size : 47,5 Mb
Release : 1987
Category : Electronic
ISBN : OCLC:643032666

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Therapeutic drug monitoring by Benjamin Gerson Pdf

Author : Amitava Dasgupta
Publisher : Springer Science & Business Media
Page : 441 pages
File Size : 44,7 Mb
Release : 2007-10-23
Category : Medical
ISBN : 9781588297808

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Handbook of Drug Monitoring Methods by Amitava Dasgupta Pdf

Written in a handbook style with specific methods and tips on eliminating false positive and false negative results, this book is a practical guide to the detailed mechanisms of such occurrences.

Author : Weimin Cai,Zhaoqian Liu,Liyan Miao,Xiaoqiang Xiang
Publisher : Springer
Page : 289 pages
File Size : 41,9 Mb
Release : 2021-06-13
Category : Medical
ISBN : 9811538972

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Pharmacogenomics in Precision Medicine by Weimin Cai,Zhaoqian Liu,Liyan Miao,Xiaoqiang Xiang Pdf

This book provides an introduction to the principles of pharmacogenomics and precision medicine, followed by the pharmacogenomics aspects of major therapeutic areas such as cardiovascular disease, cancer, organ transplantation, psychiatry, infection, antithrombotic drugs. It also includes genotyping technology and therapeutic drug monitoring in Pharmacogenomics; ethical, Legal and Regulatory Issues; cost-effectiveness of pharmacogenetics-guided treatment; application of pharmacogenomics in drug discovery and development and clinical Implementation of Pharmacogenomics for Personalized Precision Medicine. The contributors of Pharmacogenomics in Precision Medicine come from a team of experts, including professors from academic institutions and practitioner from hospital. It will give an in-depth overview of the current state of pharmacogenomics in drug therapy for all health care professionals and graduate students in the era of precision medicine.

Author : Amitava Dasgupta,Matthew Krasowski
Publisher : Academic Press
Page : 382 pages
File Size : 53,8 Mb
Release : 2019-09-14
Category : Science
ISBN : 9780128158500

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Therapeutic Drug Monitoring Data by Amitava Dasgupta,Matthew Krasowski Pdf

Therapeutic Drug Monitoring Data: A Concise Guide, Fourth Edition serves as a ready resource of information on commonly monitored drugs that will help readers make decisions relating to the monitoring and interpretation of results. It is an easy-to-read source of information on intended use, pharmacokinetics, therapeutic range, and toxic concentrations, as well as bioavailability, disposition, metabolism and the excretion of commonly monitored therapeutic drugs. This fully updated fourth edition includes sections on new anticonvulsants, anti-depressant and anti-HIV drugs, new drugs for advanced cancer treatment, and thoroughly updated chapters that address new pitfalls and problems in the lab. Serves as a ready resource of information for commonly monitored drugs Presents a useful, quick guide for those making decisions related to monitoring and interpretation of results Provides concise, easily digestible content for clinical laboratory scientists, toxicologists and clinicians

Author : Anonim
Publisher : Unknown
Page : 414 pages
File Size : 52,8 Mb
Release : 1982
Category : Chemotherapy
ISBN : UCLA:31158009743732

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Applied Therapeutic Drug Monitoring by Anonim Pdf

Author : William E. Evans,Jerome J. Schentag,William J. Jusko
Publisher : Applied Therapeutics, Incorporated
Page : 1236 pages
File Size : 54,7 Mb
Release : 1992
Category : Chemotherapy
ISBN : UOM:39015013811040

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Applied Pharmacokinetics by William E. Evans,Jerome J. Schentag,William J. Jusko Pdf

The Third Edition of Applied Pharmacokinetics remains the gold standard by which all other clinical pharmacokinetics texts are measured. Written by leading pharmacokinetics researchers and practitioners, this book is the most advanced kinetics reference available. All chapters have been extensively updated or completely rewritten for this edition, and six new chapters have been added on pharmacodynamics, pharmacogenetics, pharmacokinetic considerations in the obese, dietary influences on drug disposition, zidovudine, and corticosteroids. Each chapter is tightly focused on the most important concepts and issues. Chapters on specific drugs are organized in a consistent format for quick, easy information retrieval. Major subheadings include Clinical Pharmacokinetics, Pharmacodynamics, Clinical Application of Pharmacokinetic Data, Analytical Methods, and Prospectus.

Author : Kewal K. Jain
Publisher : Humana Press
Page : 762 pages
File Size : 40,7 Mb
Release : 2015-03-17
Category : Medical
ISBN : 9781493925537

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Textbook of Personalized Medicine by Kewal K. Jain Pdf

Advances in the technology used in personalized medicine and increased applications for clinical use have created a need for this expansion and revision of Kewal K. Jain’s Textbook of Personalized Medicine. As the first definitive work on this topic, this book reviews the fundamentals and development of personalized medicine and subsequent adoptions of the concepts by the biopharmaceutical industry and the medical profession. It also discusses examples of applications in key therapeutic areas, as well as ethical and regulatory issues, providing a concise and comprehensive source of reference for those involved in healthcare management, planning and politics. Algorithms are included as a guide to those involved in the management of important diseases where decision-making is involved due to the multiple choices available. Textbook of Personalized Medicine, Second Edition will serve as a convenient source of information for physicians, scientists, decision makers in the biopharmaceutical and healthcare industries and interested members of the public.

Author : Catherine A. Hammett-Stabler,Amitava Dasgupta
Publisher : Unknown
Page : 241 pages
File Size : 48,8 Mb
Release : 2007-01-01
Category : Drug monitoring
ISBN : 1594250758

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Therapeutic Drug Monitoring Data by Catherine A. Hammett-Stabler,Amitava Dasgupta Pdf

Author : Alan Talevi,Pablo A. M. Quiroga
Publisher : Springer
Page : 362 pages
File Size : 47,8 Mb
Release : 2018-11-30
Category : Medical
ISBN : 9783319995939

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ADME Processes in Pharmaceutical Sciences by Alan Talevi,Pablo A. M. Quiroga Pdf

Absorption, Distribution, Metabolism and Excretion (ADME) processes and their relationship with the design of dosage forms and the success of pharmacotherapy form the basis of this upper level undergraduate/graduate textbook. As an introduction oriented to pharmacy students, it is also written for scientist from different fields outside of pharmaceutics. (e.g. material scientist, material engineers, medicinal chemists) who might be working in a positions in pharmaceutical companies or whose work might benefit from basic training in the ADME concepts and some biological background. Pedagogical features such as objectives, keywords, discussion questions, summaries and case studies add valuable teaching tools. This book will provide not only general knowledge on ADME processes but also an updated insight on some hot topics such as drug transporters, multi-drug resistance related to pharmacokinetic phenomena, last generation pharmaceutical carriers (nanopharmaceuticals), in vitro and in vivo bioequivalence studies, biopharmaceuticals, pharmacogenomics, drug-drug and food-drug interactions, and in silico and in vitro prediction of ADME properties. In comparison with other similar textbooks, around half of the volume would be focused on the relationship between expanding scientific fields and ADME processes. Each of these burgeoning fields has a separate chapter in the second part of the volume, and was written with leading experts on the correspondent topic, including scientists and academics from USA and UK (Duquesne University School of Pharmacy, Indiana University School of Medicine, University of Utah College of Pharmacy, University of Maryland, University of Bath). Additionally, each of the initial chapters dealing with the generalities of drug absorption, distribution, metabolism and excretion would include relevant, classic examples related to each topic with appropriate illustrations (e.g. importance of active absorption of levodopa, implications in levodopa administration, drug drug interactions and food drug interactions emerging from the active uptake; intoxication with paracetamol as a result of glutathione depletion, CYP induction and its relationship with acute liver failure caused by paracetamol, etc). ADME Processes and Pharmaceutical Sciences is written as a core textbook for ADME processes, pharmacy, pharmacokinetics, drug delivery, biopharmaceutics, drug disposition, drug design and medicinal chemistry courses.